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Natasha J. Caplen
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Journal Articles

Abstract B049: Oncolytic HSV1716-GMCSF combination strategies to remodel the immunosuppressive osteosarcoma tumor-microenvironment and promote anti-tumor immunity

Free
Tyler K. Barr, Victoria A. Jennings, Alison Taylor, Jessica Murby, Natasha J. Caplen, Javed Khan, Richard Baugh, Heather E. Owston, Dennis McGonagle, Fiona Errington-Mais, Graham P. Cook
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B049.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B049
Published: 05 September 2024
View articletitled, Abstract B049: Oncolytic HSV1716-GMCSF combination strategies to remodel the immunosuppressive osteosarcoma tumor-microenvironment and promote anti-tumor immunity
Journal Articles

Abstract A004 The ETS1-driven expression of TNS3 in Ewing sarcoma cells enhances the formation of the focal adhesions that promote cell movement

Free
Vernon J. Ebegboni, Tamara J. Jones, Shaoli Das, Erica C. Pehrsson, Soumya Sundara Rajan, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A004.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A004
Published: 05 September 2024
View articletitled, Abstract A004 The ETS1-driven expression of TNS3 in Ewing sarcoma cells enhances the formation of the focal adhesions that promote cell movement
Journal Articles

Abstract A016 EWSR1 in Ewing sarcoma cells exhibits enhanced recruitment to sites of active transcription compared to that observed in non-Ewing sarcoma cells

Free
Soumya Sundara Rajan, Tamara L. Jones, Vernon J. Ebegboni, Langston Lim, Michael J. Kruhlak, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A016.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A016
Published: 05 September 2024
View articletitled, Abstract A016 EWSR1 in Ewing sarcoma cells exhibits enhanced recruitment to sites of active transcription compared to that observed in non-Ewing sarcoma cells
Journal Articles

Abstract 2855: ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3

Free
Vernon Justice Ebegboni, Tamara L. Jones, Tayvia Brownmiller, Erica Pehrsson, Patrick Zhao, Soumya Sundara Rajan, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2855.
https://doi.org/10.1158/1538-7445.AM2024-2855
Published: 22 March 2024
View articletitled, Abstract 2855: ETS1, a target gene of the EWSR1::FLI1 fusion oncoprotein, regulates the expression of the focal adhesion protein TENSIN3
Journal Articles

Abstract 1469: Visualization of endogenous EWSR1 in Ewing sarcoma cells reveals a regular nucleoplasmic organization that includes concentration at regions of active transcription

Free
Soumya Sundara Rajan, Vernon Ebegboni, Tamara L. Jones, Patrick Pichling, Katelyn R. Ludwig, Raj Chari, Michael Kruhlak, Jadranka Loncarek, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1469.
https://doi.org/10.1158/1538-7445.AM2023-1469
Published: 04 April 2023
View articletitled, Abstract 1469: Visualization of endogenous EWSR1 in Ewing sarcoma cells reveals a regular nucleoplasmic organization that includes concentration at regions of active transcription
Journal Articles

Abstract B25: HNRNPH1-dependent splicing of the fusion oncogene EWS-FLI1 reveals a targetable RNA G-quadruplex interaction

Free
Carla Neckles, Robert E. Boer, Nicholas Aboreden, Allison M. Cross, Robert L. Walker, Bong-Hyun Kim, Suntae Kim, John S. Schneekloth, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): B25.
https://doi.org/10.1158/1538-7445.PEDCA19-B25
Published: 15 July 2020
View articletitled, Abstract B25: HNRNPH1-dependent splicing of the fusion oncogene EWS-FLI1 reveals a targetable RNA G-quadruplex interaction
Journal Articles

Abstract 4494: HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction

Free
Carla Neckles, Robert Boer, Nicholas Aboreden, Robert L. Walker, Bong-Hyun Kim, Suntae Kim, John S. Schneekloth, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4494.
https://doi.org/10.1158/1538-7445.AM2019-4494
Published: 01 July 2019
View articletitled, Abstract 4494: HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction
Journal Articles

Abstract 5471: EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis

Free
Nirmalya Sen, Allison M. Cross, Philip L. Lorenzi, Javed Khan, Berkley E. Gryder, Suntae Kim, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5471.
https://doi.org/10.1158/1538-7445.AM2018-5471
Published: 01 July 2018
View articletitled, Abstract 5471: EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis
Journal Articles

Abstract 2008: Ewing sarcoma cells harboring a translocation that retains EWSR1 exon 8 require HNRNPH1 to express the in-frame oncogenic fusion transcript EWS-FLI1

Free
Suntae Kim, Christiane Olivero, Guillermo O. Rangel Rivera, Nirmalya Sen, Sara Haddock, Konrad Huppi, Lee J. Helman, Patrick J. Grohar, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2008.
https://doi.org/10.1158/1538-7445.AM2016-2008
Published: 15 July 2016
View articletitled, Abstract 2008: Ewing sarcoma cells harboring a translocation that retains EWSR1 exon 8 require HNRNPH1 to express the in-frame oncogenic fusion transcript EWS-FLI1
Journal Articles

Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma

Free
Patrick J. Grohar, Suntae Kim, Sara Haddock, Guillermo Rangel Rivera, Matt Harlow, Nichole K. Maloney, Konrad Huppi, Kristen Gehlhaus, Magdalena Grandin, Carleen Klumpp-Thomas, Eugen Buehler, Lee J. Helman, Scott E. Martin, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 479.
https://doi.org/10.1158/1538-7445.AM2015-479
Published: 01 August 2015
View articletitled, Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma
Journal Articles

Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1

Free
Suntae Kim, Patrick J. Grohar, Carleen Klumpp, Ashish Lal, Scott E. Martin, Lee J. Helman, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 520.
https://doi.org/10.1158/1538-7445.AM2014-520
Published: 01 October 2014
View articletitled, Abstract 520: Functional genomic screens identify microRNA regulators of the oncogenic fusion transcription factor EWS-FLI1
Journal Articles

Abstract 1584: Targeting the mitotic checkpoint with inhibition of MPS1 kinase enhances radiosensitivity of glioblastoma cancer cells.

Free
Anita T. Tandle, Ryan Hanson, Uday B. Maachani, Tamalee Meushaw, Shuping Zhao, Uma Shankavaram, Philip Tofilon, Natasha J. Caplen, Kevin Camphausen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1584.
https://doi.org/10.1158/1538-7445.AM2013-1584
Published: 15 April 2013
View articletitled, Abstract 1584: Targeting the mitotic checkpoint with inhibition of MPS1 kinase enhances radiosensitivity of glioblastoma cancer cells.
Journal Articles

Abstract 1834: Noncoding RNAs of the 8q24 locus: Consequences of the over-expression or suppression of miR-1204 and PVT1 in developing B cells.

Free
Konrad Huppi, Oliver L. Ou, Jason J. Pitt, Brady Wahlberg, Tamara L. Jones, Vishala Neppalli, Siegfried Janz, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1834.
https://doi.org/10.1158/1538-7445.AM2013-1834
Published: 15 April 2013
View articletitled, Abstract 1834: Noncoding RNAs of the 8q24 locus: Consequences of the over-expression or suppression of miR-1204 and PVT1 in developing B cells.
Journal Articles

Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer

Free
Jordi Camps, Jason J. Pitt, Georg Emons, Amanda B. Hummon, Chanelle M. Case, Marian Grade, Tamara L. Jones, Quang T. Nguyen, B. Michael Ghadimi, Tim Beissbarth, Michael J. Difilippantonio, Natasha J. Caplen, Thomas Ried
Journal: Cancer Research
Cancer Res (2013) 73 (6): 2003–2013.
https://doi.org/10.1158/0008-5472.CAN-12-3159
Published: 14 March 2013
View articletitled, Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer
Open the PDF for Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/β-Catenin Pathway in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 96: From genome-wide association studies (GWAS) to functional genomics of prostate cancer: exploring the role of candidate transcripts through RNAi-based analysis

Free
Wei Tang, Tamara L. Jones, Jason Pitt, Stefan Ambs, Natasha J. Caplen, Ludmila Prokunina
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 96.
https://doi.org/10.1158/1538-7445.AM2012-96
Published: 15 April 2012
View articletitled, Abstract 96: From genome-wide association studies (GWAS) to functional genomics of prostate cancer: exploring the role of candidate transcripts through RNAi-based analysis
Journal Articles

Abstract 199: Noncoding RNAs of the 8q24 locus

Free
Konrad Huppi, Oliver L. Ou, Jason J Pitt, Brady Wahlberg, Tamara L. Jones, Jaime Rodriguez-Canales, Heidi S Erickson, Michael Emmert-Buck, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 199.
https://doi.org/10.1158/1538-7445.AM2012-199
Published: 15 April 2012
View articletitled, Abstract 199: Noncoding RNAs of the 8q24 locus
Journal Articles

Abstract 1181: Expression studies from the PVT1 region of 8q24

Free
Konrad Huppi, Jason Pitt, Brady Wahlberg, Tamara L. Jones, J. Frederic Mushinski, Siegfried Janz, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1181.
https://doi.org/10.1158/1538-7445.AM2011-1181
Published: 15 April 2011
View articletitled, Abstract 1181: Expression studies from the PVT1 region of 8q24
Journal Articles

Abstract 1683: ATF4 down-regulation potentiates L-asparaginase activity in ovarian cancer cell lines

Free
Philip L. Lorenzi, Jenny Llamas, Natasha J. Caplen, John N. Weinstein
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1683.
https://doi.org/10.1158/1538-7445.AM10-1683
Published: 15 April 2010
View articletitled, Abstract 1683: ATF4 down-regulation potentiates L-asparaginase activity in ovarian cancer cell lines
Journal Articles

Abstract 1952: The rapid generation of mouse B cell lymphomas by lentiviral mediated overexpression of miR-1204 from a genetically unstable region of human 8q24

Free
Konrad Huppi, Brady Wahlberg, Jason Pitt, Tamara L. Jones, Kristen Gehlhaus, Mark Mackiewicz, J. Frederic Mushinski, Vishala Neppalli, Siegfried Janz, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 1952.
https://doi.org/10.1158/1538-7445.AM10-1952
Published: 15 April 2010
View articletitled, Abstract 1952: The rapid generation of mouse B cell lymphomas by lentiviral mediated overexpression of miR-1204 from a genetically unstable region of human 8q24
Journal Articles

Abstract 2098: The receptor tyrosine kinase AXL is a target for the human miR-34a microRNA

Free
Mark Mackiewicz, Konrad Huppi, Robert Cornelison, Natasha J. Caplen
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2098.
https://doi.org/10.1158/1538-7445.AM10-2098
Published: 15 April 2010
View articletitled, Abstract 2098: The receptor tyrosine kinase AXL is a target for the human miR-34a microRNA