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Journal Articles

Abstract LB399: Trop-2 expression and association with efficacy in patients treated with sacituzumab govitecan + pembrolizumab +/- carboplatin in the EVOKE-02 study of non-small cell lung cancer

Jyoti D. Patel, Marianna Zavodovskaya, Byoung Chul Cho, Martin Reck, Jhanelle E. Gray, Noemí Reguart, Enriqueta Felip, Joel W. Neal, Kai-Wen Lin, Juliane M. Jürgensmeier, Sabeen Mekan, Farnoush Safavi, Michael Chisamore, Edward Garon

Cancer Res (2025) 85 (8_Supplement_2): LB399.

https://doi.org/10.1158/1538-7445.AM2025-LB399

Published: 25 April 2025

View articletitled, Abstract LB399: Trop-2 expression and association with efficacy in patients treated with sacituzumab govitecan + pembrolizumab +/- carboplatin in the EVOKE-02 study of non-small cell lung cancer

Journal Articles

Abstract 5920: Nanomechanical signatures: a breakthrough in personalized diagnosis and treatment optimization for lung cancer

Cancer Res (2025) 85 (8_Supplement_1): 5920.

https://doi.org/10.1158/1538-7445.AM2025-5920

Published: 21 April 2025

View articletitled, Abstract 5920: Nanomechanical signatures: a breakthrough in personalized diagnosis and treatment optimization for lung cancer

Journal Articles

Abstract 4542: B cells mediate antitumor immune response and predict pathological response in locally advanced NSCLC patients treated with perioperative chemoimmunotherapy (NADIM trials)

Cancer Res (2025) 85 (8_Supplement_1): 4542.

https://doi.org/10.1158/1538-7445.AM2025-4542

Published: 21 April 2025

View articletitled, Abstract 4542: B cells mediate antitumor immune response and predict pathological response in locally advanced NSCLC patients treated with perioperative chemoimmunotherapy (NADIM trials)

Journal Articles

Abstract 6540: Lung adenocarcinoma cancer cells that metastasize to the brain bring their own soil

Alejandro Bernardo Suárez, Gabriela Caballero, Iban Aldecoa Ansorregui, Natalia Isabel Diaz-Valdivia, Patricia Fernandez-Nogueira, Noemi Reguart, Jordi Alcaraz Casademunt

Cancer Res (2025) 85 (8_Supplement_1): 6540.

https://doi.org/10.1158/1538-7445.AM2025-6540

Published: 21 April 2025

View articletitled, Abstract 6540: Lung adenocarcinoma cancer cells that metastasize to the brain bring their own soil

Journal Articles

Abstract 5554: Intrinsic resistance mechanism of squamous cell lung carcinomas to the multiangiokinase receptor inhibitor Nintedanib through CXCL-1 upregulation in tumor associated fibroblasts

Natalia Isabel Diaz Valdivia, Paula Duch, Alejandro Bernardo, Marselina Arshakyan, Noemi Reguart, Derek Radisky, Oriol Casanovas, Jordi Alcaraz

Cancer Res (2025) 85 (8_Supplement_1): 5554.

https://doi.org/10.1158/1538-7445.AM2025-5554

Published: 21 April 2025

View articletitled, Abstract 5554: Intrinsic resistance mechanism of squamous cell lung carcinomas to the multiangiokinase receptor inhibitor Nintedanib through CXCL-1 upregulation in tumor associated fibroblasts

Journal Articles

Abstract 3759: First clinical evidence of the tissue nanomechanical signature as a novel diagnostic and prognostic tool in patients with non-small-cell lung cancer

Jordi Alcaraz, Héctor Sanz-Fraile, Elba Marin, Paula Gausa Busquets, Kate Neal, Marselina Arshakyan, Marc Rico, Marc Boada, David Sanchez, Reinier Oropesa Nunez, Gitika Srivastava, Ahmed Jizawi, Sara Nizzero, Tobias Appenzeller, Mariam Gachechiladze, Marko Loparic, Marija Plodinec, Noemi Reguart

Cancer Res (2024) 84 (6_Supplement): 3759.

https://doi.org/10.1158/1538-7445.AM2024-3759

Published: 22 March 2024

View articletitled, Abstract 3759: First clinical evidence of the tissue nanomechanical signature as a novel diagnostic and prognostic tool in patients with non-small-cell lung cancer

Journal Articles

Abstract 6684: Impact of fecal microbiome on the efficacy of neoadjuvant chemo-immunotherapy and colitis adverse events: Findings from the NADIM II Trial

Cancer Res (2024) 84 (6_Supplement): 6684.

https://doi.org/10.1158/1538-7445.AM2024-6684

Published: 22 March 2024

View articletitled, Abstract 6684: Impact of fecal microbiome on the efficacy of neoadjuvant chemo-immunotherapy and colitis adverse events: Findings from the NADIM II Trial

Journal Articles

Abstract 2356: Aberrant TIMP-1 secretion by tumor-associated fibroblasts is a major contributor to the selective positive response to nintedanib in lung adenocarcinoma

Paula Duch, Natalia Díaz-Valdivia, Marta Gabasa, Rafael Ikemori, Frank Hilberg, Noemí Reguart, Derek Radisky, Jordi Alcaraz

Cancer Res (2023) 83 (7_Supplement): 2356.

https://doi.org/10.1158/1538-7445.AM2023-2356

Published: 04 April 2023

View articletitled, Abstract 2356: Aberrant TIMP-1 secretion by tumor-associated fibroblasts is a major contributor to the selective positive response to nintedanib in lung adenocarcinoma

Journal Articles

Abstract 4597: TIMP1 is a major contributor of the angiogenic priming of tumor associated fibroblasts in lung adenocarcinoma

Natalia Isabel Diaz Valdivia, Paula Duch, Rafael Ikemori, Eduard Monso, Noemi Reguart, Jordi Alcaraz

Cancer Res (2023) 83 (7_Supplement): 4597.

https://doi.org/10.1158/1538-7445.AM2023-4597

Published: 04 April 2023

View articletitled, Abstract 4597: TIMP1 is a major contributor of the angiogenic priming of tumor associated fibroblasts in lung adenocarcinoma

Journal Articles

Abstract 5849: SMAD3 in tumor associated fibroblasts drives enhanced fibroblast accumulation in lung adenocarcinoma through increased migration

Natalia Isabel Diaz Valdivia, Yago Juste Lanas, Alejandro Llorente, Rafael Ikemori, Alejandro Bernardo, Noemi Reguart, Jose M. Garcia Aznar, Jordi Alcaraz

Cancer Res (2023) 83 (7_Supplement): 5849.

https://doi.org/10.1158/1538-7445.AM2023-5849

Published: 04 April 2023

View articletitled, Abstract 5849: SMAD3 in tumor associated fibroblasts drives enhanced fibroblast accumulation in lung adenocarcinoma through increased migration

Journal Articles

Abstract 951: Evolution of antibody titers, growth factor levels and in vitro activity in the sera of patients enrolled in the EPICAL trial of afatinib combined with anti-EGF vaccination

Silvia Garcia-Roman, Jordi Codony, Miguel Angel Molina-Vila, Nuria Jordana-Ariza, Beatriz Garcia, Monica Garzon, Clara Mayo de las Casas, Maria Jose Catalan, Andres Aguilar, Santiago Viteri, Andres F. Cardona, Delvys Rodríguez, Manuel Cobo, Noemi Reguart, Erik d'Hondt, Rafael Rosell

Cancer Res (2021) 81 (13_Supplement): 951.

https://doi.org/10.1158/1538-7445.AM2021-951

Published: 01 July 2021

View articletitled, Abstract 951: Evolution of antibody titers, growth factor levels and in vitro activity in the sera of patients enrolled in the EPICAL trial of afatinib combined with anti-EGF vaccination

Journal Articles

Abstract 469: Comprehensive, large scale analysis of ALK, ROS1, RET, NTRK1 and NRG1 transcripts in lung cancer reveals over-expressing, potentially targetable patients

Cristina Aguado, Cristina Teixido, Ana Gimenez Capitan, Elba Marin, Ruth Roman, Sonia Rodriguez, Irene Moya, Roxana Reyes, Nuria Viñolas, Santiago Viteri, Andres Aguilar, Rafael Rosell, Noemi Reguart, Miguel Angel Molina-Vila

Cancer Res (2021) 81 (13_Supplement): 469.

https://doi.org/10.1158/1538-7445.AM2021-469

Published: 01 July 2021

View articletitled, Abstract 469: Comprehensive, large scale analysis of ALK, ROS1, RET, NTRK1 and NRG1 transcripts in lung cancer reveals over-expressing, potentially targetable patients

Journal Articles

Abstract 3167: Stromal TIMP-1 drives tumor progression in lung adenocarcinoma through CD63 interaction

Paula Duch, Natalia Díaz-Valdivia, Marta Gabasa, Rafael Ikemori, Marselina Arshakyan, Frank Hillberg, Noemí Reguart, Derek Radisky, Jordi Alcaraz

Cancer Res (2021) 81 (13_Supplement): 3167.

https://doi.org/10.1158/1538-7445.AM2021-3167

Published: 01 July 2021

View articletitled, Abstract 3167: Stromal TIMP-1 drives tumor progression in lung adenocarcinoma through CD63 interaction

Journal Articles

Abstract 2515: MMP1 and TGF-β1 cooperate to drive tumor progression in large cell carcinoma of the lung through fibroblast senescence

Marta Gabasa, Evette S. Radisky, Rafael Ikemori, Giulia Bertolini, Marselina Arshakyan, Alexandra Hockla, Paula Duch, Ornella Rondinone, Alejandro Llorente, Maria Maqueda, Alexandre Perera, Noemí Reguart, Luca Roz, Derek C. Radisky, Jordi Alcaraz

Cancer Res (2021) 81 (13_Supplement): 2515.

https://doi.org/10.1158/1538-7445.AM2021-2515

Published: 01 July 2021

View articletitled, Abstract 2515: MMP1 and TGF-β1 cooperate to drive tumor progression in large cell carcinoma of the lung through fibroblast senescence

Journal Articles

Abstract 5091: TIMP-1 in tumor-associated fibroblasts drives tumor progression in lung adenocarcinoma through CD63 interaction

Paula Duch, Marta Gabasa, Rafael Ikemori, Marselina Arshakyan, Frank Hillberg, Noemí Reguart, Derek Radisky, Jordi Alcaraz

Cancer Res (2020) 80 (16_Supplement): 5091.

https://doi.org/10.1158/1538-7445.AM2020-5091

Published: 15 August 2020

View articletitled, Abstract 5091: TIMP-1 in tumor-associated fibroblasts drives tumor progression in lung adenocarcinoma through CD63 interaction

Journal Articles

Abstract 5594: Inmune gene expression by nCounter in mucinous adenocarcinoma lung cancer

Ruth Román Lladó, Cristina Aguado Esteban, Ana Giménez-Capitán, Ueda Daisuke, Masaoki Ito, Yasuhiro Tsutani, Yoshihiro Miyata, Cristina Teixidó, Noemí Reguart, Morihito Okada, Sonia Rodríguez, Ariadna Balada, Erika Aldeguer, Santiago Viteri Ramirez, Maria Gonzalez Cao, Andrés Aguilar, Rafael Rosell, Miguel Angel Molina Vila

Cancer Res (2020) 80 (16_Supplement): 5594.

https://doi.org/10.1158/1538-7445.AM2020-5594

Published: 15 August 2020

View articletitled, Abstract 5594: Inmune gene expression by nCounter in mucinous adenocarcinoma lung cancer

Journal Articles

Abstract CT214: CANOPY-1: Safety run-in results from phase (ph) 3 study of canakinumab (CAN) or placebo (PBO) in combination (comb) with pembrolizumab (PEM) plus platinum-based doublet chemotherapy (Ctx) as 1^st line therapy in patients (pts) with advanced or metastatic NSCLC

Bruce E. Johnson, Tae Min Kim, T. Jeroen N. Hiltermann, Fabrice Barlesi, Christian Grohe, Yasushi Goto, Orvar Gunnarsson, Tobias Overbeck, Noemi Reguart, Martin Wermke, Gilberto Castro Castro, Enriqueta Felip, Alastair Greystoke, Benjamin J. Solomon, Stephanie Deudon, Anne-Laure Louveau, Vanessa Passos, Daniel SW Tan

Cancer Res (2020) 80 (16_Supplement): CT214.

https://doi.org/10.1158/1538-7445.AM2020-CT214

Published: 15 August 2020

View articletitled, Abstract CT214: CANOPY-1: Safety run-in results from phase (ph) 3 study of canakinumab (CAN) or placebo (PBO) in combination (comb) with pembrolizumab (PEM) plus platinum-based doublet chemotherapy (Ctx) as 1st line therapy in patients (pts) with advanced or metastatic NSCLC

Journal Articles

Abstract 809: nCounter for detection of clinically relevant alterations in exosomes of non-small cell lung cancer cells and patients

Ana Giménez Capitán, Jill Bracht, Chung-Ying Huang, Cristina Teixidó, Noemí Reguart, Rich Boykin, Sarah Warren, Joseph M Beechem, Santiago Viteri Ramirez, Juan José García, Andrés Aguilar, Rafael Rosell Costa, Jay Gerlach, Miguel Angel Molina-Vila

Cancer Res (2020) 80 (16_Supplement): 809.

https://doi.org/10.1158/1538-7445.AM2020-809

Published: 15 August 2020

View articletitled, Abstract 809: nCounter for detection of clinically relevant alterations in exosomes of non-small cell lung cancer cells and patients

Journal Articles

Abstract CT082: Capmatinib in METex14-mutated (mut) advanced non-small cell lung cancer (NSCLC): Results from the phase II GEOMETRY mono-1 study, including efficacy in patients (pts) with brain metastases (BM)

Edward B. Garon, Rebecca S. Heist, Takashi Seto, Ji-Youn Han, Noemi Reguart, Harry J. Groen, Daniel SW Tan, Toyoaki Hida, Maja J. de Jonge, Sergey V. Orlov, Egbert F. Smit, Pierre-Jean Souquet, Johan Vansteenkiste, Sylvie Le Mouhaer, Anna Robeva, Maeve Waldron-Lynch, Monica Giovannini, Juergen Wolf

Cancer Res (2020) 80 (16_Supplement): CT082.

https://doi.org/10.1158/1538-7445.AM2020-CT082

Published: 15 August 2020

View articletitled, Abstract CT082: Capmatinib in METex14-mutated (mut) advanced non-small cell lung cancer (NSCLC): Results from the phase II GEOMETRY mono-1 study, including efficacy in patients (pts) with brain metastases (BM)

Journal Articles

Abstract 2982: Unraveling the antifibrotic mode of action of nintedanib against the TGF-β pathway in tumor-associated fibroblasts in non-small cell lung cancer

Rafael Ikemori, Marta Gabasa, Paula Duch, Frank Hilberg, Noemí Reguart, Jordi Alcaraz

Cancer Res (2020) 80 (16_Supplement): 2982.

https://doi.org/10.1158/1538-7445.AM2020-2982

Published: 15 August 2020

View articletitled, Abstract 2982: Unraveling the antifibrotic mode of action of nintedanib against the TGF-β pathway in tumor-associated fibroblasts in non-small cell lung cancer

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Abstract LB399: Trop-2 expression and association with efficacy in patients treated with sacituzumab govitecan + pembrolizumab +/- carboplatin in the EVOKE-02 study of non-small cell lung cancer

Abstract 5920: Nanomechanical signatures: a breakthrough in personalized diagnosis and treatment optimization for lung cancer

Abstract 4542: B cells mediate antitumor immune response and predict pathological response in locally advanced NSCLC patients treated with perioperative chemoimmunotherapy (NADIM trials)

Abstract 6540: Lung adenocarcinoma cancer cells that metastasize to the brain bring their own soil

Abstract 5554: Intrinsic resistance mechanism of squamous cell lung carcinomas to the multiangiokinase receptor inhibitor Nintedanib through CXCL-1 upregulation in tumor associated fibroblasts

Abstract 3759: First clinical evidence of the tissue nanomechanical signature as a novel diagnostic and prognostic tool in patients with non-small-cell lung cancer

Abstract 6684: Impact of fecal microbiome on the efficacy of neoadjuvant chemo-immunotherapy and colitis adverse events: Findings from the NADIM II Trial

Abstract 2356: Aberrant TIMP-1 secretion by tumor-associated fibroblasts is a major contributor to the selective positive response to nintedanib in lung adenocarcinoma

Abstract 4597: TIMP1 is a major contributor of the angiogenic priming of tumor associated fibroblasts in lung adenocarcinoma

Abstract 5849: SMAD3 in tumor associated fibroblasts drives enhanced fibroblast accumulation in lung adenocarcinoma through increased migration

Abstract 951: Evolution of antibody titers, growth factor levels and in vitro activity in the sera of patients enrolled in the EPICAL trial of afatinib combined with anti-EGF vaccination

Abstract 469: Comprehensive, large scale analysis of ALK, ROS1, RET, NTRK1 and NRG1 transcripts in lung cancer reveals over-expressing, potentially targetable patients

Abstract 3167: Stromal TIMP-1 drives tumor progression in lung adenocarcinoma through CD63 interaction

Abstract 2515: MMP1 and TGF-β1 cooperate to drive tumor progression in large cell carcinoma of the lung through fibroblast senescence

Abstract 5091: TIMP-1 in tumor-associated fibroblasts drives tumor progression in lung adenocarcinoma through CD63 interaction

Abstract 5594: Inmune gene expression by nCounter in mucinous adenocarcinoma lung cancer

Abstract CT214: CANOPY-1: Safety run-in results from phase (ph) 3 study of canakinumab (CAN) or placebo (PBO) in combination (comb) with pembrolizumab (PEM) plus platinum-based doublet chemotherapy (Ctx) as 1^st line therapy in patients (pts) with advanced or metastatic NSCLC

Abstract 809: nCounter for detection of clinically relevant alterations in exosomes of non-small cell lung cancer cells and patients

Abstract CT082: Capmatinib in METex14-mutated (mut) advanced non-small cell lung cancer (NSCLC): Results from the phase II GEOMETRY mono-1 study, including efficacy in patients (pts) with brain metastases (BM)

Abstract 2982: Unraveling the antifibrotic mode of action of nintedanib against the TGF-β pathway in tumor-associated fibroblasts in non-small cell lung cancer

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