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Journal Articles

Abstract 2282: Genetic architecture of breast cancer across diverse populations: Assessing heritability, genetic correlation, and polygenicity

Free
James L. Li, Maria Zanti, Jacob Williams, Om Jahagirdar, Guochong Jia, Qiang Hu, Jean-Tristan Brandenburg, Li Yan, Weang-Kee Ho, Jingmei Li, José P. Miranda, Devika Godbole, Julie-Alexia Dias, Leila Dorling, Wenlong C. Chen, Nicholas Boddicker, Ying Wang, Alicia Martin, Martin J. Zhang, Yan Zhang, Joe Dennis, Esther M. John, Gabriela Torres-Mejia, Larry Kushi, Jeffrey Weitzel, Susan L. Neuhausen, Luis Carvajal-Carmona, Christopher Haiman, Elad Ziv, Laura Fejerman, Wei Zheng, Dezheng Huo, Douglas Easton, Nilanjan Chatterjee, Peter Kraft, Montserrat Garcia-Closas, Wendy Wong, Kyriaki Michailidou, Qianqian Zhu, Diptavo Dutta, Thomas U. Ahearn, Haoyu Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2282.
https://doi.org/10.1158/1538-7445.AM2025-2282
Published: 21 April 2025
View articletitled, Abstract 2282: Genetic architecture of breast cancer across diverse populations: Assessing heritability, genetic correlation, and polygenicity
Journal Articles

Abstract 3594: Performance of common general-population breast cancer risk prediction models in 14 cohorts

Free
Kristen D. Brantley, Thomas U. Ahearn, Emily Norton, Julie Palmer, Gary Zirpoli, Matt Barnett, Marian L. Neuhouser, Lauren Teras, James Hodge, Thomas E. Rohan, Roger Milne, A. Heather Eliassen, Hongyan Huang, Yu Chen, Katie M. O'Brien, Cari Kitahara, Garnet Anderson, I-Min Lee, Nilanjan Chatterjee, Montserrat Garcia-Closas, Peter Kraft, Breast Cancer Risk Prediction Project
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3594.
https://doi.org/10.1158/1538-7445.AM2025-3594
Published: 21 April 2025
View articletitled, Abstract 3594: Performance of common general-population breast cancer risk prediction models in 14 cohorts
Journal Articles

Abstract 2286: Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci

Free
Guochong Jia, Jie Ping, Ran Tao, Jirong Long, Lili Liu, Shuai Xu, Stefan Ambs, Mollie E. Barnard, Yu Chen, Ji-Yeob Choi, Yu-Tang Gao, Montserrat Garcia-Closas, Jian Gu, Jennifer J. Hu, Motoki Iwasaki, Esther M. John, Sun-Seog Kweon, Koichi Matsuda, Keitaro Matsuo, Katherine L. Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Tuya Pal, Sue K. Park, Boyoung Park, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Song Yao, Ying Zheng, Prisca O. Adejumo, Thomas Ahearn, Abenaa M. Brewster, Anselm J. Hennis, Hidemi Ito, Michiaki Kubo, Eun-Sook Lee, Siew-Kee Low, Timothy Makumbi, Paul Ndom, Dong-Young Noh, Katie M. O'Brien, Andrew F. Olshan, Mojisola M. Oluwasanu, Min-Ho Park, Sonya Reid, Taiki Yamaji, Gary Zirpoli, Ebonee N. Butler, Wei Zheng
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2286.
https://doi.org/10.1158/1538-7445.AM2025-2286
Published: 21 April 2025
View articletitled, Abstract 2286: Integrating multi-ancestry genomic and proteomic data to identify blood risk biomarkers and target proteins for breast cancer genetic risk loci
Journal Articles

Abstract 7361: Scientific rationale and successful implementation of biospecimen collection in the NCI Connect Cohort for Cancer Prevention

Free
Nicolas A. Wentzensen, Stephanie Weinstein, Amanda Black, Erin Schwartz, Hannah P. Yang, Michelle Brotzman, Paul Albert, Laura Beane-Freeman, Amy Berrington, Jonas De Almeida, Jonine D. Figueroa, Montserrat Garcia-Closas, Nicole Gerlanc, Gretchen Gierach, Rena Jones, Peter Kraft, Charles Matthews, Habib Ahsan, Brisa Aschebrook-Kilfoy, Chun-Hung Chan, Robert Greenlee, Stacey Honda, Ben Rybicki, Blythe Ryerson, Katherine Sanchez, Mark Schmidt, Kevin Sykes, Larissa White, Jeanette Ziegenfuss, Stephen Chanock, Christian Abnet, Mia Gaudet
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7361.
https://doi.org/10.1158/1538-7445.AM2025-7361
Published: 21 April 2025
View articletitled, Abstract 7361: Scientific rationale and successful implementation of biospecimen collection in the NCI Connect Cohort for Cancer Prevention
Journal Articles

Abstract 3583: The Breast Cancer Risk Prediction Project: a resource of 1.8 million women with diverse backgrounds from 20 prospective cohorts to improve breast cancer risk prediction and advance breast cancer epidemiology

Free
Peter Kraft, Laura Beane-Freeman, Julie Palmer, Ellen O'Meara, Jeanine Genkinger, James Lacey, Thomas Rohan, Lauren Teras, Marian L. Neuhouser, Kala Visvanathan, Celine Vachon, Roger Milne, Christopher Haiman, Yu Chen, Heather Eliassen, Cari Kitahara, Katie O'Brien, Emily White, Garnet Anderson, I-Min Lee, Archie Campbell, Renee Fortner, Ylva Lagerros, Sven Sandin, Mia Gaudet, Montserrat Garcia-Closas, Nilanjan Chatterjee
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3583.
https://doi.org/10.1158/1538-7445.AM2025-3583
Published: 21 April 2025
View articletitled, Abstract 3583: The Breast Cancer Risk Prediction Project: a resource of 1.8 million women with diverse backgrounds from 20 prospective cohorts to improve breast cancer risk prediction and advance breast cancer epidemiology
Journal Articles

Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer

Available to Purchase
Xiaohui Sun, Shiv P. Verma, Guochong Jia, Xinjun Wang, Jie Ping, Xingyi Guo, Xiao-Ou Shu, Jianhong Chen, Andriy Derkach, Qiuyin Cai, Xiaolin Liang, Jirong Long, Kenneth Offit, Jung H. Oh, Anne S. Reiner, Gordon P. Watt, Meghan Woods, Yaohua Yang, Christine B. Ambrosone, Stefan Ambs, Yu Chen, Patrick Concannon, Montserrat Garcia-Closas, Jian Gu, Christopher A. Haiman, Jennifer J. Hu, Dezheng Huo, Esther M. John, Julia A. Knight, Christopher I. Li, Charles F. Lynch, Lene Mellemkjær, Katherine L. Nathanson, Barbara Nemesure, Olufunmilayo I. Olopade, Andrew F. Olshan, Tuya Pal, Julie R. Palmer, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Melissa A. Troester, Wei Zheng, Jonine L. Bernstein, Matthew F. Buas, Xiang Shu
Journal: Cancer Research
Cancer Res (2024) 84 (15): 2533–2548.
https://doi.org/10.1158/0008-5472.CAN-23-3854
Published: 01 August 2024
View articletitled, Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer
Open the PDF for Case-Case Genome-Wide Analyses Identify Subtype-Informative Variants That Confer Risk for Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 3464: Development and prospective validation of an estrogen receptor positive breast cancer risk model to identify women who could benefit for risk-reducing therapies

Free
Thomas U. Ahearn, Srijon Mukhopadhyay, Jeya Balasubramanian, Nilanjan Chatterjee, Montserrat García-Closas, Parichoy Pal Choudhury
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3464.
https://doi.org/10.1158/1538-7445.AM2024-3464
Published: 22 March 2024
View articletitled, Abstract 3464: Development and prospective validation of an estrogen receptor positive breast cancer risk model to identify women who could benefit for risk-reducing therapies
Journal Articles

Abstract 5241: Association of polygenic risk scores with breast cancer risk among women with benign breast disease

Free
Stacey J. Winham, Mark Sherman, Robert Vierkant, Bryan McCauley, Christopher Scott, Mia Gaudet, Melissa Troester, Sandhya Pruthi, Derek Radisky, Amy Degnim, Kristan Aronson, Rachel Murphy, Pascal Guenel, Therese Truong, Jenny Chang-Claude, Heiko Becher, Montserrat Garcia-Closas, Stephen Chanock, Thomas Ahearn, Xiaohong Yang, Doug Easton, Manjeet Bolla, Celine Vachon, Breast Cancer Association Consortium
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5241.
https://doi.org/10.1158/1538-7445.AM2023-5241
Published: 04 April 2023
View articletitled, Abstract 5241: Association of polygenic risk scores with breast cancer risk among women with benign breast disease
Journal Articles

Abstract 3670: Systematic literature review of risk factor associations with breast cancer subtypes in women of African, Asian, Hispanic, and European descents

Free
Amber N. Hurson, Thomas U. Ahearn, Renske Keeman, Mustapha Abubakar, Audrey Y. Jung, Pooja Middha Kapoor, Hela Koka, Xiaohong R. Yang, Jenny Chang-Claude, Elena Martínez, Rulla M. Tamimi, Melissa A. Troester, Elisa V. Bandera, Marjanka K. Schmidt, Montserrat Garcia-Closas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3670.
https://doi.org/10.1158/1538-7445.AM2022-3670
Published: 15 June 2022
View articletitled, Abstract 3670: Systematic literature review of risk factor associations with breast cancer subtypes in women of African, Asian, Hispanic, and European descents
Journal Articles

Abstract 2256: Validation of an integrated breast cancer risk model with mammographic density in three prospective cohort studies

Free
Charlotta V. Mulder, Yon Ho Jee, Xin Yang, Christopher G. Scott, Chi Gao, Amber N. Hurson, Mikael Eriksson, Per Hall, Peter Kraft, Celine M. Vachon, Antonis C. Antoniou, Gretchen Gierach, Montserrat Garcia-Closas, Parichoy Pal Choudhury
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2256.
https://doi.org/10.1158/1538-7445.AM2022-2256
Published: 15 June 2022
View articletitled, Abstract 2256: Validation of an integrated breast cancer risk model with mammographic density in three prospective cohort studies
Journal Articles

Gene-Level Germline Contributions to Clinical Risk of Recurrence Scores in Black and White Patients with Breast Cancer

Open Access
Achal Patel, Montserrat García-Closas, Andrew F. Olshan, Charles M. Perou, Melissa A. Troester, Michael I. Love, Arjun Bhattacharya
Journal: Cancer Research
Cancer Res (2022) 82 (1): 25–35.
https://doi.org/10.1158/0008-5472.CAN-21-1207
Published: 01 January 2022
View articletitled, Gene-Level Germline Contributions to Clinical Risk of Recurrence Scores in Black and White Patients with Breast Cancer
Open the PDF for Gene-Level Germline Contributions to Clinical Risk of Recurrence Scores in Black and White Patients with Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 826: Large-scale genome-wide association study identifies multiple novel germline susceptibility variants associated with bladder cancer risk

Free
Stella Koutros, Lambertus A. Kiemeney, Roger L. Milne, Yuanqing Ye, Vijai Joseph, Jonine Figueroa, Nilanjan Chatterjee, Graham G. Giles, Michelle A. Hildebrandt, Lars Dyrskjot, Kenneth Offit, Manolis Kogevinas, Elisabete Weiderpass, Marjorie L. McCullough, Neal D. Freedman, Demetrius Albanes, Charles Kooperberg, Victoria Cortessis, Margaret R. Karagas, Dalsu Baris, Alison Johnson, Molly R. Schwenn, Helena Furberg, Dean F. Bajorin, Parichoy Pal Choudhury, Oscar Florez-Vargas, Olivier Cussenot, Geraldine Cancel-Tassin, Simone Benhamou, Peter Kraft, Stefano Porru, Mark P. Purdue, Katherine A. McGlynn, Cari M. Kitahara, Christopher A. Haiman, Mark H. Greene, Thorunn Rafnar, Stephen J. Chanock, Xifeng Wu, Francisco X. Real, Debra T. Silverman, Montserrat Garcia-Closas, Kari Stefansson, Ludmila Prokunina-Olsson, Nuria Malats, Nathaniel Rothman
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 826.
https://doi.org/10.1158/1538-7445.AM2021-826
Published: 01 July 2021
View articletitled, Abstract 826: Large-scale genome-wide association study identifies multiple novel germline susceptibility variants associated with bladder cancer risk
Journal Articles

Abstract 865: Genomic and evolutionary classification of lung cancer in never smokers from the Sherlock-Lung study

Free
Tongwu Zhang, Ludmil B. Alexandrov, Wei Zhao, Jian Sang, Jianxin Shi, Bin Zhu, Dmitry A. Gordenin, Montserrat Garcia-Closas, Qing Lan, Nathaniel Rothman, Stephen J. Chanock, David C. Wedge, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 865.
https://doi.org/10.1158/1538-7445.AM2021-865
Published: 01 July 2021
View articletitled, Abstract 865: Genomic and evolutionary classification of lung cancer in never smokers from the Sherlock-Lung study
Journal Articles

Abstract 876: TP53 pathway function, estrogen receptor status, and breast cancer risk factors in the Carolina Breast Cancer Study

Free
Amber N. Hurson, Mustapha Abubakar, Kathleen Conway-Dorsey, Katherine Hoadley, Michael I. Love, Andrew F. Olshan, Montserrat Garcia-Closas, Melissa A. Troester
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 876.
https://doi.org/10.1158/1538-7445.AM2021-876
Published: 01 July 2021
View articletitled, Abstract 876: TP53 pathway function, estrogen receptor status, and breast cancer risk factors in the Carolina Breast Cancer Study
Journal Articles

Abstract 2320: Evaluating a polygenic risk score for breast cancer in women of African ancestry

Free
Zhaohui Du, Guimin Gao, Babatunde Adedokun, Thomas Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Melissa Troester, Edward A. Ruiz-Narváez, Stephen Haddad, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa V. Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu A. Ojengbede, William Blot, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David V. Conti, Olufunmilayo I. Olopade, Julie R. Palmer, Montserrat Garcia-Closas, Dezheng Huo, Christopher A. Haiman
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 2320.
https://doi.org/10.1158/1538-7445.AM2020-2320
Published: 15 August 2020
View articletitled, Abstract 2320: Evaluating a polygenic risk score for breast cancer in women of African ancestry
Journal Articles

Abstract 28: Integrating genomic and transcriptomic data to identify genetic loci associated with breast cancer risk in women of African ancestry

Free
Guochong Jia, Jie Ping, Yaohua Yang, Maureen Sanderson, Qiuyin Cai, Xingyi Guo, William J. Blot, Bingshan Li, Elisa V. Bandera, Manjeet K. Bolla, Montserrat García-Closas, Douglas F. Easton, Mary K. Fadden, Jian Gu, Dezheng Huo, Esther M. John, Kathryn L. Lunetta, Olufunmilayo I. Olopade, Xiang Shu, Melissa A. Troester, Song Yao, Breast Cancer Association Consortium, Andrew F. Olshan, Christine B. Ambrosone, Christopher A. Haiman, Jirong Long, Julie R. Palmer, Wei Zheng
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 28.
https://doi.org/10.1158/1538-7445.AM2020-28
Published: 15 August 2020
View articletitled, Abstract 28: Integrating genomic and transcriptomic data to identify genetic loci associated with breast cancer risk in women of African ancestry
Journal Articles

Abstract 4613: Cross-ancestry genome-wide association study identifies six new loci for breast cancer in women of African and european ancestry

Free
Babatunde Adedokun, Zhaohui Du, Guimin Gao, Thomas Ahearn, Kathryn L. Lunetta, Gary Zirpoli, Jonine Figueroa, Esther M. John, Leslie Bernstein, Wei Zheng, Jennifer J. Hu, Regina G. Ziegler, Sarah Nyante, Elisa V. Bandera, Sue A. Ingles, Michael F. Press, Sandra L. Deming, Jorge L. Rodriguez-Gil, Song Yao, Temidayo O. Ogundiran, Oladosu Ojengbede, William Blot, Melissa Troester, Katherine L. Nathanson, Anselm Hennis, Barbara Nemesure, Stefan Ambs, Lara E. Sucheston-Campbell, Jeannette T. Bensen, Stephen J. Chanock, Andrew F. Olshan, Christine B. Ambrosone, David V. Conti, Olufunmilayo I. Olopade, Montserrat Garcia-Closas, Julie R. Palmer, Christopher A. Haiman, Dezheng Huo
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4613.
https://doi.org/10.1158/1538-7445.AM2020-4613
Published: 15 August 2020
View articletitled, Abstract 4613: Cross-ancestry genome-wide association study identifies six new loci for breast cancer in women of African and european ancestry
Journal Articles

Abstract 4636: Breast cancer age-specific incidence rates among Ghanaian women by breast cancer risk factors: A study using census and population-based case-control study data

Free
Brittny Davis Lynn, Jonine Figueroa, Richard Biritwum, Beatrice Wiafe Addai, Baffour Awuah, Joe Net Clegg-Lamptey, Robertson Adjei, Lucy Afriyie, Joel Yarney, Naomi Oyoe Ohene Oti, Daniel Ansong, Seth Wiafe, Louise Brinton, Montserrat Garcia-Closas, Barry Graubard
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4636.
https://doi.org/10.1158/1538-7445.AM2020-4636
Published: 15 August 2020
View articletitled, Abstract 4636: Breast cancer age-specific incidence rates among Ghanaian women by breast cancer risk factors: A study using census and population-based case-control study data
Journal Articles

Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis

Free
Kelly L. Bolton, Ryan N. Ptashkin, Teng Gao, Lior Braunstein, Sean M. Devlin, Minal Patel, Antonin Berthon, Aijazuddin Syed, Mariko Yabe, Catherine Coombs, Nicole M. Caltabellotta, Mike Walsh, Ken Offit, Zsofia Stadler, Choonsik Lee, Paul Pharoah, Konrad H. Stopsack, Barbara Spitzer, Simon Mantha, James Fagin, Laura Boucai, Christopher J. Gibson, Benjamin Ebert, Andrew L. Young, Todd Druley, Koichi Takahashi, Nancy Gillis, Markus Ball, Eric Padron, David Hyman, Jose Baselga, Larry Norton, Stuart Gardos, Virginia Klimek, Howard Scher, Dean Bajorin, Eder Paraiso, Ryma Benayed, Maria Arcilla, Marc Ladanyi, David Solit, Michael Berger, Martin Tallman, Montserrat Garcia-Closas, Nilanjan Chatterjee, Luis Diaz, Ross Levine, Lindsay Morton, Ahmet Zehir, Elli Papaemmanuil
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5703.
https://doi.org/10.1158/1538-7445.AM2020-5703
Published: 15 August 2020
View articletitled, Abstract 5703: Oncologic therapy shapes the fitness landscape of clonal hematopoiesis
Journal Articles

Abstract 4638: Associations of fecal microbial profiles with non-malignant breast disease and breast cancer in the Ghana Breast Health Study

Free
Doratha Byrd, Emily Vogtmann, Zeni Wu, Autumn Hullings, Xing Hua, Thomas Ahearn, James J. Goedert, Jianxin Shi, Jonine Figueroa, Louise Brinton, Montserrat Garcia-Closas, Rashmi Sinha
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4638.
https://doi.org/10.1158/1538-7445.AM2020-4638
Published: 15 August 2020
View articletitled, Abstract 4638: Associations of fecal microbial profiles with non-malignant breast disease and breast cancer in the Ghana Breast Health Study