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Nagaraj S. Nagathihalli
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Journal Articles

Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago De Castro Silva, Anna Bianchi, Vanessa T. Garrido, Zhiqun Zhou, Andrew Adams, Haleh Amirian, Edmond W. Box, Xiaodian Sun, Yuguang Ban, Jashodeep Datta, Nagaraj S. Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1320–1332.
https://doi.org/10.1158/0008-5472.CAN-23-1200
Published: 15 April 2024
View article titled, Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer
Open the PDF for Tumor Cell–Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1602: Leukemia inhibitory factor (LIF)-factor XIIIA mediated macrophage-stromal crosstalk in pancreatic cancer

Nishah Jaferi, Siddharth Mehra, Varun Krishnamoorthy, Sudhakar Jinka, Anna Bianchi, Vanessa T. Garrido, Luis A. Nivelo, Ban Yuguang, Nagaraj S. Nagathihalli
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1602.
https://doi.org/10.1158/1538-7445.AM2024-1602
Published: 22 March 2024
View article titled, Abstract 1602: Leukemia inhibitory factor (LIF)-factor XIIIA mediated macrophage-stromal crosstalk in pancreatic cancer
Journal Articles

Abstract B091: The mammalian 8-oxodGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma

Beatriz Mateo-Victoriano, Ling Zhang, Govindi J. Samaranayake, Vanessa Mcgaughey, Cassie Due, Clara Troccoli, Michael G. Mohsen, Nagaraj S. Nagathihalli, Oliver G. McDonald, Michael VanSaun, Eric T. Kool, Priyamvada Rai
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B091.
https://doi.org/10.1158/1538-7445.PANCA2023-B091
Published: 16 January 2024
View article titled, Abstract B091: The mammalian 8-oxodGTPase, MTH1, as a novel targetable vulnerability in pancreatic ductal adenocarcinoma
Journal Articles

Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer

Samara P. Singh, Austin R. Dosch, Siddharth Mehra, Iago de Castro Silva, Vanessa Tonin Garrido, Anna Bianchi, Haleh Amirian, Edmond W. Box, Jashodeep Datta, Nagaraj S. Nagathihalli, Nipun B. Merchant
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C025.
https://doi.org/10.1158/1538-7445.PANCA2023-C025
Published: 16 January 2024
View article titled, Abstract C025: Fibroblast-specific IL1R1-p38 MAPK signaling sustains stromal inflammation and contributes to therapeutic resistance in pancreatic cancer
Journal Articles

Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer

Anna Bianchi, Siddharth Mehra, Daisy Dai, Iago de Castro Silva, Prateek Sharma, Antonio Colaprico, Austin R. Dosch, Samara Singh, Nagaraj S. Nagathihalli, Nipun B. Merchant, Jashodeep Datta
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): PO-046.
https://doi.org/10.1158/1538-7445.PANCA20-PO-046
Published: 13 November 2020
View article titled, Abstract PO-046: Dissecting the role of tumor-intrinsic Cxcl1 in mediating immune exclusion in Ras-p53 cooperative pancreatic cancer
Journal Articles

Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer

Austin R. Dosch, Xizi Dai, Michelle L. Reyzer, Deukwoo Kwon, Richard Caprioli, Nipun B. Merchant, Nagaraj S. Nagathihalli
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A11.
https://doi.org/10.1158/1538-7445.PANCA19-A11
Published: 13 December 2019
View article titled, Abstract A11: Combined Src and EGFR inhibition targets STAT3 to induce stromal remodeling and increase drug delivery to improve survival in a mouse model of pancreatic cancer
Journal Articles

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

Nagaraj S. Nagathihalli, Jason A. Castellanos, Purushottam Lamichhane, Fanuel Messaggio, Chanjuan Shi, Xizi Dai, Priyamvada Rai, Xi Chen, Michael N. VanSaun, Nipun B. Merchant
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6235–6246.
https://doi.org/10.1158/0008-5472.CAN-18-0634
Published: 01 November 2018
View article titled, Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer
Open the PDF for Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer in another window
Journal Articles

Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer

Supriya Srinivasan, Tulasigeri Totiger, Chanjuan Shi, Jason Castellanos, Purushottam Lamichhane, Austin R. Dosch, Fanuel Messaggio, Nilesh Kashikar, Kumaraswamy Honnenahally, Yuguang Ban, Nipun B. Merchant, Michael VanSaun, Nagaraj S. Nagathihalli
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (21): 6146–6158.
https://doi.org/10.1158/0008-5472.CAN-18-0579
Published: 01 November 2018
View article titled, Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer
Open the PDF for Tobacco Carcinogen–Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract A46: AdipoRon suppresses ERK and STAT3 to inhibit pancreatic cancer growth

Fanuel Messaggio, Alisha M. Mendonsa, Jason A. Castellanos, Casey Roberts, Nagaraj S. Nagathihalli, Nipun B. Merchant, Lee D. Gorden, Michael N. VanSaun
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A46.
https://doi.org/10.1158/1538-7445.PANCA16-A46
Published: 14 December 2016
View article titled, Abstract A46: AdipoRon suppresses ERK and STAT3 to inhibit pancreatic cancer growth
Journal Articles

Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids

Nagaraj S. Nagathihalli, Yugandhar Beesetty, Wooin Lee, M. Kay Washington, Xi Chen, A. Craig Lockhart, Nipun B. Merchant
Journal: Cancer Research
Series: Author Choice
Cancer Res (2014) 74 (7): 2062–2072.
https://doi.org/10.1158/0008-5472.CAN-13-2329
Published: 31 March 2014
View article titled, Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Open the PDF for Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids in another window
Includes: Supplementary data