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Abstract B25: HNRNPH1-dependent splicing of the fusion oncogene EWS-FLI1 reveals a targetable RNA G-quadruplex interaction

Carla Neckles, Robert E. Boer, Nicholas Aboreden, Allison M. Cross, Robert L. Walker, Bong-Hyun Kim, Suntae Kim, John S. Schneekloth, Natasha J. Caplen

Cancer Res (2020) 80 (14_Supplement): B25.

DOI: https://doi.org/10.1158/1538-7445.PEDCA19-B25

Published: 15 July 2020

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Journal Articles

Abstract 4494: HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

Carla Neckles, Robert Boer, Nicholas Aboreden, Robert L. Walker, Bong-Hyun Kim, Suntae Kim, John S. Schneekloth, Natasha J. Caplen

Cancer Res (2019) 79 (13_Supplement): 4494.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4494

Published: 01 July 2019

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Journal Articles

Abstract 5471: EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis

Nirmalya Sen, Allison M. Cross, Philip L. Lorenzi, Javed Khan, Berkley E. Gryder, Suntae Kim, Natasha J. Caplen

Cancer Res (2018) 78 (13_Supplement): 5471.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5471

Published: 01 July 2018

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Journal Articles

Abstract 2008: Ewing sarcoma cells harboring a translocation that retains EWSR1 exon 8 require HNRNPH1 to express the in-frame oncogenic fusion transcript EWS-FLI1

Suntae Kim, Christiane Olivero, Guillermo O. Rangel Rivera, Nirmalya Sen, Sara Haddock, Konrad Huppi, Lee J. Helman, Patrick J. Grohar, Natasha J. Caplen

Cancer Res (2016) 76 (14_Supplement): 2008.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2008

Published: 15 July 2016

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Journal Articles

Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma

Patrick J. Grohar, Suntae Kim, Sara Haddock, Guillermo Rangel Rivera, Matt Harlow, Nichole K. Maloney, Konrad Huppi, Kristen Gehlhaus, Magdalena Grandin, Carleen Klumpp-Thomas, Eugen Buehler, Lee J. Helman, Scott E. Martin, Natasha J. Caplen

Cancer Res (2015) 75 (15_Supplement): 479.

DOI: https://doi.org/10.1158/1538-7445.AM2015-479

Published: 01 August 2015

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Journal Articles

Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1

Suntae Kim, Patrick J. Grohar, Carleen Klumpp, Ashish Lal, Scott E. Martin, Lee J. Helman, Natasha J. Caplen

Cancer Res (2014) 74 (19_Supplement): 520.

DOI: https://doi.org/10.1158/1538-7445.AM2014-520

Published: 01 October 2014

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Journal Articles

Abstract 1584: Targeting the mitotic checkpoint with inhibition of MPS1 kinase enhances radiosensitivity of glioblastoma cancer cells.

Anita T. Tandle, Ryan Hanson, Uday B. Maachani, Tamalee Meushaw, Shuping Zhao, Uma Shankavaram, Philip Tofilon, Natasha J. Caplen, Kevin Camphausen

Cancer Res (2013) 73 (8_Supplement): 1584.

DOI: https://doi.org/10.1158/1538-7445.AM2013-1584

Published: 15 April 2013

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Journal Articles

Abstract 1834: Noncoding RNAs of the 8q24 locus: Consequences of the over-expression or suppression of miR-1204 and PVT1 in developing B cells.

Konrad Huppi, Oliver L. Ou, Jason J. Pitt, Brady Wahlberg, Tamara L. Jones, Vishala Neppalli, Siegfried Janz, Natasha J. Caplen

Cancer Res (2013) 73 (8_Supplement): 1834.

DOI: https://doi.org/10.1158/1538-7445.AM2013-1834

Published: 15 April 2013

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Journal Articles

Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer

Jordi Camps, Jason J. Pitt, Georg Emons, Amanda B. Hummon, Chanelle M. Case, Marian Grade, Tamara L. Jones, Quang T. Nguyen, B. Michael Ghadimi, Tim Beissbarth, Michael J. Difilippantonio, Natasha J. Caplen, Thomas Ried

Cancer Res (2013) 73 (6): 2003–2013.

DOI: https://doi.org/10.1158/0008-5472.CAN-12-3159

Published: 14 March 2013

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Includes: Supplementary data

Journal Articles

Abstract 199: Noncoding RNAs of the 8q24 locus

Konrad Huppi, Oliver L. Ou, Jason J Pitt, Brady Wahlberg, Tamara L. Jones, Jaime Rodriguez-Canales, Heidi S Erickson, Michael Emmert-Buck, Natasha J. Caplen

Cancer Res (2012) 72 (8_Supplement): 199.

DOI: https://doi.org/10.1158/1538-7445.AM2012-199

Published: 15 April 2012

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Journal Articles

Abstract 96: From genome-wide association studies (GWAS) to functional genomics of prostate cancer: exploring the role of candidate transcripts through RNAi-based analysis

Wei Tang, Tamara L. Jones, Jason Pitt, Stefan Ambs, Natasha J. Caplen, Ludmila Prokunina

Cancer Res (2012) 72 (8_Supplement): 96.

DOI: https://doi.org/10.1158/1538-7445.AM2012-96

Published: 15 April 2012

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Journal Articles

Abstract 1181: Expression studies from the PVT1 region of 8q24

Konrad Huppi, Jason Pitt, Brady Wahlberg, Tamara L. Jones, J. Frederic Mushinski, Siegfried Janz, Natasha J. Caplen

Cancer Res (2011) 71 (8_Supplement): 1181.

DOI: https://doi.org/10.1158/1538-7445.AM2011-1181

Published: 15 April 2011

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Journal Articles

Abstract 1952: The rapid generation of mouse B cell lymphomas by lentiviral mediated overexpression of miR-1204 from a genetically unstable region of human 8q24

Konrad Huppi, Brady Wahlberg, Jason Pitt, Tamara L. Jones, Kristen Gehlhaus, Mark Mackiewicz, J. Frederic Mushinski, Vishala Neppalli, Siegfried Janz, Natasha J. Caplen

Cancer Res (2010) 70 (8_Supplement): 1952.

DOI: https://doi.org/10.1158/1538-7445.AM10-1952

Published: 15 April 2010

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Journal Articles

Abstract 247: A functional genomics and a systems biology approach identify POMP as a potential therapeutic target for colorectal cancer

Jordi Camps, Amanda H. Hummon, Georg Emons, Frank Kramer, Jason J. Pitt, Marian Grade, Quang T. Nguyen, B. Michael Ghadimi, Michael J. Difilippantonio, Tim Beissbarth, Natasha J. Caplen, Thomas Ried

Cancer Res (2010) 70 (8_Supplement): 247.

DOI: https://doi.org/10.1158/1538-7445.AM10-247

Published: 15 April 2010

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Journal Articles

Abstract 2098: The receptor tyrosine kinase AXL is a target for the human miR-34a microRNA

Mark Mackiewicz, Konrad Huppi, Robert Cornelison, Natasha J. Caplen

Cancer Res (2010) 70 (8_Supplement): 2098.

DOI: https://doi.org/10.1158/1538-7445.AM10-2098

Published: 15 April 2010

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Journal Articles

Abstract 1683: ATF4 down-regulation potentiates L-asparaginase activity in ovarian cancer cell lines

Philip L. Lorenzi, Jenny Llamas, Natasha J. Caplen, John N. Weinstein

Cancer Res (2010) 70 (8_Supplement): 1683.

DOI: https://doi.org/10.1158/1538-7445.AM10-1683

Published: 15 April 2010

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Journal Articles

A study of the organization of the mouse miRome with an analysis of the expression and functional roles of a cluster of miRNAs on mouse chromosome 15

Konrad Huppi, Brady Wahlberg, Natalia Volfovsky, Leigh-Ann Cruz, Ravi Patel, Scott E. Martin, Tamara L. Jones, Kristen Gehlhaus, Mark Mackiewicz, Robert Stephens, J. Frederic Mushinski, Natasha J. Caplen

Cancer Res (2008) 68 (9_Supplement): 5013.

Published: 01 May 2008

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Journal Articles

Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer

Joseph A. Ludwig, Gergely Szakács, Scott E. Martin, Benjamin F. Chu, Carol Cardarelli, Zuben E. Sauna, Natasha J. Caplen, Henry M. Fales, Suresh V. Ambudkar, John N. Weinstein, Michael M. Gottesman

Cancer Res (2006) 66 (9): 4808–4815.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-3322

Published: 01 May 2006

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Journal Articles

Asparagine synthetase as a biomarker for L-asparaginase activity in ovarian cancer

Philip L. Lorenzi, Cheryl L. Thomas, Michele Gunsior, Paul K. Goldsmith, Kimberly J. Bussey, Mark Raffeld, Uwe Scherf, William C. Reinhold, Scott E. Martin, Martina Rudelius, Daniel D. Von Hoff, Natasha J. Caplen, John N. Weinstein

Cancer Res (2006) 66 (8_Supplement): 735–736.

Published: 15 April 2006

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Journal Articles

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

Joseph A. Ludwig IV, Gergely Szakacs, Scott E. Martin, Natasha J. Caplen, Michael M. Gottesman

Cancer Res (2006) 66 (8_Supplement): 1274–1275.

Published: 15 April 2006

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NARROW

Abstract B25: HNRNPH1-dependent splicing of the fusion oncogene EWS-FLI1 reveals a targetable RNA G-quadruplex interaction

Abstract 4494: HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

Abstract 5471: EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis

Abstract 2008: Ewing sarcoma cells harboring a translocation that retains EWSR1 exon 8 require HNRNPH1 to express the in-frame oncogenic fusion transcript EWS-FLI1

Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma

Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1

Abstract 1584: Targeting the mitotic checkpoint with inhibition of MPS1 kinase enhances radiosensitivity of glioblastoma cancer cells.

Abstract 1834: Noncoding RNAs of the 8q24 locus: Consequences of the over-expression or suppression of miR-1204 and PVT1 in developing B cells.

Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer

Abstract 199: Noncoding RNAs of the 8q24 locus

Abstract 96: From genome-wide association studies (GWAS) to functional genomics of prostate cancer: exploring the role of candidate transcripts through RNAi-based analysis

Abstract 1181: Expression studies from the PVT1 region of 8q24

Abstract 1952: The rapid generation of mouse B cell lymphomas by lentiviral mediated overexpression of miR-1204 from a genetically unstable region of human 8q24

Abstract 247: A functional genomics and a systems biology approach identify POMP as a potential therapeutic target for colorectal cancer

Abstract 2098: The receptor tyrosine kinase AXL is a target for the human miR-34a microRNA

Abstract 1683: ATF4 down-regulation potentiates L-asparaginase activity in ovarian cancer cell lines

A study of the organization of the mouse miRome with an analysis of the expression and functional roles of a cluster of miRNAs on mouse chromosome 15

Selective Toxicity of NSC73306 in MDR1-Positive Cells as a New Strategy to Circumvent Multidrug Resistance in Cancer

Asparagine synthetase as a biomarker for L-asparaginase activity in ovarian cancer

Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer.

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