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Nicholas P. Restifo
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Journal Articles

Abstract 6593: Rejuvenation of tumor-infiltrating lymphocytes (TIL): A novel strategy to revitalize TIL antitumor function for cell therapy

Raul Vizcardo, Yin Huang, Jessica Fioravanti, Takuya Maeda, Naritaka Tamaoki, Yasuhiro Yamazaki, Burak Kutlu, Kriti Bahl, Biao Wang, Zheng Zhong, Shobha Potluri, Nicholas P. Restifo, Gary Lee
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6593.
https://doi.org/10.1158/1538-7445.AM2024-6593
Published: 22 March 2024
View article titled, Abstract 6593: Rejuvenation of tumor-infiltrating lymphocytes (TIL): A novel strategy to revitalize TIL antitumor function for cell therapy
Journal Articles

Abstract 1527: Integrated computational and experimental analysis identifies the mitochondrial uncoupling protein 2 (Ucp2) as a key regulator of T cell anti-tumor function

Madhusudhanan Sukumar, Kuoyuan Cheng, Arunakumar Gangaplara, Yogin Patel, Suman K. Vodnala, Rafiqul Islam, Arash Eidizadeh, Carolyn Subramaniam, Ping Lee, Rigel Kishton, Amanda N. Henning, Michael J. Kruhlak, Zhiya Yu, Ethan M. Shevach, Toren Finkel, Eytan Ruppin, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1527.
https://doi.org/10.1158/1538-7445.AM2021-1527
Published: 01 July 2021
View article titled, Abstract 1527: Integrated computational and experimental analysis identifies the mitochondrial uncoupling protein 2 (Ucp2) as a key regulator of T cell anti-tumor function
Journal Articles

ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer

Vivek Shukla, Mahadev Rao, Hongen Zhang, Jeanette Beers, Darawalee Wangsa, Danny Wangsa, Floryne O. Buishand, Yonghong Wang, Zhiya Yu, Holly S. Stevenson, Emily S. Reardon, Kaitlin C. McLoughlin, Andrew S. Kaufman, Eden C. Payabyab, Julie A. Hong, Mary Zhang, Sean Davis, Daniel Edelman, Guokai Chen, Markku M. Miettinen, Nicholas P. Restifo, Thomas Ried, Paul A. Meltzer, David S. Schrump
Journal: Cancer Research
Cancer Res (2017) 77 (22): 6267–6281.
https://doi.org/10.1158/0008-5472.CAN-17-0570
Published: 14 November 2017
View article titled, ASXL3 Is a Novel Pluripotency Factor in Human Respiratory Epithelial Cells and a Potential Therapeutic Target in Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract 1463: Ionic immune suppression within the tumor microenvironment limits T cell effector function

Robert L. Eil, Rahul Roychoudhuri, Madhu Sukumar, David Clever, Jenny H. Pan, Shashank Patel, Douglas C. Palmer, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1463.
https://doi.org/10.1158/1538-7445.AM2016-1463
Published: 15 July 2016
View article titled, Abstract 1463: Ionic immune suppression within the tumor microenvironment limits T cell effector function
Journal Articles

Abstract LB-242: Identification of T-cell receptors targeting KRAS-mutated human tumors

Qiong J. Wang, Zhiya Yu, Kenichi Hanada, Nicholas P. Restifo, James C. Yang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-242.
https://doi.org/10.1158/1538-7445.AM2016-LB-242
Published: 15 July 2016
View article titled, Abstract LB-242: Identification of T-cell receptors targeting KRAS-mutated human tumors
Journal Articles

Abstract 4034: Immunotherapy generates selective pressure to create an escape tumor with increased susceptibility to treatment with T cell based therapies

Jenny H. Pan, Suman Vodnala, Robert L. Eil, Zhiya Yu, Jared Gartner, David Clever, Rahul Roychoudhuri, Shashank J. Patel, Christopher A. Klebanoff, Madhu Sukumar, Tori Yamamoto, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4034.
https://doi.org/10.1158/1538-7445.AM2016-4034
Published: 15 July 2016
View article titled, Abstract 4034: Immunotherapy generates selective pressure to create an escape tumor with increased susceptibility to treatment with T cell based therapies
Journal Articles

Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics

Joseph G. Crompton, Madhusudhanan Sukumar, Rahul Roychoudhuri, David Clever, Alena Gros, Robert L. Eil, Eric Tran, Ken-ichi Hanada, Zhiya Yu, Douglas C. Palmer, Sid P. Kerkar, Ryan D. Michalek, Trevor Upham, Anthony Leonardi, Nicolas Acquavella, Ena Wang, Francesco M. Marincola, Luca Gattinoni, Pawel Muranski, Mark S. Sundrud, Christopher A. Klebanoff, Steven A. Rosenberg, Douglas T. Fearon, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2015) 75 (2): 296–305.
https://doi.org/10.1158/0008-5472.CAN-14-2277
Published: 14 January 2015
View article titled, Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
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Includes: Supplementary data
Journal Articles

Abstract SY31-02: Building highly effective anti-tumor T cells

Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY31-02.
https://doi.org/10.1158/1538-7445.AM2014-SY31-02
Published: 01 October 2014
View article titled, Abstract SY31-02: Building highly effective anti-tumor T cells
Journal Articles

Abstract IA20: Sugar high: Glycolytic flux wrecks stem-cell like T cells.

Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2013) 73 (1_Supplement): IA20.
https://doi.org/10.1158/1538-7445.TUMIMM2012-IA20
Published: 02 April 2014
View article titled, Abstract IA20: Sugar high: Glycolytic flux wrecks stem-cell like T cells.
Journal Articles

Simultaneous Targeting of Tumor Antigens and the Tumor Vasculature Using T Lymphocyte Transfer Synergize to Induce Regression of Established Tumors in Mice

Dhanalakshmi Chinnasamy, Eric Tran, Zhiya Yu, Richard A. Morgan, Nicholas P. Restifo, Steven A. Rosenberg
Journal: Cancer Research
Cancer Res (2013) 73 (11): 3371–3380.
https://doi.org/10.1158/0008-5472.CAN-12-3913
Published: 30 May 2013
View article titled, Simultaneous Targeting of Tumor Antigens and the Tumor Vasculature Using T Lymphocyte Transfer Synergize to Induce Regression of Established Tumors in Mice
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Includes: Supplementary data
Journal Articles

Abstract 3966: Development of a fully-human chimeric antigen receptor against PSCA for the treatment of pancreatic cancer.

Daniel Abate-Daga, Kiran H. Lagisetty, Luca Gattinoni, Zhiya Yu, Nicholas P. Restifo, Steven A. Rosenberg, Richard A. Morgan
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3966.
https://doi.org/10.1158/1538-7445.AM2013-3966
Published: 15 April 2013
View article titled, Abstract 3966: Development of a fully-human chimeric antigen receptor against PSCA for the treatment of pancreatic cancer.
Journal Articles

Cellular Constituents of Immune Escape within the Tumor Microenvironment

Sid P. Kerkar, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3125–3130.
https://doi.org/10.1158/0008-5472.CAN-11-4094
Published: 01 July 2012
View article titled, Cellular Constituents of Immune Escape within the Tumor Microenvironment
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Journal Articles

Tumor-Specific CD8+ T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts

Sid P. Kerkar, Pawel Muranski, Andrew Kaiser, Andrea Boni, Luis Sanchez-Perez, Zhiya Yu, Douglas C. Palmer, Robert N. Reger, Zachary A. Borman, Ling Zhang, Richard A. Morgan, Luca Gattinoni, Steven A. Rosenberg, Giorgio Trinchieri, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2010) 70 (17): 6725–6734.
https://doi.org/10.1158/0008-5472.CAN-10-0735
Published: 31 August 2010
View article titled, Tumor-Specific CD8<sup>+</sup> T Cells Expressing Interleukin-12 Eradicate Established Cancers in Lymphodepleted Hosts
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Includes: Supplementary data
Journal Articles

Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer

Rajeev K. Shrimali, Zhiya Yu, Marc R. Theoret, Dhanalakshmi Chinnasamy, Nicholas P. Restifo, Steven A. Rosenberg
Journal: Cancer Research
Cancer Res (2010) 70 (15): 6171–6180.
https://doi.org/10.1158/0008-5472.CAN-10-0153
Published: 28 July 2010
View article titled, Antiangiogenic Agents Can Increase Lymphocyte Infiltration into Tumor and Enhance the Effectiveness of Adoptive Immunotherapy of Cancer
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Journal Articles

Abstract SY03-02: Wnt signaling generates “stem-like” self-renewing T cells that can eradicate tumors

Nicholas P. Restifo, Luca Gattinoni
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): SY03-02.
https://doi.org/10.1158/1538-7445.AM10-SY03-02
Published: 15 April 2010
View article titled, Abstract SY03-02: Wnt signaling generates “stem-like” self-renewing T cells that can eradicate tumors
Journal Articles

Extrathymic Generation of Tumor-Specific T Cells from Genetically Engineered Human Hematopoietic Stem Cells via Notch Signaling

Yangbing Zhao, Maria R. Parkhurst, Zhili Zheng, Cyrille J. Cohen, John P. Riley, Luca Gattinoni, Nicholas P. Restifo, Steven A. Rosenberg, Richard A. Morgan
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2425–2429.
https://doi.org/10.1158/0008-5472.CAN-06-3977
Published: 15 March 2007
View article titled, Extrathymic Generation of Tumor-Specific T Cells from Genetically Engineered Human Hematopoietic Stem Cells via Notch Signaling
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Journal Articles

5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story

Z. Sheng Guo, Nicholas P. Restifo, David S. Schrump
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2901.
https://doi.org/10.1158/0008-5472.CAN-06-4501
Published: 15 March 2007
View article titled, 5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story
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Journal Articles

Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8+ T-Cell Responses and Tumor Immunity

Adam D. Cohen, Adi Diab, Miguel-Angel Perales, Jedd D. Wolchok, Gabrielle Rizzuto, Taha Merghoub, Deonka Huggins, Cailian Liu, Mary Jo Turk, Nicholas P. Restifo, Shimon Sakaguchi, Alan N. Houghton
Journal: Cancer Research
Cancer Res (2006) 66 (9): 4904–4912.
https://doi.org/10.1158/0008-5472.CAN-05-2813
Published: 01 May 2006
View article titled, Agonist Anti-GITR Antibody Enhances Vaccine-Induced CD8<sup>+</sup> T-Cell Responses and Tumor Immunity
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Journal Articles

De novo Induction of a Cancer/Testis Antigen by 5-Aza-2′-Deoxycytidine Augments Adoptive Immunotherapy in a Murine Tumor Model

Z. Sheng Guo, Julie A. Hong, Kari R. Irvine, G. Aaron Chen, Paul J. Spiess, Yang Liu, Gang Zeng, John R. Wunderlich, Dao M. Nguyen, Nicholas P. Restifo, David S. Schrump
Journal: Cancer Research
Cancer Res (2006) 66 (2): 1105–1113.
https://doi.org/10.1158/0008-5472.CAN-05-3020
Published: 19 January 2006
View article titled, <em>De novo</em> Induction of a Cancer/Testis Antigen by 5-Aza-2′-Deoxycytidine Augments Adoptive Immunotherapy in a Murine Tumor Model
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Journal Articles

The In vivo Expansion Rate of Properly Stimulated Transferred CD8+ T Cells Exceeds That of an Aggressively Growing Mouse Tumor

Leroy N. Hwang, Zhiya Yu, Douglas C. Palmer, Nicholas P. Restifo
Journal: Cancer Research
Cancer Res (2006) 66 (2): 1132–1138.
https://doi.org/10.1158/0008-5472.CAN-05-1679
Published: 19 January 2006
View article titled, The <em>In vivo</em> Expansion Rate of Properly Stimulated Transferred CD8<sup>+</sup> T Cells Exceeds That of an Aggressively Growing Mouse Tumor
Open the PDF for The <em>In vivo</em> Expansion Rate of Properly Stimulated Transferred CD8<sup>+</sup> T Cells Exceeds That of an Aggressively Growing Mouse Tumor in another window