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Journal Articles

Abstract 3506: CLN-619, a clinical-stage MICA/MICB-specific IgG1 antibody, restores the MICA/MICB-NKG2D axis to promote NK-mediated tumor cell lysis

Kerry A. Whalen, Naveen K. Mehta, Safak Yalcin, Kristan Meetze, Neil W. Gibson, Jennifer S. Michaelson, Patrick A. Baeuerle

Cancer Res (2022) 82 (12_Supplement): 3506.

https://doi.org/10.1158/1538-7445.AM2022-3506

Published: 15 June 2022

View article titled, Abstract 3506: CLN-619, a clinical-stage MICA/MICB-specific IgG1 antibody, restores the MICA/MICB-NKG2D axis to promote NK-mediated tumor cell lysis

Journal Articles

Abstract 5409: Ron silencing by shRNA inhibits growth, induces apoptosis and sensitizes tumor response to c-Met inhibitor treatment through down-regulating MAPK signaling in B-Raf mutant colon carcinomas

Helen Y. Zou, Qiuhua Li, Ming Qiu, Keith Tatsukawa, Karen Wu, Douglas Fang, Jean Cui, Steve Bender, Neil W. Gibson, Tod Smeal

Cancer Res (2010) 70 (8_Supplement): 5409.

https://doi.org/10.1158/1538-7445.AM10-5409

Published: 15 April 2010

View article titled, Abstract 5409: Ron silencing by shRNA inhibits growth, induces apoptosis and sensitizes tumor response to c-Met inhibitor treatment through down-regulating MAPK signaling in B-Raf mutant colon carcinomas

Journal Articles

Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors

Elizabeth Buck, Alexandra Eyzaguirre, Maryland Rosenfeld-Franklin, Stuart Thomson, Mark Mulvihill, Sharon Barr, Eric Brown, Mathew O'Connor, Yan Yao, Jonathan Pachter, Mark Miglarese, David Epstein, Kenneth K. Iwata, John D. Haley, Neil W. Gibson, Qun-Sheng Ji

Cancer Res (2008) 68 (20): 8322–8332.

https://doi.org/10.1158/0008-5472.CAN-07-6720

Published: 15 October 2008

View article titled, Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors

Includes: Supplementary data

Journal Articles

OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models

Cancer Res (2006) 66 (2): 1015–1024.

https://doi.org/10.1158/0008-5472.CAN-05-2873

Published: 19 January 2006

View article titled, OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models

Includes: Supplementary data

Journal Articles

Cell screens with siRNA for cancer target identification

Julie L. C. Kan, Feng-Lei Sun, David M. Keane, Suzanne Russo, Nancy Ng, Neil W. Gibson, Lee Arnold

Cancer Res (2005) 65 (9_Supplement): 402.

Published: 01 May 2005

View article titled, Cell screens with siRNA for cancer target identification

Journal Articles

Identification of potent CYP26 inhibitors and their potential for cancer therapy.

Cancer Res (2004) 64 (7_Supplement): 472.

Published: 01 April 2004

View article titled, Identification of potent CYP26 inhibitors and their potential for cancer therapy.

Journal Articles

Increased Activity and Expression of NAD(P)H:Quinone Acceptor Oxidoreductase in Confluent Cell Cultures and within Multicellular Spheroids

Roger M. Phillips, Aristotle de la Cruz, Robert D. Traver, Neil W. Gibson

Cancer Res (1994) 54 (14): 3766–3771.

Published: 01 July 1994

View article titled, Increased Activity and Expression of NAD(P)H:Quinone Acceptor Oxidoreductase in Confluent Cell Cultures and within Multicellular Spheroids

Journal Articles

Metabolism of Bioreductive Antitumor Compounds by Purified Rat and Human DT-Diaphorases

Howard D. Beall, R. Timothy Mulcahy, David Siegel, Robert D. Traver, Neil W. Gibson, David Ross

Cancer Res (1994) 54 (12): 3196–3201.

Published: 01 June 1994

View article titled, Metabolism of Bioreductive Antitumor Compounds by Purified Rat and Human DT-Diaphorases

Journal Articles

Mapping of DNA Alkylation Sites Induced by Aziridinylbenzoquinones in Human Cells by Ligation-mediated Polymerase Chain Reaction

Chong-Soon Lee, Gerd P. Pfeifer, Neil W. Gibson

Cancer Res (1994) 54 (7): 1622–1626.

Published: 01 April 1994

View article titled, Mapping of DNA Alkylation Sites Induced by Aziridinylbenzoquinones in Human Cells by Ligation-mediated Polymerase Chain Reaction

Journal Articles

NAD(P)H:Quinone Oxidoreductase Gene Expression in Human Colon Carcinoma Cells: Characterization of a Mutation Which Modulates DT-Diaphorase Activity and Mitomycin Sensitivity

Robert D. Traver, Tetsuro Horikoshi, Kathleen D. Danenberg, Thomas H. W. Stadlbauer, Peter V. Danenberg, David Ross, Neil W. Gibson

Cancer Res (1992) 52 (4): 797–802.

Published: 01 February 1992

View article titled, NAD(P)H:Quinone Oxidoreductase Gene Expression in Human Colon Carcinoma Cells: Characterization of a Mutation Which Modulates DT-Diaphorase Activity and Mitomycin Sensitivity

Journal Articles

Quantitation of Thymidylate Synthase, Dihydrofolate Reductase, and DT-Diaphorase Gene Expression in Human Tumors Using the Polymerase Chain Reaction

Tetsuro Horikoshi, Kathleen D. Danenberg, Thomas H. W. Stadlbauer, Matthias Volkenandt, Luke C. C. Shea, Karl Aigner, Bengt Gustavsson, Lawrence Leichman, Roland Frösing, Margaret Ray, Neil W. Gibson, C. Paul Spears, Peter V. Danenberg

Cancer Res (1992) 52 (1): 108–116.

Published: 01 January 1992

View article titled, Quantitation of Thymidylate Synthase, Dihydrofolate Reductase, and DT-Diaphorase Gene Expression in Human Tumors Using the Polymerase Chain Reaction

Journal Articles

DNA Damage and Differential Cytotoxicity Produced in Human Carcinoma Cells by CC-1065 Analogues, U-73,975 and U-77,779

Chong-Soon Lee, Neil W. Gibson

Cancer Res (1991) 51 (24): 6586–6591.

Published: 01 December 1991

View article titled, DNA Damage and Differential Cytotoxicity Produced in Human Carcinoma Cells by CC-1065 Analogues, U-73,975 and U-77,779

Journal Articles

Metabolism of Mitomycin C by DT-Diaphorase: Role in Mitomycin C-induced DNA Damage and Cytotoxicity in Human Colon Carcinoma Cells

David Siegel, Neil W. Gibson, Peter C. Preusch, David Ross

Cancer Res (1990) 50 (23): 7483–7489.

Published: 01 December 1990

View article titled, Metabolism of Mitomycin C by DT-Diaphorase: Role in Mitomycin C-induced DNA Damage and Cytotoxicity in Human Colon Carcinoma Cells

Journal Articles

In Vitro Studies on the Mechanism of Action of Hepsulfam in Chronic Myelogenous Leukemia Patients

Jeffrey R. Hincks, Arun Adlakha, Cheryl A. Cook, Candace S. Johnson, Philip Furmanski, Neil W. Gibson

Cancer Res (1990) 50 (23): 7559–7563.

Published: 01 December 1990

View article titled, In Vitro Studies on the Mechanism of Action of Hepsulfam in Chronic Myelogenous Leukemia Patients

Journal Articles

Mechanisms of Toxicity of Hepsulfam in Human Tumor Cell Lines

Diane Y. Pacheco, Cheryl Cook, Jeffrey R. Hincks, Neil W. Gibson

Cancer Res (1990) 50 (23): 7555–7558.

Published: 01 December 1990

View article titled, Mechanisms of Toxicity of Hepsulfam in Human Tumor Cell Lines

Journal Articles

Metabolism of Diaziquone by NAD(P)H:(Quinone Acceptor) Oxidoreductase (DT-Diaphorase): Role in Diaziquone-induced DNA Damage and Cytotoxicity in Human Colon Carcinoma Cells

David Siegel, Neil W. Gibson, Peter C. Preusch, David Ross

Cancer Res (1990) 50 (22): 7293–7300.

Published: 01 November 1990

View article titled, Metabolism of Diaziquone by NAD(P)H:(Quinone Acceptor) Oxidoreductase (DT-Diaphorase): Role in Diaziquone-induced DNA Damage and Cytotoxicity in Human Colon Carcinoma Cells

Journal Articles

Comparison of the Mechanism of Action of Busulfan with Hepsulfam, a New Antileukemic Agent, in the L1210 Cell Line

Diane Y. Pacheco, Nancy K. Stratton, Neil W. Gibson

Cancer Res (1989) 49 (18): 5108–5110.

Published: 01 September 1989

View article titled, Comparison of the Mechanism of Action of Busulfan with Hepsulfam, a New Antileukemic Agent, in the L1210 Cell Line

Journal Articles

Characterization of DNA Damage and Cytotoxicity Induced in Two Human Colon Carcinoma Cell Lines by Cyclodisone

Neil W. Gibson

Cancer Res (1989) 49 (1): 154–157.

Published: 01 January 1989

View article titled, Characterization of DNA Damage and Cytotoxicity Induced in Two Human Colon Carcinoma Cell Lines by Cyclodisone

Journal Articles

Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

Malcolm F. G. Stevens, John A. Hickman, Simon P. Langdon, David Chubb, Lisa Vickers, Robert Stone, Ghousia Baig, Colin Goddard, Neil W. Gibson, John A. Slack, Christopher Newton, Edward Lunt, Christian Fizames, François Lavelle

Cancer Res (1987) 47 (22): 5846–5852.

Published: 01 November 1987

View article titled, Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

Journal Articles

Combined Effects of Streptozotocin and Mitozolomide against Four Human Cell Lines of the Mer⁺ Phenotype

Neil W. Gibson, John A. Hartley, Diane Barnes, Leonard C. Erickson

Cancer Res (1986) 46 (10): 4995–4998.

Published: 01 October 1986

View article titled, Combined Effects of Streptozotocin and Mitozolomide against Four Human Cell Lines of the Mer+ Phenotype

NARROW

Abstract 3506: CLN-619, a clinical-stage MICA/MICB-specific IgG1 antibody, restores the MICA/MICB-NKG2D axis to promote NK-mediated tumor cell lysis

Abstract 5409: Ron silencing by shRNA inhibits growth, induces apoptosis and sensitizes tumor response to c-Met inhibitor treatment through down-regulating MAPK signaling in B-Raf mutant colon carcinomas

Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors

OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models

Cell screens with siRNA for cancer target identification

Identification of potent CYP26 inhibitors and their potential for cancer therapy.

Increased Activity and Expression of NAD(P)H:Quinone Acceptor Oxidoreductase in Confluent Cell Cultures and within Multicellular Spheroids

Metabolism of Bioreductive Antitumor Compounds by Purified Rat and Human DT-Diaphorases

Mapping of DNA Alkylation Sites Induced by Aziridinylbenzoquinones in Human Cells by Ligation-mediated Polymerase Chain Reaction

NAD(P)H:Quinone Oxidoreductase Gene Expression in Human Colon Carcinoma Cells: Characterization of a Mutation Which Modulates DT-Diaphorase Activity and Mitomycin Sensitivity

Quantitation of Thymidylate Synthase, Dihydrofolate Reductase, and DT-Diaphorase Gene Expression in Human Tumors Using the Polymerase Chain Reaction

DNA Damage and Differential Cytotoxicity Produced in Human Carcinoma Cells by CC-1065 Analogues, U-73,975 and U-77,779

Metabolism of Mitomycin C by DT-Diaphorase: Role in Mitomycin C-induced DNA Damage and Cytotoxicity in Human Colon Carcinoma Cells

In Vitro Studies on the Mechanism of Action of Hepsulfam in Chronic Myelogenous Leukemia Patients

Mechanisms of Toxicity of Hepsulfam in Human Tumor Cell Lines

Metabolism of Diaziquone by NAD(P)H:(Quinone Acceptor) Oxidoreductase (DT-Diaphorase): Role in Diaziquone-induced DNA Damage and Cytotoxicity in Human Colon Carcinoma Cells

Comparison of the Mechanism of Action of Busulfan with Hepsulfam, a New Antileukemic Agent, in the L1210 Cell Line

Characterization of DNA Damage and Cytotoxicity Induced in Two Human Colon Carcinoma Cell Lines by Cyclodisone

Antitumor Activity and Pharmacokinetics in Mice of 8-Carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a Novel Drug with Potential as an Alternative to Dacarbazine

Combined Effects of Streptozotocin and Mitozolomide against Four Human Cell Lines of the Mer⁺ Phenotype

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