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Abstract 2287: Dissecting the heterogeneity of central nervous system hemangioblastomas by single-cell and single-nuclei RNA sequencing

Eumorphia Konstantakou, Elizabeth Perez, Alex Barbera, Nicholas Haradhvala, Marcello Stanzione, Fred Barker, Brian Nahed, Anat Stemmer-Rachamimov, Nick Dyson, Gad Getz, Mario Suva, Othon Iliopoulos

Cancer Res (2022) 82 (12_Supplement): 2287.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2287

Published: 15 June 2022

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Journal Articles

Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction

Hanumantha Rao Madala, Iiro Taneli Helenius, Wen Zhou, Evanna Mills, Yiyun Zhang, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Surendra Punganuru, Kyung Bo Kim, Benjamin Olenchock, Eugene Rhee, Andrew M. Intlekofer, Othon Iliopoulos, Edward Chouchani, Jing-Ruey Joanna Yeh

Cancer Res (2020) 80 (17): 3492–3506.

DOI: https://doi.org/10.1158/0008-5472.CAN-20-0246

Published: 02 September 2020

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Includes: Supplementary data

Journal Articles

Abstract LB-253: Suppression of clear cell ovarian carcinoma growth by glutaminase-1 inhibitor as single agent and in combination with PARP-1 inhibitor

Tianjin Yi, Danos Christodoulou, Arimichi Okazaki, Michael Birrer, Othon Iliopoulos

Cancer Res (2018) 78 (13_Supplement): LB-253.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-253

Published: 01 July 2018

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Journal Articles

Abstract A13: Functional genomic analysis of central nervous system hemangioblastomas

Ana Martins Metelo, Atanas Kamburov, James Kim, Elizabeth Lockerman, Dana Lee, Frederick Barker, Jeffrey Engelman, Anat Stemmer-Rachamimov, Gad Getz, Othon Iliopoulos

Cancer Res (2015) 75 (23_Supplement): A13.

DOI: https://doi.org/10.1158/1538-7445.BRAIN15-A13

Published: 09 December 2015

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Journal Articles

Abstract 1123: Glutaminase inhibitors suppress pyrimidine synthesis and promote DNA replication stress in VHL-deficient human renal cancer cells

Arimichi Okazaki, Paulo Gameiro, Gregory Stephanopoulos, Othon Iliopoulos

Cancer Res (2015) 75 (15_Supplement): 1123.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1123

Published: 01 August 2015

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Journal Articles

Abstract 2038: Establishment and analysis of an in vitro model for hemangioblastomas of the central nervous system

Ana Martins Metelo, Elizabeth Lockerman, Fred Barker, Jeffrey Engelman, Othon Iliopoulos

Cancer Res (2014) 74 (19_Supplement): 2038.

DOI: https://doi.org/10.1158/1538-7445.AM2014-2038

Published: 01 October 2014

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Journal Articles

Abstract B1: Hypoxia inducible factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation

Paulo Gameiro, Ana Metelo, Rojo Pérez-Carro, Arreola Alexandra, Zongwei Wang, Kimryn W. Rathmell, Aria Olumi, Pilar López-Larrubia, Gregory Stephanopoulos, Othon Iliopoulos

Cancer Res (2013) 73 (3_Supplement): B1.

DOI: https://doi.org/10.1158/1538-7445.TIM2013-B1

Published: 01 May 2014

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Journal Articles

Abstract 1881: Hypoxia Inducible Factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation.

Paulo Gameiro, Ana Metelo, Rocio Pérez-Carro, Alexandra Arreolla, Rania Baker, Zongwei Wang, Aria Olumi, Kimryn Rathmell, Pilar López-Larrubia, Gregory Stephanopoulos, Othon Iliopoulos

Cancer Res (2013) 73 (8_Supplement): 1881.

DOI: https://doi.org/10.1158/1538-7445.AM2013-1881

Published: 15 April 2013

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Journal Articles

Abstract 1132: Regulation of the glutamine-to-lipid pathway by HIF: Reductive TCA cycle is a metabolic signature of VHL deficiency

Juanjuan Yang, Paulo A. Gameiro, Gregory Stephanopoulos, Othon Iliopoulos

Cancer Res (2012) 72 (8_Supplement): 1132.

DOI: https://doi.org/10.1158/1538-7445.AM2012-1132

Published: 15 April 2012

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Journal Articles

Abstract 2171: Human FLCN delays cell cycle progression through late S and G2/M-phases: Effect of phosphorylation and tumor-associated mutations

Laura A. Laviolette, Jonas Wilson, Julia Koller, Michael Zimmer, Othon Iliopoulos

Cancer Res (2012) 72 (8_Supplement): 2171.

DOI: https://doi.org/10.1158/1538-7445.AM2012-2171

Published: 15 April 2012

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Journal Articles

Abstract 4253: In vivo activity of small molecule HIF2α inhibitors

Ana Marguerita Metelo, Li Xiang, Rania Baker, Alexa Burger, Randall Peterson, Othon Iliopoulos

Cancer Res (2012) 72 (8_Supplement): 4253.

DOI: https://doi.org/10.1158/1538-7445.AM2012-4253

Published: 15 April 2012

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Journal Articles

The Connectivity Map Links Iron Regulatory Protein-1–Mediated Inhibition of Hypoxia-Inducible Factor-2a Translation to the Anti-inflammatory 15-deoxy-Δ^12,14-Prostaglandin J₂

Michael Zimmer, Justin Lamb, Benjamin L. Ebert, Mary Lynch, Christopher Neil, Emmett Schmidt, Todd R. Golub, Othon Iliopoulos

Cancer Res (2010) 70 (8): 3071–3079.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-2877

Published: 14 April 2010

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Includes: Supplementary data

Journal Articles

Hypoxia-Inducible Factor-1-Independent Regulation of Vascular Endothelial Growth Factor by Hypoxia in Colon Cancer

Yusuke Mizukami, Jingnan Li, Xiaobo Zhang, Michael A. Zimmer, Othon Iliopoulos, Daniel C. Chung

Cancer Res (2004) 64 (5): 1765–1772.

DOI: https://doi.org/10.1158/0008-5472.CAN-03-3017

Published: 02 March 2004

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Journal Articles

von Hippel-Lindau Gene-mediated Growth Suppression and Induction of Differentiation in Renal Cell Carcinoma Cells Grown as Multicellular Tumor Spheroids

Blandine Lieubeau-Teillet, Janusz Rak, Serge Jothy, Othon Iliopoulos, William Kaelin, Robert S. Kerbel

Cancer Res (1998) 58 (21): 4957–4962.

Published: 01 November 1998

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NARROW

Abstract 2287: Dissecting the heterogeneity of central nervous system hemangioblastomas by single-cell and single-nuclei RNA sequencing

Nitrogen Trapping as a Therapeutic Strategy in Tumors with Mitochondrial Dysfunction

Abstract LB-253: Suppression of clear cell ovarian carcinoma growth by glutaminase-1 inhibitor as single agent and in combination with PARP-1 inhibitor

Abstract A13: Functional genomic analysis of central nervous system hemangioblastomas

Abstract 1123: Glutaminase inhibitors suppress pyrimidine synthesis and promote DNA replication stress in VHL-deficient human renal cancer cells

Abstract 2038: Establishment and analysis of an in vitro model for hemangioblastomas of the central nervous system

Abstract B1: Hypoxia inducible factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation

Abstract 1881: Hypoxia Inducible Factor (HIF) promotes reductive carboxylation by regulating citrate levels and renders VHL-deficient and hypoxic cells sensitive to glutamine deprivation.

Abstract 1132: Regulation of the glutamine-to-lipid pathway by HIF: Reductive TCA cycle is a metabolic signature of VHL deficiency

Abstract 2171: Human FLCN delays cell cycle progression through late S and G2/M-phases: Effect of phosphorylation and tumor-associated mutations

Abstract 4253: In vivo activity of small molecule HIF2α inhibitors

The Connectivity Map Links Iron Regulatory Protein-1–Mediated Inhibition of Hypoxia-Inducible Factor-2a Translation to the Anti-inflammatory 15-deoxy-Δ^12,14-Prostaglandin J₂

Hypoxia-Inducible Factor-1-Independent Regulation of Vascular Endothelial Growth Factor by Hypoxia in Colon Cancer

von Hippel-Lindau Gene-mediated Growth Suppression and Induction of Differentiation in Renal Cell Carcinoma Cells Grown as Multicellular Tumor Spheroids

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