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Abstract 1209: Detection of EGFR T790M mutation in non-small-cell lung cancer patients using colony hybridization assay

Yoshihiko Fujita, Kenichi Suda, Hideharu Kimura, Kazuko Matsumoto, Tokuzo Arao, Tomoyuki Nagai, Hidetoshi Hayashi, Kazuyuki Furuta, Hiroaki Kato, Nagahiro Saijo, Yasushi Yatabe, Tetsuya Mitsudomi, kazuto Nishio

Cancer Res (2012) 72 (8_Supplement): 1209.

DOI: https://doi.org/10.1158/1538-7445.AM2012-1209

Published: 15 April 2012

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Journal Articles

Abstract 1900: HSP 70 may cause EGFR-TKIs-resistance due to inhibit drug binding to EGFR in the cells that expressed mutant EGFR

Tohru Ohmori, Tsuyoki Kadofuku, Yoko Ichihashi, Toshimitsu Yamaoka, Takashi Hirose, Mitsuru Adachi, Nagahiro Saijo

Cancer Res (2012) 72 (8_Supplement): 1900.

DOI: https://doi.org/10.1158/1538-7445.AM2012-1900

Published: 15 April 2012

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Journal Articles

Abstract 699: HSP70 specifically binds to 15 bp deletion mutant EGFR and modulates sensitivity to EGFR-TKI

Tsuyoki Kadofuku, Tomoko Kanome, Yoko Ichihashi, Toshimitsu Yamaoka, Takashi Hirose, Mitsuru Adachi, Nagahiro Saijo, Tohru Ohmori

Cancer Res (2011) 71 (8_Supplement): 699.

DOI: https://doi.org/10.1158/1538-7445.AM2011-699

Published: 15 April 2011

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Journal Articles

Abstract 3424: Slug-mediated epithelial mesenchymal transition in lung cancer cells

Tamura Daisuke, Tokuzo Arao, Tomoyuki Nagai, Kazuyuki Furuta, Kazuko Sakai, Kanae Kudo, Hiroyasu Kaneda, Keiichi Aomatsu, Yoshihiko Fujita, Kazuko Matsumoto, Yoshikazu Kotani, Yoshihiro Nishimura, Nagahiro Saijo, Kazuto Nishio

Cancer Res (2011) 71 (8_Supplement): 3424.

DOI: https://doi.org/10.1158/1538-7445.AM2011-3424

Published: 15 April 2011

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Journal Articles

Abstract 1639: The novel c-MET inhibitor, ARQ 197, shows additive growrh-inhibitory effect with erlotinib through enhanced degradation of c-MET protein via ubiquitin/proteasome pathway

Tomoko Kanome, Tsuyoki Kadofuku, Toshimitsu Yamaoka, Takashi Hirose, Shiro Akinaga, Mitsuru Adachi, Nagahiro Saijo, Tohru Ohmori

Cancer Res (2010) 70 (8_Supplement): 1639.

DOI: https://doi.org/10.1158/1538-7445.AM10-1639

Published: 15 April 2010

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Journal Articles

Abstract 2296: Sorafenib inhibits hepatocyte growth factor-induced epithelial mesenchymal transition in hepatocellular carcinoma

nagai tomoyuki, Tokuzo Arao, Kazuyuki Furuta, Kazuko Sakai, Kanae Kudo, Hiroyasu Kaneda, Daisuke Tamura, Keiichi Aomatsu, Yoshihiko Fujita, Kazuko Matsumoto, Nagahiro Saijo, Masatoshi Kudo, Kazuto Nishio

Cancer Res (2010) 70 (8_Supplement): 2296.

DOI: https://doi.org/10.1158/1538-7445.AM10-2296

Published: 15 April 2010

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Journal Articles

Abstract 3313: Snail and slug-mediated epithelial mesenchymal transition in lung cancer cells

Tamura Daisuke, Tokuzo Arao Arao, Tomoyuki Nagai Nagai, Keiichi Aomatsu, Kazuko Sakai, Kanae Kudo, Hiroyasu Kaneda, Kazuko Matsumoto, Kazuyuki Furuta, Yoshihiko Fujita, Yoshikazu Kotani, Yoshihiro Nishimura, Nagahiro Saijo, Kazuto Nishio

Cancer Res (2010) 70 (8_Supplement): 3313.

DOI: https://doi.org/10.1158/1538-7445.AM10-3313

Published: 15 April 2010

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Journal Articles

mTOR Signal and Hypoxia-Inducible Factor-1α Regulate CD133 Expression in Cancer Cells

Kazuko Matsumoto, Tokuzo Arao, Kaoru Tanaka, Hiroyasu Kaneda, Kanae Kudo, Yoshihiko Fujita, Daisuke Tamura, Keiichi Aomatsu, Tomohide Tamura, Yasuhide Yamada, Nagahiro Saijo, Kazuto Nishio

Cancer Res (2009) 69 (18): 7160–7164.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-1289

Published: 14 September 2009

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Includes: Supplementary data

Journal Articles

Abstract #695: Predictive biomarker for hematological toxicities of gemcitabine identified by proteomics

Junichi Matsubara, Masaya Ono, Hideki Ueno, Takuji Okusaka, Junji Furuse, Koh Furuta, Emiko Sugiyama, Yoshiro Saito, Nahoko Kaniwa, Junichi Sawada, Tomohiro Sakuma, Tsutomu Chiba, Nagahiro Saijo, Tesshi Yamada

Cancer Res (2009) 69 (9_Supplement): 695.

Published: 01 May 2009

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Journal Articles

Relationship between MET and EGFR expressions in acquired gefitinib-resistant non-small cell lung cancer

Tomoko Kanome, Tsuyoki Kadofuku, Fumiko Inoue, Motoi Ohba, Toshimitsu Yamaoka, Koichi Ando, Sojiro Kusumoto, Masanao Nakashima, Takashi Hirose, Naoya Horichi, Kazuto Nishio, Nagahiro Saijo, Mitsuru Adachi, Toshio Kuroki, Tohru Ohmori

Cancer Res (2008) 68 (9_Supplement): 4842.

Published: 01 May 2008

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Journal Articles

Difference of EGFR-binding proteins between wild type and mutant EGFR

Tsuyoki Kadofuku, Tomoko Kanome, Satoru Arata, Sojiro Kusumoto, Tomohide Sugiyama, Masanao Nakashima, Takao Shirai, Kentaro Okuda, Takashi Hirose, Naoya Horichi, Nagahiro Saijo, Mitsuru Adachi, Toshio Kuroki, Tohru Ohmori

Cancer Res (2008) 68 (9_Supplement): 4857.

Published: 01 May 2008

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Journal Articles

Difference of binding-affinity for gefitinib between wild type EGFR and a mutant EGFR

Sojiro Kusumoto, Hiroo Ishida, Tomohide Sugiyama, Takamichi Hosaka, Koichi Ando, Masanao Nakashima, Toshimitsu Yamaoka, Kentaro Okuda, Tsukasa Ohnishi, Takashi Hirose, Naoya Horichi, Tsuyoki Kadofuku, Nagahiro Saijo, Mitsuru Adachi, Toshio Kuroki, Tohru Ohmori

Cancer Res (2007) 67 (9_Supplement): 4562.

Published: 01 May 2007

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Journal Articles

Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human NSCLC cells mediated by the HER3 signaling pathway

Kazuko Sakai, Hideyuki Yokote, Tomohide Tamura, Nagahiro Saijo, Kazuto Nishio

Cancer Res (2006) 66 (8_Supplement): 356.

Published: 15 April 2006

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Journal Articles

AZD2171 shows potent anti-tumor activity against gastric cancer expressing variant K-SAM/FGFR2

Masayuki Takeda, Tokuzo Arao, Hideyuki Yokote, Kazuko Sakai, Hideharu Kimura, Kazuyoshi Yanagihara, Hiroki Sasaki, Tomohide Tamura, Nagahiro Saijo, Kazuto Nishio

Cancer Res (2006) 66 (8_Supplement): 890.

Published: 15 April 2006

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Journal Articles

ZD6474 (ZACTIMA™), a novel inhibitor of VEGF receptor-2 tyrosine kinase, inhibits cellular growth of mesothelioma cell lines in vitro

Soenke Korfee, Clarissa Sharma, Diana Cortes-Incio, Mark-Roland Mueller, Tokuzo Arao, Thomas Krbek, Klaus Feldmann, Siegfried Seeber, Kazuto Nishio, Nagahiro Saijo, Wilfried E. Eberhardt

Cancer Res (2006) 66 (8_Supplement): 1115–1116.

Published: 15 April 2006

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Journal Articles

Eg5 expression is closely correlated with response of advanced non-small cell lung cancer to antimitotic agents combined with platinum chemotherapy

Takamoto Saijo, Genichiro Ishii, Atsushi Ochiai, Kiyotaka Yoh, Koichi Gotoh, Kaoru Kubota, Kanji Nagai, Yutaka Nishiwaki, Nagahiro Saijo

Cancer Res (2006) 66 (8_Supplement): 1065.

Published: 15 April 2006

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Journal Articles

Enhancement of TNF-α-sensitivity in gefitinib-acquired resistant non-small cell lung cancer cell lines

Koichi Ando, Tohru Ohmori, Takamichi Hosaka, Hiroo Ishida, Takao Shirai, Kentaro Okuda, Takashi Hirose, Tsukasa Ohnishi, Naoya Horichi, Kazuto Nishio, Nagahiro Saijo, Mitsuru Adachi, Carlos L. Arteaga, Toshio Kuroki

Cancer Res (2005) 65 (9_Supplement): 620.

Published: 01 May 2005

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Journal Articles

Long term exposure of gefitinib (IRESSA) may induce alternation of activating signaling on MAPK signaling pathway and may cause gefitinib-resistance

Hiroo Ishida, Tohru Ohmori, Fumiko Inoue, Tsuyoki Kadofuku, Koichi Ando, Takamichi Hosaka, Takao Shirai, Kentaro Okuda, Takashi Hirose, Tsukasa Ohnishi, Naoya Horichi, Kazuto Nishio, Nagahiro Saijo, Mitsuru Adachi, Carlos L. Arteaga, Toshio Kuroki

Cancer Res (2005) 65 (9_Supplement): 1200.

Published: 01 May 2005

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Journal Articles

Increased anti-tumor effect of photodynamic therapy using a second generation photosensitizer, NPe6 against vascular endothelial growth factor-secreting human lung cancer in vivo

Jitsuo Usuda, Tatsuya Inoue, Takeshi Hirata, Keishi Ohtani, Kinaya Furukawa, Tetsuya Okunaka, Tatsuo Ohira, Kazuto Nishio, Nagahiro Saijo, Harubumi Kato

Cancer Res (2005) 65 (9_Supplement): 1118.

Published: 01 May 2005

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Journal Articles

Active mutant epidermal growth factor receptor undergoes less protein degradation due to diminished binding to c-Cbl ubiquitin ligase

Takamichi Hosaka, Tohru Ohmori, Fumiko Inoue, Tsuyoki Kadofuku, Koichi Ando, Hiroo Ishida, Takao Shirai, Kentaro Okuda, Takashi Hirose, Tsukasa Onishi, Naoya Horichi, Kazuto Nishio, Hisao Fukumoto, Nagahiro Saijo, Mitsuru Adachi, Toshio Nakadate, Carlos L. Arteaga, Toshio Kuroki

Cancer Res (2005) 65 (9_Supplement): 1020.

Published: 01 May 2005

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NARROW

Abstract 1209: Detection of EGFR T790M mutation in non-small-cell lung cancer patients using colony hybridization assay

Abstract 1900: HSP 70 may cause EGFR-TKIs-resistance due to inhibit drug binding to EGFR in the cells that expressed mutant EGFR

Abstract 699: HSP70 specifically binds to 15 bp deletion mutant EGFR and modulates sensitivity to EGFR-TKI

Abstract 3424: Slug-mediated epithelial mesenchymal transition in lung cancer cells

Abstract 1639: The novel c-MET inhibitor, ARQ 197, shows additive growrh-inhibitory effect with erlotinib through enhanced degradation of c-MET protein via ubiquitin/proteasome pathway

Abstract 2296: Sorafenib inhibits hepatocyte growth factor-induced epithelial mesenchymal transition in hepatocellular carcinoma

Abstract 3313: Snail and slug-mediated epithelial mesenchymal transition in lung cancer cells

mTOR Signal and Hypoxia-Inducible Factor-1α Regulate CD133 Expression in Cancer Cells

Abstract #695: Predictive biomarker for hematological toxicities of gemcitabine identified by proteomics

Relationship between MET and EGFR expressions in acquired gefitinib-resistant non-small cell lung cancer

Difference of EGFR-binding proteins between wild type and mutant EGFR

Difference of binding-affinity for gefitinib between wild type EGFR and a mutant EGFR

Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human NSCLC cells mediated by the HER3 signaling pathway

AZD2171 shows potent anti-tumor activity against gastric cancer expressing variant K-SAM/FGFR2

ZD6474 (ZACTIMA™), a novel inhibitor of VEGF receptor-2 tyrosine kinase, inhibits cellular growth of mesothelioma cell lines in vitro

Eg5 expression is closely correlated with response of advanced non-small cell lung cancer to antimitotic agents combined with platinum chemotherapy

Enhancement of TNF-α-sensitivity in gefitinib-acquired resistant non-small cell lung cancer cell lines

Long term exposure of gefitinib (IRESSA) may induce alternation of activating signaling on MAPK signaling pathway and may cause gefitinib-resistance

Increased anti-tumor effect of photodynamic therapy using a second generation photosensitizer, NPe6 against vascular endothelial growth factor-secreting human lung cancer in vivo

Active mutant epidermal growth factor receptor undergoes less protein degradation due to diminished binding to c-Cbl ubiquitin ligase

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