Page 1 | Search Results | Cancer Research | American Association for Cancer Research

1-20 of 20

Sort by

Sort Order Select

Journal Articles

New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging

Hailey E. Brighton, Steven P. Angus, Tao Bo, Jose Roques, Alicia C. Tagliatela, David B. Darr, Kubra Karagoz, Noah Sciaky, Michael L. Gatza, Norman E. Sharpless, Gary L. Johnson, James E. Bear

Cancer Res (2018) 78 (2): 542–557.

https://doi.org/10.1158/0008-5472.CAN-17-1653

Published: 15 January 2018

View article titled, New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging

Includes: Supplementary data

Journal Articles

Abstract 4499: Integration of targeted RNA sequencing to targeted DNA sequencing for the characterization of clinically relevant variants in a population of thousands of patients treated on clinical trial

Woochang Lee, Heejoon Jo, Xiaoying Yin, David A. Eberhard, Nirali M. Patel, Michele C. Hayward, Ashley H. Salazar, Joel S. Parker, William Y. Kim, Henry S. Earp, Norman E. Sharpless, David N. Hayes

Cancer Res (2016) 76 (14_Supplement): 4499.

https://doi.org/10.1158/1538-7445.AM2016-4499

Published: 15 July 2016

View article titled, Abstract 4499: Integration of targeted RNA sequencing to targeted DNA sequencing for the characterization of clinically relevant variants in a population of thousands of patients treated on clinical trial

Journal Articles

Abstract 4382: Intravital imaging of endogenous BRAFV600E melanoma reveals plasticity of tumor response and resistance to trametinib over time

Hailey E. Brighton, Steven Angus, Tao Bo, David Darr, Norman E. Sharpless, Gary L. Johnson, James E. Bear

Cancer Res (2016) 76 (14_Supplement): 4382.

https://doi.org/10.1158/1538-7445.AM2016-4382

Published: 15 July 2016

View article titled, Abstract 4382: Intravital imaging of endogenous BRAFV600E melanoma reveals plasticity of tumor response and resistance to trametinib over time

Journal Articles

Abstract 941: G1T28-1, a novel CDK4/6 inhibitor, protects murine hematopoietic stem and progenitor cells from cytotoxic chemotherapy

Jessica A. Sorrentino, Shenghui He, John E. Bisi, Patrick J. Roberts, Jay C. Strum, Norman E. Sharpless

Cancer Res (2015) 75 (15_Supplement): 941.

https://doi.org/10.1158/1538-7445.AM2015-941

Published: 01 August 2015

View article titled, Abstract 941: G1T28-1, a novel CDK4/6 inhibitor, protects murine hematopoietic stem and progenitor cells from cytotoxic chemotherapy

Journal Articles

Abstract CT133: The impact of gene panel sequencing on clinical care in patients with cancer

David Neil Hayes, Juneko E. Grilley-Olson, David A. Eberhard, Nirali M. Patel, Joel S. Parker, Karen E. Weck, William Y. Kim, Michele C. Hayward, H. Shelton Earp, Norman E. Sharpless

Cancer Res (2015) 75 (15_Supplement): CT133.

https://doi.org/10.1158/1538-7445.AM2015-CT133

Published: 01 August 2015

View article titled, Abstract CT133: The impact of gene panel sequencing on clinical care in patients with cancer

Journal Articles

Abstract 4761: Defining the adaptive kinome response to BRAF and MEK inhibition in melanoma

Steven P. Angus, Timothy J. Stuhlmiller, Rachel Reuther, Trang T. Pham, Deborah A. Granger, David B. Darr, Jamie L. Jordan, Stergios J. Moschos, Gary L. Johnson, Norman E. Sharpless

Cancer Res (2014) 74 (19_Supplement): 4761.

https://doi.org/10.1158/1538-7445.AM2014-4761

Published: 01 October 2014

View article titled, Abstract 4761: Defining the adaptive kinome response to BRAF and MEK inhibition in melanoma

Journal Articles

Abstract 947: A small molecule Mer tyrosine kinase inhibitor (UNC MerTKi) effectively inhibits growth of murine melanoma

H Shelton Earp, David Darr, Albert Zimmermann, Kelly Clark, Norman E. Sharpless, Wolfgang Bergmeier, Weihe Zhang, Xiaodong Wang, Deborah DeRyckere, Stephen Frye, Douglas Graham

Cancer Res (2014) 74 (19_Supplement): 947.

https://doi.org/10.1158/1538-7445.AM2014-947

Published: 01 October 2014

View article titled, Abstract 947: A small molecule Mer tyrosine kinase inhibitor (UNC MerTKi) effectively inhibits growth of murine melanoma

Journal Articles

Abstract 5024: mDX400, the murine analog against the anti-PD1 antibody MK-347 is active in immunocompetent, autochthonous murine models of melanoma and breast cancer

David Darr, Kelly S. Clark, Joseph H. Phillips, Elaine Pinheiro, Venkataraman Sriram, Jessie Xiong, Jamie Jordan, Norman E. Sharpless, Charles Perou, Stergios Moschos

Cancer Res (2014) 74 (19_Supplement): 5024.

https://doi.org/10.1158/1538-7445.AM2014-5024

Published: 01 October 2014

View article titled, Abstract 5024: mDX400, the murine analog against the anti-PD1 antibody MK-347 is active in immunocompetent, autochthonous murine models of melanoma and breast cancer

Journal Articles

Abstract 4943: Visualization of endogenous melanoma initiation and progression using intravital microscopy

James E. Bear, Hailey E. Brighton, Norman E. Sharpless, David B. Darr, Kelly S. Clark

Cancer Res (2014) 74 (19_Supplement): 4943.

https://doi.org/10.1158/1538-7445.AM2014-4943

Published: 01 October 2014

View article titled, Abstract 4943: Visualization of endogenous melanoma initiation and progression using intravital microscopy

Journal Articles

Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma

Keefe T. Chan, Sreeja B. Asokan, Tao Bo, Matthew E. Berginski, Wenjin Liu, Shelly D. Cochran, Norman E. Sharpless, James E. Bear

Cancer Res (2013) 73 (3_Supplement): C14.

https://doi.org/10.1158/1538-7445.TIM2013-C14

Published: 01 May 2014

View article titled, Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma

Journal Articles

Abstract 2400: Differential phosphorylation of signaling targets as a function of RAS mutation status and tumor histology in non-small cell lung cancer.

Sang-Won Um, Jingxiang Chen, Carrie Lee, Norman E. Sharpless, Patrick J. Roberts, D. Neil Hayes

Cancer Res (2013) 73 (8_Supplement): 2400.

https://doi.org/10.1158/1538-7445.AM2013-2400

Published: 15 April 2013

View article titled, Abstract 2400: Differential phosphorylation of signaling targets as a function of RAS mutation status and tumor histology in non-small cell lung cancer.

Journal Articles

Abstract 1087: Differential oncogenicity of N-RAS mutations in melanoma.

Christin Burd, William R. Jeck, Kailing Fu, Kelly S. Clark, Jessie C. Xiong, George P. Souroullas, Norman E. Sharpless

Cancer Res (2013) 73 (8_Supplement): 1087.

https://doi.org/10.1158/1538-7445.AM2013-1087

Published: 15 April 2013

View article titled, Abstract 1087: Differential oncogenicity of N-RAS mutations in melanoma.

Journal Articles

Abstract 5271: p16-LUC: an in vivo reporter allele for de novo tumor formation and therapeutic response

Christin E. Burd, Kelly Clark, Norman E. Sharpless

Cancer Res (2011) 71 (8_Supplement): 5271.

https://doi.org/10.1158/1538-7445.AM2011-5271

Published: 15 April 2011

View article titled, Abstract 5271: p16-LUC: an in vivo reporter allele for de novo tumor formation and therapeutic response

Journal Articles

Abstract 4203: Plasma and tumor pharmacokinetics (PK) of carboplatin in Genetically Engineered Mouse Models of melanoma (GEMMs), murine melanoma, and in patients with cutaneous melanoma

Austin J. Combest, Patrick J. Roberts, Patrick J. Dillon, Sohrab Habibi, Julie L. Eiseman, Sandra Strychor, Suzan K. Hanna, Markus Muller, Matthias Brunner, Charlene M. Ross, Norman E. Sharpless, Willam C. Zamboni

Cancer Res (2010) 70 (8_Supplement): 4203.

https://doi.org/10.1158/1538-7445.AM10-4203

Published: 15 April 2010

View article titled, Abstract 4203: Plasma and tumor pharmacokinetics (PK) of carboplatin in Genetically Engineered Mouse Models of melanoma (GEMMs), murine melanoma, and in patients with cutaneous melanoma

Journal Articles

LKB1 and Lung Cancer: More Than the Usual Suspects

Usman Shah, Norman E. Sharpless, D. Neil Hayes

Cancer Res (2008) 68 (10): 3562–3565.

https://doi.org/10.1158/0008-5472.CAN-07-6620

Published: 15 May 2008

View article titled, LKB1 and Lung Cancer: More Than the Usual Suspects

Journal Articles

Expression of p16^Ink4a Compensates for p18^Ink4c Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues

Matthew R. Ramsey, Janakiraman Krishnamurthy, Xin-Hai Pei, Chad Torrice, Weili Lin, Daniel R. Carrasco, Keith L. Ligon, Yue Xiong, Norman E. Sharpless

Cancer Res (2007) 67 (10): 4732–4741.

https://doi.org/10.1158/0008-5472.CAN-06-3437

Published: 17 May 2007

View article titled, Expression of p16Ink4a Compensates for p18Ink4c Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues

Includes: Supplementary data

Journal Articles

Lack of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Signaling Shows a New Type of Melanoma

Janiel M. Shields, Nancy E. Thomas, Melissa Cregger, Aaron J. Berger, Michael Leslie, Chad Torrice, Honglin Hao, Shannon Penland, Jack Arbiser, Glynis Scott, Tong Zhou, Menashe Bar-Eli, James E. Bear, Channing J. Der, William K. Kaufmann, David L. Rimm, Norman E. Sharpless

Cancer Res (2007) 67 (4): 1502–1512.

https://doi.org/10.1158/0008-5472.CAN-06-3311

Published: 16 February 2007

View article titled, Lack of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Signaling Shows a New Type of Melanoma

Includes: Supplementary data

Journal Articles

Dissecting the oncogenic consequences of p19Arf/p53- and p16Ink4a/pRB-pathway disruption

Takeshi Ichikawa, Elena Sviderskaya, Linan Ha, Miriam Anver, Norman E. Sharpless, Ronald A. Depinho, Dorothy C. Bennett, Glenn Merlino

Cancer Res (2006) 66 (8_Supplement): 591.

Published: 15 April 2006

View article titled, Dissecting the oncogenic consequences of p19Arf/p53- and p16Ink4a/pRB-pathway disruption

Journal Articles

Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma

Rónán C. O’Hagan, Cameron W. Brennan, Andrew Strahs, Xuegong Zhang, Karuppiah Kannan, Melissa Donovan, Craig Cauwels, Norman E. Sharpless, Wing Hung Wong, Lynda Chin

Cancer Res (2003) 63 (17): 5352–5356.

Published: 18 September 2003

View article titled, Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma

Journal Articles

p16^INK4a and p53 Deficiency Cooperate in Tumorigenesis

Norman E. Sharpless, Scott Alson, Suzanne Chan, Daniel P. Silver, Diego H. Castrillon, Ronald A. DePinho

Cancer Res (2002) 62 (10): 2761–2765.

Published: 01 May 2002

View article titled, p16INK4a and p53 Deficiency Cooperate in Tumorigenesis

NARROW

New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging

Abstract 4499: Integration of targeted RNA sequencing to targeted DNA sequencing for the characterization of clinically relevant variants in a population of thousands of patients treated on clinical trial

Abstract 4382: Intravital imaging of endogenous BRAFV600E melanoma reveals plasticity of tumor response and resistance to trametinib over time

Abstract 941: G1T28-1, a novel CDK4/6 inhibitor, protects murine hematopoietic stem and progenitor cells from cytotoxic chemotherapy

Abstract CT133: The impact of gene panel sequencing on clinical care in patients with cancer

Abstract 4761: Defining the adaptive kinome response to BRAF and MEK inhibition in melanoma

Abstract 947: A small molecule Mer tyrosine kinase inhibitor (UNC MerTKi) effectively inhibits growth of murine melanoma

Abstract 5024: mDX400, the murine analog against the anti-PD1 antibody MK-347 is active in immunocompetent, autochthonous murine models of melanoma and breast cancer

Abstract 4943: Visualization of endogenous melanoma initiation and progression using intravital microscopy

Abstract C14: Loss of haptotaxis facilitates invasion in LKB1-deficient melanoma

Abstract 2400: Differential phosphorylation of signaling targets as a function of RAS mutation status and tumor histology in non-small cell lung cancer.

Abstract 1087: Differential oncogenicity of N-RAS mutations in melanoma.

Abstract 5271: p16-LUC: an in vivo reporter allele for de novo tumor formation and therapeutic response

Abstract 4203: Plasma and tumor pharmacokinetics (PK) of carboplatin in Genetically Engineered Mouse Models of melanoma (GEMMs), murine melanoma, and in patients with cutaneous melanoma

LKB1 and Lung Cancer: More Than the Usual Suspects

Expression of p16^Ink4a Compensates for p18^Ink4c Loss in Cyclin-Dependent Kinase 4/6–Dependent Tumors and Tissues

Lack of Extracellular Signal-Regulated Kinase Mitogen-Activated Protein Kinase Signaling Shows a New Type of Melanoma

Dissecting the oncogenic consequences of p19Arf/p53- and p16Ink4a/pRB-pathway disruption

Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma

p16^INK4a and p53 Deficiency Cooperate in Tumorigenesis

Email alerts

AACR Journals

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only