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Mohd Zainuddin
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Journal Articles

Abstract B029: LSD1-HDAC6 dual inhibitor JBI-802 is an epigenetic modulating agent with a novel mechanism of action that target MYC amplification in multiple neuroendocrine tumor types

Free
Dhanalakshmi Sivanandhan, Sridharan Rajagopal, Chandru Gajendran, Naveen Sadhu, Mohd Zainuddin, Ramachandraiah Gosu, Luca Rastelli
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): B029.
https://doi.org/10.1158/1538-7445.CancEpi22-B029
Published: 01 December 2022
View articletitled, Abstract B029: LSD1-HDAC6 dual inhibitor JBI-802 is an epigenetic modulating agent with a novel mechanism of action that target MYC amplification in multiple neuroendocrine tumor types
Journal Articles

A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression

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Hui Deng, Cindy Lin, Laura Garcia-Gerique, Shuyu Fu, Zachary Cruz, Erin E. Bonner, Matthew Rosenwasser, Sridharan Rajagopal, M Naveen Sadhu, Chandru Gajendran, Mohd Zainuddin, Ramachandraiah Gosu, Dhanalakshmi Sivanandhan, Miriam A. Shelef, Brian Nam, Dan T. Vogl, Dmitry I. Gabrilovich, Yulia Nefedova
Journal: Cancer Research
Cancer Res (2022) 82 (19): 3561–3572.
https://doi.org/10.1158/0008-5472.CAN-21-4045
Published: 04 October 2022
View articletitled, A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression
Open the PDF for A Novel Selective Inhibitor JBI-589 Targets PAD4-Mediated Neutrophil Migration to Suppress Tumor Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 2646: Novel, isoform selective PAD4 inhibitors for the treatment of cancer

Free
Dhanalakshmi Sivanandhan, Sridharan Rajagopal, Chandru G, Mohd Zainuddin, Naveen Sadhu, Ramachandraiah Gosu, Luca Rastelli, Amir Siddiqui, Sharad Singh, Rudresh G, Sadanand Mullurwar, Saravanan Kandan, Santosh Vishwakarma, Gurulingappa Hallur, Ravi Trivedi, Jeyaraj D A
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2646.
https://doi.org/10.1158/1538-7445.AM2022-2646
Published: 15 June 2022
View articletitled, Abstract 2646: Novel, isoform selective PAD4 inhibitors for the treatment of cancer
Journal Articles

Abstract 1756: JBI-802, novel dual inhibitor of LSD1-HDAC6 for treatment of cancer

Free
Dhanalakshmi Sivanandhan, Sridharan Rajagopal, Sreekala Nair, Basavaprabhu B, Reshma Dhkar, Santosh Viswakarma, Amir Siddiqui, Mohd Zainuddin, Rudresh G, Prashanthi Daram, Sunil Mohire, Krishnakumar V
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1756.
https://doi.org/10.1158/1538-7445.AM2020-1756
Published: 15 August 2020
View articletitled, Abstract 1756: JBI-802, novel dual inhibitor of LSD1-HDAC6 for treatment of cancer
Journal Articles

Abstract 11: Novel dual inhibitors of LSD1-HDAC6/8 for treatment of cancer

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Dhanalakshmi Sivanandhan, Sridharan Rajagopal, Sreekala Nair, Chandru Gajendran, Dimpy Ghosh, P Nagaraj, Subramanyam J. Tantry, Purushottam Dewang, Mahanandeesha S. Hallur, Kannan Murugan, Srinatha K. C, Damodara Kuntrapaku, M Dilipkumar, R Sharma, S Meghashree, Durga Prasanna Kumar, Suraj P. Ingle, Mohd Zainuddin, A B. Vinod, Sriram Rajagopal
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 11.
https://doi.org/10.1158/1538-7445.AM2019-11
Published: 01 July 2019
View articletitled, Abstract 11: Novel dual inhibitors of LSD1-HDAC6/8 for treatment of cancer
Journal Articles

Abstract 4856: Novel, small-molecule PRMT5 inhibitors for treatment of cancer

Free
Dhanalakshmi Sivanandhan, Shivani Garapaty, Saravanan Vadivelu, Guru Pavan Kumar Seerapu, Reshma Das, Ronodip Kar, Anuj Kumar Singh, Venkatesha Ashokkumar Venkateshappa, Natarajan Tamizharasan, Indu N. Swamy, Nagendra Nagaraju, Subramaniyam Kanagaraj, Sayanti Sarkar, Jagadish D. Tibhe, Rudresh G, Mohd Zainuddin, Saravanan Kandan, Sridharan Rajagopal, Sriram Rajagopal
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4856.
https://doi.org/10.1158/1538-7445.AM2018-4856
Published: 01 July 2018
View articletitled, Abstract 4856: Novel, small-molecule PRMT5 inhibitors for treatment of cancer
Journal Articles

Abstract 5552: Novel, heterocyclic small molecule inhibitors of PD-1 and PD-L1 pathway

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Sivanandhan Dhanalakshmi, Shivani Garapaty, Chandregowda Venkateshappa, Guru Pavan Seerapu, Reshma Das, Pradeep Nagaraj, Ronodip Kar, Anuj Kumar Singh, Venkatesha Ashokkumar Venkatesubbiah, Ramakishore VP Putta, Muralidhar Pendyala, Girisha Lokesh, Hari Madaka, Harikrishna Reddy Thummuru, Shikas AP, Prateeksha Anchan, Prathima Bhat, Rudresha G, Mohd Zainuddin, Krishnakumar V, Ramachandraiah Gosu, Rajendra Kristam, Jeyaraj DA, Sriram Rajagopal
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5552.
https://doi.org/10.1158/1538-7445.AM2018-5552
Published: 01 July 2018
View articletitled, Abstract 5552: Novel, heterocyclic small molecule inhibitors of PD-1 and PD-L1 pathway
Journal Articles

Abstract 1382: Novel dual inhibitors of LSD1-HDAC6/8 for treatment of cancer

Free
Sivanandhan Dhanalakshmi, Sridharan Rajagopal, Sreekala Nair, Chandru Gajendran, Dimpy Ghosh, Subramanyam Janardhan Tantry, Purushottam Dewang, Mahanandeesha Hallur, M Kannan, Srinatha KC, Damodara Kuntrapaku, M Dilipkumar, Radha Sharma, S Meghashree, D P. Kumar, Mohd Zainuddin, A B. Vinod, Sriram Rajagopal
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1382.
https://doi.org/10.1158/1538-7445.AM2018-1382
Published: 01 July 2018
View articletitled, Abstract 1382: Novel dual inhibitors of LSD1-HDAC6/8 for treatment of cancer
Journal Articles

Abstract 5860: Novel, first-in-class dual inhibitors of lysine specific demethylase 1 (LSD1) and histone deacetylatse 1 (HDAC) for treatment of cancer

Free
Dhanalakshmi Sivanandhan, Sreekala Nair, Subramaniyam Tantry, Sridharan Rajagopal, Mahanandeesha Hallur, Kannan M, Srinatha KC, Damodara K, Dilipkumar M, Chandru G, Dimpy Ghosh, Pradeep N, Anuj Kumar Singh, Mohd Zainuddin, Rudresh G, Radha Sharma, Meghashree S, Durga P. Kumar, Purushottam Dewang, Sriram Rajagopal
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5860.
https://doi.org/10.1158/1538-7445.AM2018-5860
Published: 01 July 2018
View articletitled, Abstract 5860: Novel, first-in-class dual inhibitors of lysine specific demethylase 1 (LSD1) and histone deacetylatse 1 (HDAC) for treatment of cancer
Journal Articles

Abstract 187: ASN0007, a potent ERK1/2 inhibitor with strong antitumor activity in multiple RAS mutant models

Free
Sanjeeva P. Reddy, Dhanalakshmi Sivanandhan, Raghava Reddy Kethiri, Sreekala Nair, Purushottam Dewang, Mohd Zainuddin, Krishnakumar Vaithilingam, Roger A. Smith, Sandeep Gupta, Scott K. Thompson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 187.
https://doi.org/10.1158/1538-7445.AM2016-187
Published: 15 July 2016
View articletitled, Abstract 187: ASN0007, a potent ERK1/2 inhibitor with strong antitumor activity in multiple RAS mutant models
Journal Articles

Abstract 3286: Oral bioavailability, permeability, CYP profiling, identification of major metabolites, tissue distribution and excretion profile of a novel triple kinase inhibitor, JI-101 in rats

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Sandip Dhondiram Gurav, Ravindranath Reddy Gilibili, Sherine Jeniffer, Mohd Zainuddin, Sanjeev Giri, Raman Govindrajan, Mark Velleca, Srinivas Nuggehally, Ramesh Mullangi
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3286.
https://doi.org/10.1158/1538-7445.AM2011-3286
Published: 15 April 2011
View articletitled, Abstract 3286: Oral bioavailability, permeability, CYP profiling, identification of major metabolites, tissue distribution and excretion profile of a novel triple kinase inhibitor, JI-101 in rats