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Nicholas C. Denko
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Journal Articles

Abstract 4052: Biological Variations in NRF2 Hotspot Mutants

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Syed A. Ashraf, Anh Thi Thai, Jinghai Wu, McKenzie Kreamer, Katarina Benejova, Terry M. Williams, Martin Benej, Ioanna Papandreou, Nicholas C. Denko
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4052.
https://doi.org/10.1158/1538-7445.AM2025-4052
Published: 21 April 2025
View articletitled, Abstract 4052: Biological Variations in NRF2 Hotspot Mutants
Journal Articles

Abstract 7057: Validation of OXPHOS gene amplification as a driver of treatment resistance in non-small cell lung cancer

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Martin Benej, Katarina Benejova, Rebecca Hoyd, Caroline Wheeler, Daniel Spakowicz, Nicholas C. Denko
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7057.
https://doi.org/10.1158/1538-7445.AM2024-7057
Published: 22 March 2024
View articletitled, Abstract 7057: Validation of OXPHOS gene amplification as a driver of treatment resistance in non-small cell lung cancer
Journal Articles

Abstract 4832: Copy number amplification of OXPHOS genes drives tumor hypoxia in NSCLC

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Martin Benej, Katarina Benejova, McKenzie Kreamer, Jinghai Wu, Syed Ashraf, Caroline Wheeler, Rebecca Hoyd, Daniel Spakowicz, Nicholas C. Denko
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4832.
https://doi.org/10.1158/1538-7445.AM2023-4832
Published: 04 April 2023
View articletitled, Abstract 4832: Copy number amplification of OXPHOS genes drives tumor hypoxia in NSCLC
Journal Articles

Abstract 3067: Exploring strategies to modulate mitochondrial metabolism to alleviate tumor hypoxia

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Martin Benej, Jinghai Wu, McKenzie Kreamer, Sandip Vibhute, Ioanna Papandreou, Nicholas C. Denko
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3067.
https://doi.org/10.1158/1538-7445.AM2021-3067
Published: 01 July 2021
View articletitled, Abstract 3067: Exploring strategies to modulate mitochondrial metabolism to alleviate tumor hypoxia
Journal Articles

Abstract 233: Tumor-associated carbonic anhydrase IX maintains cellular proliferation by regulating tumor metabolism: a novel link revealed by proteomics

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Martin Benej, Eliska Svastova, Radivojka Banova, Juraj Kopacek, Adriana Gibadulinova, Martin Kery, Simona Arena, Andrea Scaloni, Monica Vitale, Nicola Zambrano, Ioanna Papandreou, Nicholas C. Denko, Silvia Pastorekova
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 233.
https://doi.org/10.1158/1538-7445.AM2020-233
Published: 15 August 2020
View articletitled, Abstract 233: Tumor-associated carbonic anhydrase IX maintains cellular proliferation by regulating tumor metabolism: a novel link revealed by proteomics
Journal Articles

Abstract 2927: Papaverine and its novel derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

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Martin Benej, Xiangqian Hong, Sandip Vibhute, Sabina Scott, Jinghai Wu, Edward Graves, Quynh-Thu Le, Albert C. Koong, Amato J. Giaccia, Ching-Shih Chen, Bing Yu, Ioanna Papandreou, Nicholas C. Denko
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2927.
https://doi.org/10.1158/1538-7445.AM2019-2927
Published: 01 July 2019
View articletitled, Abstract 2927: Papaverine and its novel derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism
Journal Articles

Imaging the Unfolded Protein Response in Primary Tumors Reveals Microenvironments with Metabolic Variations that Predict Tumor Growth

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Michael T. Spiotto, Alice Banh, Ioanna Papandreou, Hongbin Cao, Michael G. Galvez, Geoffrey C. Gurtner, Nicholas C. Denko, Quynh Thu Le, Albert C. Koong
Journal: Cancer Research
Cancer Res (2010) 70 (1): 78–88.
https://doi.org/10.1158/0008-5472.CAN-09-2747
Published: 04 January 2010
View articletitled, Imaging the Unfolded Protein Response in Primary Tumors Reveals Microenvironments with Metabolic Variations that Predict Tumor Growth
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Journal Articles

Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment

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Ioanna Papandreou, Chaya Krishna, Fiona Kaper, Deli Cai, Amato J. Giaccia, Nicholas C. Denko
Journal: Cancer Research
Cancer Res (2005) 65 (8): 3171–3178.
https://doi.org/10.1158/0008-5472.CAN-04-3395
Published: 15 April 2005
View articletitled, Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment
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Journal Articles

XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth

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Lorenzo Romero-Ramirez, Hongbin Cao, Daniel Nelson, Ester Hammond, Ann-Hwee Lee, Hiderou Yoshida, Kazutoshi Mori, Laurie H. Glimcher, Nicholas C. Denko, Amato J. Giaccia, Quynh-Thu Le, Albert C. Koong
Journal: Cancer Research
Cancer Res (2004) 64 (17): 5943–5947.
https://doi.org/10.1158/0008-5472.CAN-04-1606
Published: 01 September 2004
View articletitled, XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth
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Journal Articles

Topical Treatment with Inhibitors of the Phosphatidylinositol 3′-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice

Free
Barbara Bedogni, Melony S. O’Neill, Scott M. Welford, Donna M. Bouley, Amato J. Giaccia, Nicholas C. Denko, Marianne Broome Powell
Journal: Cancer Research
Cancer Res (2004) 64 (7): 2552–2560.
https://doi.org/10.1158/0008-5472.CAN-03-3327
Published: 01 April 2004
View articletitled, Topical Treatment with Inhibitors of the Phosphatidylinositol 3′-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice
Open the PDF for Topical Treatment with Inhibitors of the Phosphatidylinositol 3′-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice in another window
Journal Articles

Tumor Hypoxia, the Physiological Link between Trousseau’s Syndrome (Carcinoma-induced Coagulopathy) and Metastasis

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Nicholas C. Denko, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2001) 61 (3): 795–798.
Published: 02 February 2001
View articletitled, Tumor Hypoxia, the Physiological Link between Trousseau’s Syndrome (Carcinoma-induced Coagulopathy) and Metastasis
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Journal Articles

Candidate Genes for the Hypoxic Tumor Phenotype

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Albert C. Koong, Nicholas C. Denko, Karen M. Hudson, Cornelia Schindler, Lillian Swiersz, Cameron Koch, Sydney Evans, Hani Ibrahim, Quynh T. Le, David J. Terris, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (2000) 60 (4): 883–887.
Published: 01 February 2000
View articletitled, Candidate Genes for the Hypoxic Tumor Phenotype
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Journal Articles

Loss of p21Waf1/Cip1 Sensitizes Tumors to Radiation by an Apoptosis-independent Mechanism

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Bradly G. Wouters, Amato J. Giaccia, Nicholas C. Denko, J. Martin Brown
Journal: Cancer Research
Cancer Res (1997) 57 (21): 4703–4706.
Published: 01 November 1997
View articletitled, Loss of p21Waf1/Cip1 Sensitizes Tumors to Radiation by an Apoptosis-independent Mechanism
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Journal Articles

Hypoxic Activation of Nuclear Factor-κB Is Mediated by a Ras and Raf Signaling Pathway and Does Not Involve MAP Kinase (ERK1 or ERK2)

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Albert C. Koong, Eunice Y. Chen, Nahid F. Mivechi, Nicholas C. Denko, Peter Stambrook, Amato J. Giaccia
Journal: Cancer Research
Cancer Res (1994) 54 (20): 5273–5279.
Published: 01 October 1994
View articletitled, Hypoxic Activation of Nuclear Factor-κB Is Mediated by a Ras and Raf Signaling Pathway and Does Not Involve MAP Kinase (ERK1 or ERK2)
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Journal Articles

The Hypersensitivity of the Chinese Hamster Ovary Variant BL-10 to Bleomycin Killing Is Due to a Lack of Glutathione S-Transferase-α Activity

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Amato J. Giaccia, Alexander D. Lewis, Nicholas C. Denko, Annette Cholon, James W. Evans, Charles A. Waldren, Thomas D. Stamato, J. Martin Brown
Journal: Cancer Research
Cancer Res (1991) 51 (16): 4463–4469.
Published: 01 August 1991
View articletitled, The Hypersensitivity of the Chinese Hamster Ovary Variant BL-10 to Bleomycin Killing Is Due to a Lack of Glutathione S-Transferase-α Activity
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