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Murray J. Towle
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Journal Articles

Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice

Krystyna M. Wozniak, Kenichi Nomoto, Rena G. Lapidus, Ying Wu, Valentina Carozzi, Guido Cavaletti, Kazuhiro Hayakawa, Satoru Hosokawa, Murray J. Towle, Bruce A. Littlefield, Barbara S. Slusher
Journal: Cancer Research
Cancer Res (2011) 71 (11): 3952–3962.
https://doi.org/10.1158/0008-5472.CAN-10-4184
Published: 31 May 2011
View article titled, Comparison of Neuropathy-Inducing Effects of Eribulin Mesylate, Paclitaxel, and Ixabepilone in Mice
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Includes: Supplementary data
Journal Articles

Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for In vivo Efficacy under Intermittent Dosing Conditions

Murray J. Towle, Kathleen A. Salvato, Bruce F. Wels, Kimberley K. Aalfs, Wanjun Zheng, Boris M. Seletsky, Xiaojie Zhu, Bryan M. Lewis, Yoshito Kishi, Melvin J. Yu, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (2011) 71 (2): 496–505.
https://doi.org/10.1158/0008-5472.CAN-10-1874
Published: 13 January 2011
View article titled, Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for <em>In vivo</em> Efficacy under Intermittent Dosing Conditions
Open the PDF for Eribulin Induces Irreversible Mitotic Blockade: Implications of Cell-Based Pharmacodynamics for <em>In vivo</em> Efficacy under Intermittent Dosing Conditions in another window
Includes: Supplementary data
Journal Articles

Abstract 4438: Comparison of neuropathy-inducing effects of eribulin versus paclitaxel in mice

Krystyna M. Wozniak, Rena G. Lapidus, Ying Wu, Valentina Carozzi, Guido Cavalleti, Kazuhiro Hayakawa, Satoru Hosokawa, Murray J. Towle, Bruce A. Littlefield, Kenichi Nomoto, Barbara S. Slusher
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 4438.
https://doi.org/10.1158/1538-7445.AM10-4438
Published: 15 April 2010
View article titled, Abstract 4438: Comparison of neuropathy-inducing effects of eribulin versus paclitaxel in mice
Journal Articles

In vitro and in vivo antitumor activities of novel hemiasterlin analog E7974

Galina Kuznetsov, Karen Tendyke, Murray J. Towle, Hongsheng Cheng, Diana Liu, Cheryl Rowell, Jiayi Wu, James J. Kowalczyk, Veronique Marceau, Silvio Campagna, Shawn E. R. Schiller, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 809.
Published: 01 May 2005
View article titled, <em>In vitro</em> and <em>in vivo</em> antitumor activities of novel hemiasterlin analog E7974
Journal Articles

Tubulin-based antimitotic mechanism of novel hemiasterlin analog E7974

Galina Kuznetsov, Murray J. Towle, Junke Liu, Hongsheng Cheng, Karen Tendyke, Jim J. Kowalczyk, Silvio Campagna, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 810.
Published: 01 May 2005
View article titled, Tubulin-based antimitotic mechanism of novel hemiasterlin analog E7974
Journal Articles

Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389

Galina Kuznetsov, Murray J. Towle, Hongsheng Cheng, Takanori Kawamura, Karen TenDyke, Diana Liu, Yoshito Kishi, Melvin J. Yu, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5760–5766.
https://doi.org/10.1158/0008-5472.CAN-04-1169
Published: 16 August 2004
View article titled, Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389
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Journal Articles

A 96-well plate cell-based assay to quantify undesired cytotoxic effects against quiescent non-dividing cells

Laura A. Rudolph-Owen, Kathleen Salvato, Hongsheng Cheng, Jiayi Wu, Murray J. Towle, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 264–265.
Published: 01 April 2004
View article titled, A 96-well plate cell-based assay to quantify undesired cytotoxic effects against quiescent non-dividing cells
Journal Articles

In Vitro and In Vivo Anticancer Activities of Synthetic Macrocyclic Ketone Analogues of Halichondrin B

Murray J. Towle, Kathleen A. Salvato, Jacqueline Budrow, Bruce F. Wels, Galina Kuznetsov, Kimberley K. Aalfs, Susan Welsh, Wanjun Zheng, Boris M. Seletsky, Monica H. Palme, Gregory J. Habgood, Lori A. Singer, Lucian V. DiPietro, Yuan Wang, Jack J. Chen, David A. Quincy, Ashley Davis, Kentaro Yoshimatsu, Yoshito Kishi, Melvin J. Yu, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (2001) 61 (3): 1013–1021.
Published: 02 February 2001
View article titled, <em>In Vitro</em> and <em>In Vivo</em> Anticancer Activities of Synthetic Macrocyclic Ketone Analogues of Halichondrin B
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Journal Articles

Inhibition of Urokinase by 4-substituted Benzo[b]thiophene-2-carboxamidines: An Important New Class of Selective Synthetic Urokinase Inhibitor

Murray J. Towle, Arthur Lee, Emmanuel C. Maduakor, C. Eric Schwartz, Alexander J. Bridges, Bruce A. Littlefield
Journal: Cancer Research
Cancer Res (1993) 53 (11): 2553–2559.
Published: 01 June 1993
View article titled, Inhibition of Urokinase by 4-substituted Benzo[<em>b</em>]thiophene-2-carboxamidines: An Important New Class of Selective Synthetic Urokinase Inhibitor
Open the PDF for Inhibition of Urokinase by 4-substituted Benzo[<em>b</em>]thiophene-2-carboxamidines: An Important New Class of Selective Synthetic Urokinase Inhibitor in another window