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Neeraj K. Saxena
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Journal Articles

Abstract PS18-32: Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen coordinating a crosstalk between Med1, miR205 and Erb B kinases

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Arumugam Nagalingam, Nethaji Muniraj, Sumit Siddharth, Dimiter Avtanski, Sheetal Parida, Pajamurthy Kuppusamy, Neeraj K Saxena, Nethaji Muniraj
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS18-32.
https://doi.org/10.1158/1538-7445.SABCS20-PS18-32
Published: 15 February 2021
View articletitled, Abstract PS18-32: Hyperleptinemia in obese state renders luminal breast cancers refractory to tamoxifen coordinating a crosstalk between Med1, miR205 and Erb B kinases
Journal Articles

Abstract 4271: Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon Honokiol treatment

Free
Nethaji Muniraj, Marey Shriver, Arumugam Nagalingam, Sumit Siddharth, Sheetal Parida, Neeraj K Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4271.
https://doi.org/10.1158/1538-7445.AM2019-4271
Published: 01 July 2019
View articletitled, Abstract 4271: Induction of STK11-dependent cytoprotective autophagy in breast cancer cells upon Honokiol treatment
Journal Articles

Abstract 1335: Withaferin A induces nonprotective autophagy in a STK11-independent manner and mediates breast cancer inhibition via energetic impairment

Free
Nethaji Muniraj, Arumugam Nagalingam, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1335.
https://doi.org/10.1158/1538-7445.AM2018-1335
Published: 01 July 2018
View articletitled, Abstract 1335: Withaferin A induces nonprotective autophagy in a STK11-independent manner and mediates breast cancer inhibition via energetic impairment
Journal Articles

Abstract 1334: Withaferin A induces cytoprotective autophagy in hepatocellular cancer cells and concomitant autophagic inhibition augments the efficacy of Withaferin A in hepatocellular carcinoma

Free
Sumit Siddharth, Nethaji Muniraj, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1334.
https://doi.org/10.1158/1538-7445.AM2018-1334
Published: 01 July 2018
View articletitled, Abstract 1334: Withaferin A induces cytoprotective autophagy in hepatocellular cancer cells and concomitant autophagic inhibition augments the efficacy of Withaferin A in hepatocellular carcinoma
Journal Articles

Abstract 3301: A three-pronged attack on cancer cells: Induction of non-protective autophagy, inhibition of lysosomal acidification and promotion of energetic impairment

Free
Nethaji Muniraj, Arumugam Nagalingam, Panjamurthy Kuppusamy, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3301.
https://doi.org/10.1158/1538-7445.AM2017-3301
Published: 01 July 2017
View articletitled, Abstract 3301: A three-pronged attack on cancer cells: Induction of non-protective autophagy, inhibition of lysosomal acidification and promotion of energetic impairment
Journal Articles

Abstract 3319: Elevating adipokine adiponectin level can induce cytotoxic autophagy in breast cancer cells and potentiate the efficacy of chemotherapeutic regimens: preclinical studies

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Seung J Chung, Ganji Purnachandra Nagaraju, Arumugam Nagalingam, Nethaji Muniraj, Panjamurthy Kuppusamy, Alyssa Walker, Juhyung woo, Balázs Győrffy, Edward Gabrielson, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3319.
https://doi.org/10.1158/1538-7445.AM2017-3319
Published: 01 July 2017
View articletitled, Abstract 3319: Elevating adipokine adiponectin level can induce cytotoxic autophagy in breast cancer cells and potentiate the efficacy of chemotherapeutic regimens: preclinical studies
Journal Articles

Abstract LB-187: Novel mechanistic insights into the bioactive compound honokiol-mediated inhibition of epithelial to mesenchymal transition in breast cancer: Therapeutic modulation of miR-34a via tumor suppressor LKB1

Free
Dimiter B. Avtanski, Michael Y. Bonner, Timothy P. Tiutan, Jack L. Arbiser, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-187.
https://doi.org/10.1158/1538-7445.AM2014-LB-187
Published: 01 October 2014
View articletitled, Abstract LB-187: Novel mechanistic insights into the bioactive compound honokiol-mediated inhibition of epithelial to mesenchymal transition in breast cancer: Therapeutic modulation of miR-34a via tumor suppressor LKB1
Journal Articles

Abstract LB-61: Inhibiting “Dedifferentiation” in breast cancer cells using Honokiol - a plant derived polyphenol

Free
Sonali Sengupta, Michael Y. Bonner, Jack L. Arbiser, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-61.
https://doi.org/10.1158/1538-7445.AM2014-LB-61
Published: 01 October 2014
View articletitled, Abstract LB-61: Inhibiting “Dedifferentiation” in breast cancer cells using Honokiol - a plant derived polyphenol
Journal Articles

Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer

Free
Arumugam Nagalingam, Panjamurthy Kuppusamy, Shivendra V. Singh, Dipali Sharma, Neeraj K. Saxena
Journal: Cancer Research
Cancer Res (2014) 74 (9): 2617–2629.
https://doi.org/10.1158/0008-5472.CAN-13-2081
Published: 30 April 2014
View articletitled, Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer
Open the PDF for Mechanistic Elucidation of the Antitumor Properties of Withaferin A in Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 5497: A novel bioactive approach to inhibit leptin-induced epithelial-mesenchymal transition in breast cancer.

Free
Dimiter B. Avtanski, Arumugam Nagalingam, Panjamurthy Kuppusamy, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5497.
https://doi.org/10.1158/1538-7445.AM2013-5497
Published: 15 April 2013
View articletitled, Abstract 5497: A novel bioactive approach to inhibit leptin-induced epithelial-mesenchymal transition in breast cancer.
Journal Articles

Abstract 299: Targeting epithelial-mesenchymal transition in breast cancer cells using Honokiol, a natural phenolic compound.

Free
Dimiter B. Avtanski, Arumugam Nagalingam, Panjamurthi Kupusamy, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 299.
https://doi.org/10.1158/1538-7445.AM2013-299
Published: 15 April 2013
View articletitled, Abstract 299: Targeting epithelial-mesenchymal transition in breast cancer cells using Honokiol, a natural phenolic compound.
Journal Articles

Abstract 349: Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3-dependent and MTA1/Wnt1-dependent pathways

Free
Dan Yan, Dimiter B. Avtanski, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 349.
https://doi.org/10.1158/1538-7445.AM2012-349
Published: 15 April 2012
View articletitled, Abstract 349: Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3-dependent and MTA1/Wnt1-dependent pathways
Journal Articles

Abstract 860: Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3

Free
Su-Hyeong Kim, Arumugam Nagalingam, Neeraj K Saxena, Shivendra V Singh, Dipali Sharma
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 860.
https://doi.org/10.1158/1538-7445.AM2011-860
Published: 15 April 2011
View articletitled, Abstract 860: Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3
Journal Articles

Abstract LB-224: Leptin-induced breast cancer cell migration requires upregulation of antiapoptotic protein, survivin

Free
Brandi B. Knight, Gabriela M. Oprea-Ilies, Elaine Oberlick, Arumugam Nagalingam, LaTonia Taliaferro-Smith, Lily Yang, Cynthia Cohen, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-224.
https://doi.org/10.1158/1538-7445.AM10-LB-224
Published: 15 April 2010
View articletitled, Abstract LB-224: Leptin-induced breast cancer cell migration requires upregulation of antiapoptotic protein, survivin
Journal Articles

Abstract LB-269: Activation of energy sensor AMP-activated protein kinase by rosiglitazone: A novel means to rescue triple-negative breast cancer cells from metastasis

Free
LaTonia D. Taliaferro-Smith, Arumugam Nagalingam, Brandi B. Knight, Elaine Oberlick, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-269.
https://doi.org/10.1158/1538-7445.AM10-LB-269
Published: 15 April 2010
View articletitled, Abstract LB-269: Activation of energy sensor AMP-activated protein kinase by rosiglitazone: A novel means to rescue triple-negative breast cancer cells from metastasis
Journal Articles

Abstract LB-57: Integral role of Med1 in conferring tamoxifen resistance to poor prognosis (luminal-B) estrogen receptor positive breast cancer

Free
Arumugam Nagalingam, Gabriela M. Oprea-Ilies, LaTonia Taliaferro-Smith, Cynthia Cohen, Neeraj K. Saxena, Dipali Sharma
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-57.
https://doi.org/10.1158/1538-7445.AM10-LB-57
Published: 15 April 2010
View articletitled, Abstract LB-57: Integral role of Med1 in conferring tamoxifen resistance to poor prognosis (luminal-B) estrogen receptor positive breast cancer
Journal Articles

Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor

Free
Neeraj K. Saxena, LaTonia Taliaferro-Smith, Brandi B. Knight, Didier Merlin, Frank A. Anania, Ruth M. O'Regan, Dipali Sharma
Journal: Cancer Research
Cancer Res (2008) 68 (23): 9712–9722.
https://doi.org/10.1158/0008-5472.CAN-08-1952
Published: 01 December 2008
View articletitled, Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor
Open the PDF for Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor in another window
Includes: Supplementary data
Journal Articles

Abstract LB-331: Bidirectional crosstalk between leptin and IGF-1 signaling transactivates epidermal growth factor receptor and promotes invasion and migration of triple-negative breast cancer cells

Free
Neeraj K Saxena, LaTonia Taliaferro Smith, Brandi Brandon, Frank A Anania, Dipali Sharma
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-331.
https://doi.org/10.1158/1538-7445.AM2008-LB-331
Published: 15 May 2008
View articletitled, Abstract LB-331: Bidirectional crosstalk between leptin and IGF-1 signaling transactivates epidermal growth factor receptor and promotes invasion and migration of triple-negative breast cancer cells
Journal Articles

Concomitant Activation of the JAK/STAT, PI3K/AKT, and ERK Signaling Is Involved in Leptin-Mediated Promotion of Invasion and Migration of Hepatocellular Carcinoma Cells

Free
Neeraj K. Saxena, Dipali Sharma, Xiaokun Ding, Songbai Lin, Fabio Marra, Didier Merlin, Frank A. Anania
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2497–2507.
https://doi.org/10.1158/0008-5472.CAN-06-3075
Published: 15 March 2007
View articletitled, Concomitant Activation of the JAK/STAT, PI3K/AKT, and ERK Signaling Is Involved in Leptin-Mediated Promotion of Invasion and Migration of Hepatocellular Carcinoma Cells
Open the PDF for Concomitant Activation of the JAK/STAT, PI3K/AKT, and ERK Signaling Is Involved in Leptin-Mediated Promotion of Invasion and Migration of Hepatocellular Carcinoma Cells in another window
Journal Articles

Restoration of Tamoxifen Sensitivity in Estrogen Receptor–Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes

Free
Dipali Sharma, Neeraj K. Saxena, Nancy E. Davidson, Paula M. Vertino
Journal: Cancer Research
Cancer Res (2006) 66 (12): 6370–6378.
https://doi.org/10.1158/0008-5472.CAN-06-0402
Published: 15 June 2006
View articletitled, Restoration of Tamoxifen Sensitivity in Estrogen Receptor–Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes
Open the PDF for Restoration of Tamoxifen Sensitivity in Estrogen Receptor–Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes in another window