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Moorthy P. Ponnusamy
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Journal Articles

Abstract 1794: PAF1 reprograms metabolism in pancreatic cancer by interacting with HIF1α

Ayoola O. Ogunleye, Neelanjana Gayen, Saravanakumar Marimuthu, Rama Krishna Nimmakayala, Sanchita Rauth, Zahraa Alsafwani, Jesse L. Cox, Surinder K. Batra, Moorthy P. Ponnusamy
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1794.
https://doi.org/10.1158/1538-7445.AM2024-1794
Published: 22 March 2024
View article titled, Abstract 1794: PAF1 reprograms metabolism in pancreatic cancer by interacting with HIF1α
Journal Articles

Abstract 1756: Targeting LIFR/c-Myc Axis to Overcome Docetaxel Resistance in Prostate Cancer

Sushanta Halder, Sakthivel Muniyan, Ramakanth Chirravuri-Venkata, Rama Krishna Nimmakayala, Palanisamy Nallasamy, Hareesh B. Nair, Moorthy P Ponnusamy, Surinder K. Batra, Parthasarathy Seshacharyulu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1756.
https://doi.org/10.1158/1538-7445.AM2023-1756
Published: 04 April 2023
View article titled, Abstract 1756: Targeting LIFR/c-Myc Axis to Overcome Docetaxel Resistance in Prostate Cancer
Journal Articles

Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness

Koelina Ganguly, Shiv Ram Krishn, Satyanarayana Rachagani, Rahat Jahan, Ashu Shah, Palanisamy Nallasamy, Sanchita Rauth, Pranita Atri, Jesse L. Cox, Ramesh Pothuraju, Lynette M. Smith, Sudhua Ayala, Christopher Evans, Moorthy P. Ponnusamy, Sushil Kumar, Sukhwinder Kaur, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2021) 81 (1): 91–102.
https://doi.org/10.1158/0008-5472.CAN-20-1293
Published: 04 January 2021
View article titled, Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness
Open the PDF for Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness in another window
Includes: Supplementary data
Journal Articles

Abstract 2289: Evaluation of novel genetically engineered anti-MUC16 antibody for therapeutic targeting in pancreatic cancer

Ashu Shah, Abhijit Aithal, Catherine Orzechowski, Saravanakumar Marimuthu, Prakash Kshirsagar, Moorthy P. Ponnusamy, Maneesh Jain, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2289.
https://doi.org/10.1158/1538-7445.AM2020-2289
Published: 15 August 2020
View article titled, Abstract 2289: Evaluation of novel genetically engineered anti-MUC16 antibody for therapeutic targeting in pancreatic cancer
Journal Articles

Abstract 6030: Role of immature CD44 o-glycosylation in enrichment of cancer stem cell population for aggressive pancreatic cancer

Frank Leon, Rama K. Nimmakayala, Seema Chugh, Rohitesh Gupta, Satyanarayana Rachagani, Surinder K. Batra, Moorthy P. Ponnusamy
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6030.
https://doi.org/10.1158/1538-7445.AM2020-6030
Published: 15 August 2020
View article titled, Abstract 6030: Role of immature CD44 o-glycosylation in enrichment of cancer stem cell population for aggressive pancreatic cancer
Journal Articles

Abstract 6072: MUC16-Cter cleavage increases the metastatic potential in pancreatic cancer

Saravanakumar Marimuthu, Imayavaramban Lakshmanan, Sakthivel Muniyan, Pranita Atri, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6072.
https://doi.org/10.1158/1538-7445.AM2020-6072
Published: 15 August 2020
View article titled, Abstract 6072: MUC16-Cter cleavage increases the metastatic potential in pancreatic cancer
Journal Articles

Abstract 3679: A novel mechanism for pancreatic cancer stem cell maintenance: PAF1C-independent role of PAF1

Saswati Karmakar, Sanchita Rauth, Rama Krishna Nimmakayala, Srikanth Barkeer, Mohd W. Nasser, Satyanarayana Rachagani, Dario Ghersi, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3679.
https://doi.org/10.1158/1538-7445.AM2019-3679
Published: 01 July 2019
View article titled, Abstract 3679: A novel mechanism for pancreatic cancer stem cell maintenance: PAF1C-independent role of PAF1
Journal Articles

Abstract 4684: Afatinib targets glioblastoma stem cells by inhibiting EGFRVIII-cMet co-activation

Raghupathy Vengoji, Muzafar A. Macha, Ramakrishna Nimmakayala, Satyanarayana Rachagani, Kavita Mallya, Maneesh Jain, Moorthy P. Ponnusamy, Surinder K. Batra, Nicole Shonka
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4684.
https://doi.org/10.1158/1538-7445.AM2019-4684
Published: 01 July 2019
View article titled, Abstract 4684: Afatinib targets glioblastoma stem cells by inhibiting EGFRVIII-cMet co-activation
Journal Articles

Abstract 4804: Pre-clinical development of ISOX; A novel therapy for pancreatic cancer identified utilizing system biology approach(s)

Pranita Atri, Parthasarathy Seshacharyulu, Satyanaryana Rachagani, Palanisamy Nallasamy, Sanchita Rauth, Garima Kaushik, Koelina Ganguly, Dario Ghersi, Moorthy P. Ponnusamy, Sukhwinder Kaur, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4804.
https://doi.org/10.1158/1538-7445.AM2019-4804
Published: 01 July 2019
View article titled, Abstract 4804: Pre-clinical development of ISOX; A novel therapy for pancreatic cancer identified utilizing system biology approach(s)
Journal Articles

Abstract 5897: Role of polymerase II associated factor 1, PAF1, in docetaxel resistant prostate cancer cells

Sakthivel Muniyan, Rama Krishna Nimmakayala, Saswati Karmakar, Satyanarayana Rachagani, Jawed A. Siddiqui, Parthasarathy Seshacharyulu, Ming-Fong Lin, Kaustubh Datta, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5897.
https://doi.org/10.1158/1538-7445.AM2018-5897
Published: 01 July 2018
View article titled, Abstract 5897: Role of polymerase II associated factor 1, PAF1, in docetaxel resistant prostate cancer cells
Journal Articles

Abstract 672: Targeting metabolic pathways to radiosensitize pancreatic cancer

Parthasarathy Seshacharyulu, Ramakrishna Nimmakayala, Satyanarayana Rachagani, Shuo Wang, Sicong Li, Geoffrey Talmon, Sukhwinder Kaur, Moorthy P. Ponnusamy, Maneesh Jain, Chi Lin, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 672.
https://doi.org/10.1158/1538-7445.AM2018-672
Published: 01 July 2018
View article titled, Abstract 672: Targeting metabolic pathways to radiosensitize pancreatic cancer
Journal Articles

PD2/PAF1 at the Crossroads of the Cancer Network

Saswati Karmakar, Parama Dey, Arokia P. Vaz, Sukesh R. Bhaumik, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (2): 313–319.
https://doi.org/10.1158/0008-5472.CAN-17-2175
Published: 15 January 2018
View article titled, PD2/PAF1 at the Crossroads of the Cancer Network
Open the PDF for PD2/PAF1 at the Crossroads of the Cancer Network in another window
Journal Articles

Abstract 5801: Loss of core 1 β1,3-galactosyltransferase (C1GALT1) in pancreatic cancer leads to altered mucin glycosylation and increased tumor aggressiveness

Seema Chugh, Satyanarayana Rachagani, Xinheng Yu, Sriram Neelamegham, Lijun Xia, Michel M. Ouellette, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5801.
https://doi.org/10.1158/1538-7445.AM2017-5801
Published: 01 July 2017
View article titled, Abstract 5801: Loss of core 1 β1,3-galactosyltransferase (C1GALT1) in pancreatic cancer leads to altered mucin glycosylation and increased tumor aggressiveness
Journal Articles

Abstract 5762: PR55-alpha associated PP2A promotes pancreatic tumorigenesis

Ying Yan, Ashley L. Hein, Parthasarathy Seshacharyulu, Satyanarayana Rachagani, Yuri M. Sheinin, Michel M. Ouellette, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5762.
https://doi.org/10.1158/1538-7445.AM2017-5762
Published: 01 July 2017
View article titled, Abstract 5762: PR55-alpha associated PP2A promotes pancreatic tumorigenesis
Journal Articles

Abstract 2490: Smoking enriches cancer stem cell population and activates Sox9 through NF-kB signaling in pancreatic ductal adenocarcinoma

Ramakrishna Nimmakayala, Parthasarathy Seshacharyulu, Seema Chugh, Imayavaramban Lakshmanan, Satyanarayana Rachagani, Surinder K Batra, Moorthy P Ponnusamy.
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2490.
https://doi.org/10.1158/1538-7445.AM2016-2490
Published: 15 July 2016
View article titled, Abstract 2490: Smoking enriches cancer stem cell population and activates Sox9 through NF-kB signaling in pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1629: Novel interaction of MUC16 with FAK activate EMT process and metastasis of pancreatic ductal adenocarcinoma

Sakthivel Muniyan, Dhanya Haridas, Satyanarayana Rachagani, Imayavaramban Lakshmanan, Suprit Gupta, Seema Chugh, Parthasarathy Seshacharyulu, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1629.
https://doi.org/10.1158/1538-7445.AM2016-1629
Published: 15 July 2016
View article titled, Abstract 1629: Novel interaction of MUC16 with FAK activate EMT process and metastasis of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 1726: Targeting pancreatic cancer stem cells by afatinib in organoid culture

Garima Kaushik, Parthasarathy Seshacharyulu, Satyanarayana Rachagani, Muzafar A. Macha, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1726.
https://doi.org/10.1158/1538-7445.AM2016-1726
Published: 15 July 2016
View article titled, Abstract 1726: Targeting pancreatic cancer stem cells by afatinib in organoid culture
Journal Articles

PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling

Ashley L. Hein, Parthasarathy Seshacharyulu, Satyanarayana Rachagani, Yuri M. Sheinin, Michel M. Ouellette, Moorthy P. Ponnusamy, Marc C. Mumby, Surinder K. Batra, Ying Yan
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2243–2253.
https://doi.org/10.1158/0008-5472.CAN-15-2119
Published: 14 April 2016
View article titled, PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling
Open the PDF for PR55α Subunit of Protein Phosphatase 2A Supports the Tumorigenic and Metastatic Potential of Pancreatic Cancer Cells by Sustaining Hyperactive Oncogenic Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 1256: MUC4 is negatively regulated by hypoxia in ROS-dependent manner in pancreatic cancer

Suhasini Joshi, Sushil Kumar, Moorthy P. Ponnusamy, Surinder K. Batra
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1256.
https://doi.org/10.1158/1538-7445.AM2015-1256
Published: 01 August 2015
View article titled, Abstract 1256: MUC4 is negatively regulated by hypoxia in ROS-dependent manner in pancreatic cancer
Journal Articles

Abstract 271: Overexpression of hPaf1/PD2 in pancreatic cancer stem cells results in stemness and drug resistance: a novel target for pancreatic cancer therapy.

Arokia Priyanka Vaz, Moorthy P. Ponnusamy, Satyanarayana Rachagani, Parama Dey, Surinder Batra
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 271.
https://doi.org/10.1158/1538-7445.AM2013-271
Published: 15 April 2013
View article titled, Abstract 271: Overexpression of hPaf1/PD2 in pancreatic cancer stem cells results in stemness and drug resistance: a novel target for pancreatic cancer therapy.