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Motonobu Osada
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Journal Articles

Abstract CT094: Phase I study of fibroblast growth factor receptor 2 antibody-drug conjugate (FGFR2-ADC) BAY 1187982 in patients with advanced cancer

Sung-Bae Kim, Funda Meric-Bernstam, Jordan Berlin, Sabine Wittemer-Rump, Motonobu Osada, Ray Valencia, Aleksei Babich, Rong Liu, Andy Hwang, Takahiko Tanigawa, Frank Reetz, Dirk Laurent, Aparna Kalyan
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT094.
https://doi.org/10.1158/1538-7445.AM2017-CT094
Published: 01 July 2017
View article titled, Abstract CT094: Phase I study of fibroblast growth factor receptor 2 antibody-drug conjugate (FGFR2-ADC) BAY 1187982 in patients with advanced cancer
Journal Articles

Abstract 672: Pharmacokinetic and pharmacodynamic (PK/PD) modeling of preclinical data of a novel anti-fibroblast growth factor receptor 2(FGFR2) antibody (BAY 1179470) to guide dosing in Phase 1

Sabine Wittemer-Rump, Charlotte Kopitz, Hung Huynh, Lars Lindbom, Bernhard Beckermann, Motonobu Osada, Dirk Laurent, Jörg Lippert
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 672.
https://doi.org/10.1158/1538-7445.AM2014-672
Published: 01 October 2014
View article titled, Abstract 672: Pharmacokinetic and pharmacodynamic (PK/PD) modeling of preclinical data of a novel anti-fibroblast growth factor receptor 2(FGFR2) antibody (BAY 1179470) to guide dosing in Phase 1
Journal Articles

Abstract 4766: Pharmacodynamic and stratification biomarker for the anti-FGFR2 antibody (BAY1179470) and the FGFR2-ADC

Christoph A. Schatz, Charlotte Kopitz, Sabine Wittemer-Rump, Anette Sommer, Lars Lindbom, Motonobu Osada, Hiroshi Yamanouchi, Hung Huynh, Thomas Krahn, Khusru Asadullah
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4766.
https://doi.org/10.1158/1538-7445.AM2014-4766
Published: 01 October 2014
View article titled, Abstract 4766: Pharmacodynamic and stratification biomarker for the anti-FGFR2 antibody (BAY1179470) and the FGFR2-ADC
Journal Articles

Abstract 29: Phase I study of intravenous PI3K inhibitor BAY 80-6946 in Japanese subjects.

Toshihiko Doi, Nozomu Fuse, Takayuki Yoshino, Takashi Kojima, Hideaki Bando, Hideaki Miyamoto, Masato Kaneko, Motonobu Osada, Atsushi Ohtsu
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 29.
https://doi.org/10.1158/1538-7445.AM2013-29
Published: 15 April 2013
View article titled, Abstract 29: Phase I study of intravenous PI3K inhibitor BAY 80-6946 in Japanese subjects.
Journal Articles

Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer

Guojun Wu, Zhongmin Guo, Aditi Chatterjee, Xin Huang, Ethel Rubin, Feng Wu, Elizabeth Mambo, Xiaofei Chang, Motonobu Osada, Myoung Sook Kim, Chulso Moon, Joseph A. Califano, Edward A. Ratovitski, Susanne M. Gollin, Saraswati Sukumar, David Sidransky, Barry Trink
Journal: Cancer Research
Cancer Res (2006) 66 (20): 9829–9836.
https://doi.org/10.1158/0008-5472.CAN-06-0506
Published: 17 October 2006
View article titled, Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer
Open the PDF for Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer in another window
Includes: Supplementary data
Journal Articles

NMDA receptor type 2A at 16p13 is epigenetically inactivated in human colorectal carcinoma

Myoung Sook Kim, Junwei Liu, Keishi Yamashita, Xiaofei Chang, Jin Hyen Baek, Hannah L. Park, Jang- Hee Woo, Motonobu Osada, Sunil Upadhyay, Chulso Moon, David Sidransky
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 13.
Published: 15 April 2006
View article titled, NMDA receptor type 2A at 16p13 is epigenetically inactivated in human colorectal carcinoma
Journal Articles

DCC promoter hypermethylation in esophageal squamous cell carcinoma

Hannah Lui Park, Keishi Yamashita, Myoung Sook Kim, William H. Westra, Andre Lopes Carvalho, Jin Hyen Baek, Wei Wen Jiang, Jun-Wei Liu, Motonobu Osada, Joseph A. Califano, Masaki Mori, David Sidransky
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 8.
Published: 15 April 2006
View article titled, DCC promoter hypermethylation in esophageal squamous cell carcinoma
Journal Articles

NMDAR2B is hypermetylated in ESCC

Myoung S. Kim, Keishi Yamashita, Jin H. Baek, Hannah L. Park, Andre L. Carvalho, Motonobu Osada, Mohammad O. Hoque, Sunil Upadhyay, Chulso Moon, David Sidransky, Masaki Mori
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 763.
Published: 15 April 2006
View article titled, NMDAR2B is hypermetylated in ESCC
Journal Articles

N-Methyl-d-Aspartate Receptor Type 2B Is Epigenetically Inactivated and Exhibits Tumor-Suppressive Activity in Human Esophageal Cancer

Myoung Sook Kim, Keishi Yamashita, Jin Hyen Baek, Hannah Lui Park, Andre Lopes Carvalho, Motonobu Osada, Mohammad Obaidul Hoque, Sunil Upadhyay, Masaki Mori, Chulso Moon, David Sidransky
Journal: Cancer Research
Cancer Res (2006) 66 (7): 3409–3418.
https://doi.org/10.1158/0008-5472.CAN-05-1608
Published: 03 April 2006
View article titled, <em>N-</em>Methyl-<sc>d</sc>-Aspartate Receptor Type 2B Is Epigenetically Inactivated and Exhibits Tumor-Suppressive Activity in Human Esophageal Cancer
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Includes: Supplementary data
Journal Articles

PGP9.5 Methylation in Diffuse-Type Gastric Cancer

Keishi Yamashita, Hannah Lui Park, Myoung Sook Kim, Motonobu Osada, Yutaka Tokumaru, Hiroshi Inoue, Masaki Mori, David Sidransky
Journal: Cancer Research
Cancer Res (2006) 66 (7): 3921–3927.
https://doi.org/10.1158/0008-5472.CAN-05-1511
Published: 03 April 2006
View article titled, PGP9.5 Methylation in Diffuse-Type Gastric Cancer
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Includes: Supplementary data
Journal Articles

PGP9.5 Promoter Methylation Is an Independent Prognostic Factor for Esophageal Squamous Cell Carcinoma

Diana L. Mandelker, Keishi Yamashita, Yutaka Tokumaru, Koshi Mimori, David L. Howard, Yoichi Tanaka, Andre Lopes Carvalho, Wei-Wen Jiang, Hannah Lui Park, Myoung Sook Kim, Motonobu Osada, Masaki Mori, David Sidransky
Journal: Cancer Research
Cancer Res (2005) 65 (11): 4963–4968.
https://doi.org/10.1158/0008-5472.CAN-04-3923
Published: 01 June 2005
View article titled, PGP9.5 Promoter Methylation Is an Independent Prognostic Factor for Esophageal Squamous Cell Carcinoma
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Journal Articles

Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in breast carcinoma

Hannah L. Park, Keishi Yamashita, Andre L. Carvalho, Chetan S. Nayak, Myoung S. Kim, Motonobu Osada, Yutaka Tokumaru, David Sidransky
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 214.
Published: 01 May 2005
View article titled, Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in breast carcinoma
Journal Articles

Novel tumor suppressor genes silenced by aberrant Promoter methylation in colorectal carcinoma

Myoung S. Kim, Keishi Yamashita, Min J. Park, Hannah L. Park, Motonobu Osada, Yutaka Tokumaru, Masaki Mori, Joseph A. Califano, Chulso Moon, David Sidransky
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 839–840.
Published: 01 May 2005
View article titled, Novel tumor suppressor genes silenced by aberrant Promoter methylation in colorectal carcinoma
Journal Articles

ΔNp63α Up-Regulates the Hsp70 Gene in Human Cancer

Guojun Wu, Motonobu Osada, Zhongmin Guo, Alexey Fomenkov, Shahnaz Begum, Ming Zhao, Sunil Upadhyay, Mingzhao Xing, Feng Wu, Chulso Moon, William H. Westra, Wayne M. Koch, Roberto Mantovani, Joseph A. Califano, Edward Ratovitski, David Sidransky, Barry Trink
Journal: Cancer Research
Cancer Res (2005) 65 (3): 758–766.
https://doi.org/10.1158/0008-5472.758.65.3
Published: 10 February 2005
View article titled, ΔNp63α Up-Regulates the <em>Hsp70</em> Gene in Human Cancer
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Includes: Supplementary data
Journal Articles

Inverse Correlation between Cyclin A1 Hypermethylation and p53 Mutation in Head and Neck Cancer Identified by Reversal of Epigenetic Silencing

Yutaka Tokumaru, Keishi Yamashita, Motonobu Osada, Shuji Nomoto, Dong-Il Sun, Yan Xiao, Mohammad Obaidul Hoque, William H. Westra, Joseph A. Califano, David Sidransky
Journal: Cancer Research
Cancer Res (2004) 64 (17): 5982–5987.
https://doi.org/10.1158/0008-5472.CAN-04-0993
Published: 01 September 2004
View article titled, Inverse Correlation between Cyclin A1 Hypermethylation and p53 Mutation in Head and Neck Cancer Identified by Reversal of Epigenetic Silencing
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Journal Articles

A role for p53 in neo-vascularization through direct up-regulation of FGF-1

Shuji Nomoto, Yuichi Nagakawa, Motonobu Osada, Sunil Upadhyay, Kenji Minami, Rui Henrique, Carmen Jeronimo, Andrew S. Klein, David Sidransky, Barry Trink
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1140.
Published: 01 April 2004
View article titled, A role for p53 in neo-vascularization through direct up-regulation of FGF-1
Journal Articles

Effects of p51/p63 Missense Mutations on Transcriptional Activities of p53 Downstream Gene Promoters

Shunsuke Kato, Akira Shimada, Motonobu Osada, Shuntaro Ikawa, Masuo Obinata, Akira Nakagawara, Ryunosuke Kanamaru, Chikashi Ishioka
Journal: Cancer Research
Cancer Res (1999) 59 (23): 5908–5911.
Published: 01 December 1999
View article titled, Effects of <em>p51/p63</em> Missense Mutations on Transcriptional Activities of <em>p53</em> Downstream Gene Promoters
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Journal Articles

The Transcriptional Activities of p53 and Its Homologue p51/p63: Similaritiesand Differences

Akira Shimada, Shunsuke Kato, Kentaro Enjo, Motonobu Osada, Yoji Ikawa, Kenji Kohno, Masuo Obinata, Ryunosuke Kanamaru, Shuntaro Ikawa, Chikashi Ishioka
Journal: Cancer Research
Cancer Res (1999) 59 (12): 2781–2786.
Published: 15 June 1999
View article titled, The Transcriptional Activities of p53 and Its Homologue p51/p63: Similaritiesand Differences
Open the PDF for The Transcriptional Activities of p53 and Its Homologue p51/p63: Similaritiesand Differences in another window