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Journal Articles

Abstract #330: Interleukin-6 in the bone marrow microenvironment induces BclXL and survivin expression in neuroblastoma and confers resistance to drug-induced apoptosis

Tasnim Ara, Nino Keshelava, Robert Seeger, Yves DeClerck
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 330.
Published: 01 May 2009
View article titled, Abstract #330: Interleukin-6 in the bone marrow microenvironment induces Bcl<sub>XL</sub> and survivin expression in neuroblastoma and confers resistance to drug-induced apoptosis
Journal Articles

Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells

Tasnim Ara, Liping Song, Hiroyuki Shimada, Nino Keshelava, Heidi V. Russell, Leonid S. Metelitsa, Susan G. Groshen, Robert C. Seeger, Yves A. DeClerck
Journal: Cancer Research
Cancer Res (2009) 69 (1): 329–337.
https://doi.org/10.1158/0008-5472.CAN-08-0613
Published: 31 December 2008
View article titled, Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells
Open the PDF for Interleukin-6 in the Bone Marrow Microenvironment Promotes the Growth and Survival of Neuroblastoma Cells in another window
Includes: Supplementary data
Journal Articles

Drug resistance patterns of Ewing’s Sarcoma Family of Tumor cell lines derived from patients at different phases of therapy

Rita Grigoryan, Nino Keshelava, Daniel Cabral, C. Reynolds
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 3756.
Published: 01 May 2008
View article titled, Drug resistance patterns of Ewing’s Sarcoma Family of Tumor cell lines derived from patients at different phases of therapy
Journal Articles

Schedule-dependent synergistic cytotoxicity of vorinostat and flavopiridol against multi-drug resistant neuroblastoma cell lines with loss of p53 function

Jen-Ming Huang, Nino Keshelava
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 731.
Published: 01 May 2008
View article titled, Schedule-dependent synergistic cytotoxicity of vorinostat and flavopiridol against multi-drug resistant neuroblastoma cell lines with loss of p53 function
Journal Articles

Pediatric Preclinical Testing Program (PPTP) evaluation of the multi-targeted kinase inhibitor Sunitinib

Peter Houghton, John Maris, Henry Friedman, Stephen Keir, Richard Lock, Hernan Carol, Mayamin Tajbakhsh, Richard Gorlick, E. Kolb, Nino Keshelava, C. Reynolds, Christopher Morton, Malcolm Smith
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 527.
Published: 01 May 2007
View article titled, Pediatric Preclinical Testing Program (PPTP) evaluation of the multi-targeted kinase inhibitor Sunitinib
Journal Articles

Paracrine enhancement of human neuroblastoma cell proliferation and resistance to chemotherapy by IL-6 in the bone marrow microenvironment

Tasnim Ara, Robert Seeger, Nino Keshelava, Heidi Russell, Judith Villablanca, Katherine Matthay, Yves DeClerck
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2451.
Published: 01 May 2007
View article titled, Paracrine enhancement of human neuroblastoma cell proliferation and resistance to chemotherapy by IL-6 in the bone marrow microenvironment
Journal Articles

Pediatric preclinical testing program (PPTP) evaluation of the Bcl-2 inhibitor ABT-263

Malcolm Smith, John Maris, Stephen Keir, Henry Friedman, Richard Lock, Hernan Carol, Mayamin Tajbakhsh, Richard Gorlick, E. Anders Kolb, Nino Keshelava, C. Patrick Reynolds, Christopher Morton, Peter Houghton
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4951.
Published: 01 May 2007
View article titled, Pediatric preclinical testing program (PPTP) evaluation of the Bcl-2 inhibitor ABT-263
Journal Articles

Quantifying overexpression of p53 and MDM2 by flow cytometry identified multi-drug resistant neuroblastoma cell lines, including those retaining p53 function

Tsen-Yin Lin, Jerry Barnhart, Nino Keshelava, C. Reynolds
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 523.
Published: 01 May 2007
View article titled, Quantifying overexpression of p53 and MDM2 by flow cytometry identified multi-drug resistant neuroblastoma cell lines, including those retaining p53 function
Journal Articles

Flow cytometry analysis of single strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody

Rita Grigoryan, Bo Yang, Nino Keshelava, Jerry Barnhart, C. Reynolds
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1806.
Published: 01 May 2007
View article titled, Flow cytometry analysis of single strand DNA damage in neuroblastoma cell lines using the F7-26 monoclonal antibody
Journal Articles

E-Cadherin Cell-Cell Adhesion in Ewing Tumor Cells Mediates Suppression of Anoikis through Activation of the ErbB4 Tyrosine Kinase

Hyung-Gyoo Kang, Jasmine M. Jenabi, Jingsong Zhang, Nino Keshelava, Hiroyuki Shimada, William A. May, Tony Ng, C. Patrick Reynolds, Timothy J. Triche, Poul H.B. Sorensen
Journal: Cancer Research
Cancer Res (2007) 67 (7): 3094–3105.
https://doi.org/10.1158/0008-5472.CAN-06-3259
Published: 04 April 2007
View article titled, E-Cadherin Cell-Cell Adhesion in Ewing Tumor Cells Mediates Suppression of Anoikis through Activation of the ErbB4 Tyrosine Kinase
Open the PDF for E-Cadherin Cell-Cell Adhesion in Ewing Tumor Cells Mediates Suppression of Anoikis through Activation of the ErbB4 Tyrosine Kinase in another window
Includes: Supplementary data
Journal Articles

TRAIL-R2 expression correlates with the sensitivity of neuroblastoma cells to activated NK cells, but high TRAIL-R2 expression correlates with poor prognosis

Michael A. Sheard, Shahab Asgharzadeh, Hong-Wei Wu, Wei Ye, Susan Groshen, Nino Keshelava, Patrick Reynolds, Robert C. Seeger
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 148–149.
Published: 15 April 2006
View article titled, TRAIL-R2 expression correlates with the sensitivity of neuroblastoma cells to activated NK cells, but high TRAIL-R2 expression correlates with poor prognosis
Journal Articles

Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against Ewing’s family tumor cell lines in hypoxia

Rita Grigoryan, Nino Keshelava, Barry J. Maurer, Sun Bee-Chun, Susan M. Ludeman, O. Michael Colvin, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1111–1112.
Published: 01 May 2005
View article titled, Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against Ewing’s family tumor cell lines in hypoxia
Journal Articles

E-cadherin mediates cell-cell adhesion and resistance to anoikis during anchorage independent growth of ewing tumor cells

Hyung-Gyoo Kang, Jinsong Zhang, Nino Keshelava, Betsy Johnson, C. Partick Reynolds, Timothy J. Triche, Poul H. B. Sorensen*
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1111.
Published: 01 May 2005
View article titled, E-cadherin mediates cell-cell adhesion and resistance to anoikis during anchorage independent growth of ewing tumor cells
Journal Articles

TRAIL on activated human NK cells contributes to cytotoxicity against human neuroblastoma cell lines that express TRAIL-R2

Michael A. Sheard, Hong-Wei Wu, Shahab Azgharzadeh, Nino Keshelava, C. Patrick Reynolds, Wei Ye, Susan Groshen, Robert C. Seeger
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 570–571.
Published: 01 May 2005
View article titled, TRAIL on activated human NK cells contributes to cytotoxicity against human neuroblastoma cell lines that express TRAIL-R2
Journal Articles

In multidrug resistant neuroblastoma cell lines HDAC1 is overexpressed and the HDAC1 inhibitor FK228 synergistically enhanced activity of etoposide, melphalan, or carboplatin

Nino Keshelava, Xuan Chen, Timothy J. Triche, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 693.
Published: 01 May 2005
View article titled, In multidrug resistant neuroblastoma cell lines HDAC1 is overexpressed and the HDAC1 inhibitor FK228 synergistically enhanced activity of etoposide, melphalan, or carboplatin
Journal Articles

Multidrug resistance in neuroblastoma cell lines is not associated with altered mRNA expression for ceramide pathway enzymes

Osnat Zmora, Michael J. Cascio, Zesheng Wan, Bo Yang, Nino Keshelava, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 140.
Published: 01 April 2004
View article titled, Multidrug resistance in neuroblastoma cell lines is not associated with altered mRNA expression for ceramide pathway enzymes
Journal Articles

Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against neuroblastoma cell lines in hypoxia

Rita S. Grigoryan, Nino Keshelava, Barry J. Maurer, Sun Bee-Chun, Susan M. Ludeman, O. Michael Colvin, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 629.
Published: 01 April 2004
View article titled, Cyclophosphamide, but not melphalan or carboplatin, synergistically enhanced topotecan activity against neuroblastoma cell lines in hypoxia
Journal Articles

Antagonism of Buthionine Sulfoximine Cytotoxicity for Human Neuroblastoma Cell Lines by Hypoxia Is Reversed by the Bioreductive Agent Tirapazamine

Bo Yang, Nino Keshelava, Clarke P. Anderson, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2003) 63 (7): 1520–1526.
Published: 01 April 2003
View article titled, Antagonism of Buthionine Sulfoximine Cytotoxicity for Human Neuroblastoma Cell Lines by Hypoxia Is Reversed by the Bioreductive Agent Tirapazamine
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Journal Articles

Loss of p53 Function Confers High-Level Multidrug Resistance in Neuroblastoma Cell Lines

Nino Keshelava, Juan J. Zuo, Ping Chen, Sitara N. Waidyaratne, Marian C. Luna, Charles J. Gomer, Timothy J. Triche, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2001) 61 (16): 6185–6193.
Published: 01 August 2001
View article titled, Loss of p53 Function Confers High-Level Multidrug Resistance in Neuroblastoma Cell Lines
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Journal Articles

Drug Resistance Patterns of Human Neuroblastoma Cell Lines Derived from Patients at Different Phases of Therapy

Nino Keshelava, Robert C. Seeger, Susan Groshen, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (1998) 58 (23): 5396–5405.
Published: 01 December 1998
View article titled, Drug Resistance Patterns of Human Neuroblastoma Cell Lines Derived from Patients at Different Phases of Therapy
Open the PDF for Drug Resistance Patterns of Human Neuroblastoma Cell Lines Derived from Patients at Different Phases of Therapy in another window