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Journal Articles

Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery

Huang-Chiao Huang, Imran Rizvi, Joyce Liu, Sriram Anbil, Ashish Kalra, Helen Lee, Yan Baglo, Nancy Paz, Douglas Hayden, Steve Pereira, Brian W. Pogue, Jonathan Fitzgerald, Tayyaba Hasan
Journal: Cancer Research
Cancer Res (2018) 78 (2): 558–571.
https://doi.org/10.1158/0008-5472.CAN-17-1700
Published: 15 January 2018
View article titled, Photodynamic Priming Mitigates Chemotherapeutic Selection Pressures and Improves Drug Delivery
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Includes: Supplementary data
Journal Articles

Abstract B47: Nanoliposomal irinotecan (nal-IRI) is an active treatment and reduces hypoxia as measured through longitudinal imaging using [18F]FAZA-PET in an orthotopic patient-derived model of pancreatic cancer

Stephan Klinz, Jinzi Zheng, Raquel De Souza, Manuela Ventura, Nancy Paz, David Hedley, David Jaffray, Jonathan Fitzgerald
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B47.
https://doi.org/10.1158/1538-7445.PANCA16-B47
Published: 14 December 2016
View article titled, Abstract B47: Nanoliposomal irinotecan (nal-IRI) is an active treatment and reduces hypoxia as measured through longitudinal imaging using [18F]FAZA-PET in an orthotopic patient-derived model of pancreatic cancer
Journal Articles

Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer

Daniel F. Gaddy, Helen Lee, Nancy Paz, Shannon C. Leonard, Ashish Kalra, Ninfa L. Straubinger, Robert M. Straubinger, Bryan M. Gillard, Michael T. Moser, Daryl C. Drummond, Stephan G. Klinz, Bart S. Hendriks, Jonathan B. Fitzgerald
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4830.
https://doi.org/10.1158/1538-7445.AM2016-4830
Published: 15 July 2016
View article titled, Abstract 4830: Preclinical anti-tumor activity of nanoliposomal irinotecan (Nal-IRI, MM-398) + 5-FU + oxaliplatin in pancreatic cancer
Journal Articles

Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Prodrug Conversion

Ashish V. Kalra, Jaeyeon Kim, Stephan G. Klinz, Nancy Paz, Jason Cain, Daryl C. Drummond, Ulrik B. Nielsen, Jonathan B. Fitzgerald
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (23): 7003–7013.
https://doi.org/10.1158/0008-5472.CAN-14-0572
Published: 30 November 2014
View article titled, Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Prodrug Conversion
Open the PDF for Preclinical Activity of Nanoliposomal Irinotecan Is Governed by Tumor Deposition and Intratumor Prodrug Conversion in another window
Includes: Supplementary data
Journal Articles

Abstract A6: Sustained intratumoral activation of MM-398 results in superior activity over irinotecan demonstrated by using a systems pharmacology approach

Jaeyeon Kim, Eliel Bayever, Peter Laivins, Clet Niyikiza, Ulrik Nielsen, Jonathan Fitzgerald, Ashish Kalra, Milind Chalishazar, Stephan Klinz, Nancy Paz, Bart Hendriks, Daryl Drummond, Dmitri Kirpotin, Victor Moyo
Journal: Cancer Research
Cancer Res (2012) 72 (13_Supplement): A6.
https://doi.org/10.1158/1538-7445.CSB12-A6
Published: 06 November 2014
View article titled, Abstract A6: Sustained intratumoral activation of MM-398 results in superior activity over irinotecan demonstrated by using a systems pharmacology approach
Journal Articles

Abstract 2065: Magnetic resonance imaging with an iron oxide nanoparticle demonstrates the preclinical feasibility of predicting intratumoral uptake and activity of MM-398, a nanoliposomal irinotecan (nal-IRI)

Ashish V. Kalra, Joseph Spernyak, Jaeyeon Kim, Arnold Sengooba, Stephan Klinz, Nancy Paz, Jason Cain, Walid Kamoun, Ninfa Straubinger, Yang Qu, Sheryl Trueman, Eliel Bayever, Ulrik Nielsen, Daryl Drummond, Jonathan Fitzgerald, Robert Straubinger
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2065.
https://doi.org/10.1158/1538-7445.AM2014-2065
Published: 01 October 2014
View article titled, Abstract 2065: Magnetic resonance imaging with an iron oxide nanoparticle demonstrates the preclinical feasibility of predicting intratumoral uptake and activity of MM-398, a nanoliposomal irinotecan (nal-IRI)
Journal Articles

Abstract 4626: Evaluating the pharmacodynamics and pharmacokinetic effects of MM-398, a nanoliposomal irinotecan (nal-IRI) in subcutaneous xenograft tumor models of human squamous cell carcinoma and small cell lung cancers

Daniel C. Chan, Ashish Kalra, Zhiyong Zhang, Nancy Paz, Dmitri Kirpotin, Daryl Drummond, Ulrik Nielsen, Paul A. Bunn, Jonathan Fitzgerald
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4626.
https://doi.org/10.1158/1538-7445.AM2014-4626
Published: 01 October 2014
View article titled, Abstract 4626: Evaluating the pharmacodynamics and pharmacokinetic effects of MM-398, a nanoliposomal irinotecan (nal-IRI) in subcutaneous xenograft tumor models of human squamous cell carcinoma and small cell lung cancers
Journal Articles

Abstract 3972: Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewings family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression

Min H. Kang, Michael M. Song, Monish Makena, Joo-Sang Lee, Connor P. Hall, Ashly Hindle, Winford Ko, Nancy Paz, Jonathan Fitzgerald, Daryl C. Drummond, Timothy J. Triche, C. Patrick Reynolds
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3972.
https://doi.org/10.1158/1538-7445.AM2014-3972
Published: 01 October 2014
View article titled, Abstract 3972: Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewings family tumor xenografts is associated with high exposure of tumor to drug and high <em>SLFN11</em> expression
Journal Articles

Abstract A41: Sustained intratumoral activation of MM-398 results in superior activity over irinotecan demonstrated by using a systems pharmacology approach.

Jaeyeon Kim, Eliel Bayever, Peter Laivins, Clet Niyikiza, Ulrik Nielsen, Jonathan Fitzgerald, Ashish Kalra, Milind Chalishazar, Stephan Klinz, Nancy Paz, Bart Hendriks, Daryl Drummond, Dmitri Kirpotin, Victor Moyo
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A41.
https://doi.org/10.1158/1538-7445.PANCA2012-A41
Published: 03 April 2014
View article titled, Abstract A41: Sustained intratumoral activation of MM-398 results in superior activity over irinotecan demonstrated by using a systems pharmacology approach.
Journal Articles

Abstract A63: MM-398/PEP02, a novel liposomal formulation of irinotecan, demonstrates stromal-modifying anticancer properties.

Nancy Paz, Peter Laivins, Clet Niyikiza, Ulrik Nielsen, Jonathan Fitzgerald, Ashish Kalra, Milind Chalishazar, Stephan Klinz, Jaeyeon Kim, Daryl Drummond, Dmitri Kirpotin, Victor Moyo, Eliel Bayever
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): A63.
https://doi.org/10.1158/1538-7445.PANCA2012-A63
Published: 03 April 2014
View article titled, Abstract A63: MM-398/PEP02, a novel liposomal formulation of irinotecan, demonstrates stromal-modifying anticancer properties.
Journal Articles

Abstract 5622: The tumor microenvironment modulates the delivery and activation of liposomal encapsulated irinotecan, MM-398.

Ashish Kalra, Jaeyeon Kim, Stephan Klinz, Nancy Paz, Joseph Reutt, Daryl Drummond, Dmitri Kirpotin, Victor Moyo, Eliel Bayever, Peter Laivins, Clet Niyikiza, Ulrik Nielsen, Jonathan Fitzgerald
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5622.
https://doi.org/10.1158/1538-7445.AM2013-5622
Published: 15 April 2013
View article titled, Abstract 5622: The tumor microenvironment modulates the delivery and activation of liposomal encapsulated irinotecan, MM-398.
Journal Articles

Abstract 5696: Evaluating determinants for enhanced activity of MM-398/PEP02; a novel nanotherapeutic encapsulation of irinotecan (CPT-11)

Ashish Kalra, Stephan Klinz, Nancy Paz, Jaeyeon Kim, Milind Chalishazar, Daryl Drummond, Dmitri Kirpotin, Victor Moyo, Clet Niyikiza, Jonathan Fitzgerald
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5696.
https://doi.org/10.1158/1538-7445.AM2012-5696
Published: 15 April 2012
View article titled, Abstract 5696: Evaluating determinants for enhanced activity of MM-398/PEP02; a novel nanotherapeutic encapsulation of irinotecan (CPT-11)