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Journal Articles

The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer

Open Access
Arian Lundberg, Meng Zhang, Rahul Aggarwal, Haolong Li, Li Zhang, Adam Foye, Martin Sjöström, Jonathan Chou, Kevin Chang, Thaidy Moreno-Rodriguez, Raunak Shrestha, Avi Baskin, Xiaolin Zhu, Alana S. Weinstein, Noah Younger, Joshi J. Alumkal, Tomasz M. Beer, Kim N. Chi, Christopher P. Evans, Martin Gleave, Primo N. Lara, Rob E. Reiter, Matthew B. Rettig, Owen N. Witte, Alexander W. Wyatt, Felix Y. Feng, Eric J. Small, David A. Quigley
Journal: Cancer Research
Cancer Res (2023) 83 (16): 2763–2774.
https://doi.org/10.1158/0008-5472.CAN-23-0593
Published: 15 August 2023
View articletitled, The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer
Open the PDF for The Genomic and Epigenomic Landscape of Double-Negative Metastatic Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B012: Genomic and epigenomic drivers of double-negative metastatic prostate cancer

Free
Arian Lundberg, Meng Zhang, Rahul R. Aggarwal, Haolong Li, Li Zhang, Adam Foye, Martin Sjöström, Jonathan Chou, Kevin Chang, Thaidy Moreno-Rodriguez, Raunak Shrestha, Avi Baskin, Xiaolin Zhu, Alana S. Weinstein, Noah Younger, Joshi J. Alumkal, Tomasz M. Beer, Kim N. Chi, Christopher P. Evans, Martin Gleave, Primo N. Lara, Robert E. Reiter, Matthew B. Rettig, Owen N. Witte, Alexander W. Wyatt, Felix Y. Feng, Eric J. Small, David A. Quigley
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B012.
https://doi.org/10.1158/1538-7445.PRCA2023-B012
Published: 02 June 2023
View articletitled, Abstract B012: Genomic and epigenomic drivers of double-negative metastatic prostate cancer
Journal Articles

The 5-Hydroxymethylcytosine Landscape of Prostate Cancer

Open Access
Martin Sjöström, Shuang G. Zhao, Samuel Levy, Meng Zhang, Yuhong Ning, Raunak Shrestha, Arian Lundberg, Cameron Herberts, Adam Foye, Rahul Aggarwal, Junjie T. Hua, Haolong Li, Anna Bergamaschi, Corinne Maurice-Dror, Ashutosh Maheshwari, Sujun Chen, Sarah W.S. Ng, Wenbin Ye, Jessica Petricca, Michael Fraser, Lisa Chesner, Marc D. Perry, Thaidy Moreno-Rodriguez, William S. Chen, Joshi J. Alumkal, Jonathan Chou, Alicia K. Morgans, Tomasz M. Beer, George V. Thomas, Martin Gleave, Paul Lloyd, Tierney Phillips, Erin McCarthy, Michael C. Haffner, Amina Zoubeidi, Matti Annala, Robert E. Reiter, Matthew B. Rettig, Owen N. Witte, Lawrence Fong, Rohit Bose, Franklin W. Huang, Jianhua Luo, Anders Bjartell, Joshua M. Lang, Nupam P. Mahajan, Primo N. Lara, Christopher P. Evans, Phuoc T. Tran, Edwin M. Posadas, Chuan He, Xiao-Long Cui, Jiaoti Huang, Wilbert Zwart, Luke A. Gilbert, Christopher A. Maher, Paul C. Boutros, Kim N. Chi, Alan Ashworth, Eric J. Small, Housheng H. He, Alexander W. Wyatt, David A. Quigley, Felix Y. Feng
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3888–3902.
https://doi.org/10.1158/0008-5472.CAN-22-1123
Published: 02 November 2022
View articletitled, The 5-Hydroxymethylcytosine Landscape of Prostate Cancer
Open the PDF for The 5-Hydroxymethylcytosine Landscape of Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3604: PSC-derived T cells as a novel source of tumor antigen-specific T cell receptors

Free
Chloe S. Wang, Suwen Li, Zhiyuan Mao, Olivia Zhou, Carlos Botero, William Satyadi, Patrick Chang, Sang Pil Yoo, Ho-Chung Chen, Shawn Lopez, Jami McLaughlin, Amélie Montel-Hagen, Owen N. Witte, Gay M. Crooks, Christopher S. Seet
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3604.
https://doi.org/10.1158/1538-7445.AM2022-3604
Published: 15 June 2022
View articletitled, Abstract 3604: PSC-derived T cells as a novel source of tumor antigen-specific T cell receptors
Journal Articles

Abstract 2438: Determining the role of non-mutated C-Raf kinase in metastatic disease

Free
Lisa H. Ta, Janai R. Carr-Ascher, Weixian Deng, Brandon L. Tsai, Wendy Tran, Donny Gun, Donghui Cheng, Jihui Sha, Yeonjoo Hwang, John W. Phillips, Matthew B. Obusan, Nathanael J. Bangayan, Miyako Noguchi, Zhiyuan Mao, Chia-Chun Chen, Liang Wang, Grigor Varuzhanyan, John D. Gordon, James W. Wohlschlegel, Owen N. Witte
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2438.
https://doi.org/10.1158/1538-7445.AM2022-2438
Published: 15 June 2022
View articletitled, Abstract 2438: Determining the role of non-mutated C-Raf kinase in metastatic disease
Journal Articles

Abstract 3882: Patient-specific druggable networks in lethal prostate cancer through proteome-guided multi-omic integration

Free
Justin M. Drake, Evan O. Paull, Nicholas A. Graham, John K. Lee, Bryan A. Smith, Tanya Stoyanova, Claire M. Faltermeier, Daniel E. Carlin, Ajay Vashisht, Jiaoti Huang, James A. Wohlschlegel, Thomas G. Graeber, Owen N. Witte, Joshua M. Stuart
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3882.
https://doi.org/10.1158/1538-7445.AM2016-3882
Published: 15 July 2016
View articletitled, Abstract 3882: Patient-specific druggable networks in lethal prostate cancer through proteome-guided multi-omic integration
Journal Articles

Abstract LB-279: N-cadherin promotes castration-resistant prostate cancer progression by enhancing stem cell properties of prostate cancer cells

Free
Shu Lin, Tanya Stonyanova, Evelyn Kono, Jaclyn Matsuura, Naoko Kobayashi, Joyce Yamashiro, Dai Hong, Owen N. Witte, Andrew S. Goldstein, Robert E. Reiter
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-279.
https://doi.org/10.1158/1538-7445.AM2016-LB-279
Published: 15 July 2016
View articletitled, Abstract LB-279: N-cadherin promotes castration-resistant prostate cancer progression by enhancing stem cell properties of prostate cancer cells
Journal Articles

An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy

Free
Richard Tavaré, Helena Escuin-Ordinas, Stephen Mok, Melissa N. McCracken, Kirstin A. Zettlitz, Felix B. Salazar, Owen N. Witte, Antoni Ribas, Anna M. Wu
Journal: Cancer Research
Cancer Res (2016) 76 (1): 73–82.
https://doi.org/10.1158/0008-5472.CAN-15-1707
Published: 03 January 2016
View articletitled, An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy
Open the PDF for An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 1860: DNA-PK-mediated transcriptional regulation drives tumor progression and metastasis

Free
Jonathan F. Goodwin, Vishal Kothari, Justin M. Drake, Shuang Zhao, Emanuela Dylgjeri, Jeffry L. Dean, Matthew J. Schiewer, Christopher McNair, Michael S. Magee, Robert B. Den, Ziqi Zhu, Nicholas A. Graham, Ajay A. Vashisht, James A. Wohlschlegel, Thomas G. Graeber, R Jeffrey Karnes, Mandeep Takhar, Elai Davicioni, Scott A. Tomlins, Nima Sharifi, Owen N. Witte, Felix Y. Feng, Karen E. Knudsen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1860.
https://doi.org/10.1158/1538-7445.AM2015-1860
Published: 01 August 2015
View articletitled, Abstract 1860: DNA-PK-mediated transcriptional regulation drives tumor progression and metastasis
Journal Articles

Abstract SY05-01: Non-immunogenic PET reporter imaging of HSC transplants and T cell immunotherapies

Free
Owen N. Witte
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): SY05-01.
https://doi.org/10.1158/1538-7445.AM2015-SY05-01
Published: 01 August 2015
View articletitled, Abstract SY05-01: Non-immunogenic PET reporter imaging of HSC transplants and T cell immunotherapies
Journal Articles

Abstract SY13-03: Signal pathways in prostate cancer stem cells

Free
Owen N. Witte
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY13-03.
https://doi.org/10.1158/1538-7445.AM2014-SY13-03
Published: 01 October 2014
View articletitled, Abstract SY13-03: Signal pathways in prostate cancer stem cells
Journal Articles

HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice

Free
Eric H. Gschweng, Melissa N. McCracken, Michael L. Kaufman, Michelle Ho, Roger P. Hollis, Xiaoyan Wang, Navdeep Saini, Richard C. Koya, Thinle Chodon, Antoni Ribas, Owen N. Witte, Donald B. Kohn
Journal: Cancer Research
Cancer Res (2014) 74 (18): 5173–5183.
https://doi.org/10.1158/0008-5472.CAN-14-0376
Published: 14 September 2014
View articletitled, HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice
Open the PDF for HSV-sr39TK Positron Emission Tomography and Suicide Gene Elimination of Human Hematopoietic Stem Cells and Their Progeny in Humanized Mice in another window
Includes: Multimedia, Supplementary data
Journal Articles

Progesterone Receptor Signaling in the Microenvironment of Endometrial Cancer Influences Its Response to Hormonal Therapy

Free
Deanna M. Janzen, Miguel A. Rosales, Daniel Y. Paik, Daniel S. Lee, Daniel A. Smith, Owen N. Witte, M. Luisa Iruela-Arispe, Sanaz Memarzadeh
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (15): 4697–4710.
https://doi.org/10.1158/0008-5472.CAN-13-0930
Published: 31 July 2013
View articletitled, Progesterone Receptor Signaling in the Microenvironment of Endometrial Cancer Influences Its Response to Hormonal Therapy
Open the PDF for Progesterone Receptor Signaling in the Microenvironment of Endometrial Cancer Influences Its Response to Hormonal Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract B67: The epigenetic regulator Hmga2 is sufficient to initiate prostate cancer via paracrine Wnt signaling

Free
Yang Zong, Jiaoti Huang, Owen N. Witte
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): B67.
https://doi.org/10.1158/1538-7445.PRCA2012-B67
Published: 09 May 2013
View articletitled, Abstract B67: The epigenetic regulator Hmga2 is sufficient to initiate prostate cancer via paracrine Wnt signaling
Journal Articles

Abstract PR5: Therapeutic targeting of oncogene-specific tyrosine kinase networks during prostate cancer progression

Free
Justin M. Drake, Jiaoti Huang, Thomas G. Graeber, Owen N. Witte, Nicholas A. Graham, Tanya Stoyanova, Amir Sedghi, Andrew S. Goldstein, Houjian Cai, Daniel A. Smith, Hong Zhang, Komisopoulou Evangelia
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): PR5.
https://doi.org/10.1158/1538-7445.PRCA2012-PR5
Published: 09 May 2013
View articletitled, Abstract PR5: Therapeutic targeting of oncogene-specific tyrosine kinase networks during prostate cancer progression
Journal Articles

Abstract C70: Trop2 regulates prostate tumorigenesis and stem cell self-renewal

Free
Tanya Stoyanova, Andrew Goldstein, Houjian Cai, Justin M. Drake, Jiaoti Huang, Hong Zhang, Owen N. Witte
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): C70.
https://doi.org/10.1158/1538-7445.PRCA2012-C70
Published: 09 May 2013
View articletitled, Abstract C70: Trop2 regulates prostate tumorigenesis and stem cell self-renewal
Journal Articles

Abstract B57: Oncostatin M promotes progression of Pten-deficient prostate cancer

Free
Daniel A. Smith, Yang Zong, Atsushi Kiba, Owen N. Witte
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): B57.
https://doi.org/10.1158/1538-7445.PRCA2012-B57
Published: 09 May 2013
View articletitled, Abstract B57: Oncostatin M promotes progression of Pten-deficient prostate cancer
Journal Articles

Abstract IA17: Stem cells and prostate cancer

Free
Owen N. Witte
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): IA17.
https://doi.org/10.1158/1538-7445.PRCA2012-IA17
Published: 09 May 2013
View articletitled, Abstract IA17: Stem cells and prostate cancer
Journal Articles

Abstract 4964: Signaling through the progesterone receptor in the tumor microenvironment regulates hormonal sensitivity in endometrial carcinoma.

Free
Deanna M. Janzen, Miguel A. Rosales, Daniel Y. Paik, Daniel A. Smith, Donghui Cheng, Owen N. Witte, Luisa Iruela-Arispe, Sanaz Memarzadeh
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4964.
https://doi.org/10.1158/1538-7445.AM2013-4964
Published: 15 April 2013
View articletitled, Abstract 4964: Signaling through the progesterone receptor in the tumor microenvironment regulates hormonal sensitivity in endometrial carcinoma.
Journal Articles

Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer

Free
Houjian Cai, Sanaz Memarzadeh, Tanya Stoyanova, Zanna Beharry, Andrew S. Kraft, Owen N. Witte
Journal: Cancer Research
Cancer Res (2012) 72 (18): 4672–4681.
https://doi.org/10.1158/0008-5472.CAN-12-0228
Published: 16 September 2012
View articletitled, Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer
Open the PDF for Collaboration of Kras and Androgen Receptor Signaling Stimulates EZH2 Expression and Tumor-Propagating Cells in Prostate Cancer in another window
Includes: Supplementary data