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Morag Park
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Journal Articles

Abstract B028: Functional precision medicine in challenging breast cancer subtypes: Developing preclinical models for tailored therapy in complex and rare histologies

Hellen Kuasne, Anne Marie Fortier, Sandrine Busque, Paul Savage, Constanza Martinez Ramirez, Anie Monast, Nebras Koudieh, Atilla Omeroglu, Lara Richer, Jamil Asselah, Nathaniel Bouganim, Francine Tremblay, Ari Nareg Meguerditchian, Sarkis Meterissian, Morag Park
Journal: Cancer Research
Cancer Res (2025) 85 (5_Supplement): B028.
https://doi.org/10.1158/1538-7445.GENFUNC25-B028
Published: 11 March 2025
View article titled, Abstract B028: Functional precision medicine in challenging breast cancer subtypes: Developing preclinical models for tailored therapy in complex and rare histologies
Journal Articles

Abstract PO2-25-01: Tumor Derived Chitinase-3 like 1 Induces Neutrophil Extracellular Traps that Promote T cell Exclusion and Resistance to Immunotherapies in Breast Cancer

Tarek Taifour, Sherif Samer Attalla, Dongmei Zuo, Yu Gu, Virginie Sanguin-Gendreau, Hailey Dall-Proud, Emilie Solymoss, Tung Bui, Hellen Kuasne, Vasilios Papavasiliou, Chun Geun Lee, Suchitra Kamle, Peter Siegel, Jack Elias, Morag Park, William Muller
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO2-25-01.
https://doi.org/10.1158/1538-7445.SABCS23-PO2-25-01
Published: 02 May 2024
View article titled, Abstract PO2-25-01: Tumor Derived Chitinase-3 like 1 Induces Neutrophil Extracellular Traps that Promote T cell Exclusion and Resistance to Immunotherapies in Breast Cancer
Journal Articles

Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer

Xianbing Zhu, Zheng Fu, Kendall Dutchak, Azadeh Arabzadeh, Simon Milette, Jutta Steinberger, Geneviève Morin, Anie Monast, Virginie Pilon, Tim Kong, Bianca N. Adams, Erika Prando Munhoz, Hannah J.B. Hosein, Tianxu Fang, Jing Su, Yibo Xue, Roni Rayes, Veena Sangwan, Logan A. Walsh, Guojun Chen, Daniela F. Quail, Jonathan D. Spicer, Morag Park, David Dankort, Sidong Huang
Journal: Cancer Research
Cancer Res (2024) 84 (8): 1333–1351.
https://doi.org/10.1158/0008-5472.CAN-23-1749
Published: 15 April 2024
View article titled, Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer
Open the PDF for Cotargeting CDK4/6 and BRD4 Promotes Senescence and Ferroptosis Sensitivity in Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3500: Refining diagnosis of renal cell carcinoma subtypes through single-cell resolution transcriptomic signatures

Minjun Kim, Ariel Madrigal, Zohreh Mehrjoo, Kate I. Glennon, Madeleine Arseneault, Morag Park, Fadi Brimo, Simon Tanguay, Hamed S. Najafabadi, Yasser Riazalhosseini
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3500.
https://doi.org/10.1158/1538-7445.AM2024-3500
Published: 22 March 2024
View article titled, Abstract 3500: Refining diagnosis of renal cell carcinoma subtypes through single-cell resolution transcriptomic signatures
Journal Articles

Abstract B067: Identification of Gemcitabine-resistant Populations using scRNA-Sequencing in Triple Negative Breast Cancer Patient-Derived Xenografts

Sandrine Busque, Constanza Martinez Ramirez, Ariel Madrigal Aguirre, Paul Savage, Anie Monast, Anne-Marie Fortier, Gerardo Zapata, Atilla Omeroglu, Jamil Asselah, Nathaniel Bouganim, Sarkis Meterissian, Francine Tremblay, Ari Meguerditchian, Yasser Riaz Alhosseini, Hamed S. Najafabadi, Hellen Kuasne, Morag Park
Journal: Cancer Research
Cancer Res (2024) 84 (3_Supplement_1): B067.
https://doi.org/10.1158/1538-7445.ADVBC23-B067
Published: 01 February 2024
View article titled, Abstract B067: Identification of Gemcitabine-resistant Populations using scRNA-Sequencing in Triple Negative Breast Cancer Patient-Derived Xenografts
Journal Articles

Abstract B011: An atlas of cellular heterogeneity in primary and metastatic renal cell carcinomas

Ariel Madrigal, Minjun Kim, Adrien Osakwe, Tianyuan Lu, Zohreh Mehrjoo, Elham Moslemi, Rick Farouni, Larisa Morales-Soto, Yu Chang Wang, Matthew Dankner, Haig Djambazian, Kevin Petrecca, Jonathan Spicer, Fadi Brimo, Peter Siegel, Morag Park, Jiannis Ragoussis, Simon Tanguay, Yasser Riazalhosseini, Hamed S. Najafabadi
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): B011.
https://doi.org/10.1158/1538-7445.KIDNEY23-B011
Published: 15 August 2023
View article titled, Abstract B011: An atlas of cellular heterogeneity in primary and metastatic renal cell carcinomas
Journal Articles

Abstract PR005: An atlas of cellular heterogeneity in primary and metastatic renal cell carcinomas

Ariel Madrigal, Minjun Kim, Adrien Osakwe, Tianyuan Lu, Zohreh Mehrjoo, Elham Moslemi, Rick Farouni, Larisa Morales-Soto, Yu Chang Wang, Matthew Dankner, Haig Djambazian, Kevin Petrecca, Jonathan Spicer, Fadi Brimo, Peter Siegel, Morag Park, Jiannis Ragoussis, Simon Tanguay, Yasser Riazalhosseini, Hamed S. Najafabadi
Journal: Cancer Research
Cancer Res (2023) 83 (16_Supplement): PR005.
https://doi.org/10.1158/1538-7445.KIDNEY23-PR005
Published: 15 August 2023
View article titled, Abstract PR005: An atlas of cellular heterogeneity in primary and metastatic renal cell carcinomas
Journal Articles

Abstract 69: Minimally invasive brain metastases are characterized by elevated immune cell infiltrate

Sarah M. Maritan, Elham Karimi, Matthew Dankner, Miranda W. Yu, Aldo Hernandez-Corchado, Morteza Rezanejad, Parvaneh Fallah, Benoit Fiset, Yuhong Wei, Stephanie Lam, Ali Nehme, Ian R. Watson, Morag Park, Yasser Riazalhosseini, Hamed Najafabadi, Kevin Petrecca, Marie-Christine Guiot, Daniela F. Quail, Logan A. Walsh, Peter M. Siegel
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 69.
https://doi.org/10.1158/1538-7445.AM2023-69
Published: 04 April 2023
View article titled, Abstract 69: Minimally invasive brain metastases are characterized by elevated immune cell infiltrate
Journal Articles

Abstract 1413: Chromosome arm aneuploidies as genetic vulnerabilities of triple-negative breast cancer

Rohan Dandage, Michael Schwartz, Lynn Karam, Alain Pacis, Traver Hart, Guillaume Bourque, Morag Park, Elena Kuzmin
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1413.
https://doi.org/10.1158/1538-7445.AM2023-1413
Published: 04 April 2023
View article titled, Abstract 1413: Chromosome arm aneuploidies as genetic vulnerabilities of triple-negative breast cancer
Journal Articles

Abstract 1512: Evolution of large copy number variants in breast cancer through genetic network rewiring

Elena Kuzmin, Jean Monlong, Mathieu Bourgey, Tom Lesluyes, Toby Barker, Genevieve Morin, Dongmei Zou, Michael Schwartz, Yang Yang, Alain Pacis, Constanza Martinez, Hellen Kuasne, Anne-Marie Fortier, Rui Li, Claudia Kleinman, Sidong Huang, Peter van Loo, Jiannis Ragoussis, Guillaume Bourque, Morag Park
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1512.
https://doi.org/10.1158/1538-7445.AM2023-1512
Published: 04 April 2023
View article titled, Abstract 1512: Evolution of large copy number variants in breast cancer through genetic network rewiring
Journal Articles

Abstract P3-08-09: Development and molecular characterization of hard-to-treat breast cancer pre-clinical models to enhance precision medicine

Hellen Kuasne, Anne-Marie fortier, Sandrine Busque, Simon Mathien, Paul Savage, Constanza Martinez Ramirez, Anie Monast, Margarita Soleinova, Atilla Omeroglu, Jamil Asselah, Nathaniel Bouganim, Sarkis Meterissian, Mark Basik, Morag Park
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P3-08-09.
https://doi.org/10.1158/1538-7445.SABCS22-P3-08-09
Published: 01 March 2023
View article titled, Abstract P3-08-09: Development and molecular characterization of hard-to-treat breast cancer pre-clinical models to enhance precision medicine
Journal Articles

Abstract A033: Identification of gemcitabine-resistant populations using scRNA-sequencing in triple negative breast cancer patient-derived xenograft

Sandrine Busque, Constanza Martinez Ramirez, Hellen Kuasne, Paul Savage, Anne-Marie Fortier, Anie Monast, Atilla Omeroglu, Jamil Asselah, Nathaniel Bouganim, Sarkis Meterissian, Claudia Kleinman, Mark Basik, Morag Park
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): A033.
https://doi.org/10.1158/1538-7445.METASTASIS22-A033
Published: 15 January 2023
View article titled, Abstract A033: Identification of gemcitabine-resistant populations using scRNA-sequencing in triple negative breast cancer patient-derived xenograft
Journal Articles

Breast Cancer Metastatic Dormancy and Relapse: An Enigma of Microenvironment(s)

Islam E. Elkholi, Andréane Lalonde, Morag Park, Jean-François Côté
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4497–4510.
https://doi.org/10.1158/0008-5472.CAN-22-1902
Published: 16 December 2022
View article titled, Breast Cancer Metastatic Dormancy and Relapse: An Enigma of Microenvironment(s)
Open the PDF for Breast Cancer Metastatic Dormancy and Relapse: An Enigma of Microenvironment(s) in another window
Includes: Supplementary data
Journal Articles

Abstract 2436: CIRBP is a functional mediator of leptomeningeal metastasis

Rima Ezzeddine, Matthew Dankner, Paul Savage, Steven Hebert, William Brothers, Matthew G. Annis, Sarah M. Maritan, Marc R. Fabian, Claudia Kleinman, Morag Park, Peter M. Siegel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2436.
https://doi.org/10.1158/1538-7445.AM2022-2436
Published: 15 June 2022
View article titled, Abstract 2436: CIRBP is a functional mediator of leptomeningeal metastasis
Journal Articles

Abstract 47: Identifying genetic vulnerabilities of chromosome 4p large copy number variants in triple negative breast cancer

Michael Schwartz, Rohan Dandage, Lynn Karam, Alain Pacis, Hellen Kuasne, Anne-Marie Fortier, Sidong Huang, Guillaume Bourque, Traver Hart, Elena Kuzmin, Morag Park
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 47.
https://doi.org/10.1158/1538-7445.AM2022-47
Published: 15 June 2022
View article titled, Abstract 47: Identifying genetic vulnerabilities of chromosome 4p large copy number variants in triple negative breast cancer
Journal Articles

Abstract 44: Evolution of large copy number variants in breast cancer through genetic network rewiring

Elena Kuzmin, Jean Monlong, Mathieu Bourgey, Jarry Barber, Tom Lesluyes, Toby Baker, Genevieve Morin, Dongmei Zou, Michael Schwartz, Yang Yang, Alain Pacis, Constanza Martinez, Hellen Kuasne, Anne-Marie Fortier, Rui Li, Claudia Kleinman, Sidong Huang, Peter van Loo, Quaid Morris, Jiannis Ragoussis, Guillaume Bourque, Morag Park
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 44.
https://doi.org/10.1158/1538-7445.AM2022-44
Published: 15 June 2022
View article titled, Abstract 44: Evolution of large copy number variants in breast cancer through genetic network rewiring
Journal Articles

Abstract 1569: pSTAT3+ stromal cells drive the invasive growth of brain metastases

Matthew Dankner, Sarah M. Maritan, Neibla Priego, Javad Nadaf, Andy Nkili, Rebecca Zhuang, Georgia Kruck, Dongmei Zuo, Alexander Nowakowski, Yanis Inglebert, Paul Savage, Morag Park, Marie-Christine Guiot, Anne McKinney, William J. Muller, Manuel Valiente, Kevin Petrecca, Peter M. Siegel
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1569.
https://doi.org/10.1158/1538-7445.AM2022-1569
Published: 15 June 2022
View article titled, Abstract 1569: pSTAT3+ stromal cells drive the invasive growth of brain metastases
Journal Articles

Abstract PO006: Heating up the fight against cancer using 3D bioprinting

Anne-Marie Fortier, Erin Bedford, Salvador Flores Torres, Spiro Getsios, J. Matt Kinsella, Sam Wadsworth, Morag Park
Journal: Cancer Research
Cancer Res (2021) 81 (5_Supplement): PO006.
https://doi.org/10.1158/1538-7445.TME21-PO006
Published: 01 March 2021
View article titled, Abstract PO006: Heating up the fight against cancer using 3D bioprinting
Journal Articles

Abstract PO-053: Investigating intra-tumour metabolic heterogeneity in triple-negative breast cancer

Marina Fukano, Geneviève Deblois, Dongmei Zuo, Constanza Martinez, Yang Yang, Ioannis Ragoussis, Claudia Kleinman, Morag Park
Journal: Cancer Research
Cancer Res (2020) 80 (23_Supplement): PO-053.
https://doi.org/10.1158/1538-7445.EPIMETAB20-PO-053
Published: 02 December 2020
View article titled, Abstract PO-053: Investigating intra-tumour metabolic heterogeneity in triple-negative breast cancer
Journal Articles

Abstract PO-080: Predicting relapse in patients with triple negative breast cancer (TNBC) using a deep-learning approach

Guangyuan Yu, Xuefei Li, Ting-Fang He, Tina Gruosso, Dongmei Zuo, Margarita Souleimanova, Valentina Muñoz Ramos, Atilla Omeroglu, Sarkis Meterissian, Marie-Christine Guiot, Li Yang, Yuan Yuan, Morag Park, Peter P. Lee, Herbert Levine
Journal: Cancer Research
Cancer Res (2020) 80 (21_Supplement): PO-080.
https://doi.org/10.1158/1538-7445.TUMHET2020-PO-080
Published: 03 November 2020
View article titled, Abstract PO-080: Predicting relapse in patients with triple negative breast cancer (TNBC) using a deep-learning approach