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Nicholas Mitsiades
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Journal Articles

LX1 Dual Targets AR Variants and AKR1C3 in Advanced Prostate Cancer Therapy

Shu Ning, Cameron M. Armstrong, Enming Xing, Amy R. Leslie, Richard Y. Gao, Masuda Sharifi, Zachary A. Schaaf, Wei Lou, Xiangrui Han, Desiree H. Xu, Rui Yang, Jeffrey Cheng, Shabber Mohammed, Nicholas Mitsiades, Chengfei Liu, Alan P. Lombard, Chun-Yi Wu, Xiaolin Cheng, Pui-Kai Li, Allen C. Gao
Journal: Cancer Research
Cancer Res (2024) 84 (21): 3617–3628.
https://doi.org/10.1158/0008-5472.CAN-24-0440
Published: 04 November 2024
View article titled, LX1 Dual Targets AR Variants and AKR1C3 in Advanced Prostate Cancer Therapy
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Includes: Supplementary data
Journal Articles

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, Li Chen, Ali Foroughi pour, John D. Landua, R. Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill C. Rubinstein, Brian J. Sanderson, Michael W. Lloyd, Sergii Domanskyi, Lacey E. Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, Saul Acevedo, PDXNet Consortium, Brandi N. Davis-Dusenbery, Peter N. Robinson, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bult, Dennis A. Dean, II, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2024) 84 (13): 2060–2072.
https://doi.org/10.1158/0008-5472.CAN-23-1349
Published: 02 July 2024
View article titled, A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
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Includes: Supplementary data
Journal Articles

Abstract 6816: Prevention of cancer cachexia by inhibition of soluble epoxide hydrolase

Rachel L. Bayer, Sarina Virani, Michael Gillespie, Jacqueline Capuano, Keira Smith, Katherine Quinlivan, Kimberly Vasquez, Jun Yang, Haixia Yang, Nicholas Mitsiades, Bruce D. Hammock, Dipak Panigrahy
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6816.
https://doi.org/10.1158/1538-7445.AM2024-6816
Published: 22 March 2024
View article titled, Abstract 6816: Prevention of cancer cachexia by inhibition of soluble epoxide hydrolase
Journal Articles

Retraction: Cytokines Modulate Telomerase Activity in a Human Multiple Myeloma Cell Line

Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S. Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2024) 84 (6): 940.
https://doi.org/10.1158/0008-5472.CAN-24-0516
Published: 15 March 2024
View article titled, Retraction: Cytokines Modulate Telomerase Activity in a Human Multiple Myeloma Cell Line
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Journal Articles

Retraction: Nuclear Factor-κB p65 Mediates Tumor Necrosis Factor α-induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein

Masaharu Akiyama, Teru Hideshima, Toshiaki Hayashi, Yu-Tzu Tai, Constantine S. Mitsiades, Nicholas Mitsiades, Dharminder Chauhan, Paul Richardson, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2024) 84 (6): 939.
https://doi.org/10.1158/0008-5472.CAN-24-0517
Published: 15 March 2024
View article titled, Retraction: Nuclear Factor-κB p65 Mediates Tumor Necrosis Factor α-induced Nuclear Translocation of Telomerase Reverse Transcriptase Protein
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Journal Articles

Retraction: Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of β1-Integrin and Phosphatidylinositol 3′-Kinase/AKT Signaling

Yu-Tzu Tai, Klaus Podar, Laurence Catley, Yu-Hua Tseng, Masaharu Akiyama, Reshma Shringarpure, Renate Burger, Teru Hideshima, Dharminder Chauhan, Nicholas Mitsiades, Paul Richardson, Nikhil C. Munshi, C. Ronald Kahn, Constantine Mitsiades, Kenneth C. Anderson
Journal: Cancer Research
Cancer Res (2024) 84 (6): 938.
https://doi.org/10.1158/0008-5472.CAN-24-0519
Published: 15 March 2024
View article titled, Retraction: Insulin-like Growth Factor-1 Induces Adhesion and Migration in Human Multiple Myeloma Cells via Activation of β1-Integrin and Phosphatidylinositol 3′-Kinase/AKT Signaling
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Journal Articles

Abstract B069: SPOP loss places the prostate luminal epithelial cells at a selective disadvantage

Kinza Rizwan, Darlene Skapura, Cammy Mason, Cristian Coarfa, Nicholas Mitsiades, Damian Young, Salma Kaochar
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B069.
https://doi.org/10.1158/1538-7445.PRCA2023-B069
Published: 02 June 2023
View article titled, Abstract B069: SPOP loss places the prostate luminal epithelial cells at a selective disadvantage
Journal Articles

Abstract 1705: SPOP: An essential gene for normal and prostate tumor cells

Kinza Rizwan, Darlene Skapura, Cammy Mason, Cristian Coarfa, Nicholas Mitsiades, Damian Young, Salma Kaochar
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1705.
https://doi.org/10.1158/1538-7445.AM2023-1705
Published: 04 April 2023
View article titled, Abstract 1705: <em>SPOP</em>: An essential gene for normal and prostate tumor cells
Journal Articles

Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, John David Landua, R Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill Rubinstein, Ali Foroughi pour, Lacey Elizabeth Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet consortium, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bolt, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5407.
https://doi.org/10.1158/1538-7445.AM2023-5407
Published: 04 April 2023
View article titled, Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis
Journal Articles

The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response

Jacob E. Berchuck, Elio Adib, Sarah Abou Alaiwi, Amit K. Dash, Jin Na Shin, Dallin Lowder, Collin McColl, Patricia Castro, Ryan Carelli, Elisa Benedetti, Jenny Deng, Matthew Robertson, Sylvan C. Baca, Connor Bell, Heather M. McClure, Talal El Zarif, Matthew P. Davidsohn, Gitanjali Lakshminarayanan, Kinza Rizwan, Darlene G. Skapura, Sandra L. Grimm, Christel M. Davis, Erik A. Ehli, Kaitlin M. Kelleher, Ji-Heui Seo, Nicholas Mitsiades, Cristian Coarfa, Mark M. Pomerantz, Massimo Loda, Michael Ittmann, Matthew L. Freedman, Salma Kaochar
Journal: Cancer Research
Cancer Res (2022) 82 (16): 2848–2859.
https://doi.org/10.1158/0008-5472.CAN-21-3552
Published: 16 August 2022
View article titled, The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response
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Includes: Supplementary data
Journal Articles

Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics

Brian S. White, Xingyi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Akshat M. Savaliya, Lacey E. Dobrolecki, John D. Landua, Matthew H. Bailey, Maihi Fujita, Kurt W. Evans, Bingliang Fang, Junya Fujimoto, Maria Gabriela Raso, Shidan Wang, Guanghua Xiao, Yang Xie, Sherri R. Davies, Ryan C. Fields, R Jay Mashl, Jacqueline L. Mudd, Yeqing Chen, Min Xiao, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet Consortium, Yvonne A. Evrard, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2022-1202
Published: 15 June 2022
View article titled, Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics
Journal Articles

Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer

Xuxu Gou, Meenakshi Anurag, Jonathan T. Lei, Beom-Jun Kim, Purba Singh, Sinem Seker, Diana Fandino, Airi Han, Saif Rehman, Jianhong Hu, Viktoriya Korchina, Harshavardhan Doddapaneni, Lacey E. Dobrolecki, Nicholas Mitsiades, Michael T. Lewis, Alana L. Welm, Shunqiang Li, Adrian V. Lee, Dan R. Robinson, Charles E. Foulds, Matthew J. Ellis
Journal: Cancer Research
Cancer Res (2021) 81 (24): 6259–6272.
https://doi.org/10.1158/0008-5472.CAN-21-1256
Published: 15 December 2021
View article titled, Transcriptional Reprogramming Differentiates Active from Inactive ESR1 Fusions in Endocrine Therapy-Refractory Metastatic Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract 549: Genomic characterization and monitoring molecular response to treatment in African American (AA) advanced prostate cancer (PC) patients (pts) via next-generation sequencing (NGS): Real-world experience in a safety net hospital Oncology clinic

Tamer Khashab, Salma Kaochar, Alexander D. Le, Samantha Cohen, Attiya B. Noor, Heidi Dowst, Neda Zarrin-Khameh, Michael A. Brooks, Guilherme Godoy, Maria A. Berezina, Anna E. Schwarzbach, Michael E. Scheurer, Martha P. Mims, Nicholas Mitsiades
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 549.
https://doi.org/10.1158/1538-7445.AM2021-549
Published: 01 July 2021
View article titled, Abstract 549: Genomic characterization and monitoring molecular response to treatment in African American (AA) advanced prostate cancer (PC) patients (pts) via next-generation sequencing (NGS): Real-world experience in a safety net hospital Oncology clinic
Journal Articles

Pleiotropic Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment

Eugen Dhimolea, Ricardo de Matos Simoes, Dhvanir Kansara, Xiang Weng, Shruti Sharma, Pallavi Awate, Zhiyi Liu, Dong Gao, Nicholas Mitsiades, Joseph H. Schwab, Yu Chen, Rinath Jeselsohn, Aedín C. Culhane, Myles Brown, Irene Georgakoudi, Constantine S. Mitsiades
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (2): 371–383.
https://doi.org/10.1158/0008-5472.CAN-20-0571
Published: 15 January 2021
View article titled, Pleiotropic Mechanisms Drive Endocrine Resistance in the Three-Dimensional Bone Microenvironment
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Includes: Supplementary data
Journal Articles

Correction: Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer

Chuandong Geng, Kimal Rajapakshe, Shrijal S. Shah, John Shou, Vijay Kumar Eedunuri, Christopher Foley, Warren Fiskus, Mahitha Rajendran, Sue Anne Chew, Martin Zimmermann, Richard Bond, Bin He, Cristian Coarfa, Nicholas Mitsiades
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4552.
https://doi.org/10.1158/0008-5472.CAN-19-1981
Published: 03 September 2019
View article titled, Correction: Androgen Receptor Is the Key Transcriptional Mediator of the Tumor Suppressor SPOP in Prostate Cancer
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Journal Articles

Abstract 1565: A novel therapeutic target in lethal prostate cancer in African American males

Salma Kaochar, Michael Ittmann, Matthew Robertson, Jin Wang, Darlene Skapura, Christel Davis, Erik Ehli, Matthew Freedman, Cristian Coarfa, Bert O'Malley, Nicholas Mitsiades
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1565.
https://doi.org/10.1158/1538-7445.AM2019-1565
Published: 01 July 2019
View article titled, Abstract 1565: A novel therapeutic target in lethal prostate cancer in African American males
Journal Articles

Abstract 4961: A highly potent novel class of SRC-3 inhibitors for the treatment of uveal melanoma

Salma Kaochar, Cristian Coarfa, Jin Wang, Bert O'Malley, Nicholas Mitsiades
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4961.
https://doi.org/10.1158/1538-7445.AM2018-4961
Published: 01 July 2018
View article titled, Abstract 4961: A highly potent novel class of SRC-3 inhibitors for the treatment of uveal melanoma
Journal Articles

Abstract 1514: A novel approach for targeting androgen receptor signaling axis in prostate cancer

Salma Kaochar, Christopher Foley, Cristian Coarfa, Nicholas Mitsiades
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1514.
https://doi.org/10.1158/1538-7445.AM2017-1514
Published: 01 July 2017
View article titled, Abstract 1514: A novel approach for targeting androgen receptor signaling axis in prostate cancer
Journal Articles

Abstract 1056: Inhibition of hexose monophosphate pathway promotes castration resistant prostate cancer

Akash K. Kaushik, Ali Shojaie, Katrin Panzitt, Rajni Sonavane, Harene Venghatakrishnan, Mohan Manikkam, Alexander Zaslavsky, Vasanta Putluri, Vihas Vasu, Yiqing Zhang, Ayesha Khan, Stacy Lloyd, Adam Szafran, Subhamoy Dasgupta, David Bader, Fabio Stossi, Hangwen Li, Susmita Samanta, Xuhong Cao, Efrosini Tsouko, Shixia Huang, Daniel Frigo, Lawrence Chan, Dean Edwards, Benny Kaipparettu, Nicholas Mitsiades, Nancy Weigel, Michael Mancini, Michael Ittmann, Arul Chinnaiyan, Nagireddy Putluri, Ganesh Palapattu, George Michailidis, Arun Sreekumar
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1056.
https://doi.org/10.1158/1538-7445.AM2016-1056
Published: 15 July 2016
View article titled, Abstract 1056: Inhibition of hexose monophosphate pathway promotes castration resistant prostate cancer
Journal Articles

HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes

Bryan C. Nikolai, Rainer B. Lanz, Brian York, Subhamoy Dasgupta, Nicholas Mitsiades, Chad J. Creighton, Anna Tsimelzon, Susan G. Hilsenbeck, David M. Lonard, Carolyn L. Smith, Bert W. O'Malley
Journal: Cancer Research
Cancer Res (2016) 76 (6): 1463–1475.
https://doi.org/10.1158/0008-5472.CAN-15-2383
Published: 14 March 2016
View article titled, HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes
Open the PDF for HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes in another window
Includes: Supplementary data