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Murray D. Norris
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Journal Articles

Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression

Jixuan Gao, MoonSun Jung, Chelsea Mayoh, Pooja Venkat, Katherine M. Hannan, Jamie I. Fletcher, Alvin Kamili, Andrew J. Gifford, Eric P. Kusnadi, Richard B. Pearson, Ross D. Hannan, Michelle Haber, Murray D. Norris, Klaartje Somers, Michelle J. Henderson
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3706–3718.
https://doi.org/10.1158/0008-5472.CAN-19-3914
Published: 02 September 2020
View articletitled, Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression
Open the PDF for Suppression of ABCE1-Mediated mRNA Translation Limits N-MYC–Driven Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract SY09-02: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia

Michelle Haber, Mark J. Cowley, Paul Ekert, Loretta Lau, Emily Mould, ZCC PRISM Omics Core, ZCC Prelinical Drug Testing Core, Andrew Gifford, Richard B. Lock, Glenn M. Marshall, Murray D. Norris, Tracey O'Brien, Dong Anh Khuong Quang, David Thomas, Toby Trahair, Katherine Tucker, David S. Ziegler, Vanessa Tyrrell
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): SY09-02.
https://doi.org/10.1158/1538-7445.AM2020-SY09-02
Published: 15 August 2020
View articletitled, Abstract SY09-02: Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia
Journal Articles

Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies

Michelle Haber, Laura Gamble, Lin Xiao, Ruby Pandher, Klaartje Somers, Jayne Murray, Aaminah Khan, Denise Yu, Laura Franshaw, Mark R. Burns, Maria Tsoli, Anahid Ehteda, Anthony Cesare, Aisling O’Connor, Francis Mussai, Carmela de Santo, Paul Cheng, Lioubov Korotchkina, Katerina Gurova, Vanessa Tyrrell, Emily Mould, Loretta Lau, Dong Anh Khuong Quang, Chelsea Mayoh, Greg Arndt, Paulette Barahona, Tim Failes, Jamie Fletcher, Noemi Fuentes- Bolanos, Marie-Emilie Gauthier, Andrew Gifford, Dylan Grebert-Wade, Alvin Kamili, Amit Kumar, Sumanth Nagabushan, Tracey O’Brien, Patrick Strong, Alexandra Sherstyuk, David Thomas, Toby Trahair, Katherine Tucker, Meera Warby, Marie Wong, Jinhan Xie, Kathryn Evans, Richard Lock, Olga B. Chernova, Michelle Henderson, Andrei V Gudkov, Paul Ekert, Mark J. Cowley, Glenn M. Marshall, David S. Ziegler, Murray D. Norris
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): IA13.
https://doi.org/10.1158/1538-7445.PEDCA19-IA13
Published: 15 July 2020
View articletitled, Abstract IA13: Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies
Journal Articles

Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface

Jessica Koach, Jessica K. Holien, Hassina Massudi, Daniel R. Carter, Olivia C. Ciampa, Mika Herath, Taylor Lim, Janith A. Seneviratne, Giorgio Milazzo, Jayne E. Murray, Joshua A. McCarroll, Bing Liu, Chelsea Mayoh, Bryce Keenan, Brendan W. Stevenson, Michael A. Gorman, Jessica L. Bell, Larissa Doughty, Stefan Hüttelmaier, Andre Oberthuer, Matthias Fischer, Andrew J. Gifford, Tao Liu, Xiaoling Zhang, Shizhen Zhu, W. Clay Gustafson, Michelle Haber, Murray D. Norris, Jamie I. Fletcher, Giovanni Perini, Michael W. Parker, Belamy B. Cheung, Glenn M. Marshall
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (21): 5652–5667.
https://doi.org/10.1158/0008-5472.CAN-19-1112
Published: 01 November 2019
View articletitled, Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface
Open the PDF for Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface in another window
Includes: Supplementary data
Journal Articles

Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies

Caroline Atkinson, Carole M. Tactacan, Alvin Kamili, Federica Saletta, Christine Gana, Georgina L. Eden, Chelsea Mayoh, Richard B. Lock, Murray D. Norris, Michelle Haber, Andrew J. Gifford, Toby N. Trahair, Jamie I. Fletcher
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4741.
https://doi.org/10.1158/1538-7445.AM2019-4741
Published: 01 July 2019
View articletitled, Abstract 4741: Re-evaluating the role of P-glycoprotein in the resistance of high-risk neuroblastoma to standard-of-care chemotherapies
Journal Articles

Abstract 3809: Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells

Kimberley M. Hanssen, Christine C. Gana, Madeleine S. Wheatley, Denise M. Yu, Claudia L. Flemming, Richard Young, Gavin M. Wright, Gwenaelle Conseil, Catherine J. Kennedy, Anna deFazio, Ben Solomon, Susan P. Cole, Murray D. Norris, Michelle Haber, Jamie I. Fletcher
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3809.
https://doi.org/10.1158/1538-7445.AM2019-3809
Published: 01 July 2019
View articletitled, Abstract 3809: Modulation of MRP1 activity reverses chemotherapy resistance in adult cancer cells
Journal Articles

Abstract 2884: Establishment of patient-derived xenograft models for high-risk neuroblastoma

Alvin Kamili, Andrew J. Gifford, Nancy Li, Chelsea Mayoh, Georgina L. Eden, Jinhan Xie, Robyn E. Lukeis, Murray D. Norris, Michelle Haber, Geoffrey McCowage, Toby N. Trahair, Jamie I. Fletcher
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2884.
https://doi.org/10.1158/1538-7445.AM2019-2884
Published: 01 July 2019
View articletitled, Abstract 2884: Establishment of patient-derived xenograft models for high-risk neuroblastoma
Journal Articles

Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

Livingstone Fultang, Laura D. Gamble, Luciana Gneo, Andrea M. Berry, Sharon A. Egan, Fenna De Bie, Orli Yogev, Georgina L. Eden, Sarah Booth, Samantha Brownhill, Ashley Vardon, Carmel M. McConville, Paul N. Cheng, Murray D. Norris, Heather C. Etchevers, Jayne Murray, David S. Ziegler, Louis Chesler, Ronny Schmidt, Susan A. Burchill, Michelle Haber, Carmela De Santo, Francis Mussai
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (3): 611–624.
https://doi.org/10.1158/0008-5472.CAN-18-2139
Published: 01 February 2019
View articletitled, Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma
Open the PDF for Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma in another window
Includes: Supplementary data
Journal Articles

Abstract 2453: Eradication of neuroblastoma by suppressing the expression of a single noncoding RNA

Andrew E. Tee, Pei Y. Liu, Giorgio Milazzo, Kate M. Hannan, Jesper Maag, Nenad Bartonicek, Renhua Song, Chen C. Jiang, Xu D. Zhang, Murray D. Norris, Michelle Haber, Glenn M. Marshall, Jinyan Li, Jo Vandesompele, John S. Mattick, Pieter Mestdagh, Giovanni Perini, Ross D. Hannan, Marcel E. Dinger, Tao Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2453.
https://doi.org/10.1158/1538-7445.AM2018-2453
Published: 01 July 2018
View articletitled, Abstract 2453: Eradication of neuroblastoma by suppressing the expression of a single noncoding RNA
Journal Articles

Network Modeling of microRNA–mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN

Chi Yan Ooi, Daniel R. Carter, Bing Liu, Chelsea Mayoh, Anneleen Beckers, Amit Lalwani, Zsuzsanna Nagy, Sara De Brouwer, Bieke Decaesteker, Tzong-Tyng Hung, Murray D. Norris, Michelle Haber, Tao Liu, Katleen De Preter, Frank Speleman, Belamy B. Cheung, Glenn M. Marshall
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (12): 3122–3134.
https://doi.org/10.1158/0008-5472.CAN-17-3034
Published: 14 June 2018
View articletitled, Network Modeling of microRNA–mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN
Open the PDF for Network Modeling of microRNA–mRNA Interactions in Neuroblastoma Tumorigenesis Identifies miR-204 as a Direct Inhibitor of MYCN in another window
Includes: Supplementary data
Journal Articles

Abstract 1956: ABCE1 regulates the translational profile of neuroblastoma to drive tumor progression

Jixuan Gao, Klaartje Somers, Katherine M. Hannan, Jamie I. Fletcher, Bing Liu, Ross D. Hannan, Richard B. Pearson, Michelle Haber, Murray D. Norris, Michelle J. Henderson
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1956.
https://doi.org/10.1158/1538-7445.AM2017-1956
Published: 01 July 2017
View articletitled, Abstract 1956: ABCE1 regulates the translational profile of neuroblastoma to drive tumor progression
Journal Articles

Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia

Klaartje Somers, Shiloh Middlemiss, Asel Biktasova, Mawar Karsa, Leanna Cheung, Angelika Kosciolek, Kathryn Evans, Chelsea Mayoh, Ursula R. Kees, Lioubov Korotchkina, Olga B. Chernova, Richard B. Lock, Andrei V. Gudkov, Michelle Haber, Murray D. Norris, Michelle J. Henderson
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1175.
https://doi.org/10.1158/1538-7445.AM2017-1175
Published: 01 July 2017
View articletitled, Abstract 1175: Inhibition of NAMPT as a novel therapeutic strategy for infant leukemia
Journal Articles

A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers

MoonSun Jung, Amanda J. Russell, Bing Liu, Joshy George, Pei Yan Liu, Tao Liu, Anna DeFazio, David D.L. Bowtell, André Oberthuer, Wendy B. London, Jamie I. Fletcher, Michelle Haber, Murray D. Norris, Michelle J. Henderson
Journal: Cancer Research
Cancer Res (2017) 77 (4): 971–981.
https://doi.org/10.1158/0008-5472.CAN-15-2906
Published: 14 February 2017
View articletitled, A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers
Open the PDF for A Myc Activity Signature Predicts Poor Clinical Outcomes in Myc-Associated Cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 2450: MYCN and TFAP4 promote neuroblastoma malignancy by cooperating in the regulation a subset of target genes involved in cancer cell growth and metastasis

Chengyuan Xue, Denise M. Yu, Samuele Gherardi, Jessica Koach, Giorgio Milazzo, Laura Gamble, Bing Liu, Amanda Russell, Tao Liu, Belamy B. Cheung, Glenn M. Marshall, Giovanni Perini, Michelle Haber, Murray D. Norris
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2450.
https://doi.org/10.1158/1538-7445.AM2016-2450
Published: 15 July 2016
View articletitled, Abstract 2450: MYCN and TFAP4 promote neuroblastoma malignancy by cooperating in the regulation a subset of target genes involved in cancer cell growth and metastasis
Journal Articles

Abstract 1917: Suppression of miR-101a contributes to leukemogenesis by regulating epigenetic and pro-survival pathways in MLL AML stem cells

Estrella Gonzales-Aloy, Murray D. Norris, Jenny Y. Wang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1917.
https://doi.org/10.1158/1538-7445.AM2016-1917
Published: 15 July 2016
View articletitled, Abstract 1917: Suppression of miR-101a contributes to leukemogenesis by regulating epigenetic and pro-survival pathways in MLL AML stem cells
Journal Articles

MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin

Rosemary O'Brien, Sieu L. Tran, Michelle F. Maritz, Bing Liu, Cheng Fei Kong, Stefania Purgato, Chen Yang, Jayne Murray, Amanda J. Russell, Claudia L. Flemming, Georg von Jonquieres, Hilda A. Pickett, Wendy B. London, Michelle Haber, Preethi H. Gunaratne, Murray D. Norris, Giovanni Perini, Jamie I. Fletcher, Karen L. MacKenzie
Journal: Cancer Research
Cancer Res (2016) 76 (12): 3604–3617.
https://doi.org/10.1158/0008-5472.CAN-15-0879
Published: 14 June 2016
View articletitled, MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin
Open the PDF for MYC-Driven Neuroblastomas Are Addicted to a Telomerase-Independent Function of Dyskerin in another window
Includes: Supplementary data
Journal Articles

Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes

Rosemary O'Brien, Michelle F. Maritz, Cheng Fei Kong, Stefania Purgato, Bing Liu, Chen Yang, Amanda Russell, Jayne Murray, Claudia Flemming, Michelle Haber, Giovanni Perini, Murray D. Norris, Jamie I. Fletcher, Karen L. Mackenzie
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 488.
https://doi.org/10.1158/1538-7445.AM2015-488
Published: 01 August 2015
View articletitled, Abstract 488: High DKC1 expression supports neuroblastoma tumor cell proliferation and is strongly associated with poor patient outcomes
Journal Articles

Abstract 962: PA2G4 predicts poor prognosis in neuroblastoma patients and promotes neuroblastoma progression by enhancing MYCN protein stability

Jessica Koach, Bing Liu, Jessica L. Bell, Stefan Hüttelmaier, Tao Liu, Daniel R. Carter, Michelle Haber, Murray D. Norris, Jamie Fletcher, Belamy B. Cheung, Glenn M. Marshall
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 962.
https://doi.org/10.1158/1538-7445.AM2015-962
Published: 01 August 2015
View articletitled, Abstract 962: PA2G4 predicts poor prognosis in neuroblastoma patients and promotes neuroblastoma progression by enhancing MYCN protein stability
Journal Articles

Abstract 146: The long noncoding RNA MALAT1 promotes hypoxia-driven angiogenesis by upregulating pro-angiogenic gene expression in neuroblastoma cells

Andrew E. Tee, Peiyan Liu, Jesper Maag, Renhua Song, Jinyan Li, Belamy B. Cheung, Michelle Haber, Murray D. Norris, Glenn M. Marshall, Marcel Dinger, Tao Liu
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 146.
https://doi.org/10.1158/1538-7445.AM2015-146
Published: 01 August 2015
View articletitled, Abstract 146: The long noncoding RNA MALAT1 promotes hypoxia-driven angiogenesis by upregulating pro-angiogenic gene expression in neuroblastoma cells
Journal Articles

Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting

Michelle Haber, Jayne Murray, Laura Gamble, Ashleigh Carnegie-Clark, Hannah Webber, Michelle Ruhle, Michelle J. Henderson, Shiloh Middlemass, Daniel Carter, Maria Tsoli, Anahid Ehteda, Sandy Simon, Andre Oberthuer, Matthias Fischer, Katerina Gurova, Catherine Burkhart, Andrei Purmal, Richard B. Lock, David Ziegler, Glenn M. Marshall, Andrei V. Gudkov, Murray D. Norris
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1611.
https://doi.org/10.1158/1538-7445.AM2015-1611
Published: 01 August 2015
View articletitled, Abstract 1611: The FACT histone chaperone complex is highly expressed in aggressive drug refractory childhood cancers and the anti-FACT compound CBL0137 represents a highly promising therapeutic approach in this setting