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Nipun B. Merchant
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Journal Articles

Abstract A019: Black race and CA 19-9 nonproduction is associated with limited pathologic response to neoadjuvant chemotherapy in patients with localized pancreatic cancer

Mary P. Martos, Erin M. Dickey, Kawther Abdilleh, Syed A. Ahmad, Shishir K. Maithel, Chet W. Hammill, Hong Jin Kim, Daniel E. Abbott, David A. Kooby, Alexander A. Parikh, Peter J. Hosein, Nipun B. Merchant, Jashodeep Datta, Caitlin A. Hester
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A019.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A019
Published: 15 September 2024
View article titled, Abstract A019: Black race and CA 19-9 nonproduction is associated with limited pathologic response to neoadjuvant chemotherapy in patients with localized pancreatic cancer
Journal Articles

Abstract A047: Fibroblast-specific IL1 receptor inhibition reprograms the inflammatory stroma to overcome the immunosuppressive tumor microenvironment in pancreatic cancer

Camille Acevedo, Samara Singh, Austin Dosch, Edmond W Box, Iago C Silva, Anna Bianchi, Siddharth Mehra, Haleh Amirian, Andrew Adams, Nagaraj Nagathihalli, Jashodeep Datta, Nipun B Merchant
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A047.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A047
Published: 15 September 2024
View article titled, Abstract A047: Fibroblast-specific IL1 receptor inhibition reprograms the inflammatory stroma to overcome the immunosuppressive tumor microenvironment in pancreatic cancer
Journal Articles

Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago De Castro Silva, Anna Bianchi, Vanessa T. Garrido, Zhiqun Zhou, Andrew Adams, Haleh Amirian, Edmond W. Box, Xiaodian Sun, Yuguang Ban, Jashodeep Datta, Nagaraj S. Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1320–1332.
https://doi.org/10.1158/0008-5472.CAN-23-1200
Published: 15 April 2024
View article titled, Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer
Open the PDF for Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract C021: Granulocytic MDSC-derived NLRP3 inflammasome activation is a novel regulator of inflammatory CAF skewness in pancreatic cancer

Karthik Rajkumar, Nilesh U. Deshpande, Iago de Castro Silva, Anna Bianchi, Ifeanyichukwu Ogobuiro, Haleh Amirian, Andrews Adams, Vanessa Garrido, Siddharth Mehra, Samara Singh, Nagaraj Nagathihalli, Nipun B. Merchant, Jashodeep Datta
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C021.
https://doi.org/10.1158/1538-7445.PANCA2023-C021
Published: 16 January 2024
View article titled, Abstract C021: Granulocytic MDSC-derived NLRP3 inflammasome activation is a novel regulator of inflammatory CAF skewness in pancreatic cancer
Journal Articles

Abstract B093: Alcoholic chronic inflammation driven CREB mediates acinar-to-ductal reprogramming and promote neoplastic progression

Siddharth Mehra, Supriya Srinivasan, Anna Bianchi, Austin Dosch, Samara Singh, Vanessa Garrido, Iago De Castro Silva, Varunkumar Krishnamoorthy, Sudhakar Jinka, Jashodeep Datta, Nipun B. Merchant, Nagaraj Nagathihalli
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B093.
https://doi.org/10.1158/1538-7445.PANCA2023-B093
Published: 16 January 2024
View article titled, Abstract B093: Alcoholic chronic inflammation driven CREB mediates acinar-to-ductal reprogramming and promote neoplastic progression
Journal Articles

Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Vanessa Tonin Garrido, Anna Bianchi, Haleh Amirian, Edmond W. Box, Jashodeep Datta, Nagaraj S. Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C025.
https://doi.org/10.1158/1538-7445.PANCA2023-C025
Published: 16 January 2024
View article titled, Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer
Journal Articles

Abstract 3627: Inhibition of tumor cell-autonomous p38 MAPK suppresses IL1α-mediated inflammatory tumor-stromal crosstalk in pancreatic adenocarcinoma

Samara Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Anna Bianchi, Vanessa Tonin Garrido, Zhiqun Zhou, Haleh Amirian, Edmond W. Box, Jashodeep Datta, Nagaraj Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3627.
https://doi.org/10.1158/1538-7445.AM2023-3627
Published: 04 April 2023
View article titled, Abstract 3627: Inhibition of tumor cell-autonomous p38 MAPK suppresses IL1α-mediated inflammatory tumor-stromal crosstalk in pancreatic adenocarcinoma
Journal Articles

Abstract C059: Targeting tumor intrinsic p38 MAPK signaling to block IL-1α-mediated inflammatory tumor-stromal crosstalk in pancreatic cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Anna Bianchi, Vanessa Tonin-Garrido, Nilesh U. Deshpande, Zhiqun Zhou, Nagaraj Nagathihalli, Jashodeep Datta, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C059.
https://doi.org/10.1158/1538-7445.PANCA22-C059
Published: 15 November 2022
View article titled, Abstract C059: Targeting tumor intrinsic p38 MAPK signaling to block IL-1α-mediated inflammatory tumor-stromal crosstalk in pancreatic cancer
Journal Articles

Abstract C040: CREB-LIF axis drives immune suppression by promoting macrophage polarization in pancreatic cancer

Siddharth Mehra, Vanessa T. Garrido, Samara Singh, Iago De Castro Silva, Anna Bianchi, Luis A. Nivelo, Nilesh U. Deshpande, Austin R. Dosch, Zhou Zhiqun, Supriya Srinivasan, Christine I. Rafie, Ifeanyichukwu C. Ogobuiro, Xi Chen, Alejandro Villarino, Jashodeep Datta, Nipun B. Merchant, Nagaraj Nagathihalli
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C040.
https://doi.org/10.1158/1538-7445.PANCA22-C040
Published: 15 November 2022
View article titled, Abstract C040: CREB-LIF axis drives immune suppression by promoting macrophage polarization in pancreatic cancer
Journal Articles

Abstract C033: KRAS-TP53 cooperativity regulates Cxcl1 to sustain tumor-permissive circuitry via granulocyte-derived CXCR2-TNF signaling in pancreatic cancer

Anna Bianchi, Iago De Castro Silva, Nilesh U. Deshpande, Siddharth Mehra, Vanessa T. Garrido, Samara Singh, Christine I. Rafie, Zhou Zhiqun, Ifeanyichukwu C. Ogobuiro, Austin R. Dosch, Nagaraj Nagathihalli, Nipun B. Merchant, Jashodeep Datta
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C033.
https://doi.org/10.1158/1538-7445.PANCA22-C033
Published: 15 November 2022
View article titled, Abstract C033: KRAS-TP53 cooperativity regulates Cxcl1 to sustain tumor-permissive circuitry via granulocyte-derived CXCR2-TNF signaling in pancreatic cancer
Journal Articles

Abstract C031: Targeting granulocytic MDSC-derived inflammasome activation to overcome stromal inflammation in pancreatic cancer

Nilesh Deshpande, Anna Bianchi, Iago De Castro Silva, Vanessa Garrido, Siddharth Mehra, Samara Singh, Ifeanyichukwu Ogobuiro, Nagaraj Nagathihalli, Nipun B. Merchant, Jashodeep Datta
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C031.
https://doi.org/10.1158/1538-7445.PANCA22-C031
Published: 15 November 2022
View article titled, Abstract C031: Targeting granulocytic MDSC-derived inflammasome activation to overcome stromal inflammation in pancreatic cancer
Journal Articles

Abstract P3-13-05: Comprehensive analysis of global genetic ancestry and socioeconomic status on breast cancer outcomes

Daniel A Rodriguez, Sina Yadegarynia, J. William Harbour, Nipun B. Merchant, Erin N. Kobetz, Neha Goel
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P3-13-05.
https://doi.org/10.1158/1538-7445.SABCS21-P3-13-05
Published: 15 February 2022
View article titled, Abstract P3-13-05: Comprehensive analysis of global genetic ancestry and socioeconomic status on breast cancer outcomes
Journal Articles

Abstract PO-049: Single-cell transcriptomic analysis reveals interleukin-1 inhibition suppresses inflammatory cancer-associated fibroblast signaling and improves the immune response in pancreatic cancer

Austin R. Dosch, Samara Singh, Xizi Dai, Siddharth Mehra, Anna Bianchi, Iago De Castro Silva, Supriya Srinivasan, Nagaraj Nagathihalli, Jashodeep Datta, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-049.
https://doi.org/10.1158/1538-7445.PANCA20-PO-049
Published: 13 November 2020
View article titled, Abstract PO-049: Single-cell transcriptomic analysis reveals interleukin-1 inhibition suppresses inflammatory cancer-associated fibroblast signaling and improves the immune response in pancreatic cancer
Journal Articles

Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer

Anna Bianchi, Siddharth Mehra, Daisy Dai, Iago de Castro Silva, Prateek Sharma, Antonio Colaprico, Austin R. Dosch, Samara Singh, Nagaraj S. Nagathihalli, Nipun B. Merchant, Jashodeep Datta
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-046.
https://doi.org/10.1158/1538-7445.PANCA20-PO-046
Published: 13 November 2020
View article titled, Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer
Journal Articles

Abstract 1172: Disparities in pancreatic ductal adenocarcinoma - the significance of Hispanic ethnicity, by subgroup analysis, and treatment facility on clinical outcomes

Andrea N. Riner, Patrick W. Underwood, Kai Yang, Kelly M. Herremans, Miles E. Cameron, Srikar Chamala, Peihua Qiu, Thomas George, Jennifer Permuth, Nipun B. Merchant, Jose G. Trevino
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1172.
https://doi.org/10.1158/1538-7445.AM2020-1172
Published: 15 August 2020
View article titled, Abstract 1172: Disparities in pancreatic ductal adenocarcinoma - the significance of Hispanic ethnicity, by subgroup analysis, and treatment facility on clinical outcomes
Journal Articles

Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer

Austin R. Dosch, Xizi Dai, Michelle L. Reyzer, Deukwoo Kwon, Richard Caprioli, Nipun B. Merchant, Nagaraj S. Nagathihalli
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A11.
https://doi.org/10.1158/1538-7445.PANCA19-A11
Published: 13 December 2019
View article titled, Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer
Journal Articles

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Nagaraj S. Nagathihalli, Jason A. Castellanos, Purushottam Lamichhane, Fanuel Messaggio, Chanjuan Shi, Xizi Dai, Priyamvada Rai, Xi Chen, Michael N. VanSaun, Nipun B. Merchant
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6235–6246.
https://doi.org/10.1158/0008-5472.CAN-18-0634
Published: 01 November 2018
View article titled, Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
Open the PDF for Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer in another window
Journal Articles

Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Supriya Srinivasan, Tulasigeri Totiger, Chanjuan Shi, Jason Castellanos, Purushottam Lamichhane, Austin R. Dosch, Fanuel Messaggio, Nilesh Kashikar, Kumaraswamy Honnenahally, Yuguang Ban, Nipun B. Merchant, Michael VanSaun, Nagaraj S. Nagathihalli
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6146–6158.
https://doi.org/10.1158/0008-5472.CAN-18-0579
Published: 01 November 2018
View article titled, Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Open the PDF for Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract A46: AdipoRon suppresses ERK and STAT3 to inhibit pancreatic cancer growth

Fanuel Messaggio, Alisha M. Mendonsa, Jason A. Castellanos, Casey Roberts, Nagaraj S. Nagathihalli, Nipun B. Merchant, Lee D. Gorden, Michael N. VanSaun
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A46.
https://doi.org/10.1158/1538-7445.PANCA16-A46
Published: 14 December 2016
View article titled, Abstract A46: AdipoRon suppresses ERK and STAT3 to inhibit pancreatic cancer growth
Journal Articles

Abstract B75: Targeting the immune-microenvironment with combined inhibition of MEK and STAT3 in a mouse model of pancreatic cancer

Casey Roberts, Michael N. VanSaun, Purushottam Lamichhane, Fanuel Messaggio, Krisztina Kovacs, Supriya Srinivasan, Xizi Dai, Jennifer Barretta, Nagaraj Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B75.
https://doi.org/10.1158/1538-7445.PANCA16-B75
Published: 14 December 2016
View article titled, Abstract B75: Targeting the immune-microenvironment with combined inhibition of MEK and STAT3 in a mouse model of pancreatic cancer