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Journal Articles

MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer

Si Min Zheng, Yu Chen Feng, Qin Zhu, Ruo Qi Li, Qian Qian Yan, Liu Teng, Yi Meng Yue, Man Man Han, Kaihong Ye, Sheng Nan Zhang, Teng Fei Qi, Cai Xia Tang, Xiao Hong Zhao, Yuan Yuan Zhang, Liang Xu, Ran Xu, Jun Xing, Mark Baker, Tao Liu, Rick F. Thorne, Lei Jin, Thomas Preiss, Xu Dong Zhang, Shundong Cang, Jin Nan Gao
Journal: Cancer Research
Cancer Res (2024) 84 (9): 1460–1474.
https://doi.org/10.1158/0008-5472.CAN-23-3046
Published: 02 May 2024
View article titled, MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Open the PDF for MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity

Yulong Qiang, Jiachen Fan, Chuanshuai Xie, Leilei Yan, Xiaofei Song, Nan Zhang, Yan Lin, Jie Xiong, Wei Zhang, Yu Liu, Lei Wei, Yu Li, Shizhen Chen, Kaiwei Liang, Feng Li
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1252–1269.
https://doi.org/10.1158/0008-5472.CAN-23-2888
Published: 15 April 2024
View article titled, KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity
Open the PDF for KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity in another window
Includes: Supplementary data
Journal Articles

Abstract 2149: West African genetic ancestry and origin of the BRCA1 locus in Jamaican men with high grade prostate cancer

Sandra M. Gaston, Anthony J. Griswold, Oleksandr N. Kryvenko, Tianjie Gu, Guan-Nan Zhang, Nachiketh S. Prakash, Yuval Avda, Tarek Ajami, Chad R. Ritch
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2149.
https://doi.org/10.1158/1538-7445.AM2024-2149
Published: 22 March 2024
View article titled, Abstract 2149: West African genetic ancestry and origin of the BRCA1 locus in Jamaican men with high grade prostate cancer
Journal Articles

Abstract 2129: Efficacy and underlying mechanisms of surufatinib combined with PD-1 monoclonal antibody and chemotherapy in pancreatic cancer

Nan Zhang, Ru Jia, Guanghai Dai
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2129.
https://doi.org/10.1158/1538-7445.AM2024-2129
Published: 22 March 2024
View article titled, Abstract 2129: Efficacy and underlying mechanisms of surufatinib combined with PD-1 monoclonal antibody and chemotherapy in pancreatic cancer
Journal Articles

Abstract A005: Alanine metabolism is an ARID1A-dependent vulnerability in clear cell ovarian carcinoma

Hao Nie, Wei Zhou, Chen Wang, Nan Zhang, Shuai Wu, Rugang Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): A005.
https://doi.org/10.1158/1538-7445.OVARIAN23-A005
Published: 04 March 2024
View article titled, Abstract A005: Alanine metabolism is an ARID1A-dependent vulnerability in clear cell ovarian carcinoma
Journal Articles

Abstract B086: Novel myeloid activation therapy promotes regression of metastatic ovarian cancer

Brennah Murphy, Taito Miyamoto, Bryan Manning, Toshitha Kannan, Anastasia Ghilkovsky, Yulia Nefedova, Daniel Claiborne, Rugang Zhang, Andrew Kossenkov, Nan Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B086.
https://doi.org/10.1158/1538-7445.OVARIAN23-B086
Published: 04 March 2024
View article titled, Abstract B086: Novel myeloid activation therapy promotes regression of metastatic ovarian cancer
Journal Articles

Abstract B076: Targeting cancer glycomes sensitizes ovarian tumors to immunotherapy

Hao Nie, Pratima Saini, Heng Liu, Wei Zhou, Chen Wang, Daniel Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): B076.
https://doi.org/10.1158/1538-7445.OVARIAN23-B076
Published: 04 March 2024
View article titled, Abstract B076: Targeting cancer glycomes sensitizes ovarian tumors to immunotherapy
Journal Articles

GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner

Zijing Wang, Nan Zhang, Miao Zhang, Yao Jiang, Aik Seng Ng, Esther Bridges, Wei Zhang, Xin Zeng, Qi Luo, Jiabien Liang, Balázs Győrffy, Philip Hublitz, Zhu Liang, Roman Fischer, David Kerr, Adrian L. Harris, Shijie Cai
Journal: Cancer Research
Cancer Res (2023) 83 (20): 3400–3413.
https://doi.org/10.1158/0008-5472.CAN-22-3471
Published: 13 October 2023
View article titled, GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner
Open the PDF for GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner in another window
Includes: Supplementary data
Journal Articles

Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma

Yuncheng Bei, Jian He, Xuhui Dong, Yuxin Wang, Sijie Wang, Wan Guo, Chengjie Cai, Zhiye Xu, Jia Wei, Baorui Liu, Nan Zhang, Pingping Shen
Journal: Cancer Research
Cancer Res (2023) 83 (14): 2405–2420.
https://doi.org/10.1158/0008-5472.CAN-23-0510
Published: 14 July 2023
View article titled, Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma
Open the PDF for Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract LB058: Performance of a cell-free DNA-based multi-cancer detection test as a tool for diagnostic resolution of symptomatic cancers

Alan H. Bryce, Minetta C. Liu, Michael V. Seiden, David D. Thiel, Donald Richards, Carlos Becerra, Kathryn N. Kurtzman, Xiaoji Chen, Tony Wu, Quan Zhang, Jingjing Gao, Nan Zhang, Earl Hubbell, Arash Jamshidi, Eric T. Fung, Eric A. Klein
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB058.
https://doi.org/10.1158/1538-7445.AM2021-LB058
Published: 01 July 2021
View article titled, Abstract LB058: Performance of a cell-free DNA-based multi-cancer detection test as a tool for diagnostic resolution of symptomatic cancers
Journal Articles

Abstract CT021: Prediction of cancer and tissue of origin in individuals with suspicion of cancer using a cell-free DNA multi-cancer early detection test

David D. Thiel, Xiaoji Chen, Kathryn N. Kurtzman, Jessica Yecies, Tony Wu, Quan Zhang, Hai Liu, Nan Zhang, Eric T. Fung, Michael V. Seiden, Minetta C. Liu, Geoffrey R. Oxnard, Earl Hubbell, Alexander M. Aravanis, Anne-Renee Hartman, Eric A. Klein
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): CT021.
https://doi.org/10.1158/1538-7445.AM2020-CT021
Published: 15 August 2020
View article titled, Abstract CT021: Prediction of cancer and tissue of origin in individuals with suspicion of cancer using a cell-free DNA multi-cancer early detection test
Journal Articles

Abstract LB-343: Development of plasma cell-free DNA (cfDNA) assays for early cancer detection: first insights from the Circulating Cell-Free Genome Atlas Study (CCGA)

Alexander A. Aravanis, Geoffrey R. Oxnard, Tara Maddala, Earl Hubbell, Oliver Venn, Arash Jamshidi, Ling Shen, Hamed Amini, John A. Beausang, Craig Betts, Daniel Civello, Konstantin Davydov, Saniya Fazullina, Darya Filippova, Sante Gnerre, Samuel Gross, Chenlu Hou, Roger Jiang, Byoungsok Jung, Kathryn Kurtzman, Collin Melton, Shivani Nautiyal, Jonathan Newman, Joshua Newman, Cosmos Nicolaou, Richard Rava, Onur Sakarya, Ravi Vijaya Satya, Seyedmehdi Shojaee, Kristan Steffen, Anton Valouev, Hui Xu, Jeanne Yue, Nan Zhang, Jose Baselga, Rosanna Lapham, Daron G. Davis, David Smith, Donald Richards, Michael V. Seiden, Charles Swanton, Timothy J. Yeatman, Robert Tibshirani, Christina Curtis, Sylvia K. Plevritis, Richard Williams, Eric Klein, Anne-Renee Hartman, Minetta C. Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-343.
https://doi.org/10.1158/1538-7445.AM2018-LB-343
Published: 01 July 2018
View article titled, Abstract LB-343: Development of plasma cell-free DNA (cfDNA) assays for early cancer detection: first insights from the Circulating Cell-Free Genome Atlas Study (CCGA)
Journal Articles

Abstract 4408: Development and validation of a serum miRNA biomarker panel for the detection of early stage lung cancer

Lisha Ying, Ruiyang Zou, Lingbin Du, Lei Shi, Nan Zhang, Jiaoyue Jin, Junzhou Wu, Fanrong Zhang, Kaiyan Chen, Herbert Yu, Weimin Mao, Dan Su
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4408.
https://doi.org/10.1158/1538-7445.AM2018-4408
Published: 01 July 2018
View article titled, Abstract 4408: Development and validation of a serum miRNA biomarker panel for the detection of early stage lung cancer
Journal Articles

Abstract 1192: Regorafenib (Stivarga®) reverses BCRP-mediated multidrug resistance in vitro and in vivo

Yun-Kai Zhang, Yi-Jun Wang, Guan-Nan Zhang, Wen-Ji Zhang, Meng-Ning Wei, Zhi Shi, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1192.
https://doi.org/10.1158/1538-7445.AM2017-1192
Published: 01 July 2017
View article titled, Abstract 1192: Regorafenib (Stivarga®) reverses BCRP-mediated multidrug resistance <em>in vitro</em> and <em>in vivo</em>
Journal Articles

Abstract 2201: Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin

Yi-Jun Wang, Yujian Huang, Nagaraju Anreddy, Guan-Nan Zhang, Yun-Kai Zhang, Meina Xie, Derrick Lin, Dong-Hua Yang, Mingjun Zhang, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2201.
https://doi.org/10.1158/1538-7445.AM2016-2201
Published: 15 July 2016
View article titled, Abstract 2201: Tea nanoparticle, a safe and biocompatible nanocarrier, greatly potentiates the anticancer activity of doxorubicin
Journal Articles

Abstract 1259: Identification of p97 as a prime target to inhibit cancer growth and stemness

Chuang Li, Meng Nie, Hongyang Quan, Qianqian Fan, Nan Zhang, Quancai Cui, Lin Wang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1259.
https://doi.org/10.1158/1538-7445.AM2015-1259
Published: 01 August 2015
View article titled, Abstract 1259: Identification of p97 as a prime target to inhibit cancer growth and stemness
Journal Articles

Abstract 4422: TTT-28, a newly synthesized thiazole-valine peptide, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1 transporter

Yi-Jun Wang, Nagaraju Anreddy, Bhargav A. Patel, Eduardo E. Chufan, Satyakam Singh, Guan-Nan Zhang, Yun-Kai Zhang, Anna Maria Barbuti, Suresh V. Ambudkar, Tanaji T. Talele, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4422.
https://doi.org/10.1158/1538-7445.AM2015-4422
Published: 01 August 2015
View article titled, Abstract 4422: TTT-28, a newly synthesized thiazole-valine peptide, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1 transporter
Journal Articles

Abstract 101: Surgical orthotopic implantation (SOI) lung cancer model with 95% survival and 100% take rate for spectral imaging

Yong Zhang, Nan Zhang, Ming A. Zhao, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 101.
https://doi.org/10.1158/1538-7445.AM2014-101
Published: 01 October 2014
View article titled, Abstract 101: Surgical orthotopic implantation (SOI) lung cancer model with 95% survival and 100% take rate for spectral imaging
Journal Articles

Abstract 709: Efficacy of Salmonella typhimurium A1-R on experimental breast cancer brain metastasis

Yong Zhang, Shinji Miwa, Nan Zhang, Robert M. Hoffman, Ming Zhao
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 709.
https://doi.org/10.1158/1538-7445.AM2014-709
Published: 01 October 2014
View article titled, Abstract 709: Efficacy of Salmonella typhimurium A1-R on experimental breast cancer brain metastasis
Journal Articles

Abstract 712: Salmonella typhimurium A1-R inhibits surgically induced breast cancer metastasis

Yong Zhang, Nan Zhang, Robert M. Hoffman, Ming Zhao
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 712.
https://doi.org/10.1158/1538-7445.AM2014-712
Published: 01 October 2014
View article titled, Abstract 712: Salmonella typhimurium A1-R inhibits surgically induced breast cancer metastasis