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Owen J. Sansom
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Journal Articles

Abstract 4878: Ablation of neutrophil-specific CXCR2 and PD-L1 alters neutrophil phenotype and can reduce disease burden in a murine model of advanced colorectal cancer liver metastases

Free
Alistair S. McLaren, John Falconer, Sarah Ressel, Leo M. Carlin, Owen J. Sansom, Colin W. Steele
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4878.
https://doi.org/10.1158/1538-7445.AM2025-4878
Published: 21 April 2025
View articletitled, Abstract 4878: Ablation of neutrophil-specific CXCR2 and PD-L1 alters neutrophil phenotype and can reduce disease burden in a murine model of advanced colorectal cancer liver metastases
Journal Articles

Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma

Open Access
Catriona A. Ford, Dana Koludrovic, Patricia P. Centeno, Mona Foth, Elpida Tsonou, Nikola Vlahov, Nathalie Sphyris, Kathryn Gilroy, Courtney Bull, Colin Nixon, Bryan Serrels, Alison F. Munro, John C. Dawson, Neil O. Carragher, Valeria Pavet, David C. Hornigold, Philip D. Dunne, Julian Downward, Heidi C.E. Welch, Simon T. Barry, Owen J. Sansom, Andrew D. Campbell
Journal: Cancer Research
Cancer Res (2025) 85 (4): 808–824.
https://doi.org/10.1158/0008-5472.CAN-23-2814
Published: 17 February 2025
View articletitled, Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma
Open the PDF for Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma in another window
Includes: Supplementary data
Journal Articles

KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition

Open Access
Sigrid K. Fey, Arafath K. Najumudeen, Dale M. Watt, Laura M. Millett, Catriona A. Ford, Kathryn Gilroy, Rosalin J. Simpson, Kathy McLay, Rosanna Upstill-Goddard, David Chang, William Clark, Colin Nixon, Joanna L. Birch, Simon T. Barry, Jennifer P. Morton, Andrew D. Campbell, Owen J. Sansom
Journal: Cancer Research
Cancer Res (2025) 85 (2): 251–262.
https://doi.org/10.1158/0008-5472.CAN-23-2709
Published: 15 January 2025
View articletitled, KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition
Open the PDF for KRAS Loss of Heterozygosity Promotes MAPK-Dependent Pancreatic Ductal Adenocarcinoma Initiation and Induces Therapeutic Sensitivity to MEK Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 6806: Single cell RNA sequencing of human and murine cancers demonstrates metastases-specific neutrophil phenotypes driven by the IL-1β/CXCR2 signaling axis - Disruption of this pathway abrogates neutrophil immunosuppressive effects and reduces tumor burden

Free
Alistair S. McLaren, Rana Fetit, Mark White, Megan L. Mills, Tamsin Lannagan, John Falconer, Xabier Cortes-Lavaud, Kathryn Gilroy, Rachel Ridgway, Colin Nixon, Varushka Naiker, Renee Njunge, Cassie J. Clarke, Declan Whyte, Kristina Kirschner, Rene Jackstadt, Jim C. Norman, Leo M. Carlin, Andrew D. Campbell, Owen J. Sansom, Colin W. Steele
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6806.
https://doi.org/10.1158/1538-7445.AM2024-6806
Published: 22 March 2024
View articletitled, Abstract 6806: Single cell RNA sequencing of human and murine cancers demonstrates metastases-specific neutrophil phenotypes driven by the IL-1β/CXCR2 signaling axis - Disruption of this pathway abrogates neutrophil immunosuppressive effects and reduces tumor burden
Journal Articles

Abstract PR04: Therapeutic development platform for pancreatic cancer in the UK national health service: Lessons learned and initial results from Precision-Panc

Free
Fieke E.M. Froeling, Juan Valle, Rosie Upstill-Goddard, Paul Grimwood, Paul Westwood, Stephan B. Dreyer, Caroline Kelly, Fraser Duthie, Judith Dixon, Sarah Bradley, T.R. Jeffry Evans, Owen J. Sansom, Andrew V. Biankin, David K. Chang
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): PR04.
https://doi.org/10.1158/1538-7445.PANCA2023-PR04
Published: 16 January 2024
View articletitled, Abstract PR04: Therapeutic development platform for pancreatic cancer in the UK national health service: Lessons learned and initial results from Precision-Panc
Journal Articles

Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases

Open Access
Colin S. Wood, Kathryn A.F. Pennel, Holly Leslie, Assya Legrini, Andrew J. Cameron, Lydia Melissourgou-Syka, Jean A. Quinn, Hester C. van Wyk, Jennifer Hay, Antonia K. Roseweir, Colin Nixon, Campbell S.D. Roxburgh, Donald C. McMillan, Andrew V. Biankin, Owen J. Sansom, Paul G. Horgan, Joanne Edwards, Colin W. Steele, Nigel B. Jamieson
Journal: Cancer Research
Cancer Res (2023) 83 (8): 1329–1344.
https://doi.org/10.1158/0008-5472.CAN-22-2794
Published: 14 April 2023
View articletitled, Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases
Open the PDF for Spatially Resolved Transcriptomics Deconvolutes Prognostic Histological Subgroups in Patients with Colorectal Cancer and Synchronous Liver Metastases in another window
Includes: Supplementary data
Journal Articles

Abstract 1080: JAK inhibition as a therapeutic approach to enhance radiation response in rectal cancer

Free
Kathryn A. Pennel, Phimmada Hathakarnkul, Sara S. Al-Badran, Umar Hashmi, Lily Hillson, Jean A. Quinn, Leia Jones, Colin W. Steele, Donald C. McMillan, James H. Park, Owen J. Sansom, Joanna Birch, Campbell S. Roxburgh, Joanne Edwards
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1080.
https://doi.org/10.1158/1538-7445.AM2023-1080
Published: 04 April 2023
View articletitled, Abstract 1080: JAK inhibition as a therapeutic approach to enhance radiation response in rectal cancer
Journal Articles

Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression

Open Access
Rachana Patel, Catriona A. Ford, Lisa Rodgers, Linda K. Rushworth, Janis Fleming, Ernest Mui, Tong Zhang, David Watson, Victoria Lynch, Gillian Mackay, David Sumpton, Owen J. Sansom, Johan Vande Voorde, Hing Y. Leung
Journal: Cancer Research
Cancer Res (2022) 82 (14): 2565–2575.
https://doi.org/10.1158/0008-5472.CAN-21-1301
Published: 18 July 2022
View articletitled, Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression
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Includes: Supplementary data
Journal Articles

Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth

Available to Purchase
Danielle R. Cook, Melissa Kang, Timothy D. Martin, Joseph A. Galanko, Gabriela H. Loeza, Dimitri G. Trembath, Verline Justilien, Karen A. Pickering, David F. Vincent, Armin Jarosch, Philipp Jurmeister, Andrew M. Waters, Priya S. Hibshman, Andrew D. Campbell, Catriona A. Ford, Temitope O. Keku, Jen Jen Yeh, Michael S. Lee, Adrienne D. Cox, Alan P. Fields, Robert S. Sandler, Owen J. Sansom, Christine Sers, Antje Schaefer, Channing J. Der
Journal: Cancer Research
Cancer Res (2022) 82 (1): 90–104.
https://doi.org/10.1158/0008-5472.CAN-20-4218
Published: 04 January 2022
View articletitled, Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth
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Includes: Supplementary data
Journal Articles

Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition

Free
George Sharbeen, Joshua A. McCarroll, Anouschka Akerman, Chantal Kopecky, Janet Youkhana, John Kokkinos, Jeff Holst, Cyrille Boyer, Mert Erkan, David Goldstein, Paul Timpson, Thomas R. Cox, Brooke A. Pereira, Jessica L. Chitty, Sigrid K. Fey, Arafath K. Najumudeen, Andrew D. Campbell, Owen J. Sansom, Rosa Mistica C. Ignacio, Stephanie Naim, Jie Liu, Nelson Russia, Julia Lee, Angela Chou, Amber Johns, Anthony J. Gill, Estrella Gonzales-Aloy, Val Gebski, Yi Fang Guan, Marina Pajic, Nigel Turner, Minoti V. Apte, Thomas P. Davis, Jennifer P. Morton, Koroush S. Haghighi, Jorjina Kasparian, Benjamin J. McLean, Yordanos F. Setargew, Phoebe A. Phillips
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (13): 3461–3479.
https://doi.org/10.1158/0008-5472.CAN-20-2496
Published: 01 July 2021
View articletitled, Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition
Open the PDF for Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 3867: STAT1-related antigen processing and presentation dictates prognosis in the fibroblast-rich subtype of stage II/III colon cancer

Free
Amy M. McCorry, Niamh A. Leonard, Rene Jackstadt, Dustin J. Flanagan, Owen J. Sansom, Tim Maughan, Simon Leedham, Emma M. Kerr, Aideen E. Ryan, Mark Lawler, Philip D. Dunne, ACRCelerate and S:CORT consortia
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3867.
https://doi.org/10.1158/1538-7445.AM2020-3867
Published: 15 August 2020
View articletitled, Abstract 3867: STAT1-related antigen processing and presentation dictates prognosis in the fibroblast-rich subtype of stage II/III colon cancer
Journal Articles

RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome

Free
Nicholas Rooney, Susan M. Mason, Laura McDonald, J. Henry M. Däbritz, Kirsteen J. Campbell, Ann Hedley, Steven Howard, Dimitris Athineos, Colin Nixon, William Clark, Joshua D.G. Leach, Owen J. Sansom, Joanne Edwards, Ewan R. Cameron, Karen Blyth
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (11): 2325–2339.
https://doi.org/10.1158/0008-5472.CAN-19-3870
Published: 02 June 2020
View articletitled, RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome
Open the PDF for RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome in another window
Includes: Supplementary data
Journal Articles

Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer

Free
Rachana Patel, Elspeth A. Brzezinska, Peter Repiscak, Imran Ahmad, Ernest Mui, Meiling Gao, Arnaud Blomme, Victoria Harle, Ee Hong Tan, Gaurav Malviya, Agata Mrowinska, Carolyn J. Loveridge, Linda K. Rushworth, Joanne Edwards, Chara Ntala, Colin Nixon, Ann Hedley, Gillian Mackay, Saverio Tardito, Owen J. Sansom, Hing Y. Leung
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (3): 576–590.
https://doi.org/10.1158/0008-5472.CAN-19-1684
Published: 03 February 2020
View articletitled, Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer
Open the PDF for Activation of β-Catenin Cooperates with Loss of Pten to Drive AR-Independent Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response

Free
Grace H. McGregor, Andrew D. Campbell, Sigrid K. Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vazquez, Owen J. Sansom, Jurre J. Kamphorst
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (2): 175–188.
https://doi.org/10.1158/0008-5472.CAN-19-0644
Published: 15 January 2020
View articletitled, Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response
Open the PDF for Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response in another window
Includes: Supplementary data
Journal Articles

Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress

Free
Irem Kaymak, Carina R. Maier, Werner Schmitz, Andrew D. Campbell, Beatrice Dankworth, Carsten P. Ade, Susanne Walz, Madelon Paauwe, Charis Kalogirou, Hecham Marouf, Mathias T. Rosenfeldt, David M. Gay, Grace H. McGregor, Owen J. Sansom, Almut Schulze
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (2): 189–203.
https://doi.org/10.1158/0008-5472.CAN-19-0650
Published: 15 January 2020
View articletitled, Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress
Open the PDF for Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress in another window
Includes: Supplementary data
Journal Articles

Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma

Free
Brittany L. Allen-Petersen, Tyler Risom, Zipei Feng, Zhiping Wang, Zina P. Jenny, Mary C. Thoma, Katherine R. Pelz, Jennifer P. Morton, Owen J. Sansom, Charles D. Lopez, Brett Sheppard, Dale J. Christensen, Michael Ohlmeyer, Goutham Narla, Rosalie C. Sears
Journal: Cancer Research
Cancer Res (2019) 79 (1): 209–219.
https://doi.org/10.1158/0008-5472.CAN-18-0717
Published: 02 January 2019
View articletitled, Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma
Open the PDF for Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 5661: A multi modal mass spectrometry imaging strategy to profile the metabolic hallmarks of colorectal cancer

Free
Josephine Bunch, Rory T. Steven, Adam J. Taylor, Spencer A. Thomas, Alan M. Race, Alex Dexter, Gregory Hamm, Nicole Strittmatter, Rasmus Havelund, Renata F. Soares, Andrew D. Campbell, Owen J. Sansom, Richard J. Goodwin, Zoltan Takats
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5661.
https://doi.org/10.1158/1538-7445.AM2018-5661
Published: 01 July 2018
View articletitled, Abstract 5661: A multi modal mass spectrometry imaging strategy to profile the metabolic hallmarks of colorectal cancer
Journal Articles

Abstract 17: Inhibition of LRG1 normalizes tumor vessels and improves efficacy of cancer therapeutics

Free
John Greenwood, Marie N. O'Connor, David Kallenberg, Rene-Filip Jackstadt, Angharad Watson, Julia Ohme, Laura Dowsett, Jestin George, Xiaomeng Wang, Ann Ager, Owen J. Sansom, Stephen E. Moss
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 17.
https://doi.org/10.1158/1538-7445.AM2018-17
Published: 01 July 2018
View articletitled, Abstract 17: Inhibition of LRG1 normalizes tumor vessels and improves efficacy of cancer therapeutics
Journal Articles

Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer

Free
Zenobia D'Costa, Keaton Jones, Abul Azad, Ruud van Stiphout, Su Y. Lim, Ana L. Gomes, Paul Kinchesh, Sean C. Smart, W. Gillies McKenna, Francesca M. Buffa, Owen J. Sansom, Ruth J. Muschel, Eric O'Neill, Emmanouil Fokas
Journal: Cancer Research
Cancer Res (2017) 77 (21): 5952–5962.
https://doi.org/10.1158/0008-5472.CAN-16-2833
Published: 31 October 2017
View articletitled, Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer
Open the PDF for Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PR07: A biosensor mouse to predict the dissociation and spread of pancreatic cancer

Free
David Herrmann, Zahra Erami, Sean Warren, Max Nobis, Astrid Magenau, Morghan Lucas, Claire Vennin, Ewan J. McGhee, Wilfred Leung, Nadine Reischmann, Agata Mrowinska, Juliane P. Schwarz, Shereen Kadir, Saadia A. Karim, Andrew D. Campbell, David Gallego-Ortega, Jeffry Evans, Owen J. Sansom, Jennifer P. Morton, Kurt I. Anderson, Paul Timpson
Journal: Cancer Research
Cancer Res (2017) 77 (2_Supplement): PR07.
https://doi.org/10.1158/1538-7445.EPSO16-PR07
Published: 16 January 2017
View articletitled, Abstract PR07: A biosensor mouse to predict the dissociation and spread of pancreatic cancer