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Abstract 2325: Targeting kynurenine pathway using novel IDO/TDO dual inhibitor (AT0174) to modulate tumor microenvironment in platinum resistant non-small cell lung cancer cancer: An immunometabolism compliment markers

Sydney Spector, Chunjing Wu, Dan Nguyen, George Theodore, Ashley Garcia, Lynn Feun, Niramol Savaraj, Medhi Wangpaichitr

Cancer Res (2022) 82 (12_Supplement): 2325.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2325

Published: 15 June 2022

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Abstract 2771: Circulating biomarkers to predict antitumor response to immunotherapy in advanced unresectable hepatoma

Lynn G. Feun, Ying-Ying Li, Chunjing Wu, Medhi Wangpaichitr, Alfred Chicco, Niramol Savaraj

Cancer Res (2022) 82 (12_Supplement): 2771.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2771

Published: 15 June 2022

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Journal Articles

Abstract 988: Targeting immunological and apoptotic cell death to improve therapeutic efficacy in melanoma

Niramol Savaraj, Min You, Ying-Ying Li, Chunjing Wu, Medhi Wangpaichitr, Saurez Miguel, Alfred Chicco, Macus T. Kuo, Lynn G. Feun

Cancer Res (2021) 81 (13_Supplement): 988.

DOI: https://doi.org/10.1158/1538-7445.AM2021-988

Published: 01 July 2021

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Abstract 4747: Surviving skills in melanoma cells: An important consideration to both targeted and immunological approach in the treatment of melanoma

Niramol Savaraj, Ying-Ying Li, Chunjing Wu, Medhi Wangpaichitr, Seth Spector, Michael Sentome, Lynn G. Feun

Cancer Res (2019) 79 (13_Supplement): 4747.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4747

Published: 01 July 2019

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Abstract 4361: Kynurenine - Aryl hydrocarbon receptor axis: A crucial modulator of immunometabolism in cisplatin resistant lung cancer

Medhi Wangpaichitr, Dan JM Nguyen, Ying-Ying Li, Chunjing Wu, Lynn G. Feun, Niramol Savaraj

Cancer Res (2019) 79 (13_Supplement): 4361.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4361

Published: 01 July 2019

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Abstract 3642: Relationship of argininosuccinate synthetase (ASS) and PD-L1 expression in arginine enriched or depleted environment in melanoma

Chunjing Wu, Ying-Ying Li, Medhi Wangpaichitr, Lynn G. Feun, Macus T. Kuo, Niramol Savaraj

Cancer Res (2018) 78 (13_Supplement): 3642.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3642

Published: 01 July 2018

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Abstract 5478: Targeting kynurenine pathway for the treatment of cisplatin-resistant lung cancer

Medhi Wangpaichitr, Chunjing Wu, Dan JM Nguyen, Ying-Ying Li, Lynn G. Feun, Niramol Savaraj

Cancer Res (2018) 78 (13_Supplement): 5478.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5478

Published: 01 July 2018

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Abstract 4404: Novel approach to circumvent cisplatin resistant lung cancer by targeting metabolism

Medhi Wangpaichitr, Chunjing Wu, Ying Ying Li, Lynn G. Feun, Macus T. Kuo, Niramol Savaraj

Cancer Res (2017) 77 (13_Supplement): 4404.

DOI: https://doi.org/10.1158/1538-7445.AM2017-4404

Published: 01 July 2017

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Journal Articles

Abstract 3712: The relationship of Procollagen alpha 1 type 1 (Col1A1) / DDR2 signaling in malignant glioma and sensitivity to STAT 3/5 inhibitor

Shumei Chen, Chunjing Wu, Ying-Ying Li, Medhi Wangpaichitr, Ronald J. Benveniste, James Turkson, Niramol Savaraj, Lynn G. Feun

Cancer Res (2016) 76 (14_Supplement): 3712.

DOI: https://doi.org/10.1158/1538-7445.AM2016-3712

Published: 15 July 2016

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Abstract 2671: BRAF inhibitor resistance reprograms metabolic and survival pathways to sensitize melanoma cells to arginine deprivation

Ying-Ying Li, Chunjing Wu, Sumedh Shah, Shu-Mei Chen, Medhi Wangpaichitr, Lynn Feun, Macus Kuo, Miguel Suarez, Niramol Savaraj

Cancer Res (2016) 76 (14_Supplement): 2671.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2671

Published: 15 July 2016

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Abstract 1038: Exploiting ROS and metabolic differences to selectively killing cisplatin resistant lung cancer

Medhi Wangpaichitr, Chunjing Wu, Ying Ying Li, Sumedh Shah, Shu-Mei Chen, Vy Dinh, Macus T. Kuo, Lynn G. Feun, Niramol Savaraj

Cancer Res (2016) 76 (14_Supplement): 1038.

DOI: https://doi.org/10.1158/1538-7445.AM2016-1038

Published: 15 July 2016

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Abstract 1206: Cisplatin resistant non small cell lung cancer is sensitive to arginine deprivation therapy

Medhi Wangpaichitr, Chunjing Wu, Dao M. Nguyen, Min You, Ying Ying Li, Shumei Chen, Lynn G. Feun, Niramol Savaraj

Cancer Res (2015) 75 (15_Supplement): 1206.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1206

Published: 01 August 2015

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Journal Articles

Abstract 2900: Biochemical alterations in BRAF inhibitor (BRAFi) resistant melanoma cells increase their vulnerability to arginine deprivation

Ying-Ying Li, Niramol Savaraj, Chunjing Wu, Shumei Chen, Medhi Wangpaichitr, Macus T. Kuo, Lynn G. Feun

Cancer Res (2015) 75 (15_Supplement): 2900.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2900

Published: 01 August 2015

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Abstract 43: The role of discoidin domain receptor 2 (DDR2) and its relationship with procollagen alpha 1 type 1(Col1A1) in malignant glioma

Shumei Chen, Chunjing Wu, Ying Ying Li, Medhi Wangpaichitr, Lynn G. Feun, Ronald Benveniste, Vy Dinh, Niramol Savaraj

Cancer Res (2015) 75 (15_Supplement): 43.

DOI: https://doi.org/10.1158/1538-7445.AM2015-43

Published: 01 August 2015

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Journal Articles

Abstract 1428: Targeting metabolic alteration in cisplatin-resistant lung cancer

Medhi Wangpaichitr, Chunjing Wu, Ying Ying Li, Shumei Chen, Min You, Vy Dinh, Lynn G. Feun, Macus T. Kuo, Niramol Savaraj

Cancer Res (2014) 74 (19_Supplement): 1428.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1428

Published: 01 October 2014

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Journal Articles

Abstract 1435: Exploiting obligate arginine auxotrophy in tumor cells lacking arginino-succinate synthetase (ASS) expression to develop targeted molecular therapy for non-small cell lung cancer (NSCLC)

Min You, Medhi Wangpaichitr, Jonathan D. Nguyen, Jennifer R. Chapman, Maureen Cioffi-Lavina, Niramol Savaraj, Dao M. Nguyen

Cancer Res (2014) 74 (19_Supplement): 1435.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1435

Published: 01 October 2014

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Journal Articles

Abstract 3701: BRAF inhibitor (vemurafenib) resistance confers sensitivity to arginine deprivation in melanoma

Ying-Ying Li, Chunjing Wu, Shu-Mei Chen, Medhi Wangpaichitr, Min You, Seth Spector, Lynn G. Feun, Macus T. Kuo, Niramol Savaraj

Cancer Res (2014) 74 (19_Supplement): 3701.

DOI: https://doi.org/10.1158/1538-7445.AM2014-3701

Published: 01 October 2014

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Abstract 4192: Exploiting discoidin domain receptor (DDR) and collagen signaling as a new approach to treat human malignant gliomas

Shumei Chen, Chunjing Wu, Min You, Minh Tran, Medhi Wangpaichitr, Ying Ying Li, Ronald J. Benveniste, Macus T. Kuo, Niramol Savaraj, Lynn G. Feun

Cancer Res (2014) 74 (19_Supplement): 4192.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4192

Published: 01 October 2014

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Journal Articles

Abstract 4674: Pilot study of intrahepatic artery chemotherapy in combination with sorafenib in hepatocellular carcinoma patients.

Lynn G. Feun, Govindarajan Narayanan, Jose Yrizarry, Vy Dinh, Niramol Savaraj, Christopher O'Brien, Paul Martin

Cancer Res (2013) 73 (8_Supplement): 4674.

DOI: https://doi.org/10.1158/1538-7445.AM2013-4674

Published: 15 April 2013

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Journal Articles

Abstract 961: Selectively kill cisplatin resistant lung cancer cells by exploiting ROS and metabolic differences.

Medhi Wangpaichitr, George Theodoropoulos, Chunjing Wu, Nivit Poochareon, Ying Ying Li, Min You, Macus T. Kuo, Lynn G. Feun, Niramol Savaraj

Cancer Res (2013) 73 (8_Supplement): 961.

DOI: https://doi.org/10.1158/1538-7445.AM2013-961

Published: 15 April 2013

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NARROW

Abstract 2325: Targeting kynurenine pathway using novel IDO/TDO dual inhibitor (AT0174) to modulate tumor microenvironment in platinum resistant non-small cell lung cancer cancer: An immunometabolism compliment markers

Abstract 2771: Circulating biomarkers to predict antitumor response to immunotherapy in advanced unresectable hepatoma

Abstract 988: Targeting immunological and apoptotic cell death to improve therapeutic efficacy in melanoma

Abstract 4747: Surviving skills in melanoma cells: An important consideration to both targeted and immunological approach in the treatment of melanoma

Abstract 4361: Kynurenine - Aryl hydrocarbon receptor axis: A crucial modulator of immunometabolism in cisplatin resistant lung cancer

Abstract 3642: Relationship of argininosuccinate synthetase (ASS) and PD-L1 expression in arginine enriched or depleted environment in melanoma

Abstract 5478: Targeting kynurenine pathway for the treatment of cisplatin-resistant lung cancer

Abstract 4404: Novel approach to circumvent cisplatin resistant lung cancer by targeting metabolism

Abstract 3712: The relationship of Procollagen alpha 1 type 1 (Col1A1) / DDR2 signaling in malignant glioma and sensitivity to STAT 3/5 inhibitor

Abstract 2671: BRAF inhibitor resistance reprograms metabolic and survival pathways to sensitize melanoma cells to arginine deprivation

Abstract 1038: Exploiting ROS and metabolic differences to selectively killing cisplatin resistant lung cancer

Abstract 1206: Cisplatin resistant non small cell lung cancer is sensitive to arginine deprivation therapy

Abstract 2900: Biochemical alterations in BRAF inhibitor (BRAFi) resistant melanoma cells increase their vulnerability to arginine deprivation

Abstract 43: The role of discoidin domain receptor 2 (DDR2) and its relationship with procollagen alpha 1 type 1(Col1A1) in malignant glioma

Abstract 1428: Targeting metabolic alteration in cisplatin-resistant lung cancer

Abstract 1435: Exploiting obligate arginine auxotrophy in tumor cells lacking arginino-succinate synthetase (ASS) expression to develop targeted molecular therapy for non-small cell lung cancer (NSCLC)

Abstract 3701: BRAF inhibitor (vemurafenib) resistance confers sensitivity to arginine deprivation in melanoma

Abstract 4192: Exploiting discoidin domain receptor (DDR) and collagen signaling as a new approach to treat human malignant gliomas

Abstract 4674: Pilot study of intrahepatic artery chemotherapy in combination with sorafenib in hepatocellular carcinoma patients.

Abstract 961: Selectively kill cisplatin resistant lung cancer cells by exploiting ROS and metabolic differences.

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