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Mitchell J. Machiela
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Journal Articles

Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification

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Aubrey K. Hubbard, Derek W. Brown, Jie Liu, Irenaeus C. Chan, Weiyin Zhou, Giulio Genovese, Alexander DePaulis, Sruthi Srinivasan, Shu-Hong Lin, Batel Blechter, Ian D. Buller, Qinglin Zeng, Yin Cao, Wen-Yi Huang, Neal D. Freedman, Haoyu Zhang, Diptavo Dutta, Stephen J. Chanock, Kelly L. Bolton, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-4251
Published: 30 April 2025
View articletitled, Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification
Open the PDF for Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification in another window
Includes: Supplementary data
Journal Articles

Abstract 7415: Association between sleep traits and risk of non-Hodgkin's lymphoma subtypes: a mendelian randomization study in the International Lymphoma Epidemiology (InterLymph) Consortium

Free
Pankhil Shah, Brittany Crawford, Anwar Merchant, Brenda Birmann, Angelica Macauda, Michelle A. Hildebrandt, Aaron Norman, Neil E. Caporaso, Meredith Yeager, Michael Dean, Immaculata De Vivo, Lynn Goldin, Nicola J. Camp, Rosalie Griffin, Delphine Casabonne, Federico Canzian, Pelin Unal, Elad Ziv, Catherine R. Marinac, Alexandra Nieters, Stephen J. Chanock, Mitchell J. Machiela, Michael Conry, Charlie Zhong, Hanla A. Park, Simon Cheah, Jonathan N. Hofmann, Elizabeth E. Brown, Celine Vachon, Susan Slager, Sonja Berndt, Sophia S. Wang, Vijai Joseph, James McKay, Henrik Hjalgrim, Lara Sucheston-Campbell, Karl Smith-Byrne, Alyssa Clay-Gilmour
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7415.
https://doi.org/10.1158/1538-7445.AM2025-7415
Published: 21 April 2025
View articletitled, Abstract 7415: Association between sleep traits and risk of non-Hodgkin's lymphoma subtypes: a mendelian randomization study in the International Lymphoma Epidemiology (InterLymph) Consortium
Journal Articles

Abstract 4916: Co-occurring clonal hematopoiesis in UK Biobank participants with prior cancer

Free
Kara Marie Barnao, Aubrey K. Hubbard, Irenaeus Chan, Weiyin Zhou, Corey D. Young, Rebecca L. Kelly, Derek W. Brown, Giulio Genovese, Duc Tran, Yin Cao, Stephen J. Chanock, Kelly L. Bolton, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4916.
https://doi.org/10.1158/1538-7445.AM2025-4916
Published: 21 April 2025
View articletitled, Abstract 4916: Co-occurring clonal hematopoiesis in UK Biobank participants with prior cancer
Journal Articles

Abstract 4096: Altered epigenetic aging in leukocytes with detectable mosaic chromosomal alterations

Free
Corey D. Young, Derek W. Brown, Charles Breeze, Rebecca L. Kelly, Kara M. Barnao, Aubrey K. Hubbard, Weiyin Zhou, Amy A. Hutchinson, Belynda D. Hicks, Aurélie L. Vogt, Wen-Yi Huang, Steven C. Moore, Stephen J. Chanock, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4096.
https://doi.org/10.1158/1538-7445.AM2025-4096
Published: 21 April 2025
View articletitled, Abstract 4096: Altered epigenetic aging in leukocytes with detectable mosaic chromosomal alterations
Journal Articles

Abstract 7368: Serum concentrations of per- and polyfluoroalkyl substances and mosaic loss of chromosome Y among men in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

Free
Jongeun Rhee, Vicky C. Chang, Weiyin Zhou, Mitchell J. Machiela, Jonathan N. Hofmann, Mark P. Purdue, Sonja I. Berndt
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7368.
https://doi.org/10.1158/1538-7445.AM2025-7368
Published: 21 April 2025
View articletitled, Abstract 7368: Serum concentrations of per- and polyfluoroalkyl substances and mosaic loss of chromosome Y among men in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
Journal Articles

Abstract 6154: Targeted CRISPRi screen identifies functional variants and novel target genes at multiple renal cell carcinoma (RCC) susceptibility loci

Free
Timothy Winter, Timothy Myers, Leandro Colli, Lea Jessop, Jiyeon Choi, Mitchell J. Machiela, Mark P. Purdue, Kevin Brown, Stephen Chanock
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6154.
https://doi.org/10.1158/1538-7445.AM2024-6154
Published: 22 March 2024
View articletitled, Abstract 6154: Targeted CRISPRi screen identifies functional variants and novel target genes at multiple renal cell carcinoma (RCC) susceptibility loci
Journal Articles

Abstract 2205: Modifiable risk factors are associated with clonal hematopoiesis

Free
Corey D. Young, Aubrey K. Hubbard, Pedro Saint-Maurice, Irenaeus Chan, Kelly L. Bolton, Stephen J. Chanock, Charles Matthews, Steven C. Moore, Erikka Loftfield, Yin Cao, Mitchell J. Machiela, Duc Tran
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2205.
https://doi.org/10.1158/1538-7445.AM2024-2205
Published: 22 March 2024
View articletitled, Abstract 2205: Modifiable risk factors are associated with clonal hematopoiesis
Journal Articles

Abstract 775: Underlying germline genetic architecture of pediatric sarcomas: Evaluating the role of common and rare variants in 4,160 patients

Free
Lisa Mirabello, Laura E. Egolf, Bin Zhu, D. Matthew Gianferante, Kevin Wang, Shengchao Alfred Li, Mitchell J. Machiela, Logan G. Spector, Joshua D. Schiffman, Aniko Sabo, Alexander Renwick, Bailey Martin-Giacalone, Michael E. Scheurer, Sharon Plon, Douglas Hawkins, Rajkumar Venkatramani, Douglas Stewart, Lindsay M. Morton, Melissa M. Hudson, Gregory T. Armstrong, Smita Bhatia, Michael Dean, Katherine A. Janeway, Ana Patiño-Garcia, Fernando Lecanda, Massimo Serra, Claudia Hattinger, Katia Scotlandi, Adrienne M. Flanagan, Fernanda Amary, Irene L. Andrulis, Jay S. Wunder, Mandy L. Ballinger, David M. Thomas, Olivier Delattre, Aubrey K. Hubbard, Jia Liu, Wen Luo, Belynda D. Hicks, Meredith Yeager, Maryam Rafati, Wen-Yi Huang, Maria T. Landi, Adriana Lori, Ryan Diver, Sharon A. Savage, Stephen J. Chanock, Philip J. Lupo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 775.
https://doi.org/10.1158/1538-7445.AM2024-775
Published: 22 March 2024
View articletitled, Abstract 775: Underlying germline genetic architecture of pediatric sarcomas: Evaluating the role of common and rare variants in 4,160 patients
Journal Articles

Abstract 3433: Characterization of co-occurring clonal hematopoiesis to identify high risk clones associated with hematologic cancer risk

Free
Kara M. Barnao, Aubrey K. Hubbard, Weiyin Zhou, Irenaeus Chan, Duc Tran, Yin Cao, Stephen J. Chanock, Kelly L. Bolton, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3433.
https://doi.org/10.1158/1538-7445.AM2024-3433
Published: 22 March 2024
View articletitled, Abstract 3433: Characterization of co-occurring clonal hematopoiesis to identify high risk clones associated with hematologic cancer risk
Journal Articles

Abstract 3430: Mosaic loss of the Y chromosome is associated with prostate cancer risk

Free
Rebecca L. Kelly, Weiyin Zhou, Kara M. Barnao, Corey D. Young, Aubrey K. Hubbard, Sairah M. Khan, Wen-Yi Huang, Stephen J. Chanock, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3430.
https://doi.org/10.1158/1538-7445.AM2024-3430
Published: 22 March 2024
View articletitled, Abstract 3430: Mosaic loss of the Y chromosome is associated with prostate cancer risk
Journal Articles

Abstract 6151: Relationship between polygenic risk score, lifestyle factors, and colorectal cancer risk

Free
Wen-Yi Huang, Erikka Loftfield, Rebecca Landy, Difei Wang, Hormuzd A. Katki, Jianxin Shi, Lingxiao Wang, Mitchell J. Machiela, Neal D. Freedman, Sonja I. Berndt
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6151.
https://doi.org/10.1158/1538-7445.AM2024-6151
Published: 22 March 2024
View articletitled, Abstract 6151: Relationship between polygenic risk score, lifestyle factors, and colorectal cancer risk
Journal Articles

Abstract 6148: Multiple new Ewing sarcoma susceptibility loci expand knowledge of germline genetic etiology and nominate mechanisms of risk

Free
Aubrey K. Hubbard, Weiyin Zhou, Carrie Boyce, Javed Khan, Melissa M. Hudson, Kirsten K. Ness, Zhaoming Wang, Katherine A. Janeway, Philip J. Lupo, Lindsay M. Morton, Stephen J. Chanock, Thomas G. Grünewald, Olivier Delattre, Mitchell J. Machiela, Ewing Sarcoma Germline Genetics Group
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6148.
https://doi.org/10.1158/1538-7445.AM2024-6148
Published: 22 March 2024
View articletitled, Abstract 6148: Multiple new Ewing sarcoma susceptibility loci expand knowledge of germline genetic etiology and nominate mechanisms of risk
Journal Articles

Abstract 6144: A polymorphic TERT tandem repeat creating an expandable intronic G4 quadruplex is associated with TERT expression, relative leukocyte telomere length and cancer risk

Free
Oscar Florez-Vargas, Michelle Ho, Max Hogshead, Chia-Han Lee, Kaitlin Forsythe, Brenen Papenberg, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Mikhail Kolmogorov, Stephen J. Chanock, Mitchell J. Machiela, John Schneekloth, Shahinaz Gadalla, Sharon A. Savage, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6144.
https://doi.org/10.1158/1538-7445.AM2024-6144
Published: 22 March 2024
View articletitled, Abstract 6144: A polymorphic TERT tandem repeat creating an expandable intronic G4 quadruplex is associated with TERT expression, relative leukocyte telomere length and cancer risk
Journal Articles

Abstract 4220: Occupational pesticide use and relative leukocyte telomere length in the biomarkers of exposure and effect in agriculture study

Free
Patricia A. Erickson, Vicky C. Chang, Casey L. Dagnall, Kedest Teshome, Mitchell J. Machiela, Kathryn H. Barry, Shahinaz M. Gadalla, Laura E. Beane Freeman, Gabriella Andreotti, Jonathan N. Hofmann
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4220.
https://doi.org/10.1158/1538-7445.AM2023-4220
Published: 04 April 2023
View articletitled, Abstract 4220: Occupational pesticide use and relative leukocyte telomere length in the biomarkers of exposure and effect in agriculture study
Journal Articles

Abstract 1185: Mosaic chromosomal alterations are independent predictors of chronic lymphocytic leukemia risk

Free
Aubrey K. Hubbard, Alexander DePaulis, Sruthi Srinivasan, Ian D. Buller, Shu-Hong Lin, Weiyin Zhou, Stephen J. Chanock, Neal D. Freedman, Derek W. Brown, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1185.
https://doi.org/10.1158/1538-7445.AM2023-1185
Published: 04 April 2023
View articletitled, Abstract 1185: Mosaic chromosomal alterations are independent predictors of chronic lymphocytic leukemia risk
Journal Articles

Abstract 980: Genomic characterization of lymph node metastases in papillary thyroid carcinoma following the Chernobyl accident reveals an expression profile specific to metastatic process

Free
Olivia W. Lee, Danielle M. Karyadi, Chip Stewart, Tetiana I. Bogdanova, Jieqiong Dai, Stephen W. Hartley, Sara J. Schonfeld, Vidushi Kapoor, Marko Krznaric, Meredith Yeager, Amy Hutchinson, Belynda D. Hicks, Casey L. Dagnall, Julie M. Gastier-Foster, Jay Bowen, Mitchell J. Machiela, Elizabeth K. Cahoon, Kiyohiko Mabuchi, Vladimir Drozdovitch, Sergii Masiuk, Mykola Chepurny, Liudmyla Y. Zurnadzhy, Amy Berrington de González, Gad Getz, Gerry A. Thomas, Mykola D. Tronko, Lindsay M. Morton, Stephen J. Chanock
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 980.
https://doi.org/10.1158/1538-7445.AM2022-980
Published: 15 June 2022
View articletitled, Abstract 980: Genomic characterization of lymph node metastases in papillary thyroid carcinoma following the Chernobyl accident reveals an expression profile specific to metastatic process
Journal Articles

Abstract 1202: Genetically inferred telomere length is associated with clonal copy number alterations in peripheral leukocytes

Free
Derek W. Brown, Shu-Hong Lin, Stephen J. Chanock, Sharon A. Savage, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2020-1202
Published: 15 August 2020
View articletitled, Abstract 1202: Genetically inferred telomere length is associated with clonal copy number alterations in peripheral leukocytes
Journal Articles

LDtrait: An Online Tool for Identifying Published Phenotype Associations in Linkage Disequilibrium

Free
Shu-Hong Lin, Derek W. Brown, Mitchell J. Machiela
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (16): 3443–3446.
https://doi.org/10.1158/0008-5472.CAN-20-0985
Published: 14 August 2020
View articletitled, LDtrait: An Online Tool for Identifying Published Phenotype Associations in Linkage Disequilibrium
Open the PDF for LDtrait: An Online Tool for Identifying Published Phenotype Associations in Linkage Disequilibrium in another window
Includes: Supplementary data
Journal Articles

Abstract 607: Clonal hematopoiesis alters blood cell counts in the UK Biobank

Free
Mitchell J. Machiela, Weiyin Zhou, Erikka Loftfield, Meredith Yeager, Neal D. Freedman, Stephen J. Chanock
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 607.
https://doi.org/10.1158/1538-7445.AM2019-607
Published: 01 July 2019
View articletitled, Abstract 607: Clonal hematopoiesis alters blood cell counts in the UK Biobank
Journal Articles

Abstract 1587: Integrated renal cancer post-GWAS functional studies implicates the SWI/SNF DPF3 gene on 14q24 risk locus

Free
Leandro Machado Colli, Lea Jessop, Sabrina Y. Camp, Timothy Myers, Mitchell J. Machiela, Jiyeon Choi, Kai Yu, Mark Purdue, Kevin Brown, Stephen J. Chanock
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1587.
https://doi.org/10.1158/1538-7445.AM2019-1587
Published: 01 July 2019
View articletitled, Abstract 1587: Integrated renal cancer post-GWAS functional studies implicates the SWI/SNF DPF3 gene on 14q24 risk locus