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Nathanael S. Gray
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Journal Articles

Abstract 5777: Rewiring EWS/FLI1 with transcriptional chemical inducers of proximity (TCIPs)

Michael J. Bond, Ryan P. Golden, Roman C. Sarott, Giulia DiGiovanni, Basel A. Karim, Briana Howard, Kenneth Ross, Nathanael S. Gray, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5777.
https://doi.org/10.1158/1538-7445.AM2024-5777
Published: 22 March 2024
View article titled, Abstract 5777: Rewiring EWS/FLI1 with transcriptional chemical inducers of proximity (TCIPs)
Journal Articles

Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy

Suman Mukhopadhyay, Hsin-Yi Huang, Ziyan Lin, Michela Ranieri, Shuai Li, Soumyadip Sahu, Yingzhuo Liu, Yi Ban, Kayla Guidry, Hai Hu, Alfonso Lopez, Fiona Sherman, Yi Jer Tan, Yeuan Ting Lee, Amanda P. Armstrong, Igor Dolgalev, Priyanka Sahu, Tinghu Zhang, Wenchao Lu, Nathanael S. Gray, James G. Christensen, Tracy T. Tang, Vamsidhar Velcheti, Alireza Khodadadi-Jamayran, Kwok-Kin Wong, Benjamin G. Neel
Journal: Cancer Research
Cancer Res (2023) 83 (24): 4095–4111.
https://doi.org/10.1158/0008-5472.CAN-23-2729
Published: 15 December 2023
View article titled, Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRAS<sup>G12C</sup> Inhibitor Efficacy
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Includes: Supplementary data
Journal Articles

Abstract 3424: Template-assisted covalent modification of DCAF16 enables BRD4 molecular glue degraders

Yen-Der Li, Michelle W. Ma, Muhammad Murtaza Hassan, Kedar Puvar, Mingxing Teng, Brittany Sandoval, Ryan Lumpkin, Scott B. Ficarro, Michelle Y. Wang, Shawn Xu, Brian J. Groendyke, Logan H. Sigua, Isidoro Tavares, Charles Zou, Jonathan M. Tsai, Paul M. Park, Hojong Yoon, Radosław P. Nowak, Jarrod A. Marto, Jun Qi, Katherine A. Donovan, Mikołaj Słabicki, Nathanael S. Gray, Eric S. Fischer, Benjamin L. Ebert
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3424.
https://doi.org/10.1158/1538-7445.AM2023-3424
Published: 04 April 2023
View article titled, Abstract 3424: Template-assisted covalent modification of DCAF16 enables BRD4 molecular glue degraders
Journal Articles

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

Clare F. Malone, Minjee Kim, Gabriela Alexe, Kathleen Engel, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, Ashleigh Meyer, Delan Khalid, Allen Thayakumar, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2023) 83 (2): 285–300.
https://doi.org/10.1158/0008-5472.CAN-21-4309
Published: 18 January 2023
View article titled, Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors
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Includes: Supplementary data
Journal Articles

Abstract A057: Therapeutic efficacy of selective CDK7 inhibition in pancreatic cancer mediated by induction of R-loop formation, DNA replication stress and genomic instability

Annan Yang, Jie Jiang, Ziyue Li, Kevin S. Kapner, Hanrong Feng, Kristen E. Lowder, Miljan Kuljanin, Whiteny Johnson, Giselle Uribe, Jasper E. Neggers, Shengwu Liu, Tinghu Zhang, James Decaprio, Ewa Sicinska, Brian M. Wolpin, Nicholas P. Kwiatkowski, Stephanie K. Dougan, Joseph D. Mancias, Nathanael S. Gray, Andrew J. Aguirre
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A057.
https://doi.org/10.1158/1538-7445.PANCA22-A057
Published: 15 November 2022
View article titled, Abstract A057: Therapeutic efficacy of selective CDK7 inhibition in pancreatic cancer mediated by induction of R-loop formation, DNA replication stress and genomic instability
Journal Articles

Abstract 2010: Transcriptional antagonism by CDK8 inhibition improves therapeutic efficacy of MEK inhibitors

Clare F. Malone, Minjee Kim, Gabriela Alexe, Alexandra B. Forman, Amanda Robichaud, Amy Saur Conway, Amy Goodale, John M. Hatcher, Nathanael S. Gray, Federica Piccioni, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2010.
https://doi.org/10.1158/1538-7445.AM2022-2010
Published: 15 June 2022
View article titled, Abstract 2010: Transcriptional antagonism by CDK8 inhibition improves therapeutic efficacy of MEK inhibitors
Journal Articles

Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts

Jana M. Ellegast, Gabriela Alexe, Amanda Hamze, Shan Lin, Hannah J. Uckelmann, Philipp J. Rauch, Maxim Pimkin, Linda Ross, Neekesh V. Dharia, Amanda L. Robichaud, Amy Conway Saur, Delan Khalid, Mark Wunderlich, Lina Benajiba, Behnam Nabet, Nathanael S. Gray, Stuart H. Orkin, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB076.
https://doi.org/10.1158/1538-7445.AM2022-LB076
Published: 15 June 2022
View article titled, Abstract LB076: Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts
Journal Articles

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer

Jieun Son, Jaebong Jang, Tyler S. Beyett, Yoonji Eum, Heidi M. Haikala, Alyssa Verano, Mika Lin, John M. Hatcher, Nicholas P. Kwiatkowski, Pinar Ö. Eser, Michael J. Poitras, Stephen Wang, Man Xu, Prafulla C. Gokhale, Michael D. Cameron, Michael J. Eck, Nathanael S. Gray, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1633–1645.
https://doi.org/10.1158/0008-5472.CAN-21-2693
Published: 15 April 2022
View article titled, A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non–Small Cell Lung Cancer
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Includes: Supplementary data
Journal Articles

Abstract LB216: Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

Hadley E. Sheppard, Alessandra Dall'Agnese, Woojun D. Park, Hamza Shamim, Julien Dubrulle, Hannah L. Johnson, Fabio Stossi, Patricia Cogswell, Josh Sommer, Joan Levy, Tanaz Sharifnia, Mathias J. Wawer, Paul A. Clemons, Behnam Nabet, Nathanael S. Gray, Stuart L. Schreiber, Paul Workman, Richard A. Young, Charles Y. Lin
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB216.
https://doi.org/10.1158/1538-7445.AM2021-LB216
Published: 01 July 2021
View article titled, Abstract LB216: Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
Journal Articles

Abstract 3408: Targeting cancer cells with potent activators of the PP2A protein phosphatase tumor suppressor

Ken Morita, Shuning He, Radosław P. Nowak, Jinhua Wang, Mark W. Zimmerman, Cong Fu, Adam D. Durbin, Nathanael S. Gray, Eric S. Fischer, A. Thomas Look
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3408.
https://doi.org/10.1158/1538-7445.AM2020-3408
Published: 15 August 2020
View article titled, Abstract 3408: Targeting cancer cells with potent activators of the PP2A protein phosphatase tumor suppressor
Journal Articles

Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis

Emanuele Giurisato, Silvia Lonardi, Brian Telfer, Sarah Lussoso, Blanca Risa-Ebrí, Jingwei Zhang, Ilaria Russo, Jinhua Wang, Annalisa Santucci, Katherine G. Finegan, Nathanael S. Gray, William Vermi, Cathy Tournier
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (16): 3319–3330.
https://doi.org/10.1158/0008-5472.CAN-19-2416
Published: 14 August 2020
View article titled, Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis
Open the PDF for Extracellular-Regulated Protein Kinase 5-Mediated Control of p21 Expression Promotes Macrophage Proliferation Associated with Tumor Growth and Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract C48: Defining mechanisms of adaptation to KRAS G12C inhibitors: Using quantitative proteomics to design combinatorial strategies in pancreatic cancer

Naiara Santana-Codina, Amrita Singh Chandhoke, Qijia Yu, Beata Malachowska, Miljan Kuljanin, Mark P. Jedrychowski, Ajami Gikandi, Marcin Stanczak, David A. Scott, Wojciech Fendler, Nathanael S. Gray, Joseph D. Mancias
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C48.
https://doi.org/10.1158/1538-7445.PANCA19-C48
Published: 13 December 2019
View article titled, Abstract C48: Defining mechanisms of adaptation to KRAS G12C inhibitors: Using quantitative proteomics to design combinatorial strategies in pancreatic cancer
Journal Articles

Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine

Benika Pinch, Zainab Doctor, Christopher M. Browne, Hyuk-Soo Seo, Behnam Nabet, Shingo Kozono, Xiaolan Lian, Daniel Zaidman, Dina Daitchman, Nir London, Lu Gong, Theresa Manz, Yujin Chun, Li Tan, Jarrod Marto, Stephen Buratowski, Sirano Dhe-Paganon, Xiao Zhou, Kun Ping Lu, Nathanael S. Gray
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2757.
https://doi.org/10.1158/1538-7445.AM2019-2757
Published: 01 July 2019
View article titled, Abstract 2757: Discovery and characterization of covalent Pin1 inhibitors targeted to an active site cysteine
Journal Articles

BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer

Sen Chen, Changmeng Cai, Adam G. Sowalsky, Huihui Ye, Fen Ma, Xin Yuan, Nicholas I. Simon, Nathanael S. Gray, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (18): 5203–5215.
https://doi.org/10.1158/0008-5472.CAN-17-3615
Published: 14 September 2018
View article titled, BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract 4935: High-throughput immune-oncology screen identifies EGFR inhibitors as potent enhancers of CTL antigen-specific tumor cell killing

Patrick H. Lizotte, Troy Luster, Megan E. Cavanaugh, Luke J. Taus, Abha Dhaneshwar, Naomi Mayman, Aaron Yang, Mark Bittinger, Paul Kirschmeier, Nathanael S. Gray, David A. Barbie, Pasi A. Janne
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4935.
https://doi.org/10.1158/1538-7445.AM2018-4935
Published: 01 July 2018
View article titled, Abstract 4935: High-throughput immune-oncology screen identifies EGFR inhibitors as potent enhancers of CTL antigen-specific tumor cell killing
Journal Articles

Abstract 955: Combined inhibition of MEK and mTOR pathways is effective in NRAS Q61K mutant small cell lung cancer

Atsuko Ogino, Mika Lin, Prafulla C. Gokhale, Margaret K. Wilkens, Jihyun Choi, Antonio Calles, Man Xu, Marzia Capelletti, Geoffrey Oxnard, Nathanael S. Gray, Paul Kirschmeier, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 955.
https://doi.org/10.1158/1538-7445.AM2018-955
Published: 01 July 2018
View article titled, Abstract 955: Combined inhibition of MEK and mTOR pathways is effective in <em>NRAS Q61K</em> mutant small cell lung cancer
Journal Articles

ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors

Hideki Terai, Shunsuke Kitajima, Danielle S. Potter, Yusuke Matsui, Laura Gutierrez Quiceno, Ting Chen, Tae-jung Kim, Maria Rusan, Tran C. Thai, Federica Piccioni, Katherine A. Donovan, Nicholas Kwiatkowski, Kunihiko Hinohara, Guo Wei, Nathanael S. Gray, Eric S. Fischer, Kwok-Kin Wong, Teppei Shimamura, Anthony Letai, Peter S. Hammerman, David A. Barbie
Journal: Cancer Research
Cancer Res (2018) 78 (4): 1044–1057.
https://doi.org/10.1158/0008-5472.CAN-17-1904
Published: 14 February 2018
View article titled, ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors
Open the PDF for ER Stress Signaling Promotes the Survival of Cancer “Persister Cells” Tolerant to EGFR Tyrosine Kinase Inhibitors in another window
Includes: Supplementary data
Journal Articles

Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma

Yan Liu, Yuyang Li, Xiaoen Wang, Feiyang Liu, Peng Gao, Max M. Quinn, Fei Li, Ashley A. Merlino, Cyril Benes, Qingsong Liu, Nathanael S. Gray, Kwok-Kin Wong
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (18): 5068–5076.
https://doi.org/10.1158/0008-5472.CAN-17-0567
Published: 14 September 2017
View article titled, Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma
Open the PDF for Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract 15: Suppression of adaptive responses to targeted therapies by transcriptional inhibition

Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Haikuo Zhang, Hideko Terai, Tiffany Tavares, Tinghu Zhang, Tae Jung Kim, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong, Peter S. Hammerman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 15.
https://doi.org/10.1158/1538-7445.AM2017-15
Published: 01 July 2017
View article titled, Abstract 15: Suppression of adaptive responses to targeted therapies by transcriptional inhibition
Journal Articles

Abstract 1118: Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements

Amanda L. Balboni, Bjorn Stolte, Amy Saur Conway, Gabriela Alexe, Emily Jue Wang, Nicholas Kwiatkowski, Tinghu Zhang, Brian J. Abraham, Peter Kalev, Dipanjan Chowdhury, Cyril H. Benes, Richard A. Young, Nathanael S. Gray, Kimberly Stegmaier
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1118.
https://doi.org/10.1158/1538-7445.AM2017-1118
Published: 01 July 2017
View article titled, Abstract 1118: Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements