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Journal Articles

Abstract B091: Spatial Transcriptomics Unveils Intraductal Papillary Mucinous Neoplasm Heterogeneity: From Novel Clusters to Immune Dynamics

Amaya Pankaj, Michael J Raabe, Yuhui Song, Bidish K Patel, Katherine Xu, Joshua R Kocher, Nicholas J Caldwell, Maria L Ganci, Linda T Nieman, Mari Mino-Kenudson, Vikram Deshpande, Nabeel Bardeesy, Carlos Fernandez-Del Castillo, Martin J Aryee, David T Ting, Yasmin G Hernandez-Barco
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): B091.
https://doi.org/10.1158/1538-7445.PANCREATIC24-B091
Published: 15 September 2024
View article titled, Abstract B091: Spatial Transcriptomics Unveils Intraductal Papillary Mucinous Neoplasm Heterogeneity: From Novel Clusters to Immune Dynamics
Journal Articles

Abstract 5981: Treatment of cholangiocarcinoma using humanized monoclonal antibodies targeting claudin-1

Zeina Nehme, Marion Muller, Emilie Crouchet, Frank Juehling, Julien Moehlin, Romain Désert, Jade Brochon, Fabio Del Zompo, Natascha Roehlen, Christine Thumann, Patrick Pessaux, Emanuele Felli, Aïna Venkatasamy, Patrice Marchand, Mihaela Alina Onea, Roberto Iacone, Markus Meyer, Alberto Toso, Nabeel Bardeesy, Lipika Goyal, Vikas Prakash Ranvir, Mirian Fernández-Vaquero, Mathias Heikenwälder, Tessa Ostyn, Tania Roskams, Patrice Laquerriere, Catherine Schuster, Laurent Mailly, Thomas F. Baumert
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5981.
https://doi.org/10.1158/1538-7445.AM2024-5981
Published: 22 March 2024
View article titled, Abstract 5981: Treatment of cholangiocarcinoma using humanized monoclonal antibodies targeting claudin-1
Journal Articles

Abstract LB012: Claudin-1 is a driver and therapeutic target for cholangiocarcinoma

Marion Muller, Zeina Nehme, Emilie Crouchet, Frank Jühling, Natascha Röhlen, Patrick Pessaux, Emanuele Felli, Lipika Goyal, Markus Meyer, Roberto Iacone, Alberto Toso, Luigi Manenti, Patrice Laquerriere, Aïna Venkatasamy, Nabeel Bardeesy, Catherine Schuster, Laurent Mailly, Thomas F. Baumert
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB012.
https://doi.org/10.1158/1538-7445.AM2023-LB012
Published: 14 April 2023
View article titled, Abstract LB012: Claudin-1 is a driver and therapeutic target for cholangiocarcinoma
Journal Articles

Abstract 2647: Novel FGFR2 biparatopic antibodies for the treatment of cholangiocarcinoma

Saireudee Chaturantabut, Sydney Oliver, John Kim, Dennie Frederick, Foxy Robinson, Alessandro Sinopoli, Diego J. Rodriguez, Liang Chang, Nabeel Bardeesy, William Sellers
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 2647.
https://doi.org/10.1158/1538-7445.AM2023-2647
Published: 04 April 2023
View article titled, Abstract 2647: Novel FGFR2 biparatopic antibodies for the treatment of cholangiocarcinoma
Journal Articles

Abstract 1097: FGFR2 in-frame indels: A novel targetable alteration in intrahepatic cholangiocarcinoma

Yvonne Y. Li, James M. Cleary, Srivatsan Raghavan, Liam F. Spurr, Qibiao Wu, Lei Shi, Lauren K. Brais, Maureen Loftus, Lipika Goyal, Anuj K. Patel, Atul B. Shinagare, Thomas E. Clancy, Geoffrey Shapiro, Ethan Cerami, William R. Sellers, William C. Hahn, Matthew Meyerson, Nabeel Bardeesy, Andrew D. Cherniack, Brian M. Wolpin
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1097.
https://doi.org/10.1158/1538-7445.AM2020-1097
Published: 15 August 2020
View article titled, Abstract 1097: FGFR2 in-frame indels: A novel targetable alteration in intrahepatic cholangiocarcinoma
Journal Articles

Abstract 1810: The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma

Meng-Ju Wu, Lei Shi, Juan Dubrot, Christine Hudson, Joshua Merritt, Ramzi Adil, Qibiao Wu, Sebastien Ronseaux, Rohini Narayanaswamy, Robert Manguso, Brandon Nicolay, Nabeel Bardeesy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1810.
https://doi.org/10.1158/1538-7445.AM2020-1810
Published: 15 August 2020
View article titled, Abstract 1810: The mutant IDH1 inhibitor ivosidenib promotes tumor cell differentiation and anti-tumor immunity in intrahepatic cholangiocarcinoma
Journal Articles

Abstract 309: Mapping oncogenic signal transduction in PKA-driven cancers

Gary Kwan Leung Chan, Samantha M. Maisel, Y. Christina Hwang, Rebecca Wolber, Danielle L. Swaney, Nabeel Bardeesy, John D. Gordan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 309.
https://doi.org/10.1158/1538-7445.AM2020-309
Published: 15 August 2020
View article titled, Abstract 309: Mapping oncogenic signal transduction in PKA-driven cancers
Journal Articles

Abstract 6572: Integrative network propagation to uncover potential drug resistance mechanisms in FGFR2 fusion-positive cholangiocarcinoma

Yeonjoo Hwang, Danielle L. Swaney, Nabeel Bardeesy, John D. Gordan
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6572.
https://doi.org/10.1158/1538-7445.AM2020-6572
Published: 15 August 2020
View article titled, Abstract 6572: Integrative network propagation to uncover potential drug resistance mechanisms in FGFR2 fusion-positive cholangiocarcinoma
Journal Articles

Kras and Tp53 Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma

Margaret A. Hill, William B. Alexander, Bing Guo, Yasutaka Kato, Krushna Patra, Michael R. O'Dell, Matthew N. McCall, Christa L. Whitney-Miller, Nabeel Bardeesy, Aram F. Hezel
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4445–4451.
https://doi.org/10.1158/0008-5472.CAN-17-1123
Published: 14 August 2018
View article titled, <em>Kras</em> and <em>Tp53</em> Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma
Open the PDF for <em>Kras</em> and <em>Tp53</em> Mutations Cause Cholangiocyte- and Hepatocyte-Derived Cholangiocarcinoma in another window
Journal Articles

Abstract 462: Hyperactivation of ERK/MAPK pathway reduces pancreatic cancer cells' proliferation and tumor progression through phosphoproteome reprogramming

Marie-Camille Rowell, Xavier Deschênes-Simard, Benjamin Le Calvé, Stéphane Lopes-Paciência, Ana Fernandez Ruiz, Filippos Kottakis, Nabeel Bardeesy, Gerardo Ferbeyre
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 462.
https://doi.org/10.1158/1538-7445.AM2018-462
Published: 01 July 2018
View article titled, Abstract 462: Hyperactivation of ERK/MAPK pathway reduces pancreatic cancer cells' proliferation and tumor progression through phosphoproteome reprogramming
Journal Articles

Abstract 4114: Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in FGFR2 fusion-positive cholangiocarcinoma patients

Lipika Goyal, Supriya K. Saha, Leah Y. Liu, Giulia Siravegna, Ignaty Leshchiner, Leanne G. Ahronian, Jochen K. Lennerz, Phuong Vu, Benedetta Mussolin, Stephanie Reyes, Pascal Furet, A. John Iafrate, Gad Getz, Diana G. Porta, Ralph Tiedt, Alberto Bardelli, Dejan Juric, Ryan B. Corcoran, Nabeel Bardeesy, Andrew X. Zhu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4114.
https://doi.org/10.1158/1538-7445.AM2017-4114
Published: 01 July 2017
View article titled, Abstract 4114: Polyclonal secondary FGFR2 mutations drive acquired resistance to FGFR inhibition in FGFR2 fusion-positive cholangiocarcinoma patients
Journal Articles

Abstract PR09: Loss of SIRT6 reactivates the RNA-binding protein lin28b to drive pancreatic cancer

Sita Kugel, Carlos Sebastián, Julien Fitamant, Kenneth N. Ross, Supriya K. Saha, Esha Jain, Adrianne Gladden, Kshitij S. Arora, Yasutaka Kato, Miguel N. Rivera, Sridhar Ramaswamy, Ruslan I. Sadreyev, Alon Goren, Vikram Deshpande, Nabeel Bardeesy, Raul Mostoslavsky
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): PR09.
https://doi.org/10.1158/1538-7445.PANCA16-PR09
Published: 14 December 2016
View article titled, Abstract PR09: Loss of SIRT6 reactivates the RNA-binding protein lin28b to drive pancreatic cancer
Journal Articles

Abstract B16: Loss of SIRT6 reactivates the RNA-binding protein Lin28b to drive pancreatic cancer

Sita Kugel, Carlos Sebastián, Julien Fitamant, Kenneth N. Ross, Supriya K. Saha, Esha Jain, Adrianne Gladden, Kshitij S. Arora, Yasutaka Kato, Miguel N. Rivera, Sridhar Ramaswamy, Ruslan I. Sadreyev, Alon Goren, Vikram Deshpande, Nabeel Bardeesy, Raul Mostoslavsky
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): B16.
https://doi.org/10.1158/1538-7445.PANCA16-B16
Published: 14 December 2016
View article titled, Abstract B16: Loss of SIRT6 reactivates the RNA-binding protein Lin28b to drive pancreatic cancer
Journal Articles

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

David R. Driscoll, Saadia A Karim, Makoto Sano, David M. Gay, Wright Jacob, Jun Yu, Yusuke Mizukami, Aarthi Gopinathan, Duncan I. Jodrell, T.R. Jeffry Evans, Nabeel Bardeesy, Michael N. Hall, Brian J. Quattrochi, David S. Klimstra, Simon T. Barry, Owen J. Sansom, Brian C. Lewis, Jennifer P. Morton
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (23): 6911–6923.
https://doi.org/10.1158/0008-5472.CAN-16-0810
Published: 30 November 2016
View article titled, mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer
Open the PDF for mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2656: Loss of SIRT6 reactivates the oncofetal RNA-binding protein Lin28b to drive pancreatic cancer

Sita Kugel, Carlos Sebastián, Julien Fitamant, Kenneth N. Ross, Supriya K. Saha, Alon Goren, Sridhar Ramaswamy, Vikram Deshpande, Nabeel Bardeesy, Raul Mostoslavsky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2656.
https://doi.org/10.1158/1538-7445.AM2016-2656
Published: 15 July 2016
View article titled, Abstract 2656: Loss of SIRT6 reactivates the oncofetal RNA-binding protein Lin28b to drive pancreatic cancer
Journal Articles

Abstract LB-061: Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism

Heather Schofield, Filip Bednar, Meredith Collins, Wei Yan, Yaqing Zhang, Nikhil Shyam, Jaime Eberle, Kenneth Olive, Nabeel Bardeesy, Daisuke Nakada, Diane Simeone, Sean Morrison, Marina Pasca di Magliano
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-061.
https://doi.org/10.1158/1538-7445.AM2015-LB-061
Published: 01 August 2015
View article titled, Abstract LB-061: Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism
Journal Articles

Abstract 2154: ERK/MAPK pathway inhibits tumorigenesis and cellular reprogramming of pancreatic cancer cells

Benjamin le Calvé, Xavier Deschenes-Ximard, Filippos Kottakis, Véronique Bourdeau, Frédéric Lessard, Karine Moineau-Vallée, Emmanuelle Saint-Germain, Julien Fitamant, Rushika Miriam Perera, Nabeel Bardeesy, Gerardo Ferbeyre
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2154.
https://doi.org/10.1158/1538-7445.AM2015-2154
Published: 01 August 2015
View article titled, Abstract 2154: ERK/MAPK pathway inhibits tumorigenesis and cellular reprogramming of pancreatic cancer cells
Journal Articles

Abstract B42: Metabolic changes, associated with loss of the tumor suppressor LKB1, promote tumorigenesis

Filippos Kottakis, Brandon N. Nicolay, Nagle M. Julia, Marc Liesa, Orian S. Sirihai, Nicholas J. Dyson, Nabeel Bardeesy
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B42.
https://doi.org/10.1158/1538-7445.PANCA2014-B42
Published: 30 June 2015
View article titled, Abstract B42: Metabolic changes, associated with loss of the tumor suppressor LKB1, promote tumorigenesis
Journal Articles

Abstract B44: The histone deacetylase SIRT6 regulates metabolism in pancreatic ductal adenocarcinoma

Sita Kugel, Carlos Sebastián, Rushika M. Perera, Nabeel Bardeesy, Raul Mostoslavsky
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): B44.
https://doi.org/10.1158/1538-7445.PANCA2014-B44
Published: 30 June 2015
View article titled, Abstract B44: The histone deacetylase SIRT6 regulates metabolism in pancreatic ductal adenocarcinoma
Journal Articles

Abstract NG04: Diversity of circulating tumor cells in a mouse pancreatic cancer model identified by single cell RNA sequencing

David T. Ting, Ben S. Wittner, Ajay M. Shah, David T. Miyamoto, Brian W. Brannigan, Kristina Xega, Jordan Ciciliano, Olivia C. MacKenzie, Julie Trautwein, Mohammad Shahid, Haley L. Ellis, Na Qu, Nabeel Bardeesy, Miguel N. Rivera, Ravi Kapur, Sridhar Ramaswamy, Toshi Shioda, Mehmet Toner, Shyamala Maheswaran, Daniel A. Haber
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): NG04.
https://doi.org/10.1158/1538-7445.AM2014-NG04
Published: 01 October 2014
View article titled, Abstract NG04: Diversity of circulating tumor cells in a mouse pancreatic cancer model identified by single cell RNA sequencing