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Omar Abdel-Wahab
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Journal Articles

Abstract PR-11: Altered mRNA splicing mimics chromosome loss and drives pancreatic cancer

Natasha Pinto Medici, Diana Martinez-Saucedo, Danny Lee, Tianyi Chu, Robert Tseng, Vincent Cannataro, Jeffrey Townsend, Christine Iacobuzio-Donahue, Marie Robert, Omar Abdel-Wahab, Steven D. Leach, Luisa Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): PR-11.
https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-11
Published: 15 September 2024
View articletitled, Abstract PR-11: Altered mRNA splicing mimics chromosome loss and drives pancreatic cancer
Journal Articles

Abstract C075: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

Natasha Pinto Medici, Diana Martinez Saucedo, Danny Lee, Li-Ting Ku, Robert Tseng, Xinning Shan, Tianyi Chu, Pablo Perez-Piñera, Vincent Cannataro, Jeffrey Townsend, Christine Iacobuzio-Donahue, Marie Robert, Omar Abdel-Wahab, Steven D. Leach, Luisa Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C075.
https://doi.org/10.1158/1538-7445.PANCA2023-C075
Published: 16 January 2024
View articletitled, Abstract C075: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability
Journal Articles

Abstract 5742: Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

James D. Thomas, Sydney X. Lu, Emma De Neef, Erich Sabio, Benoit Rousseau, Mathieu Gigoux, David A. Knorr, Benjamin Greenbaum, Yuval Elhanati, Simon J. Hogg, Andrew Chow, Arnab Ghosh, Abigail Xie, Dmitriy Zamarin, Daniel Cui, Caroline Erickson, Michael Singer, Hana Cho, Eric Wang, Bin Lu, Benjamin H. Durham, Harshal Shah, Diego Chowell, Austin M. Gabel, Yudao Shen, Jing Liu, Jian Jin, Matthew C. Rhodes, Richard E. Taylor, Henrik Molina, Jedd D. Wolchok, Taha Merghoub, Luis A. Diaz Jr, Omar Abdel-Wahab, Robert K. Bradley
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5742.
https://doi.org/10.1158/1538-7445.AM2023-5742
Published: 04 April 2023
View articletitled, Abstract 5742: Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
Journal Articles

Abstract A055: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

Natasha Pinto Medici, Diana Martinez Saucedo, Danny Lee, Li-Ting Ku, Robert Tseng, Vincent Cannataro, Deanne Yugawa, Sumedha Chowdhury, Jeffrey Townsend, Christine A. Iacobuzio-Donahue, Omar Abdel-Wahab, Steven D. Leach, Luisa Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A055.
https://doi.org/10.1158/1538-7445.PANCA22-A055
Published: 15 November 2022
View articletitled, Abstract A055: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability
Journal Articles

The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation

Erik Ladewig, Flavia Michelini, Komal Jhaveri, Pau Castel, Javier Carmona, Lauren Fairchild, Adler G. Zuniga, Amaia Arruabarrena-Aristorena, Emiliano Cocco, Ryan Blawski, Srushti Kittane, Yuhan Zhang, Mirna Sallaku, Laura Baldino, Vasilis Hristidis, Sarat Chandarlapaty, Omar Abdel-Wahab, Christina Leslie, Maurizio Scaltriti, Eneda Toska
Journal: Cancer Research
Cancer Res (2022) 82 (12): 2269–2280.
https://doi.org/10.1158/0008-5472.CAN-22-0446
Published: 15 June 2022
View articletitled, The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation
Open the PDF for The Oncogenic PI3K-Induced Transcriptomic Landscape Reveals Key Functions in Splicing and Gene Expression Regulation in another window
Includes: Supplementary data
Journal Articles

Abstract 986: RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness

Gnana P. Krishnamoorthy, Anthony Glover, Brian Untch, Mahesh Saqcena, Dina Vukel, Katherine Berman, Omar Abdel-Wahab, Robert K. Bradley, Jeffrey A. Knauf, James A. Fagin
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 986.
https://doi.org/10.1158/1538-7445.AM2022-986
Published: 15 June 2022
View articletitled, Abstract 986: RBM10 loss in thyroid cancer leads to aberrant splicing of cytoskeletal and extracellular matrix mRNAs and increased metastatic fitness
Journal Articles

Abstract 1137: PRMT5 inhibition regulates alternative splicing and DNA damage repair pathways in SF3B1 R625G expressing uveal melanoma cells

Koichi Ito, Venkat Thodima, Jack Carter, Neha Bhagwat, Monisha Sivakumar, Alexander Grego, Joseph Rager, Mizue Terai, Takami Sato, Omar Abdel-Wahab, Bruce Ruggeri, Peggy Scherle, Kris Vaddi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1137.
https://doi.org/10.1158/1538-7445.AM2021-1137
Published: 01 July 2021
View articletitled, Abstract 1137: PRMT5 inhibition regulates alternative splicing and DNA damage repair pathways in SF3B1 R625G expressing uveal melanoma cells
Journal Articles

Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer

Aphrothiti J. Hanrahan, Brooke E. Sylvester, Matthew T. Chang, Arijh Elzein, Jianjiong Gao, Weiwei Han, Ye Liu, Dong Xu, Sizhi P. Gao, Alexander N. Gorelick, Alexis M. Jones, Amber J. Kiliti, Moriah H. Nissan, Clare A. Nimura, Abigail N. Poteshman, Zhan Yao, Yijun Gao, Wenhuo Hu, Hannah C. Wise, Elena I. Gavrila, Alexander N. Shoushtari, Shakuntala Tiwari, Agnes Viale, Omar Abdel-Wahab, Taha Merghoub, Michael F. Berger, Neal Rosen, Barry S. Taylor, David B. Solit
Journal: Cancer Research
Cancer Res (2020) 80 (19): 4233–4243.
https://doi.org/10.1158/0008-5472.CAN-20-0865
Published: 02 October 2020
View articletitled, Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer
Open the PDF for Leveraging Systematic Functional Analysis to Benchmark an In Silico Framework Distinguishes Driver from Passenger MEK Mutants in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation

Jia Yi Fong, Diana Low, Luca Pignata, Kimihito Cojin Kawabata, Stanley CW Lee, Cheryl Koh, Daniele Musiani, Enrico Massignani, Cheng Mun Wun, Pierre-Alexis V. Goy, Yudao Shen, Heike Wollmann, Florence PH Gay, Genna Luciani, Dalia Barsyte, Jian Jin, Ari M. Melnick, Tiziana Bonaldi, Omar Abdel-Wahab, Ernesto Guccione
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4731.
https://doi.org/10.1158/1538-7445.AM2019-4731
Published: 01 July 2019
View articletitled, Abstract 4731: Therapeutic targeting of RNA splicing through inhibition of protein arginine methylation
Journal Articles

Abstract 4654: Hotspot mutations in the core spliceosomal protein SF3B1 promote breast tumorigenesis

Bo Liu, Michelle Ki, Omar Abdel-Wahab, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4654.
https://doi.org/10.1158/1538-7445.AM2019-4654
Published: 01 July 2019
View articletitled, Abstract 4654: Hotspot mutations in the core spliceosomal protein SF3B1 promote breast tumorigenesis
Journal Articles

A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia

David R. Spiciarich, Stephen T. Oh, Amy Foley, Seamus B. Hughes, Michael J. Mauro, Omar Abdel-Wahab, Richard D. Press, Rosa Viner, Sarah L. Thompson, Qiushi Chen, Parastoo Azadi, Carolyn R. Bertozzi, Julia E. Maxson
Journal: Cancer Research
Cancer Res (2018) 78 (24): 6762–6770.
https://doi.org/10.1158/0008-5472.CAN-18-1638
Published: 13 December 2018
View articletitled, A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia
Open the PDF for A Novel Germline Variant in CSF3R Reduces N-Glycosylation and Exerts Potent Oncogenic Effects in Leukemia in another window
Includes: Supplementary data
Journal Articles

Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers

Silvia Buonamici, Akihide Yoshimi, Michael Thomas, Michael Seiler, Betty Chan, Benjamin Caleb, Fred Csibi, Rachel Darman, Peter Fekkes, Craig Karr, Gregg Keaney, Amy Kim, Virginia Klimek, Pavan Kumar, Kaiko Kunii, Stanley Chun-Wei Lee, Xiang Liu, Crystal MacKenzie, Carol Meeske, Yoshiharu Mizui, Eric Padron, Eunice Park, Ermira Pazolli, Sudeep Prajapati, Nathalie Rioux, Justin Taylor, John Wang, Markus Warmuth, Huilan Yao, Lihua Yu, Ping Zhu, Omar Abdel-Wahab, Peter Smith
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1185.
https://doi.org/10.1158/1538-7445.AM2017-1185
Published: 01 July 2017
View articletitled, Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers
Journal Articles

Abstract 5500: KMT2C directs estrogen receptor activity in normal and transformed mammary cells

Kinisha Gala, Amit Sinha, Francisco Sanchez-Vega, Young Rock Chung, James Hseih, Michael Berger, Nikolaus Schultz, Alessandro Pastore, Omar Abdel-Wahab, Sarat Chandarlapaty
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5500.
https://doi.org/10.1158/1538-7445.AM2017-5500
Published: 01 July 2017
View articletitled, Abstract 5500: KMT2C directs estrogen receptor activity in normal and transformed mammary cells
Journal Articles

Abstract 4737: Comprehensive profiling of immunoglobulin sequences using hybrid capture-based next generation sequencing in B-cell hematologic malignancies

Michelle K. Nahas, Lauren E. Young, Jeff Gardner, Omar Abdel-Wahab, Jie He, Amy L. Donahue, Kristina M. Knapp, Geoff A. Otto, Doron Lipson, Vincent A. Miller, Ross L. Levine, Philip J. Stephens
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4737.
https://doi.org/10.1158/1538-7445.AM2015-4737
Published: 01 August 2015
View articletitled, Abstract 4737: Comprehensive profiling of immunoglobulin sequences using hybrid capture-based next generation sequencing in B-cell hematologic malignancies
Journal Articles

Abstract 4927: Next-generation sequencing enables new approach to molecular cytogenetics

Jie He, Jeffrey Gardner, James X. Sun, Omar Abdel-Wahab, Andrew M. Intlekofer, Michelle K. Nahas, Jo-Anne Vergilio, Jeffery S. Ross, Roman Yelenskey, Ross Levine, Geoff Otto, Doron Lipson, Vincent Miller, Philip Stephens
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4927.
https://doi.org/10.1158/1538-7445.AM2015-4927
Published: 01 August 2015
View articletitled, Abstract 4927: Next-generation sequencing enables new approach to molecular cytogenetics
Journal Articles

Abstract 44: Leukemia-associated DNMT3A R882 mutations and their role in anthracycline-induced DNA damage response and therapeutic resistance

Olga A. Guryanova, Kaitlyn Shank, Luisa Luciani, Evangelia Loizou, Matthew D. Keller, Abby R. Weinstein, Omar Abdel-Wahab, Siddhartha Mukherjee, Stephen S. Nimer, Ross L. Levine
Journal: Cancer Research
Cancer Res (2014) 74 (23_Supplement): 44.
https://doi.org/10.1158/1538-7445.CANSUSC14-44
Published: 12 December 2014
View articletitled, Abstract 44: Leukemia-associated DNMT3A R882 mutations and their role in anthracycline-induced DNA damage response and therapeutic resistance
Journal Articles

Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells

Wendy Beguelin, Matt Teater, Relja Popovic, Yanwen Jiang, Leandro Cerchietti, Rita Shaknovich, Randy Gascoyne, Ross Levine, Omar Abdel-Wahab, Jonathan Licht, Olivier Elemento, Ari M. Melnick
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY09-03.
https://doi.org/10.1158/1538-7445.AM2014-SY09-03
Published: 01 October 2014
View articletitled, Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells
Journal Articles

Abstract 3706: Oncogenic RAF mutants that signal as functional dimers are resistant to current RAF inhibitors but sensitive to a novel inhibitor of RAF dimer kinase activity

Zhan Yao, Merna Torres, Min Wei, Aphrothiti Hanrahan, Omar Abdel-Wahab, David Solit, Lusong Luo, Poulikos Poulikakos, Neal Rosen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3706.
https://doi.org/10.1158/1538-7445.AM2014-3706
Published: 01 October 2014
View articletitled, Abstract 3706: Oncogenic RAF mutants that signal as functional dimers are resistant to current RAF inhibitors but sensitive to a novel inhibitor of RAF dimer kinase activity
Journal Articles

Abstract 3140: Context specific effects of the BRAFV600E mutation on hematopoiesis identifies novel models of BRAF mutant hematopoietic disorders

Eunhee Kim, Stephen S. Chung, Jae H. Park, Young Rock Chung, Piro Lito, Julie Feldstein, Wenhuo Hu, Wendy Beguilin, Sebastien Monette, Cihangir Duy, Raajit Rampal, Leon Telis, Minal Patel, Min Kyung Kim, Ari M. Melnick, Neal Rosen, Martin S. Tallman, Christopher Y. Park, Omar Abdel-Wahab
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3140.
https://doi.org/10.1158/1538-7445.AM2014-3140
Published: 01 October 2014
View articletitled, Abstract 3140: Context specific effects of the BRAFV600E mutation on hematopoiesis identifies novel models of BRAF mutant hematopoietic disorders
Journal Articles

Abstract A09: Coordinate regulation of chromatin state by JAK2 and ASXL1 mutations in myeloid malignancies

Lindsay M. LaFave, Young Rock Chung, Matt Keller, Maria Kleppe, Ann Mullally, Omar Abdel-Wahab, Ross L. Levine
Journal: Cancer Research
Cancer Res (2013) 73 (13_Supplement): A09.
https://doi.org/10.1158/1538-7445.CEC13-A09
Published: 13 May 2014
View articletitled, Abstract A09: Coordinate regulation of chromatin state by JAK2 and ASXL1 mutations in myeloid malignancies