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Nathalie Chaput
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Journal Articles

Abstract 5068: Clonal Hematopoiesis of indeterminate potential (CHIP) in patients with advanced solid tumors treated with immune checkpoint blockers (ICB) as monotherapy: Analysis of the PREMIS study

Julieta Elena Rodriguez, François Xavier Danlos, Alicia Larive, Aurelien Marabelle, Yohann Loriot, Caroline Robert, Laurence Albiges, Maxime Frelaut, Mihaela Aldea, Benjamin Besse, Michel Ducreux, Caroline Even, Jean Baptiste Micol, Santiago Ponce, Christophe Marzac, Nathalie Chaput, Christophe Massard, Capucine Baldini
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5068.
https://doi.org/10.1158/1538-7445.AM2024-5068
Published: 22 March 2024
View articletitled, Abstract 5068: Clonal Hematopoiesis of indeterminate potential (CHIP) in patients with advanced solid tumors treated with immune checkpoint blockers (ICB) as monotherapy: Analysis of the PREMIS study
Journal Articles

Abstract A027: Clonal hematopoiesis of indeterminate potential (CHIP) in patients with advanced NSCLC treated with immune checkpoint blockers (ICB) as monotherapy: Analysis of the PREMIS study. [R]

Julieta Elena Rodriguez, Capucine Baldini, Francois Xavier Danlos, Aurelien Marabelle, Maxime Frelaut, Marco Tagliamento, Mihaela Aldea, Benjamin Besse, Jean Baptiste Micol, Christophe Marzac, Nathalie Chaput, Christophe Massard
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_1): A027.
https://doi.org/10.1158/1538-7445.AGCA22-A027
Published: 15 January 2023
View articletitled, Abstract A027: Clonal hematopoiesis of indeterminate potential (CHIP) in patients with advanced NSCLC treated with immune checkpoint blockers (ICB) as monotherapy: Analysis of the PREMIS study. [R]
Journal Articles

Abstract 1251: Low plasma Arginine level is associated with resistance to immune checkpoint blockers in patients with advanced cancer

Jean-Philippe Guegan, Florent Peyraud, Aurelien Marabelle, Nathalie Chaput, Dominique Bodet, Laure Fontan, Anthony Gaultier, Imane NAFIA, Francois-Xavier Danlos, David Planchard, Caroline Robert, Caroline Even, Mohamed Khettab, Lambros Tselikas, Luc Friboulet, Jean-Charles Soria, Fabrice Andre, Fabrice Barlesi, Alban Bessede, Antoine Italiano
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1251.
https://doi.org/10.1158/1538-7445.AM2022-1251
Published: 15 June 2022
View articletitled, Abstract 1251: Low plasma Arginine level is associated with resistance to immune checkpoint blockers in patients with advanced cancer
Journal Articles

Abstract 2268: Agonistic T cell non depleting ICOS antibody strongly enhances anti-tumor activity with CTLA4 blocking monoclonal antibody without exacerbating colitis

Clélia Coutzac, Jean Jouniaux, Aurore Vozy, Marc Ballas, Sara Brett, Sapna Yadavilli, Eric Angevin, Axel Hoos, Nathalie Chaput
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2268.
https://doi.org/10.1158/1538-7445.AM2019-2268
Published: 01 July 2019
View articletitled, Abstract 2268: Agonistic T cell non depleting ICOS antibody strongly enhances anti-tumor activity with CTLA4 blocking monoclonal antibody without exacerbating colitis
Journal Articles

Abstract 2195: Combined strategy based on pre-activated analogs of oxazaphosphorines for increased therapeutic index and immune modulation

Julia Delahousse, Charles Skarbek, Valentine Gauthier, M Desbois, Emilie Roger, C. Pioche-Durieu, M. Rivard, D. Desmaële, T. Martens, E. LeCam, Jean-Pierre Benoit, P. Couvreur, Nathalie Chaput-Gras, Angelo Paci
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2195.
https://doi.org/10.1158/1538-7445.AM2017-2195
Published: 01 July 2017
View articletitled, Abstract 2195: Combined strategy based on pre-activated analogs of oxazaphosphorines for increased therapeutic index and immune modulation
Journal Articles

Abstract 2194: New oxazaphosphorine prodrugs for immunotherapy and nanomedicine against cancer

Charles Skarbek, Henri Gonde, Mélanie Desbois, Julia Delahousse, Nathalie Chaput-Gras, Jean-Pierre Benoit, Emilie Roger, Angelo Paci
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2194.
https://doi.org/10.1158/1538-7445.AM2016-2194
Published: 15 July 2016
View articletitled, Abstract 2194: New oxazaphosphorine prodrugs for immunotherapy and nanomedicine against cancer
Journal Articles

Abstract 3192: Liquid biopsies for molecular profiling of mutations in non-small cell lung cancer patients lacking tissue samples

Jordi Remon, Jean Charles Soria, David Planchard, Cecile Jovelet, Chloe Pannet, Ludovic Lacroix, Annas Gazzah, Andrew Lawson, Sarah Smalley, Kenth Howarth, David Gale, Emma Green, Vincent Plagnol, Nitzan Rosenfeld, Ken Oulassen, Nathalie Chaput, Benjamin Besse
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3192.
https://doi.org/10.1158/1538-7445.AM2016-3192
Published: 15 July 2016
View articletitled, Abstract 3192: Liquid biopsies for molecular profiling of mutations in non-small cell lung cancer patients lacking tissue samples
Journal Articles

Abstract 2577: RLI, a sushi-IL-15Rα/IL-15 fusion protein, is a potent immunomodulatory agent on NK and CD8+ T cells and synergizes with anti-PD1 treatment in preclinical mouse tumor models

Mélanie Desbois, Coralie Beal, Clelia Coutzac, Magali Terme, Geraldine Teppaz, Sebastien Morisseau, David Bechard, Erwan Mortier, Nathalie Chaput
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2577.
https://doi.org/10.1158/1538-7445.AM2014-2577
Published: 01 October 2014
View articletitled, Abstract 2577: RLI, a sushi-IL-15Rα/IL-15 fusion protein, is a potent immunomodulatory agent on NK and CD8+ T cells and synergizes with anti-PD1 treatment in preclinical mouse tumor models
Journal Articles

Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering

Ana I. Romero, Nathalie Chaput, Vichnou Poirier-Colame, Sylvie Rusakiewicz, Nicolas Jacquelot, Kariman Chaba, Erwan Mortier, Yannick Jacques, Sophie Caillat-Zucman, Caroline Flament, Anne Caignard, Meriem Messaoudene, Anne Aupérin, Philippe Vielh, Philippe Dessen, Camillo Porta, Christine Mateus, Maha Ayyoub, Danila Valmori, Alexander Eggermont, Caroline Robert, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2014) 74 (1): 68–80.
https://doi.org/10.1158/0008-5472.CAN-13-1186
Published: 05 January 2014
View articletitled, Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Open the PDF for Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering in another window
Includes: Supplementary data
Journal Articles

Potent Immunomodulatory Effects of the Trifunctional Antibody Catumaxomab

Diane Goéré, Caroline Flament, Sylvie Rusakiewicz, Vichnou Poirier-Colame, Oliver Kepp, Isabelle Martins, Julien Pesquet, Alexander Eggermont, Dominique Elias, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (15): 4663–4673.
https://doi.org/10.1158/0008-5472.CAN-12-4460
Published: 31 July 2013
View articletitled, Potent Immunomodulatory Effects of the Trifunctional Antibody Catumaxomab
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Includes: Supplementary data
Journal Articles

Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors

Sylvie Rusakiewicz, Michaela Semeraro, Matthieu Sarabi, Mélanie Desbois, Clara Locher, Rosa Mendez, Nadège Vimond, Angel Concha, Federico Garrido, Nicolas Isambert, Loic Chaigneau, Valérie Le Brun-Ly, Patrice Dubreuil, Isabelle Cremer, Anne Caignard, Vichnou Poirier-Colame, Kariman Chaba, Caroline Flament, Niels Halama, Dirk Jäger, Alexander Eggermont, Sylvie Bonvalot, Frédéric Commo, Philippe Terrier, Paule Opolon, Jean-François Emile, Jean-Michel Coindre, Guido Kroemer, Nathalie Chaput, Axel Le Cesne, Jean-Yves Blay, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2013) 73 (12): 3499–3510.
https://doi.org/10.1158/0008-5472.CAN-13-0371
Published: 13 June 2013
View articletitled, Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors
Open the PDF for Immune Infiltrates Are Prognostic Factors in Localized Gastrointestinal Stromal Tumors in another window
Includes: Supplementary data
Journal Articles

Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells

Magali Terme, Evelyn Ullrich, Laetitia Aymeric, Kathrin Meinhardt, Jérôme D. Coudert, Mélanie Desbois, François Ghiringhelli, Sophie Viaud, Bernard Ryffel, Hideo Yagita, Lieping Chen, Salaheddine Mécheri, Gilles Kaplanski, Armelle Prévost-Blondel, Masashi Kato, Joachim L. Schultze, Eric Tartour, Guido Kroemer, Mariapia Degli-Esposti, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2012) 72 (11): 2757–2767.
https://doi.org/10.1158/0008-5472.CAN-11-3379
Published: 31 May 2012
View articletitled, Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells
Open the PDF for Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells in another window
Includes: Supplementary data
Journal Articles

IL-18 Induces PD-1–Dependent Immunosuppression in Cancer

Magali Terme, Evelyn Ullrich, Laetitia Aymeric, Kathrin Meinhardt, Mélanie Desbois, Nicolas Delahaye, Sophie Viaud, Bernard Ryffel, Hideo Yagita, Gilles Kaplanski, Armelle Prévost-Blondel, Masashi Kato, Joachim L. Schultze, Eric Tartour, Guido Kroemer, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2011) 71 (16): 5393–5399.
https://doi.org/10.1158/0008-5472.CAN-11-0993
Published: 11 August 2011
View articletitled, IL-18 Induces PD-1–Dependent Immunosuppression in Cancer
Open the PDF for IL-18 Induces PD-1–Dependent Immunosuppression in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 474: Tumor CD57+ immune cell infiltration is a strong independent prognostic factor in stage II-III colorectal cancer

Valerie Boige, Clara Locher, Magali Svreck, Anne Auperin, Nathalie Chaput
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 474.
https://doi.org/10.1158/1538-7445.AM2011-474
Published: 15 April 2011
View articletitled, Abstract 474: Tumor CD57+ immune cell infiltration is a strong independent prognostic factor in stage II-III colorectal cancer
Journal Articles

Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients

Sophie Viaud, Caroline Flament, Mustapha Zoubir, Patricia Pautier, Axel LeCesne, Vincent Ribrag, Jean-Charles Soria, Virginie Marty, Philippe Vielh, Caroline Robert, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2011) 71 (3): 661–665.
https://doi.org/10.1158/0008-5472.CAN-10-1259
Published: 01 February 2011
View articletitled, Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients
Open the PDF for Cyclophosphamide Induces Differentiation of Th17 Cells in Cancer Patients in another window
Includes: Supplementary data
Journal Articles

Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?

Sophie Viaud, Clotilde Théry, Stéphanie Ploix, Thomas Tursz, Valérie Lapierre, Olivier Lantz, Laurence Zitvogel, Nathalie Chaput
Journal: Cancer Research
Cancer Res (2010) 70 (4): 1281–1285.
https://doi.org/10.1158/0008-5472.CAN-09-3276
Published: 14 February 2010
View articletitled, Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?
Open the PDF for Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next? in another window
Journal Articles

Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands

Rosa Conforti, Yuting Ma, Yannis Morel, Carine Paturel, Magali Terme, Sophie Viaud, Bernard Ryffel, Maria Ferrantini, Ravindra Uppaluri, Robert Schreiber, Christophe Combadière, Nathalie Chaput, Fabrice André, Guido Kroemer, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2010) 70 (2): 490–500.
https://doi.org/10.1158/0008-5472.CAN-09-1890
Published: 13 January 2010
View articletitled, Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands
Open the PDF for Opposing Effects of Toll-like Receptor (TLR3) Signaling in Tumors Can Be Therapeutically Uncoupled to Optimize the Anticancer Efficacy of TLR3 Ligands in another window
Includes: Supplementary data
Journal Articles

The Dendritic Cell–like Functions of IFN-Producing Killer Dendritic Cells Reside in the CD11b+ Subset and Are Licensed by Tumor Cells

Magali Terme, Grégoire Mignot, Evelyn Ullrich, Mathieu Bonmort, Véronique Minard-Colin, Alexandra Jacquet, Joachim L. Schultze, Guido Kroemer, Claude Leclerc, Nathalie Chaput, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2009) 69 (16): 6590–6597.
https://doi.org/10.1158/0008-5472.CAN-08-4473
Published: 12 August 2009
View articletitled, The Dendritic Cell–like Functions of IFN-Producing Killer Dendritic Cells Reside in the CD11b+ Subset and Are Licensed by Tumor Cells
Open the PDF for The Dendritic Cell–like Functions of IFN-Producing Killer Dendritic Cells Reside in the CD11b+ Subset and Are Licensed by Tumor Cells in another window
Includes: Supplementary data
Journal Articles

Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients

Cédric Ménard, Jean-Yves Blay, Christophe Borg, Stefan Michiels, François Ghiringhelli, Caroline Robert, Céline Nonn, Nathalie Chaput, Julien Taïeb, Nicolas F. Delahaye, Caroline Flament, Jean-François Emile, Axel Le Cesne, Laurence Zitvogel
Journal: Cancer Research
Cancer Res (2009) 69 (8): 3563–3569.
https://doi.org/10.1158/0008-5472.CAN-08-3807
Published: 15 April 2009
View articletitled, Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients
Open the PDF for Natural Killer Cell IFN-γ Levels Predict Long-term Survival with Imatinib Mesylate Therapy in Gastrointestinal Stromal Tumor–Bearing Patients in another window
Journal Articles

Molecular basis of the immunogenicity of cell death during chemotherapy

Laurence Zitvogel, Lionel Apetoh, Francois Ghiringhelli, Antoine Tesniere, Carla Ortiz, Nathalie Chaput, Theo Panaretakis, Jean Kanelopoullos, Guido Kroemer
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): SY29-04.
Published: 01 May 2008
View articletitled, Molecular basis of the immunogenicity of cell death during chemotherapy