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Nancy Kohl
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Journal Articles

Abstract 3810: Selinexor (KPT-330), a novel selective inhibitor of nuclear export (SINE), shows single agent efficacy against alveolar soft part sarcoma (ASPS) in vivo

Marsha L. Crochiere, Trinayan Kashyap, Boris Klebanov, William Senapedis, Diego del Alamo, Sharon Tamir, Erkan Baloglu, Dilara McCauley, Robert Carlson, Michael Kauffman, Sharon Shacham, George Demetri, Andrew Wagner, Ewa Sicinska, Prafulla Gokhale, Nancy Kohl, Amy Saur, Yosef Landesman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3810.
https://doi.org/10.1158/1538-7445.AM2014-3810
Published: 01 October 2014
View articletitled, Abstract 3810: Selinexor (KPT-330), a novel selective inhibitor of nuclear export (SINE), shows single agent efficacy against alveolar soft part sarcoma (ASPS) in vivo
Journal Articles

PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models

Katharine Ellwood-Yen, Heike Keilhack, Kaiko Kunii, Brian Dolinski, Yamicia Connor, Kun Hu, Kumiko Nagashima, Erin O'Hare, Yusuf Erkul, Alessandra Di Bacco, Diana Gargano, Nirah H. Shomer, Minilik Angagaw, Erica Leccese, Paula Andrade, Melissa Hurd, Myung K. Shin, Thomas F. Vogt, Alan Northrup, Ekaterina V. Bobkova, Shailaja Kasibhatla, Roderick T. Bronson, Martin L. Scott, Giulio Draetta, Victoria Richon, Nancy Kohl, Peter Blume-Jensen, Jannik N. Andersen, Manfred Kraus
Journal: Cancer Research
Cancer Res (2011) 71 (8): 3052–3065.
https://doi.org/10.1158/0008-5472.CAN-10-2282
Published: 13 April 2011
View articletitled, PDK1 Attenuation Fails to Prevent Tumor Formation in PTEN-Deficient Transgenic Mouse Models
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Includes: Supplementary data
Journal Articles

De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model

James W. Watters, Chun Cheng, Pradip K. Majumder, Ruojie Wang, Sireesha Yalavarthi, Carol Meeske, Lingxin Kong, Wenping Sun, Jie Lin, Joerg Heyer, Chris Ware, Christopher Winter, John F. Reilly, Tim Demuth, Steve Clark, M. Isabel Chiu, Murray O. Robinson, Nancy Kohl, Karuppiah Kannan
Journal: Cancer Research
Cancer Res (2009) 69 (23): 8949–8957.
https://doi.org/10.1158/0008-5472.CAN-09-1544
Published: 30 November 2009
View articletitled, De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model
Open the PDF for De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model in another window
Includes: Supplementary data
Journal Articles

Abstract #2809: Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity

Sriram Sathyanarayanan, Sharda Jha, Richard Klinghoffer, Youyuan Xu, Mark Bittinger, Jason Frazier, Alessandra Di Bacco, Michael Chastain, Astrid Kral, Nancy Kohl, Brian Haines, Katharine Yen, Shailaja Kasibhatla, Christopher Winter
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 2809.
Published: 01 May 2009
View articletitled, Abstract #2809: Combination treatment with the anti-IGF1R antibody MK-0646 and the mTOR inhibitor deforolimus leads to more effective PI3K pathway targeting and anti-tumor activity
Journal Articles

Abstract #1751: MK-8033, a selective c-Met / Ron inhibitor, suppresses tumor cell growth in vitro and in vivo

Elizabeth Harrington, Grace Chan, Melissa Chenard, William Dahlberg, Lenora Davis, Sujal Deshmukh, Christopher Dinsmore, Clayton Efferson, Gaozhen Hang, Harold Hatch, Nancy Kohl, Kaiko Kunii, Wei Lu, Bart Lutterbach, Pradip Majumder, Alan Northrup, Xianlu Qu, John Reilly, Craig Rosenstein, Alexander Szewczak, Jennifer Tammam, Christopher Ware, Qinwen Zheng, Bo-Sheng Pan
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1751.
Published: 01 May 2009
View articletitled, Abstract #1751: MK-8033, a selective c-Met / Ron inhibitor, suppresses tumor cell growth in vitro and in vivo
Journal Articles

Abstract #1887: The mTOR inhibitor deforolimus is efficacious in models of mutant KRAS lung cancer

Brian Haines, Mark Bittinger, Melissa Chenard, Marlene Artime, Amy Guertin, Shavonne Howard, Weisheng Zhang, Raquel Sevilla, Christopher Ware, Diana Gargano, Aimee Michael, Andreas Harsch, Alessandra Di Bacco, Theresa Zhang, Brian Roberts, William Arthur, Nancy Kohl, Shailaja Kasibhatla, Manfred Lehnert, Scot Ebbinghaus, Winter Christopher
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 1887.
Published: 01 May 2009
View articletitled, Abstract #1887: The mTOR inhibitor deforolimus is efficacious in models of mutant KRAS lung cancer
Journal Articles

FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival

Bart Lutterbach, Kaiko Kunii, Lenora Davis, Harold Hatch, Julie Gorenstein, Masakazu Yashiro, Victoria Richon, Nancy Kohl, Cem Elbi, Wei Lu, Bo-Sheng Pan
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 4874.
Published: 01 May 2008
View articletitled, FGFR2-amplified gastric cancer cell lines require FGFR2 and Erbb3 signaling for growth and survival
Journal Articles

Attenuation of Notch signaling pathway by gamma-secretase inhibitor exerts antitumor effects in T-ALL through apoptotic mechanisms.

Jennifer Tammam, Christopher Ware, Clay Efferson, Xianlu Qu, Hellen Kim, Julie Gorenstein, Minilik Angagaw, Candia Kenific, Kaiko Kunii, Jun Zhao, Cem Elbi, Linda Bristow, John Reilly, George Nikov, Nancy Kohl, Peter Strack, Pradip Majumder
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): LB-23.
Published: 01 May 2008
View articletitled, Attenuation of Notch signaling pathway by gamma-secretase inhibitor exerts antitumor effects in T-ALL through apoptotic mechanisms.
Journal Articles

Characterization of an inducible genetically engineered mouse model, mmtv-rtta/teto-neut-ires-luc using bioluminescence and micro-ct imaging techniques

Joe Zhu, Roseanne Wexler, Janice Woodhouse, Nancy Kohl, Cyrille Sur, Weisheng Zhang
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2934.
Published: 01 May 2008
View articletitled, Characterization of an inducible genetically engineered mouse model, mmtv-rtta/teto-neut-ires-luc using bioluminescence and micro-ct imaging techniques
Journal Articles

Inhibitors of the kinesin spindle protein induce senescence in primary epithelial cells while triggering apoptosis in primary hematopoietic progenitor cells

Yun Zhang, Vicki South, Rob Lobell, Nancy Kohl, Laura Sepp-Lorenzino, Mark Fraley, Kenneth Arrington, Weikang Tao
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 2570.
Published: 01 May 2008
View articletitled, Inhibitors of the kinesin spindle protein induce senescence in primary epithelial cells while triggering apoptosis in primary hematopoietic progenitor cells
Journal Articles

In vitro and in vivo anti-tumor activities of a novel c-Met kinase inhibitor

Bo-Sheng Pan, Melissa Chenard, Lenora Davis, Sujal Deshmukh, Jackson Gibbs, Gaozhen Hang, Harold Hatch, James Jewell, Jason Katz, Kaiko Kunii, Wei Lu, Bart Lutterbach, Xianlu Qu, John Reilly, Alexander Szewczak, Qinwen Zeng, Nancy Kohl, Christopher Dinsmore
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2368.
Published: 01 May 2007
View articletitled, In vitro and in vivo anti-tumor activities of a novel c-Met kinase inhibitor
Journal Articles

Kinetic analysis of the fatty acid synthesis pathway in HCT-116 colon cancer cells: role of FAS and ACC1 in maintaining tumor cell viability and proliferation

Nicole Ginanni, Yanai Zhan, Michael Tota, Margaret Wu, Jennifer Roth, Dennis Ridenour, Peter Strack, Nathan Bays, Eric Bachman, Victoria Richon, Nancy Kohl, Stefan Krauss
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4473.
Published: 01 May 2007
View articletitled, Kinetic analysis of the fatty acid synthesis pathway in HCT-116 colon cancer cells: role of FAS and ACC1 in maintaining tumor cell viability and proliferation
Journal Articles

Discovery of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP

Mark E. Fraley, Ken Arrington, Bill Hoffman, Rob Garbaccio, George Hartman, Rob Lobell, Carolyn Buser, Weikang Tao, Hans Huber, Nancy Kohl
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1463.
Published: 01 May 2005
View articletitled, Discovery of 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP
Journal Articles

The spindle assembly checkpoint in the induction of apoptosis by KSP inhibitors

Weikang Tao, Vicki South, Yun Zhang, Joe Davide, Nancy Kohl, Laura Sepp-Lorenzino, Rob Lobell
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 535.
Published: 01 May 2005
View articletitled, The spindle assembly checkpoint in the induction of apoptosis by KSP inhibitors
Journal Articles

Pharmacodynamic evaluation of an indolyl quinolinone KDR/Flt-3 kinase inhibitor in normal healthy volunteers.

Stephen Beck, Aimee Dallob, Lenora Davis, Mary Flynn, Wesley Tanaka, Yih Lee, Yang Xu, Chau Thach, Kathryn Mazina, Inge De Lepeleire, Kristien Van Dyck, Anne Johnson, Qinwen Zeng, Bo-Sheng Pan, Kenneth Thomas, Jackson Gibbs, Howard Greenberg, Pierre Zachee, Steven Ramael, Keith Gottesdiener, Paul Deutsch, Nancy Kohl, Marian Iwamoto, Laura Sepp-Lorenzino
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 490.
Published: 01 April 2004
View articletitled, Pharmacodynamic evaluation of an indolyl quinolinone KDR/Flt-3 kinase inhibitor in normal healthy volunteers.
Journal Articles

Novel Flt-3/KDR inhibitor is effective against activated Flt-3 and is cytotoxic against Flt-3-driven leukemias in vitro and in vivo

Stephen Beck, Lenora Davis, Jennifer Shipman, Laura Schina, Bin Shi, Kathleen Coll, Keith Rickert, Anne Johnson, Qinwen Zeng, Bo-Sheng Pan, Kenneth Thomas, Aimee Dallob, Mary Flynn, Wesley Tanaka, Maricel Torrent, Yih Lee, Kathryn Mazina, Sarah Liou, Dale Schaar, Malgorzata Wojtowicz, Paul Deutsch, Marian Iwamoto, Jackson Gibbs, Nancy Kohl, Laura Sepp-Lorenzino
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1301.
Published: 01 April 2004
View articletitled, Novel Flt-3/KDR inhibitor is effective against activated Flt-3 and is cytotoxic against Flt-3-driven leukemias in vitro and in vivo
Journal Articles

Characterization of responses to the inhibition of KSP in human tumor cells

Weikang Tao, Yun Zhang, Vicki South, Nancy Kohl, Rob Lobell
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1297.
Published: 01 April 2004
View articletitled, Characterization of responses to the inhibition of KSP in human tumor cells
Journal Articles

Anti-tumor and anti-metastatic effects of novel oral bioavailable KDR inhibitors in rat tumor models

Bin Shi, Susan Hill, Laura Schina, Rosemary McFall, Xianzhi Mao, Noelle P. Dahl, Cindy Spencer Bauer, Sandra Veggian, Ryan Desautels, Brad Smith, Jeannine Manzella, Jim Destefano, Totoe Kuffuor, Alan Savitz, Patricia Rebbeck, Lenora Davis, Jennifer Shipman, Yi Yang, James Hardwick, Seth Clark, Varaporn Treemaneekarn, Kenneth Thomas, Jackson Gibbs, Nancy Kohl, Laura Sepp-Lorenzino
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1053.
Published: 01 April 2004
View articletitled, Anti-tumor and anti-metastatic effects of novel oral bioavailable KDR inhibitors in rat tumor models
Journal Articles

A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth in Vivo

Laura Sepp-Lorenzino, Elaine Rands, Xianzhi Mao, Brett Connolly, Jennifer Shipman, Joanne Antanavage, Susan Hill, Lenora Davis, Stephen Beck, Keith Rickert, Kathleen Coll, Patrice Ciecko, Mark Fraley, William Hoffman, George Hartman, David Heimbrook, Jackson Gibbs, Nancy Kohl, Kenneth Thomas
Journal: Cancer Research
Cancer Res (2004) 64 (2): 751–756.
https://doi.org/10.1158/0008-5472.CAN-03-2871
Published: 26 January 2004
View articletitled, A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth in Vivo
Open the PDF for A Novel Orally Bioavailable Inhibitor of Kinase Insert Domain-Containing Receptor Induces Antiangiogenic Effects and Prevents Tumor Growth in Vivo in another window