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Päivi Östling
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Journal Articles

Abstract 6612: Data-driven hallmarks of cancer as a new paradigm for precision medicine: multi-omics and functional profiling in acute myeloid leukemia

Tom Erkers, Nona Struyf, Tojo James, Francesco Marabita, Mattias Vesterlund, Nghia Vu, Cornelia Arnroth, Albin Österroos, Anna Bohlin, Sofia Bengtzén, Matthias Stahl, Rozbeh Jafari, Lukas Orre, Yudi Pawitan, Brinton Seashore-Ludlow, Janne Lehtiö, Sören Lehmann, Päivi Östling, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6612.
https://doi.org/10.1158/1538-7445.AM2023-6612
Published: 04 April 2023
View article titled, Abstract 6612: Data-driven hallmarks of cancer as a new paradigm for precision medicine: multi-omics and functional profiling in acute myeloid leukemia
Journal Articles

Abstract 4578: Miniaturized and multiplexed evaluation of NK cell cytotoxicity and infiltration in patient-derived sarcoma spheroids using a novel multichambered microwell chip

Valentina Carannante, Niklas Sandström, Karl Olofsson, Shi Yong Neo, Patrick Albert Sandoz, Hanna Van Ooijen, Quentin Verron, Jacopo Fontana, Damien Toullec, Elisabeth Moussaud-Lamodière, Brinton Seashore-Ludlow, Thomas Frisk, Madoka Takai, Päivi Östling, Felix Haglund, Andreas Lundqvist, Martin Wiklund, Björn Önfelt
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4578.
https://doi.org/10.1158/1538-7445.AM2023-4578
Published: 04 April 2023
View article titled, Abstract 4578: Miniaturized and multiplexed evaluation of NK cell cytotoxicity and infiltration in patient-derived sarcoma spheroids using a novel multichambered microwell chip
Journal Articles

Abstract 1890: Development of the drug efficacy testing in ex vivo 3D cultures (DETECT) platform and its application to functional precision medicine in ovarian cancer

Emma Åkerlund, Greta Gudoityte, Elisabeth Moussaud Lamodiere, Joseph Carlson, Emelie Wallin, Josefin Fernebro, Olli Kallioniemi, Päivi Östling, Ulrika Joneborg, Brinton Seashore-Ludlow
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1890.
https://doi.org/10.1158/1538-7445.AM2022-1890
Published: 15 June 2022
View article titled, Abstract 1890: Development of the drug efficacy testing in <em>ex vivo</em> 3D cultures (DETECT) platform and its application to functional precision medicine in ovarian cancer
Journal Articles

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Kumar Sanjiv, José Manuel Calderón-Montaño, Therese M. Pham, Tom Erkers, Viktoriia Tsuber, Ingrid Almlöf, Andreas Höglund, Yaser Heshmati, Brinton Seashore-Ludlow, Akhilesh Nagesh Danda, Helge Gad, Elisee Wiita, Camilla Göktürk, Azita Rasti, Stefanie Friedrich, Anders Centio, Montserrat Estruch, Thea Kristin Våtsveen, Nona Struyf, Torkild Visnes, Martin Scobie, Tobias Koolmeister, Martin Henriksson, Olov Wallner, Teresa Sandvall, Sören Lehmann, Kim Theilgaard-Mönch, Mathew J. Garnett, Päivi Östling, Julian Walfridsson, Thomas Helleday, Ulrika Warpman Berglund
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5733–5744.
https://doi.org/10.1158/0008-5472.CAN-21-0061
Published: 15 November 2021
View article titled, MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Open the PDF for MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 2199: Establishment and high-throughput drug testing of multiple patient-derived cells from each renal cancer; intratumor heterogeneity of drug response and implications for precision medicine

Khalid Saeed, Poojitha Ojamies, Teijo Pellinen, Samuli Eldfors, Riku Turkki, Johan Lundin, Harry Nisen, Petrus Järvinen, Kimmo Taari, Taija af Hällström, Antti Rannikko, Tuomas Mirtti, Olli Kallioniemi, Päivi Östling
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2199.
https://doi.org/10.1158/1538-7445.AM2018-2199
Published: 01 July 2018
View article titled, Abstract 2199: Establishment and high-throughput drug testing of multiple patient-derived cells from each renal cancer; intratumor heterogeneity of drug response and implications for precision medicine
Journal Articles

Abstract 5302: Phenotypic heterogeneity of patient-derived tumor cells visualized by unsupervised analysis in cell-based personalized drug testing

Riku Turkki, Lassi Paavolainen, Piia Mikkonen, Päivi Östling, Peter Horvath, Vilja Pietiäinen, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5302.
https://doi.org/10.1158/1538-7445.AM2018-5302
Published: 01 July 2018
View article titled, Abstract 5302: Phenotypic heterogeneity of patient-derived tumor cells visualized by unsupervised analysis in cell-based personalized drug testing
Journal Articles

Abstract 3854: Precision medicine approach: analysis of renal cancer patient-derived cells with phenomics, genomics and drug sensitivity profiling

Vilja M. Pietiäinen, Piia Mikkonen, Khalid Saeed, Lassi Paavolainen, Teijo Pellinen, Swapnil Potdar, John Mpindi, Harry Nisén, Antti Rannikko, Tuomas Mirtti, Peter Horvath, Päivi Östling, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3854.
https://doi.org/10.1158/1538-7445.AM2017-3854
Published: 01 July 2017
View article titled, Abstract 3854: Precision medicine approach: analysis of renal cancer patient-derived cells with phenomics, genomics and drug sensitivity profiling
Journal Articles

Abstract 3838: Drug sensitivity profile of 5TGM1 murine multiple myeloma cell line emphasizes the translational potential of the syngeneic in vivo model

Jenni Mäki-Jouppila, Jenni Bernoulli, Mari I. Suominen, Tiina Kähkönen, Jussi M. Halleen, Sanna Timonen, Elina Huovari, Katja Suomi, Swapnil Potdar, Maria Nurmi, Päivi Östling, Jani Saarela, Katja M. Fagerlund
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3838.
https://doi.org/10.1158/1538-7445.AM2017-3838
Published: 01 July 2017
View article titled, Abstract 3838: Drug sensitivity profile of 5TGM1 murine multiple myeloma cell line emphasizes the translational potential of the syngeneic <em>in vivo</em> model
Journal Articles

Abstract 4207: Selective drug sensitivity score (DSS) for indolent and aggressive prostate cancer cell lines

Jenni Mäki-Jouppila, Jenni Bernoulli, Johanna Tuomela, Mari I. Suominen, Jussi M. Halleen, Sanna Timonen, Elina Huovari, Katja Suomi, Swapnil Potdar, Päivi Östling, Jani Saarela, Katja M. Fagerlund
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4207.
https://doi.org/10.1158/1538-7445.AM2017-4207
Published: 01 July 2017
View article titled, Abstract 4207: Selective drug sensitivity score (DSS) for indolent and aggressive prostate cancer cell lines
Journal Articles

Abstract 5732: PI3K/Akt activity regulates androgen receptor expression and predicts poor clinical outcome in non-metastatic hormone-naïve prostate cancer

Sami Blom, Petra Mäki-Teeri, Andrew Erickson, Lassi Paavolainen, Tuomas Mirtti, Antti Rannikko, Swapnil Potdar, Päivi Östling, Wytske van Weerden, Olli Kallioniemi, Teijo Pellinen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5732.
https://doi.org/10.1158/1538-7445.AM2017-5732
Published: 01 July 2017
View article titled, Abstract 5732: PI3K/Akt activity regulates androgen receptor expression and predicts poor clinical outcome in non-metastatic hormone-naïve prostate cancer
Journal Articles

Abstract 608: Comprehensive drug testing of patient-derived conditionally reprogrammed cells from castration-resistant prostate cancer

Khalid Saeed, Vesa Rahkama, Samuli Eldfors, Dmitrii Bychkov, John Patrick Mpindi, Bhagwan Yadav, Tero Aittokallio, Peter Horvath, Donna Peehl, Lassi Paavolainen, Caroline Heckman, Krister Wennerberg, Tuomas Mirtti, Antti Rannikko, Olli Kallioniemia, Päivi Östling, Taija af Hällström
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 608.
https://doi.org/10.1158/1538-7445.AM2016-608
Published: 15 July 2016
View article titled, Abstract 608: Comprehensive drug testing of patient-derived conditionally reprogrammed cells from castration-resistant prostate cancer
Journal Articles

Abstract 4184: Drug set enrichment analysis : A computational approach to identify functional drug sets

John Patrick Mpindi, Dimitry Bychkov, Yadav Bhagwan, Disha Malani, Hirasawa Akira, Khalid Saeed, Susanne Hultsch, Sara Kangaspeska, Astrid Murumägi, Caroline A Heckman, Kimmo Porkka, Tero Aittokallio, Krister Wennerberg, Päivi Östling, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4184.
https://doi.org/10.1158/1538-7445.AM2014-4184
Published: 01 October 2014
View article titled, Abstract 4184: Drug set enrichment analysis : A computational approach to identify functional drug sets
Journal Articles

Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells

Päivi Östling, Suvi-Katri Leivonen, Anna Aakula, Pekka Kohonen, Rami Mäkelä, Zandra Hagman, Anders Edsjö, Sara Kangaspeska, Henrik Edgren, Daniel Nicorici, Anders Bjartell, Yvonne Ceder, Merja Perälä, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2011) 71 (5): 1956–1967.
https://doi.org/10.1158/0008-5472.CAN-10-2421
Published: 01 March 2011
View article titled, Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells
Open the PDF for Systematic Analysis of MicroRNAs Targeting the Androgen Receptor in Prostate Cancer Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 2072: Systematic functional analysis of microRNAs by transfection of 1129 miRNAs into prostate cancer cells

Paivi Ostling, Suvi-Katri Leivonen, Anna Aakula, Pekka Kohonen, Rami Makela, Merja Perala, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2072.
https://doi.org/10.1158/1538-7445.AM10-2072
Published: 15 April 2010
View article titled, Abstract 2072: Systematic functional analysis of microRNAs by transfection of 1129 miRNAs into prostate cancer cells
Journal Articles

Abstract #2529: High-throughput functional screens and clinical profiling identify microRNAs regulating estrogen receptor (ER)-\#945; signaling in breast cancer

Suvi-Katri Leivonen, Rami Mäkelä, Päivi Östling, Pekka Kohonen, Saija Haapa-Paananen, Niko Sahlberg, Kirsi Hellström, Anna Aakula, Kristine Kleivi, Espen Enerly, Vessela Kristensen, Anne-Lise Børresen-Dale, Petri Saviranta, Merja Perälä, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2529.
Published: 01 May 2009
View article titled, Abstract #2529: High-throughput functional screens and clinical profiling identify microRNAs regulating estrogen receptor (ER)-\#945; signaling in breast cancer
Journal Articles

Phenotypic profiling of high-throughput transfections of anti- and pre-miRNA libraries into breast and prostate cancer cells using protein lysate microarray technology

Rami Makela, Suvi-Katri Leivonen, Paivi Ostling, Pekka Kohonen, Kirsi Hellstrom, Tao He, Saija Haapa-Paananen, Petri Saviranta, Merja Perala, Olli Kallioniemi
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5018.
Published: 01 May 2008
View article titled, Phenotypic profiling of high-throughput transfections of anti- and pre-miRNA libraries into breast and prostate cancer cells using protein lysate microarray technology