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Journal Articles

Abstract 5974: Multimodal molecular imaging detects early reoxygenation induced by hyaluronan depletion in pancreatic cancer model mouse

Yu Saida, Tomohiro Seki, Shun Kishimoto, Jeffrey R. Brender, Gadisetti VR. Chandramouli, Yasunori Otowa, Kota Yamashita, Kazutoshi Yamamoto, Nallathamby Devasahayam, Murali C. Krishna

Cancer Res (2022) 82 (12_Supplement): 5974.

https://doi.org/10.1158/1538-7445.AM2022-5974

Published: 15 June 2022

View article titled, Abstract 5974: Multimodal molecular imaging detects early reoxygenation induced by hyaluronan depletion in pancreatic cancer model mouse

Journal Articles

Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

Yu Saida, Jeffrey R. Brender, Kazutoshi Yamamoto, James B. Mitchell, Murali C. Krishna, Shun Kishimoto

Cancer Res (2021) 81 (13): 3693–3705.

https://doi.org/10.1158/0008-5472.CAN-20-3182

Published: 01 July 2021

View article titled, Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

Includes: Supplementary data

Journal Articles

Abstract 2783: Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized¹³C MRI

Nobu Oshima, Ryo Ishida, Shun Kishimoto, Jeffrey R. Brender, Tomoaki Okada, Kazuataka Obama, Yoshiharu Sakai, Murali C. Krishna, Leonard M. Neckers

Cancer Res (2020) 80 (16_Supplement): 2783.

https://doi.org/10.1158/1538-7445.AM2020-2783

Published: 15 August 2020

View article titled, Abstract 2783: Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized13C MRI

Journal Articles

Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma

Cancer Res (2020) 80 (14_Supplement): PR08.

https://doi.org/10.1158/1538-7445.PEDCA19-PR08

Published: 15 July 2020

View article titled, Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma

Journal Articles

Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma

Kazutoshi Yamamoto, Jeffrey R. Brender, Tomohiro Seki, Shun Kishimoto, Nobu Oshima, Rajani Choudhuri, Stephen S. Adler, Elaine M. Jagoda, Keita Saito, Nallathamby Devasahayam, Peter L. Choyke, James B. Mitchell, Murali C. Krishna

Cancer Res (2020) 80 (11): 2087–2093.

https://doi.org/10.1158/0008-5472.CAN-19-0928

Published: 02 June 2020

View article titled, Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma

Includes: Supplementary data

Journal Articles

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Cancer Res (2019) 79 (19): 5060–5073.

https://doi.org/10.1158/0008-5472.CAN-19-0217

Published: 01 October 2019

View article titled, Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Includes: Supplementary data

Journal Articles

Abstract 1944: Detection of metabolic change in glioblastoma after radiotherapy using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model

Tatsuya Kawai, Murali C. Krishna, Tamalee Kramp, Jeffery R. Brender, Philip Tofilon, Kevin A. Camphausen

Cancer Res (2019) 79 (13_Supplement): 1944.

https://doi.org/10.1158/1538-7445.AM2019-1944

Published: 01 July 2019

View article titled, Abstract 1944: Detection of metabolic change in glioblastoma after radiotherapy using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model

Journal Articles

A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response

Yoichi Takakusagi, Sarwat Naz, Kaori Takakusagi, Masahiro Ishima, Hiroshi Murata, Keisuke Ohta, Masahiko Miura, Fumio Sugawara, Kengo Sakaguchi, Shun Kishimoto, Jeeva P. Munasinghe, James B. Mitchell, Murali C. Krishna

Cancer Res (2018) 78 (24): 6828–6837.

https://doi.org/10.1158/0008-5472.CAN-18-1654

Published: 13 December 2018

View article titled, A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response

Journal Articles

Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice

Shingo Matsumoto, Shun Kishimoto, Keita Saito, Yoichi Takakusagi, Jeeva P. Munasinghe, Nallathamby Devasahayam, Charles P. Hart, Robert J. Gillies, James B. Mitchell, Murali C. Krishna

Cancer Res (2018) 78 (14): 3783–3792.

https://doi.org/10.1158/0008-5472.CAN-18-0491

Published: 15 July 2018

View article titled, Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice

Includes: Supplementary data

Journal Articles

Abstract 4104: Evaluation of a novel LDH inhibitor efficacy in vivo in a glycolytic cancer model using hyperpolarized ¹³C magnetic resonance imaging

Nobu Oshima, Shun Kishimoto, Kristin Beebe, Dan Crooks, Michael Moses, Kazutoshi Yamamoto, Jeffry R. Brender, Anastasia Sowers, Ganesha Rai, Daniel Urban, Goria Benavides, Giuseppe Squadrito, Victor Darley-Usmar, Matthew Hall, James B. Mitchell, Murali C. Krishna, Leonard M. Neckers

Cancer Res (2018) 78 (13_Supplement): 4104.

https://doi.org/10.1158/1538-7445.AM2018-4104

Published: 01 July 2018

View article titled, Abstract 4104: Evaluation of a novel LDH inhibitor efficacy in vivo in a glycolytic cancer model using hyperpolarized 13C magnetic resonance imaging

Journal Articles

Abstract 4110: Metabolic imaging of glioblastoma using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model

Tatsuya Kawai, Murali C. Krishna, Jeffery R. Brender, Jennifer Lee, Tamalee Kramp, Kazu Yamamoto, Shun Kishimoto, Tomohiro Seki, Kevin A. Camphausen

Cancer Res (2018) 78 (13_Supplement): 4110.

https://doi.org/10.1158/1538-7445.AM2018-4110

Published: 01 July 2018

View article titled, Abstract 4110: Metabolic imaging of glioblastoma using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model

Journal Articles

Abstract 4106: Hyperpolarized [1-¹³C]-pyruvate/lactate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts response to lactate dehydrogenase inhibition

Bradley T. Scroggins, Masayuki Matsuo, Ayla O. White, Keita Saito, Jeeva P. Munasinghe, Carole Sourbier, Kazutoshi Yamamoto, Vivian Diaz, James B. Mitchell, Murali C. Krishna, Deborah E. Citrin

Cancer Res (2018) 78 (13_Supplement): 4106.

https://doi.org/10.1158/1538-7445.AM2018-4106

Published: 01 July 2018

View article titled, Abstract 4106: Hyperpolarized [1-13C]-pyruvate/lactate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts response to lactate dehydrogenase inhibition

Journal Articles

Abstract 833: Alginate hydrogels for three-dimensional culture and real-time monitoring of cancer cell metabolism and radiation response

Aparna H. Kesarwala, Jenna L. Carter, Graham H. Read, Natsuko Miura, Kazutoshi Yamamoto, James B. Mitchell, Murali C. Krishna

Cancer Res (2017) 77 (13_Supplement): 833.

https://doi.org/10.1158/1538-7445.AM2017-833

Published: 01 July 2017

View article titled, Abstract 833: Alginate hydrogels for three-dimensional culture and real-time monitoring of cancer cell metabolism and radiation response

Journal Articles

Abstract LB-184: Hyperpolarized ¹³C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts

Bradley T. Scroggins, Masayuki Matsuo, Jeeva P. Munasinghe, Ayla O. White, Carole Sourbier, Shingo Matsumoto, W. Marston Linehan, James B. Mitchell, Murali C. Krishna, Deborah E. Citrin

Cancer Res (2016) 76 (14_Supplement): LB-184.

https://doi.org/10.1158/1538-7445.AM2016-LB-184

Published: 15 July 2016

View article titled, Abstract LB-184: Hyperpolarized 13C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts

Journal Articles

Abstract 1593: Cellular effects of the mitochondrially-directed antioxidant Tempol.

Aparna H. Kesarwala, William DeGraff, Janet Gamson, Rajani Choudhuri, John A. Cook, Murali C. Krishna, James B. Mitchell

Cancer Res (2013) 73 (8_Supplement): 1593.

https://doi.org/10.1158/1538-7445.AM2013-1593

Published: 15 April 2013

View article titled, Abstract 1593: Cellular effects of the mitochondrially-directed antioxidant Tempol.

Journal Articles

The Antioxidant Tempol Reduces Carcinogenesis and Enhances Survival in Mice When Administered after Nonlethal Total Body Radiation

James B. Mitchell, Miriam R. Anver, Anastasia L. Sowers, Philip S. Rosenberg, Maria Figueroa, Angela Thetford, Murali C. Krishna, Paul S. Albert, John A. Cook

Cancer Res (2012) 72 (18): 4846–4855.

https://doi.org/10.1158/0008-5472.CAN-12-1879

Published: 16 September 2012

View article titled, The Antioxidant Tempol Reduces Carcinogenesis and Enhances Survival in Mice When Administered after Nonlethal Total Body Radiation

Includes: Supplementary data

Journal Articles

Antiangiogenic Agent Sunitinib Transiently Increases Tumor Oxygenation and Suppresses Cycling Hypoxia

Shingo Matsumoto, Sonny Batra, Keita Saito, Hironobu Yasui, Rajani Choudhuri, Chandramouli Gadisetti, Sankaran Subramanian, Nallathamby Devasahayam, Jeeva P. Munasinghe, James B. Mitchell, Murali C. Krishna

Cancer Res (2011) 71 (20): 6350–6359.

https://doi.org/10.1158/0008-5472.CAN-11-2025

Published: 12 October 2011

View article titled, Antiangiogenic Agent Sunitinib Transiently Increases Tumor Oxygenation and Suppresses Cycling Hypoxia

Includes: Supplementary data

Journal Articles

Imaging Cycling Tumor Hypoxia

Shingo Matsumoto, Hironobu Yasui, James B. Mitchell, Murali C. Krishna

Cancer Res (2010) 70 (24): 10019–10023.

https://doi.org/10.1158/0008-5472.CAN-10-2821

Published: 14 December 2010

View article titled, Imaging Cycling Tumor Hypoxia

Journal Articles

Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice

Hironobu Yasui, Shingo Matsumoto, Nallathamby Devasahayam, Jeeva P. Munasinghe, Rajani Choudhuri, Keita Saito, Sankaran Subramanian, James B. Mitchell, Murali C. Krishna

Cancer Res (2010) 70 (16): 6427–6436.

https://doi.org/10.1158/0008-5472.CAN-10-1350

Published: 14 August 2010

View article titled, Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice

Includes: Multimedia, Supplementary data

Journal Articles

Heterogeneity of Regional Redox Status and Relation of the Redox Status to Oxygenation in a Tumor Model, Evaluated Using Electron Paramagnetic Resonance Imaging

Keizo Takeshita, Kumiko Kawaguchi, Kaori Fujii-Aikawa, Megumi Ueno, Shoko Okazaki, Mitsuhiro Ono, Murali C. Krishna, Periannan Kuppusamy, Toshihiko Ozawa, Nobuo Ikota

Cancer Res (2010) 70 (10): 4133–4140.

https://doi.org/10.1158/0008-5472.CAN-09-4369

Published: 12 May 2010

View article titled, Heterogeneity of Regional Redox Status and Relation of the Redox Status to Oxygenation in a Tumor Model, Evaluated Using Electron Paramagnetic Resonance Imaging

Includes: Supplementary data

NARROW

Abstract 5974: Multimodal molecular imaging detects early reoxygenation induced by hyaluronan depletion in pancreatic cancer model mouse

Multimodal Molecular Imaging Detects Early Responses to Immune Checkpoint Blockade

Abstract 2783: Monitoring of a novel LDH inhibitor and mitochondrial inhibitor efficacy in vivo in a glycolytic pancreatic cancer model using hyperpolarized¹³C MRI

Abstract PR08: Lactate dehydrogenase A is a pharmacologically tractable EWS-FLI1 transcriptional target that regulates the glycolytic dependence of Ewing sarcoma

Molecular Imaging of the Tumor Microenvironment Reveals the Relationship between Tumor Oxygenation, Glucose Uptake, and Glycolysis in Pancreatic Ductal Adenocarcinoma

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Abstract 1944: Detection of metabolic change in glioblastoma after radiotherapy using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model

A Multimodal Molecular Imaging Study Evaluates Pharmacological Alteration of the Tumor Microenvironment to Improve Radiation Response

Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice

Abstract 4104: Evaluation of a novel LDH inhibitor efficacy in vivo in a glycolytic cancer model using hyperpolarized ¹³C magnetic resonance imaging

Abstract 4110: Metabolic imaging of glioblastoma using hyperpolarized 13C-MRI: Glycolytic metabolism in cancer stem cell-like cell-derived tumor model

Abstract 4106: Hyperpolarized [1-¹³C]-pyruvate/lactate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts response to lactate dehydrogenase inhibition

Abstract 833: Alginate hydrogels for three-dimensional culture and real-time monitoring of cancer cell metabolism and radiation response

Abstract LB-184: Hyperpolarized ¹³C-pyruvate magnetic resonance spectroscopic imaging of prostate cancer tumor xenografts

Abstract 1593: Cellular effects of the mitochondrially-directed antioxidant Tempol.

The Antioxidant Tempol Reduces Carcinogenesis and Enhances Survival in Mice When Administered after Nonlethal Total Body Radiation

Antiangiogenic Agent Sunitinib Transiently Increases Tumor Oxygenation and Suppresses Cycling Hypoxia

Imaging Cycling Tumor Hypoxia

Low-Field Magnetic Resonance Imaging to Visualize Chronic and Cycling Hypoxia in Tumor-Bearing Mice

Heterogeneity of Regional Redox Status and Relation of the Redox Status to Oxygenation in a Tumor Model, Evaluated Using Electron Paramagnetic Resonance Imaging

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