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Nahum Sonenberg
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Journal Articles

Abstract CT521: Phase 1b trial of the MNK1/2 inhibitor tomivosertib combined with paclitaxel in patients with metastatic breast cancer

Free
Cristiano Ferrario, John Mackey, Karen Gelmon, Poul HB Sorensen, Htoo Zarni Oo, Gregg B. Morin, Sonia del Rincon, Mehdi Amiri, Premal Patel, Harvey W. Smith, Nahum Sonenberg, Michael N. Pollak
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT521.
https://doi.org/10.1158/1538-7445.AM2022-CT521
Published: 15 June 2022
View article titled, Abstract CT521: Phase 1b trial of the MNK1/2 inhibitor tomivosertib combined with paclitaxel in patients with metastatic breast cancer
Journal Articles

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer

Free
Zhiyong Wang, Xiaodong Feng, Alfredo A. Molinolo, Daniel Martin, Lynn Vitale-Cross, Nijiro Nohata, Mizuo Ando, Amy Wahba, Panomwat Amornphimoltham, Xingyu Wu, Mara Gilardi, Michael Allevato, Victoria Wu, Dana J. Steffen, Philip Tofilon, Nahum Sonenberg, Joseph Califano, Qianming Chen, Scott M. Lippman, J. Silvio Gutkind
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (7): 1438–1450.
https://doi.org/10.1158/0008-5472.CAN-18-1220
Published: 01 April 2019
View article titled, 4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer
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Includes: Supplementary data
Journal Articles

Abstract 2417: eIF4E phosphorylation licenses Myc-driven metabolic and stress reprogramming

Free
Hang Ruan, Xiangyun Li, Brian Leibowitz, Jingshan Tong, Xinghua Lu, Nahum Sonenberg, Xiang Xu, Lin Zhang, Jian Yu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2417.
https://doi.org/10.1158/1538-7445.AM2018-2417
Published: 01 July 2018
View article titled, Abstract 2417: eIF4E phosphorylation licenses Myc-driven metabolic and stress reprogramming
Journal Articles

Abstract PR03: NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer

Free
Iok In Christine Chio, Seyed Mehdi Jafarnejad, Mariano Ponz-Sarvise, Youngkyu Park, Keith Rivera, Wilhelm Palm, Daniel Ohlund, Molly Hammell, Howard Crawford, Edward Schmidt, Craig Thompson, Darryl Pappin, Nahum Sonenberg, David Tuveson
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): PR03.
https://doi.org/10.1158/1538-7445.Transcontrol16-PR03
Published: 14 March 2017
View article titled, Abstract PR03: NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer
Journal Articles

Abstract B06: Translational control of mitochondria through mTORC1/4E-BP signaling pathway

Free
Masahiro Morita, Julien Prudent, Heidi McBride, John Bergeron, Nahum Sonenberg
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): B06.
https://doi.org/10.1158/1538-7445.Transcontrol16-B06
Published: 14 March 2017
View article titled, Abstract B06: Translational control of mitochondria through mTORC1/4E-BP signaling pathway
Journal Articles

Abstract IA09: Translational control of the tumor microenvironment

Free
Nathaniel Robichaud, Qianyu Guo, Sonia del Rincon, Wilson H. Miller, Peter Siegel, Brian Hsu, Nahum Sonenberg
Journal: Cancer Research
Cancer Res (2017) 77 (6_Supplement): IA09.
https://doi.org/10.1158/1538-7445.Transcontrol16-IA09
Published: 14 March 2017
View article titled, Abstract IA09: Translational control of the tumor microenvironment
Journal Articles

Abstract PR04: Nrf2 promotes mRNA translation in pancreatic cancer

Free
Iok In Christine Chio, Seyed Mehdi Jafarnejad, Mariano Ponz-Sarvise, Keith Rivera, Daniel Öhlund, Vineet Sangar, Kevin Wright, Dea Fillippi, Yuan Hao, John Erby Wilkinson, Herve Tiriac, Molly Hammell, Edward Schmidt, Youngkyu Park, Darryl Pappin, Nahum Sonenberg, David Tuveson
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): PR04.
https://doi.org/10.1158/1538-7445.PANCA16-PR04
Published: 14 December 2016
View article titled, Abstract PR04: Nrf2 promotes mRNA translation in pancreatic cancer
Journal Articles

Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development

Free
Jerry Pelletier, Jeremy Graff, Davide Ruggero, Nahum Sonenberg
Journal: Cancer Research
Cancer Res (2015) 75 (2): 250–263.
https://doi.org/10.1158/0008-5472.CAN-14-2789
Published: 14 January 2015
View article titled, Targeting the eIF4F Translation Initiation Complex: A Critical Nexus for Cancer Development
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Journal Articles

Abstract 4329: Lipid droplets and associated proteins in hepatocellular carcinoma tumour cells

Free
Evette Yassa, Hussam Alamri, Tommy Alain, Anthoula Lazaris, Peter Ghali, Nahum Sonenberg, Peter Metrakos
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4329.
https://doi.org/10.1158/1538-7445.AM2014-4329
Published: 01 October 2014
View article titled, Abstract 4329: Lipid droplets and associated proteins in hepatocellular carcinoma tumour cells
Journal Articles

Abstract LB-302: eIF4E phosphorylation is Mnk-dependent but does not require assembly of the eIF4F translation initiation complex

Free
Chad Hall, Chad Dumstorf, Bruce Konicek, Nathaniel Robichaud, Ann McNulty, Steve Parsons, Jerry Pelltier, Nahum Sonenberg, Jeremy R. Graff
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-302.
https://doi.org/10.1158/1538-7445.AM2014-LB-302
Published: 01 October 2014
View article titled, Abstract LB-302: eIF4E phosphorylation is Mnk-dependent but does not require assembly of the eIF4F translation initiation complex
Journal Articles

Abstract IA7: Translational control of cancer via eIF4E/4E-BPs

Free
Nahum Sonenberg
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): IA7.
https://doi.org/10.1158/1538-7445.FBCR13-IA7
Published: 15 May 2014
View article titled, Abstract IA7: Translational control of cancer via eIF4E/4E-BPs
Journal Articles

eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies

Free
Tommy Alain, Masahiro Morita, Bruno D. Fonseca, Akiko Yanagiya, Nadeem Siddiqui, Mamatha Bhat, Domenick Zammit, Victoria Marcus, Peter Metrakos, Lucie-Anne Voyer, Valentina Gandin, Yi Liu, Ivan Topisirovic, Nahum Sonenberg
Journal: Cancer Research
Cancer Res (2012) 72 (24): 6468–6476.
https://doi.org/10.1158/0008-5472.CAN-12-2395
Published: 16 December 2012
View article titled, eIF4E/4E-BP Ratio Predicts the Efficacy of mTOR Targeted Therapies
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Includes: Supplementary data
Journal Articles

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Free
Bruce W. Konicek, Jennifer R. Stephens, Ann M. McNulty, Nathaniel Robichaud, Robert B. Peery, Chad A. Dumstorf, Michele S. Dowless, Philip W. Iversen, Stephen Parsons, Karen E. Ellis, Denis J. McCann, Jerry Pelletier, Luc Furic, Jonathan M. Yingling, Louis F. Stancato, Nahum Sonenberg, Jeremy R. Graff
Journal: Cancer Research
Cancer Res (2011) 71 (5): 1849–1857.
https://doi.org/10.1158/0008-5472.CAN-10-3298
Published: 01 March 2011
View article titled, Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases
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Journal Articles

Abstract 5349: Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type-I IFN production

Free
Tommy Alain, XueQing Lun, Yvan Martineau, Polen Sean, Bali Pulendran, Emmanuel Petroulakis, Franz Zemp, Chantal G. Lemay, Dominic Roy, John C. Bell, George Thomas, Sara C. Kozma, Peter A. Forsyth, Mauro Costa-Mattioli, Nahum Sonenberg
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5349.
https://doi.org/10.1158/1538-7445.AM10-5349
Published: 15 April 2010
View article titled, Abstract 5349: Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type-I IFN production
Journal Articles

Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells

Free
Ryan J.O. Dowling, Mahvash Zakikhani, I. George Fantus, Michael Pollak, Nahum Sonenberg
Journal: Cancer Research
Cancer Res (2007) 67 (22): 10804–10812.
https://doi.org/10.1158/0008-5472.CAN-07-2310
Published: 15 November 2007
View article titled, Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells
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Journal Articles

Metformin mediated AMPK activation inhibits translation initiation in breast cancer cells

Free
Ryan Dowling, Mahvash Zakikhani, Nahum Sonenberg, Michael Pollak
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4470.
Published: 01 May 2007
View article titled, Metformin mediated AMPK activation inhibits translation initiation in breast cancer cells
Journal Articles

Phenethyl Isothiocyanate, a Cancer Chemopreventive Constituent of Cruciferous Vegetables, Inhibits Cap-Dependent Translation by Regulating the Level and Phosphorylation of 4E-BP1

Free
Jing Hu, Jonathan Straub, Dong Xiao, Shivendra V. Singh, Hsin-Sheng Yang, Nahum Sonenberg, Jaya Vatsyayan
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3569–3573.
https://doi.org/10.1158/0008-5472.CAN-07-0392
Published: 17 April 2007
View article titled, Phenethyl Isothiocyanate, a Cancer Chemopreventive Constituent of Cruciferous Vegetables, Inhibits Cap-Dependent Translation by Regulating the Level and Phosphorylation of 4E-BP1
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Journal Articles

Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells

Free
Mahvash Zakikhani, Ryan Dowling, I. George Fantus, Nahum Sonenberg, Michael Pollak
Journal: Cancer Research
Cancer Res (2006) 66 (21): 10269–10273.
https://doi.org/10.1158/0008-5472.CAN-06-1500
Published: 01 November 2006
View article titled, Metformin Is an AMP Kinase–Dependent Growth Inhibitor for Breast Cancer Cells
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Includes: Supplementary data
Journal Articles

Pseudogene regulation of connexin 43 loss in cancer: A novel therapeutic target

Free
Mustapha Kandouz, Andrew Bier, Jing Zhao, Nahum Sonenberg, Gerald Batist
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 554.
Published: 01 May 2005
View article titled, Pseudogene regulation of connexin 43 loss in cancer: A novel therapeutic target
Journal Articles

Expression of a Translationally Regulated, Dominant-Negative CCAAT/Enhancer-binding Protein β Isoform and Up-Regulation of the Eukaryotic Translation Initiation Factor 2α Are Correlated with Neoplastic Transformation of Mammary Epithelial Cells

Free
Brian Raught, Anne-Claude Gingras, Alaina James, Daniel Medina, Nahum Sonenberg, Jeffrey M. Rosen
Journal: Cancer Research
Cancer Res (1996) 56 (19): 4382–4386.
Published: 01 October 1996
View article titled, Expression of a Translationally Regulated, Dominant-Negative CCAAT/Enhancer-binding Protein β Isoform and Up-Regulation of the Eukaryotic Translation Initiation Factor 2α Are Correlated with Neoplastic Transformation of Mammary Epithelial Cells
Open the PDF for Expression of a Translationally Regulated, Dominant-Negative CCAAT/Enhancer-binding Protein β Isoform and Up-Regulation of the Eukaryotic Translation Initiation Factor 2α Are Correlated with Neoplastic Transformation of Mammary Epithelial Cells in another window