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Nicholas Keen
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Journal Articles

Abstract 1976: Development of a CD137 receptor occupancy assay to support the phase I/II study of BT7480, a Bicycle tumor-targeted immune cell agonist™ (Bicycle TICA®)

Heather Cohen, Drasti Kanakia, Johanna Lahdenranta, Punit Upadhyaya, Kristen Hurov, Julia Kristensson, Chintan Jobaliya, Greg Bannish, Adam Cotty, Kevin McDonnell, Sandra Hirschberg, Phil Brandish, Sebastien Hazard, Dominic Smethurst, Nicholas Keen, Stephen J. Blakemore
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1976.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1976
Published: 15 June 2022
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Journal Articles

Abstract 4230: Modeling the cDC1 ex vivo and in vitro: Development and comparison of a conventional dendritic cell culture system for industry

Laura L. Goodfield, Johanna Lahdenranta, Heather Scott, Tamera Ashworth, Lia Luus, Anna F. Licht, Kevin McDonnell, Phil Brandish, Nicholas Keen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4230.
DOI: https://doi.org/10.1158/1538-7445.AM2022-4230
Published: 15 June 2022
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Journal Articles

Abstract 4233: Generation of a Bicycle NK-TICA™, a novel NK cell engaging molecule designed to induce targeted tumor cytotoxicity

Fay J. Dufort, Christopher J. Leitheiser, Gemma Mudd, Julia Kristensson, Alexandra Rezvaya, Katie Gaynor, Sandra Uhlenbroich, Liudvikas Urbonas, Heather Scott, Liuhong Chen, Helen Harrison, Michael Skynner, Kevin McDonnell, Philip E. Brandish, Nicholas Keen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4233.
DOI: https://doi.org/10.1158/1538-7445.AM2022-4233
Published: 15 June 2022
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Journal Articles

Abstract 1319: Rapid accumulation of cytotoxic payload in tumor tissue drives BT5528 activity in tumor models

Johanna Lahdenranta, Gavin Bennett, Philip Huxley, Gemma Mudd, Punit Upadhyaya, Phil Jeffrey, Nicholas Keen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1319.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1319
Published: 01 July 2021
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Journal Articles

Abstract 1724: Microinjection of Nectin-4/CD137 tumor-targeted immune cell agonist (TICA™) activates the local tumor microenvironment

Johanna Lahdenranta, Stephen J. Blakemore, Kristen Hurov, Marc O. Grenley, Punit Upadhyaya, Carly Campbell, Elizabeth Repash, Eric Haines, Philip E. Brandish, Richard A. Klinghoffer, Nicholas Keen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1724.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1724
Published: 01 July 2021
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Journal Articles

Abstract 1728: Nectin-4-dependent immune cell stimulation and anti-tumor efficacy by BT7480, a Nectin-4/CD137 Bicycle®tumor-targeted immune cell agonist (TICA™)

Kristen Hurov, Johanna Lahdenranta, Punit Upadhyaya, Drasti Kanakia, Elizabeth Repash, Fanglei You, Jun Ma, Eric Haines, Heather Cohen, Kevin McDonnell, Philip E. Brandish, Phil Jeffrey, Nicholas Keen
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1728.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1728
Published: 01 July 2021
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Journal Articles

Abstract 5552: BT7480, a novel fully synthetic tumor-targeted immune cell agonist (TICATM) induces tumor localized 4-1BB agonism

Kristen Hurov, Punit Upadhyaya, Johanna Lahdenranta, Jessica Kublin, Jun Ma, Elizabeth Repash, Marianna Kleyman, Julia Kristensson, Liuhong Chen, Eric Haines, Sailaja Battula, Kevin McDonnell, Nicholas Keen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5552.
DOI: https://doi.org/10.1158/1538-7445.AM2020-5552
Published: 15 August 2020
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Journal Articles

Abstract 6703: A fully synthetic EphA2/4-1BB tumor-targeted immune cell agonist (TICATM) induces tumor localized 4-1BB agonism

Sailaja Battula, Gemma Mudd, Punit Upadhyaya, Julia Kristensson, Marianna Kleyman, Elizabeth Repash, Jessica Kublin, Jun Ma, Eric Haines, Kristen Hurov, Liuhong Chen, Johanna Lahdenranta, Paul Beswick, Kevin McDonnell, Nicholas Keen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6703.
DOI: https://doi.org/10.1158/1538-7445.AM2020-6703
Published: 15 August 2020
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Journal Articles

Abstract 4481: BT5528, an EphA2-targeting Bicycle Toxin Conjugate (BTC): Profound efficacy without bleeding and coagulation abnormalities in animal models

Gavin S. Bennett, Amy Brown, Gemma Mudd, Johanna Lahdenranta, Nicholas Keen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4481.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4481
Published: 01 July 2019
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Journal Articles

Abstract 4479: BT8009: A bicyclic peptide toxin conjugate targeting Nectin-4 (PVRL4) displays efficacy in preclinical tumor models

Mike Rigby, Paul Beswick, Gemma Mudd, Katerine Van Rietschoten, Liuhong Chen, Sophie M. Watcham, Heather Allen, Amy Brown, Helen Harrison, Gavin Bennett, Phil Jeffrey, Peter U. Park, Maria Koehler, Nicholas Keen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4479.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4479
Published: 01 July 2019
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Journal Articles

Abstract 3257: Activation of CD137 using multivalent and tumor targeted Bicyclic peptides

Kristen E. Hurov, Punit Upadhyaya, Jessica Kublin, Xueyuan Zhou, Julia Kristensson, Rachid Lani, Gemma Mudd, Katerine van Rietschoten, Frank An, Johanna Lahdenranta, Liuhong Chen, Gavin Bennett, Kevin McDonnell, Peter Park, Nicholas Keen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3257.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3257
Published: 01 July 2019
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Journal Articles

Abstract 5855: Bicycle Drug Conjugates targeting EphA2 for the treatment of solid tumors: Discovery and selection of BT5528

Gavin Bennett, Philip Huxley, Amy Brown, Gemma Mudd, Katerine van Rietschoten, Silvia Pavan, Liuhong Chen, Sophie M. Watcham, Peter U. Park, Nicholas Keen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5855.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5855
Published: 01 July 2018
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Journal Articles

Abstract 5854: BT5528, a Bicycle Toxin Conjugate targeting EphA2 has potent anti-tumor activity without bleeding or coagulation abnormalities in preclinical models

Gavin Bennett, Philip Huxley, Amy Brown, Gemma Mudd, Peter U. Park, Nicholas Keen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5854.
DOI: https://doi.org/10.1158/1538-7445.AM2018-5854
Published: 01 July 2018
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Journal Articles

Abstract 3756: Small synthetic, multivalent bicyclic peptides that activate T cell costimulatory protein CD137

Peter U. Park, Rachid Lani, Gemma Mudd, Julia Kristensson, Katerine Van Rietschoten, W. Frank An, Gavin Bennett, Kevin McDonnell, Nicholas Keen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3756.
DOI: https://doi.org/10.1158/1538-7445.AM2018-3756
Published: 01 July 2018
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Journal Articles

Abstract DDT01-04: Pharmacological profile and anti-tumor properties of LXH254, a highly selective RAF kinase inhibitor

Darrin D. Stuart, Wenlin Shao, Yuji Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacey Rivera, Fang Shen, Joshua Korn, Lesley A. Mathews Griner, Giselle Nishiguchi, Benjamin Taft, Lifeng Wan, Sharadha Subramanian, Yan Lou, Lina Setti, Matthew Burger, Victor Tamez, Alice Rico, Robert Aversa, John Tellew, Jacob R. Haling, Valery Polyakov, Amy Lambert, Richard Zang, Ann Van Abbema, Mohamad Hekmat-Nejad, Payman Amiri, Mallika Singh, Nicholas Keen, Michael P. Dillon, Emma Lees, William R. Sellers, Savithri Ramurthy
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): DDT01-04.
DOI: https://doi.org/10.1158/1538-7445.AM2018-DDT01-04
Published: 01 July 2018
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Journal Articles

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Wenlin Shao, Yuji M. Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacy Rivera, Yingyun Wang, Fang Shen, Joshua M. Korn, Lesley A. Mathews Griner, Gisele Nishiguchi, Alice Rico, John Tellew, Jacob R. Haling, Robert Aversa, Valery Polyakov, Richard Zang, Mohammad Hekmat-Nejad, Payman Amiri, Mallika Singh, Nicholas Keen, Michael P. Dillon, Emma Lees, Savithri Ramurthy, William R. Sellers, Darrin D. Stuart
Journal: Cancer Research
Cancer Res (2018) 78 (6): 1537–1548.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-2033
Published: 14 March 2018
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Includes: Supplementary data
Journal Articles

Abstract LB-017: Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to marked dependence on PRMT5

Konstantinos Mavrakis, E Robert McDonald, III, Michael R. Schlabach, Eric Billy, Gregory R. Hoffman, Antoine deWeck, David A. Ruddy, Kavitha Venkatesan, Greg McAllister, Rosalie deBeaumont, Samuel Ho, Yue Liu, Yan Yan-Neale, Guizhi Yang, Fallon Lin, Hong Yin, Hui Gao, David Randal Kipp, Songping Zhao, Joshua T. McNamara, Elizabeth R. Sprague, Young Shin Cho, Justin Gu, Ken Crawford, Vladimir Capka, Kristen Hurov, Jeffrey A. Porter, John Tallarico, Craig Mickanin, Emma Lees, Raymond Pagliarini, Nicholas Keen, Tobias Schmelzle, Francesco Hofmann, Frank Stegmeier, William R. Sellers
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-017.
DOI: https://doi.org/10.1158/1538-7445.AM2016-LB-017
Published: 15 July 2016
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Journal Articles

Abstract 2847: High complexity barcoding to study clonal dynamics in response to cancer therapy

Hyo-eun C. Bhang, David A. Ruddy, Viveksagar Krishnamurthy Radhakrishna, Rui Zhao, Iris Kao, Daniel Rakiec, Pamela Shaw, Marissa Balak, Justina X. Caushi, Elizabeth Ackley, Nicholas Keen, Michael R. Schlabach, Michael Palmer, William R. Sellers, Franziska Michor, Vesselina G. Cooke, Joshua M. Korn, Frank Stegmeier
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2847.
DOI: https://doi.org/10.1158/1538-7445.AM2015-2847
Published: 01 August 2015
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Journal Articles

Abstract 2930: Global chromatin profiling reveals NSD2 mutation in pediatric ALL

Ho Man Chan, Jacob D. Jaffe, Yan Wang, Jinghui Zhang, Robert Huether, Gregory V. Kryukov, Hyo-eun C. Bhang, Jordan E. Taylor, Min Hu, Nathan P. Englund, Feng Yan, Zhaofu Wang, E Robert McDonald, III, Lei Wei, Jing Ma, John Easton, Zhengtian Yu, Rosalie deBeaumount, Veronica Gibaja, Kavitha Venkatesan, Robert Schlegel, William R. Sellers, Nicholas Keen, Jun Liu, Giordano Caponigro, Jordi Barretina, Vesselina G. Cooke, Charles Mullighan, Steven A. Carr, James R. Downing, Levi A. Garraway, Frank Stegmeier
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2930.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2930
Published: 01 October 2014
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Journal Articles

Abstract 444: BRM/SMARCA2 is a critical synthetic lethal target in BRG1-deficient cancers

Mariela Jaskelioff, Gregory Hoffman, Rami Rahal, Kay Xiang, Kristy Haas, Veronica Saenz-Vash, Huili Zhai, Nicholas Keen, Frank Stegmeier, Zainab Jagani
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 444.
DOI: https://doi.org/10.1158/1538-7445.AM2014-444
Published: 01 October 2014
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