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Journal Articles

Abstract PR013: BH3 profiling of senescent cancer cells to identify mechanisms of resistance to ABT-263

Fleur Jochems, Julie A. MacDonald, Chrysiida Baltira, Veerle Daniels, Mark de Gooijer, Olaf Van Tellingen, Anthony Letai, René Bernards

Cancer Res (2023) 83 (2_Supplement_1): PR013.

https://doi.org/10.1158/1538-7445.AGCA22-PR013

Published: 15 January 2023

View article titled, Abstract PR013: BH3 profiling of senescent cancer cells to identify mechanisms of resistance to ABT-263

Journal Articles

Abstract 92: Increasing TTFields treatment efficacy by targeting G2 cell cycle checkpoint

Paul Slangen, Mariska van Geldorp, Mark de Gooijer, Olaf van Tellingen, Gerben Borst

Cancer Res (2020) 80 (16_Supplement): 92.

https://doi.org/10.1158/1538-7445.AM2020-92

Published: 15 August 2020

View article titled, Abstract 92: Increasing TTFields treatment efficacy by targeting G2 cell cycle checkpoint

Journal Articles

Abstract LB-255: Acquired and intrinsic resistance to vemurafenib in BRAF^v600e-driven melanoma brain metastases

Mark C. de Gooijer, Ping Zhang, Levi C. Buil, Stephan Freriks, Gang Li, Jos H. Beijnen, Olaf Van Tellingen

Cancer Res (2019) 79 (13_Supplement): LB-255.

https://doi.org/10.1158/1538-7445.AM2019-LB-255

Published: 01 July 2019

View article titled, Abstract LB-255: Acquired and intrinsic resistance to vemurafenib in BRAF<sup>v600e</sup>-driven melanoma brain metastases

Journal Articles

Abstract 4419: Cell cycle analysis during TTF to exploit novel targets for increasing treatment efficacy

Paul Slangen, Mark de Gooijer, Olaf van Tellingen, Moshe Giladi, Gerben Borst

Cancer Res (2019) 79 (13_Supplement): 4419.

https://doi.org/10.1158/1538-7445.AM2019-4419

Published: 01 July 2019

View article titled, Abstract 4419: Cell cycle analysis during TTF to exploit novel targets for increasing treatment efficacy

Journal Articles

Abstract 3607: Loss-of-function screens using haploid KBM7 and HAP1 cells to identify mechanisms of anti-cancer drug resistance

Nora M. Gerhards, Charlotte Guyader, Vincent A. Blomen, Aslı Küçükosmanoğlu, Olaf van Tellingen, Daniel J. Vis, Lodewyk F. Wessels, Thijn R. Brummelkamp, Piet Borst, Sven Rottenberg

Cancer Res (2015) 75 (15_Supplement): 3607.

https://doi.org/10.1158/1538-7445.AM2015-3607

Published: 01 August 2015

View article titled, Abstract 3607: Loss-of-function screens using haploid KBM7 and HAP1 cells to identify mechanisms of anti-cancer drug resistance

Journal Articles

Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Amir Avan, Viola Caretti, Niccola Funel, Elena Galvani, Mina Maftouh, Richard J. Honeywell, Tonny Lagerweij, Olaf Van Tellingen, Daniela Campani, Dieter Fuchs, Henk M. Verheul, Gerrit-Jan Schuurhuis, Ugo Boggi, Godefridus J. Peters, Thomas Würdinger, Elisa Giovannetti

Cancer Res (2013) 73 (22): 6745–6756.

https://doi.org/10.1158/0008-5472.CAN-13-0837

Published: 14 November 2013

View article titled, Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Includes: Supplementary data

Journal Articles

Abstract 966: Effect of ABC drug transporters (BCRP, MDR1, MRP2) on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA .

Serena Marchetti, Dick Pluim, Monique van Eijndhoven, Olaf van Tellingen, Roberto Mazzanti, Jos Beijnen, Jan HM Schellens

Cancer Res (2013) 73 (8_Supplement): 966.

https://doi.org/10.1158/1538-7445.AM2013-966

Published: 15 April 2013

View article titled, Abstract 966: Effect of ABC drug transporters (BCRP, MDR1, MRP2) on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA .

Journal Articles

Abstract 5687: Development of glutathione pegylated liposomal doxorubicin (2B3-101) for the treatment of brain cancer

Pieter J. Gaillard, Werner Gladdines, Chantal C.M. Appeldoorn, Jaap Rip, Willem J. Boogerd, Jos H. Beijnen, Dieta Brandsma, Olaf van Tellingen

Cancer Res (2012) 72 (8_Supplement): 5687.

https://doi.org/10.1158/1538-7445.AM2012-5687

Published: 15 April 2012

View article titled, Abstract 5687: Development of glutathione pegylated liposomal doxorubicin (2B3-101) for the treatment of brain cancer

Journal Articles

Abstract 5718: Implementation of μ-Image Guided Radio-Therapy in the treatment of experimental glioma mouse models: Assessment of the potential of agents that interfere with DNA repair

Mark C. de Gooijer, Fan Lin, Alessia Gasparini, Nienke A. de Vries, Levi C.M. Buil, Tom Wurdinger, Jan-Jakob Sonke, Jos H. Beijnen, Olaf Van Tellingen

Cancer Res (2012) 72 (8_Supplement): 5718.

https://doi.org/10.1158/1538-7445.AM2012-5718

Published: 15 April 2012

View article titled, Abstract 5718: Implementation of μ-Image Guided Radio-Therapy in the treatment of experimental glioma mouse models: Assessment of the potential of agents that interfere with DNA repair

Journal Articles

Abstract LB-210: Impact of ABC-transporters in the blood-brain barrier on the efficacy of the PARP inhibitor ABT-888 against transplanted and spontaneous murine brain tumors

Lin Fan, Mark C. de Gooijer, Jan H. Beumer, Susan M. Christner, Jos H. Beijnen, Olaf Van Tellingen

Cancer Res (2011) 71 (8_Supplement): LB-210.

https://doi.org/10.1158/1538-7445.AM2011-LB-210

Published: 15 April 2011

View article titled, Abstract LB-210: Impact of ABC-transporters in the blood-brain barrier on the efficacy of the PARP inhibitor ABT-888 against transplanted and spontaneous murine brain tumors

Journal Articles

Abstract LB-301: The impact of Abcb1 and Abcg2 on the brain penetration of PI3K-mTOR inhibitors

Lin Fan, Mark C. de Gooijer, Levi Buil, Nienke A. de Vries, Jos H. Beijnen, Olaf van Tellingen

Cancer Res (2010) 70 (8_Supplement): LB-301.

https://doi.org/10.1158/1538-7445.AM10-LB-301

Published: 15 April 2010

View article titled, Abstract LB-301: The impact of Abcb1 and Abcg2 on the brain penetration of PI3K-mTOR inhibitors

Journal Articles

Abstract LB-49: ABC transporters in the blood-brain barrier limit the brain penetration of the PARP inhibitor ABT-888

Lin Fan, Mark C. de Gooijer, Jan H. Beumer, Susan M. Christner, Jos H. Beijnen, Olaf van Tellingen

Cancer Res (2010) 70 (8_Supplement): LB-49.

https://doi.org/10.1158/1538-7445.AM10-LB-49

Published: 15 April 2010

View article titled, Abstract LB-49: ABC transporters in the blood-brain barrier limit the brain penetration of the PARP inhibitor ABT-888

Journal Articles

Abstract 5537: GSH-conjugation improves efficacy of Doxil against intracranial xenografts

Olaf van Tellingen, Dieta Brandsma, Chantal C.M. Appeldoorn, M Francesca Manca, Jaap Rip, Rick Dorland, Joan M.R van Kregten, Willem J. Boogerd, Jos H. Beijnen, Pieter J. Gaillard

Cancer Res (2010) 70 (8_Supplement): 5537.

https://doi.org/10.1158/1538-7445.AM10-5537

Published: 15 April 2010

View article titled, Abstract 5537: GSH-conjugation improves efficacy of Doxil against intracranial xenografts

Journal Articles

Abstract 4187: A rapid and robust transgenic high-grade glioma mouse model for therapy-intervention studies

Nienke A. de Vries, Sophia W. Bruggeman, Hilda I. de Vries, John Zevenhoven, Tessa Buckle, Bob C. Hamans, William P. Leenders, Jos H. Beijnen, Maarten van Lohuizen, Anton J.M. Berns, Olaf van Tellingen

Cancer Res (2010) 70 (8_Supplement): 4187.

https://doi.org/10.1158/1538-7445.AM10-4187

Published: 15 April 2010

View article titled, Abstract 4187: A rapid and robust transgenic high-grade glioma mouse model for therapy-intervention studies

Journal Articles

Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan

Serge A.L. Zander, Ariena Kersbergen, Eline van der Burg, Niels de Water, Olaf van Tellingen, Sjöfn Gunnarsdottir, Janneke E. Jaspers, Marina Pajic, Anders O.H. Nygren, Jos Jonkers, Piet Borst, Sven Rottenberg

Cancer Res (2010) 70 (4): 1700–1710.

https://doi.org/10.1158/0008-5472.CAN-09-3367

Published: 14 February 2010

View article titled, Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan

Includes: Supplementary data

Journal Articles

Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

Robert A.B. van Waterschoot, Jurjen S. Lagas, Els Wagenaar, Cornelia M.M. van der Kruijssen, Antonius E. van Herwaarden, Ji-Ying Song, Rogier W. Rooswinkel, Olaf van Tellingen, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel

Cancer Res (2009) 69 (23): 8996–9002.

https://doi.org/10.1158/0008-5472.CAN-09-2915

Published: 30 November 2009

View article titled, Absence of Both Cytochrome <em>P</em>450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

Includes: Supplementary data

Journal Articles

Abstract #3148: The protection of bone marrow stem cells by ABC transporters using topotecan as cytotoxic agent

Olaf van Tellingen, Natalie Proost, Tessa Buckle, Johan Jonker, Jos Beijnen

Cancer Res (2009) 69 (9_Supplement): 3148.

Published: 01 May 2009

View article titled, Abstract #3148: The protection of bone marrow stem cells by ABC transporters using topotecan as cytotoxic agent

Journal Articles

Optimizing brain tumor chemotherapy with clinically relevant spontaneous high-grade glioma mouse models

Nienke de Vries, Tessa Buckle, Sophia Bruggeman, Hilda de Vries, Maarten van Lohuizen, Jos Beijnen, Olaf van Tellingen

Cancer Res (2008) 68 (9_Supplement): 2924.

Published: 01 May 2008

View article titled, Optimizing brain tumor chemotherapy with clinically relevant spontaneous high-grade glioma mouse models

Journal Articles

Inhibition of breast cancer resistance protein and P-glycoprotein enhances the brain penetration of temozolomide

Olaf van Tellingen, Nienke de Vries, Tessa Buckle, Willem Boogerd, Jos Beijnen

Cancer Res (2008) 68 (9_Supplement): 3243.

Published: 01 May 2008

View article titled, Inhibition of breast cancer resistance protein and P-glycoprotein enhances the brain penetration of temozolomide

Journal Articles

Functional interaction of the ABC transporters Bcrp1 (Abcg2) and Mrp2 (Abcc2) in methotrexate elimination

Maria Vlaming, Anita van Esch, Zeliha Pala, Els Wagenaar, Olaf van Tellingen, Alfred Schinkel

Cancer Res (2007) 67 (9_Supplement): 2293.

Published: 01 May 2007

View article titled, Functional interaction of the ABC transporters Bcrp1 (Abcg2) and Mrp2 (Abcc2) in methotrexate elimination

NARROW

Abstract PR013: BH3 profiling of senescent cancer cells to identify mechanisms of resistance to ABT-263

Abstract 92: Increasing TTFields treatment efficacy by targeting G2 cell cycle checkpoint

Abstract LB-255: Acquired and intrinsic resistance to vemurafenib in BRAF^v600e-driven melanoma brain metastases

Abstract 4419: Cell cycle analysis during TTF to exploit novel targets for increasing treatment efficacy

Abstract 3607: Loss-of-function screens using haploid KBM7 and HAP1 cells to identify mechanisms of anti-cancer drug resistance

Crizotinib Inhibits Metabolic Inactivation of Gemcitabine in c-Met–driven Pancreatic Carcinoma

Abstract 966: Effect of ABC drug transporters (BCRP, MDR1, MRP2) on the disposition, brain accumulation and myelotoxicity of the aurora kinase B inhibitor barasertib and its more active form barasertib-hydroxy-QPA .

Abstract 5687: Development of glutathione pegylated liposomal doxorubicin (2B3-101) for the treatment of brain cancer

Abstract 5718: Implementation of μ-Image Guided Radio-Therapy in the treatment of experimental glioma mouse models: Assessment of the potential of agents that interfere with DNA repair

Abstract LB-210: Impact of ABC-transporters in the blood-brain barrier on the efficacy of the PARP inhibitor ABT-888 against transplanted and spontaneous murine brain tumors

Abstract LB-301: The impact of Abcb1 and Abcg2 on the brain penetration of PI3K-mTOR inhibitors

Abstract LB-49: ABC transporters in the blood-brain barrier limit the brain penetration of the PARP inhibitor ABT-888

Abstract 5537: GSH-conjugation improves efficacy of Doxil against intracranial xenografts

Abstract 4187: A rapid and robust transgenic high-grade glioma mouse model for therapy-intervention studies

Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan

Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

Abstract #3148: The protection of bone marrow stem cells by ABC transporters using topotecan as cytotoxic agent

Optimizing brain tumor chemotherapy with clinically relevant spontaneous high-grade glioma mouse models

Inhibition of breast cancer resistance protein and P-glycoprotein enhances the brain penetration of temozolomide

Functional interaction of the ABC transporters Bcrp1 (Abcg2) and Mrp2 (Abcc2) in methotrexate elimination

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