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Mohammad Hekmat-Nejad
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Journal Articles

Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF

Wenlin Shao, Yuji M. Mishina, Yun Feng, Giordano Caponigro, Vesselina G. Cooke, Stacy Rivera, Yingyun Wang, Fang Shen, Joshua M. Korn, Lesley A. Mathews Griner, Gisele Nishiguchi, Alice Rico, John Tellew, Jacob R. Haling, Robert Aversa, Valery Polyakov, Richard Zang, Mohammad Hekmat-Nejad, Payman Amiri, Mallika Singh, Nicholas Keen, Michael P. Dillon, Emma Lees, Savithri Ramurthy, William R. Sellers, Darrin D. Stuart
Journal: Cancer Research
Cancer Res (2018) 78 (6): 1537–1548.
https://doi.org/10.1158/0008-5472.CAN-17-2033
Published: 14 March 2018
View article titled, Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF
Open the PDF for Antitumor Properties of RAF709, a Highly Selective and Potent Inhibitor of RAF Kinase Dimers, in Tumors Driven by Mutant RAS or BRAF in another window
Includes: Supplementary data
Journal Articles

Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation

Wenlin Shao, Yuji Mishina, Yun Feng, Giordano Caponigro, Savithri Ramurthy, Vesselina Cooke, Lesley Griner, Gisele Nishiguchi, Alice Rico, Ben Taft, Matthew Burger, Huw Tanner, Valery Polyakov, Brent Appleton, John Tellew, Richard Zang, Mohammad Hekmat-Nejad, Payman Amiri, Mallika Singh, Darrin Stuart
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 330.
https://doi.org/10.1158/1538-7445.AM2016-330
Published: 15 July 2016
View article titled, Abstract 330: Development of a highly selective B/CRAF kinase inhibitor that exhibits antitumor activities in RAS and BRAF mutant tumors with minimal paradoxical activation
Journal Articles

Abstract LB-121: Dissecting MAPK pathway in BRAFmut melanoma: Intricacies of ERK1 and ERK2

Tatiana Zavorotinskaya, Upasana Mehra, Yumin Dai, Michel Faure, Ken Crawford, Karen Yu, Jan Marie Cheng, Xiaolei Ma, Jan Xuan, Kelly Yan, Mohammad Hekmat-Nejad, Hanne Merritt, Darrin Stuart, Charles Voliva
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-121.
https://doi.org/10.1158/1538-7445.AM2014-LB-121
Published: 01 October 2014
View article titled, Abstract LB-121: Dissecting MAPK pathway in BRAF<sup>mut</sup> melanoma: Intricacies of ERK1 and ERK2
Journal Articles

Abstract LB-28: RAF inhibitors activate MAPK pathway through relief of RAF auto-inhibition

Matthew Holderfield, Hanne Merritt, John Chan, Marco Wallroth, Laura Tandeske, Steve Hardy, Mohammad Hekmat-Nejad, Frank McCormick, Tobi Nagel
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-28.
https://doi.org/10.1158/1538-7445.AM2011-LB-28
Published: 15 April 2011
View article titled, Abstract LB-28: RAF inhibitors activate MAPK pathway through relief of RAF auto-inhibition