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Moshe Talpaz
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Journal Articles

Abstract 3628: Combined mek and jak inhibition in vitro is an effective strategy in overcoming jak inhibitor resistance in primary myelofibrosis (PMF)

Samuel Benjamin Reynolds, Sho Matono, Malathi Kandarpa, Kristen Pettit, Mark Ribick, Moshe Talpaz, Qing Li
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3628.
https://doi.org/10.1158/1538-7445.AM2024-3628
Published: 22 March 2024
View article titled, Abstract 3628: Combined mek and jak inhibition <em>in vitro</em> is an effective strategy in overcoming jak inhibitor resistance in primary myelofibrosis (PMF)
Journal Articles

Abstract 4536: Investigating the correlation between molecular diagnostics, targeted therapies and treatment outcomes in Rosai Dorfman disease: a single-institution experience

Samuel B. Reynolds, Sabrina R. Wilcox, Moshe Talpaz, Asra Z. Ahmed
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4536.
https://doi.org/10.1158/1538-7445.AM2023-4536
Published: 04 April 2023
View article titled, Abstract 4536: Investigating the correlation between molecular diagnostics, targeted therapies and treatment outcomes in Rosai Dorfman disease: a single-institution experience
Journal Articles

Abstract 5083: A novel and highly efficacious small-molecule degrader of BET-BRD proteins for the treatment of acute leukemia

Ester Fernandez-Salas, Zhuo Chen, Mei Lin, Bing Zhou, Donna McEachern, Sally Przybranowski, Karson Kump, Luke F. Peterson, Malathi Kandarpa, Jiantao Hu, Fuming Xu, Liu Liu, Longchuan Bai, Bo Wen, Duxin Sun, Moshe Talpaz, Shaomeng Wang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5083.
https://doi.org/10.1158/1538-7445.AM2017-5083
Published: 01 July 2017
View article titled, Abstract 5083: A novel and highly efficacious small-molecule degrader of BET-BRD proteins for the treatment of acute leukemia
Journal Articles

Abstract 2881: Deubiquitinase Usp9x controls tumorigenicity through regulation of the Ets-1 transcription factor in melanoma

Harish Potu, Luke F. Peterson Peterson, Malathi Kandarpa Kandarpa, Anupama Pal Pal, Hanshi Sun Sun, Paul W. Harms Harms, Peter C. Hollenhorst Hollenhorst, Ugur Eskiocak Eskiocak, Moshe Talpaz Talpaz, Nicholas J. Donato Donato
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2881.
https://doi.org/10.1158/1538-7445.AM2016-2881
Published: 15 July 2016
View article titled, Abstract 2881: Deubiquitinase Usp9x controls tumorigenicity through regulation of the Ets-1 transcription factor in melanoma
Journal Articles

Abstract 1748: Usp9x as a novel therapeutic target in human pancreatic cancer

Anupama Pal, Marina Pasca Di Magliano, Diane Simeone, Luke Peterson, Harish Potu, Moshe Talpaz, Nicholas Donato
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1748.
https://doi.org/10.1158/1538-7445.AM2015-1748
Published: 01 August 2015
View article titled, Abstract 1748: Usp9x as a novel therapeutic target in human pancreatic cancer
Journal Articles

Abstract 3621: Deubiquitination of AXIN1 by USP9X promotes apoptosis in melanoma in response to BRAF or MEK inhibition

Harish Potu, Luke F. Peterson, Malathi Kandarpa, Eric Fearon, Moshe Talpaz, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3621.
https://doi.org/10.1158/1538-7445.AM2015-3621
Published: 01 August 2015
View article titled, Abstract 3621: Deubiquitination of AXIN1 by USP9X promotes apoptosis in melanoma in response to BRAF or MEK inhibition
Journal Articles

Abstract 2595: Deubiquitinase USP9X inhibition induces apoptosis in metastatic breast cancer cells

Anupama Pal, Ming Luo, Max Wicha, Moshe Talpaz, Nicholas Donato
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2595.
https://doi.org/10.1158/1538-7445.AM2014-2595
Published: 01 October 2014
View article titled, Abstract 2595: Deubiquitinase USP9X inhibition induces apoptosis in metastatic breast cancer cells
Journal Articles

Abstract 2698: Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)

William G. Bornmann, Zhenghong Peng, David Maxwell, Duoli Sun, Basvoju A. Bhanu, Moshe Talpaz, Nicholas Donato, Alexander Levitzki
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2698.
https://doi.org/10.1158/1538-7445.AM2014-2698
Published: 01 October 2014
View article titled, Abstract 2698: Degrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma (MM-I)
Journal Articles

Abstract 4435: Deubiquitinases Usp9x and Usp5 control tumorigenicity and apoptotic responsiveness in malignant melanoma

Harish Potu, Anupama Pal, Hanshi Sun, Luke Peterson, Moshe Talpaz, Monique Verhaegen, Juxiang Cao, Ugur Eskiocak, Sean Morrison, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4435.
https://doi.org/10.1158/1538-7445.AM2014-4435
Published: 01 October 2014
View article titled, Abstract 4435: Deubiquitinases Usp9x and Usp5 control tumorigenicity and apoptotic responsiveness in malignant melanoma
Journal Articles

Abstract 4434: Role of Deubiquitinase Usp9x in pancreatic cancers: Tumor promoter or tumor suppressor

Anupama Pal, Marina Pasca di Magliano, Moshe Talpaz, Michelle Dziubinski, Diane Simeone, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4434.
https://doi.org/10.1158/1538-7445.AM2014-4434
Published: 01 October 2014
View article titled, Abstract 4434: Role of Deubiquitinase Usp9x in pancreatic cancers: Tumor promoter or tumor suppressor
Journal Articles

Abstract LB-294: Determination of JAK2V617F allele burden in a phase II study of patients with myelofibrosis treated with SAR302503 using a sensitive and robust allele-specific qPCR assay.

Feng Liu, Moshe Talpaz, Animesh Pardanani, Catriona Jamieson, Nashat Gabrail, Ayalew Tefferi, Tianlei Lei, Rita Greco, Francisco Adrian, Nikki Daskalakis, Claudia Lebedinsky, Pamela Cohen, Donald Bergstrom
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-294.
https://doi.org/10.1158/1538-7445.AM2013-LB-294
Published: 15 April 2013
View article titled, Abstract LB-294: Determination of <em>JAK2</em>V617F allele burden in a phase II study of patients with myelofibrosis treated with SAR302503 using a sensitive and robust allele-specific qPCR assay.
Journal Articles

Abstract 2323: Mutant B-Raf-mediated activation of deubiquitinases in melanoma defines Usp5 as a potential therapeutic target.

Harish Potu, Luke F. Peterson, Monique Verhaegen, Moshe Talpaz, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2323.
https://doi.org/10.1158/1538-7445.AM2013-2323
Published: 15 April 2013
View article titled, Abstract 2323: Mutant B-Raf-mediated activation of deubiquitinases in melanoma defines Usp5 as a potential therapeutic target.
Journal Articles

Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis

Vaibhav Kapuria, Luke F. Peterson, Dexing Fang, William G. Bornmann, Moshe Talpaz, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2010) 70 (22): 9265–9276.
https://doi.org/10.1158/0008-5472.CAN-10-1530
Published: 14 November 2010
View article titled, Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis
Open the PDF for Deubiquitinase Inhibition by Small-Molecule WP1130 Triggers Aggresome Formation and Tumor Cell Apoptosis in another window
Includes: Supplementary data
Journal Articles

Abstract #3720: Inhibition of BCR-ABL signaling in imatinib sensitive and resistant chronic myelogenous leukemia and progenitor cells through small molecule-mediated BCR-ABL ubiquitination and aggresomal deposition

Nicholas Donato, Hanshi Sun, Vaibhav Kapuria, Luke Peterson, Zhenghong Peng, David Maxwell, William Bornmann, Moshe Talpaz
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3720.
Published: 01 May 2009
View article titled, Abstract #3720: Inhibition of BCR-ABL signaling in imatinib sensitive and resistant chronic myelogenous leukemia and progenitor cells through small molecule-mediated BCR-ABL ubiquitination and aggresomal deposition
Journal Articles

Abstract #4773: Activation of a novel Jak-Stat inhibitory pathway by a small molecule

Vaibhav Kapuria, Luke Peterson, Hanshi Sun, Geoffrey Bartholomeusz, William Bornmann, Moshe Talpaz, Nicholas Donato
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 4773.
Published: 01 May 2009
View article titled, Abstract #4773: Activation of a novel Jak-Stat inhibitory pathway by a small molecule
Journal Articles

Degrasyn Activates Proteasomal-Dependent Degradation of c-Myc

Geoffrey Bartholomeusz, Moshe Talpaz, William Bornmann, Ling-Yuan Kong, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2007) 67 (8): 3912–3918.
https://doi.org/10.1158/0008-5472.CAN-06-4464
Published: 17 April 2007
View article titled, Degrasyn Activates Proteasomal-Dependent Degradation of c-Myc
Open the PDF for Degrasyn Activates Proteasomal-Dependent Degradation of c-Myc in another window
Journal Articles

Silencing Lyn kinase overcomes resistance to imatinib in Bcr-Abl-dependent CML cells

Ji Yuan Wu, Moshe Talpaz, Nicholas J. Donato
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 554.
Published: 15 April 2006
View article titled, Silencing Lyn kinase overcomes resistance to imatinib in Bcr-Abl-dependent CML cells
Journal Articles

WP1130, a small molecular weight compound, inhibits JAK2-STAT3 signaling through a unique degradation mechansim

Vaibhav Kapuria, Geoffrey Bartholomeusz, Waldemar Priebe, Ling Y. Kong, Moshe Talpaz, Nicholas Donato
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 709.
Published: 15 April 2006
View article titled, WP1130, a small molecular weight compound, inhibits JAK2-STAT3 signaling through a unique degradation mechansim
Journal Articles

Degradation of c-Myc by WP1130 Through Activation of a Novel Proteasomal-Dependent Pathway

Geoffrey A. Bartholomeusz, Nicholas Donato, Waldemar Priebe, William P. Tansey, Moshe Talpaz
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 711.
Published: 15 April 2006
View article titled, Degradation of c-Myc by WP1130 Through Activation of a Novel Proteasomal-Dependent Pathway
Journal Articles

A role for Src-family kinases in imatinib resistant chronic myelogenous leukemia

Nicholas J. Donato, Ji Y. Wu, Ling Y. Kong, Francis Lee, Moshe Talpaz
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 353.
Published: 01 May 2005
View article titled, A role for Src-family kinases in imatinib resistant chronic myelogenous leukemia