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Journal Articles

The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer

Soma Samanta, Suhui Yang, Bikash Debnath, Ding Xue, Yuting Kuang, Kavya Ramkumar, Amy S. Lee, Mats Ljungman, Nouri Neamati
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1883–1895.
https://doi.org/10.1158/0008-5472.CAN-20-1540
Published: 01 April 2021
View article titled, The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer
Open the PDF for The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress–Mediated Apoptosis in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor

Yibin Xu, Armand Bankhead, III, Xiaoli Tian, Jianming Tang, Mats Ljungman, Nouri Neamati
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (17): 3692–3705.
https://doi.org/10.1158/0008-5472.CAN-20-0530
Published: 02 September 2020
View article titled, Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor
Open the PDF for Deletion of Glutathione S-Transferase Omega 1 Activates Type I Interferon Genes and Downregulates Tissue Factor in another window
Includes: Supplementary data
Journal Articles

Abstract 4395: The cMYC-associated transcription factor JPO2 is upregulated in taxane resistant prostate cancer cells and interacts with the stress oncoprotein LEDGF/p75

Greisha L. Ortiz Hernandez, Shannalee Martinez, Evelyn Sanchez-Hernandez, Leslimar Rios-Colon, Christina Cajigas-DuRoss, Tino Sanchez, Nouri Neamati, Carlos A. Casiano
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4395.
https://doi.org/10.1158/1538-7445.AM2019-4395
Published: 01 July 2019
View article titled, Abstract 4395: The cMYC-associated transcription factor JPO2 is upregulated in taxane resistant prostate cancer cells and interacts with the stress oncoprotein LEDGF/p75
Journal Articles

Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy

Yajing Liu, Wenbin Ji, Andrea Shergalis, Jiaqi Xu, Amy M. Delaney, Andrew Calcaterra, Anupama Pal, Mats Ljungman, Nouri Neamati, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2019) 79 (11): 2923–2932.
https://doi.org/10.1158/0008-5472.CAN-18-2540
Published: 03 June 2019
View article titled, Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy
Open the PDF for Activation of the Unfolded Protein Response via Inhibition of Protein Disulfide Isomerase Decreases the Capacity for DNA Repair to Sensitize Glioblastoma to Radiotherapy in another window
Includes: Supplementary data
Journal Articles

Abstract 2533: SGI-110 priming sensitizes hepatocellular carcinoma cells to oxaliplatin

Yuting Kuang, Anthony El-Khoueiry, Pietro Taverna, Mats Ljungman, Nouri Neamati
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2533.
https://doi.org/10.1158/1538-7445.AM2015-2533
Published: 01 August 2015
View article titled, Abstract 2533: SGI-110 priming sensitizes hepatocellular carcinoma cells to oxaliplatin
Journal Articles

Abstract 5411: Repositioning HIV-based small molecule inhibitors of the stress survival oncoprotein LEDGF/p75 to overcome taxane resistance in prostate cancer

Leslimar Rios Colon, Catherine Elix, Ivana Alicea, Anamika Basu, Christina Du Ross, Tino Sanchez, Nouri Neamati, Carlos Casiano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5411.
https://doi.org/10.1158/1538-7445.AM2015-5411
Published: 01 August 2015
View article titled, Abstract 5411: Repositioning HIV-based small molecule inhibitors of the stress survival oncoprotein LEDGF/p75 to overcome taxane resistance in prostate cancer
Journal Articles

Abstract 4454: Targeting the gp130 receptor in preclinical models of triple-negative breast cancer

Leonel F. Hernandez-Aya, Yajing Liu, Kelsey Kerr, Shuzo Tamura, Nouri Neamati, Max S. Wicha, Monika L. Burness
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4454.
https://doi.org/10.1158/1538-7445.AM2015-4454
Published: 01 August 2015
View article titled, Abstract 4454: Targeting the gp130 receptor in preclinical models of triple-negative breast cancer
Journal Articles

Abstract 4466: New biomarkers to optimize preclinical development of the PDI inhibitor XCE853

Gregoire Pierre Prevost, Marine Garrido, Shili Xu, Celine Lefebvre, Anne Chauchereau, Denis Carniato, Jean François Briand, Mathieu Gutmann, Maria Serova, Annemilai Tijeras-Raballand, Armand De Grammont, Eric Raymond, Christian Gespach, Michèle Sabbah, Nouri Neamati, Marc-Henry Pitty, Paul Foster
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4466.
https://doi.org/10.1158/1538-7445.AM2015-4466
Published: 01 August 2015
View article titled, Abstract 4466: New biomarkers to optimize preclinical development of the PDI inhibitor XCE853
Journal Articles

Abstract 1812: XCE853: A novel PDI inhibitor that inhibits proliferation of human tumor cells in vitro, ex-vivo and in vivo

Gregoire P. Prevost, Shili Xu, Marine Garrido, Maria Serova, Olivier D. Vewer, Christian Gespach, Jean-François Briand, Annemilaï Tijeras-Raballand, Mathieu Gutmann, An Hendrix, Michele Sabbah, Anne Chachereau, Armand de Gramont, Nouri Neamati, Denis Carniato, Marc-Henry Pitty, Paul Foster
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1812.
https://doi.org/10.1158/1538-7445.AM2014-1812
Published: 01 October 2014
View article titled, Abstract 1812: XCE853: A novel PDI inhibitor that inhibits proliferation of human tumor cells <em>in vitro</em>, <em>ex-vivo</em> and <em>in vivo</em>
Journal Articles

Abstract 775: Targeting the stress survival oncoprotein LEDGF/p75 to overcome prostate cancer resistance to taxane therapy

Leslimar Rios Colon, Catherine Elix, Anamika Basu, Tino W. Sanchez, Nouri Neamati, Carlos A. Casiano
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 775.
https://doi.org/10.1158/1538-7445.AM2014-775
Published: 01 October 2014
View article titled, Abstract 775: Targeting the stress survival oncoprotein LEDGF/p75 to overcome prostate cancer resistance to taxane therapy
Journal Articles

Abstract 5513: Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase (PDI) for ovarian cancer treatment.

Shili Xu, Alexey N. Butkevich, Roppei Yamada, Yu Zhou, Bikash Debnath, Roger Duncan, Ebrahim Zandi, Nicos A. Petasis, Nouri Neamati
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5513.
https://doi.org/10.1158/1538-7445.AM2013-5513
Published: 15 April 2013
View article titled, Abstract 5513: Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase (PDI) for ovarian cancer treatment.
Journal Articles

Abstract 4558: Discovery and mechanistic studies of novel class of CXCR2 inhibitors.

Helen Ha, Nouri Neamati
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4558.
https://doi.org/10.1158/1538-7445.AM2013-4558
Published: 15 April 2013
View article titled, Abstract 4558: Discovery and mechanistic studies of novel class of CXCR2 inhibitors.
Journal Articles

Abstract 5678: Design of GRP78 inhibitors as novel therapeutics for breast cancer.

Kavya Ramkumar, Bikash Debnath, Amy S. Lee, Nouri Neamati
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5678.
https://doi.org/10.1158/1538-7445.AM2013-5678
Published: 15 April 2013
View article titled, Abstract 5678: Design of GRP78 inhibitors as novel therapeutics for breast cancer.
Journal Articles

Abstract 4555: Design and discovery of novel small molecule redox modulators as therapies for pancreatic cancer.

Divya Pathania, Mario Sechi, Michele Palomba, Vanna Sanna, Francesco Berrettini, Angela Sias, Laleh Taheri, Nouri Neamati
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4555.
https://doi.org/10.1158/1538-7445.AM2013-4555
Published: 15 April 2013
View article titled, Abstract 4555: Design and discovery of novel small molecule redox modulators as therapies for pancreatic cancer.
Journal Articles

Abstract 2480: Discovery and mechanistic characterization of AV220, a novel small molecule targeting cancer cell metabolism.

Melissa Millard, Nouri Neamati
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2480.
https://doi.org/10.1158/1538-7445.AM2013-2480
Published: 15 April 2013
View article titled, Abstract 2480: Discovery and mechanistic characterization of AV220, a novel small molecule targeting cancer cell metabolism.
Journal Articles

Abstract 2908: Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery

Roppei Yamada, Shili Xu, Nouri Neamati
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2908.
https://doi.org/10.1158/1538-7445.AM2012-2908
Published: 15 April 2012
View article titled, Abstract 2908: Biological evaluation of paclitaxel-peptide conjugates as a model for MMP2-targeted drug delivery
Journal Articles

Abstract 1927: Mechanistic characterization of SC144 in colon cancer

Shili Xu, Takashi Oshima, Fedora Grande, Nouri Neamati, Antonio Garofalo
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1927.
https://doi.org/10.1158/1538-7445.AM2012-1927
Published: 15 April 2012
View article titled, Abstract 1927: Mechanistic characterization of SC144 in colon cancer
Journal Articles

Abstract 2542: Preclinical studies of novel phosphonium salts with broad-spectrum activity

Melissa Millard, Divya Pathania, Yumna Shabaik, Laleh Taheri, Jinxia Deng, Nouri Neamati
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2542.
https://doi.org/10.1158/1538-7445.AM2011-2542
Published: 15 April 2011
View article titled, Abstract 2542: Preclinical studies of novel phosphonium salts with broad-spectrum activity
Journal Articles

Abstract 682: Design and discovery of novel small molecule modulators of reactive oxygen species-mediated cell signaling

Divya Pathania, Mario Sechi, Michele Palomba, Alessia Cosseddu, Vanna Sanna, Francesco Berrettini, Angela Sias, Laleh Taheri, Nouri Neamati
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 682.
https://doi.org/10.1158/1538-7445.AM2011-682
Published: 15 April 2011
View article titled, Abstract 682: Design and discovery of novel small molecule modulators of reactive oxygen species-mediated cell signaling
Journal Articles

Abstract #666: Pharmacophore guided discovery of small molecule human apurinic/ apyrimidinic endonuclease 1 inhibitors

Nouri Neamati, Zahrah Zawahir, Raveendra Dayam, Jinxia Deng, Cherelene Pereira
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 666.
Published: 01 May 2009
View article titled, Abstract #666: Pharmacophore guided discovery of small molecule human apurinic/ apyrimidinic endonuclease 1 inhibitors