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Journal Articles

Abstract 1911: Platform agnostic lung cancer plasma signature identified using multidimensional proteomics and explainable machine learning

Free
Peter Jianrui Liu, Harriet R. Ferguson, Luke Hankey, Honglei Huang, Junetha Syed, Iliyana Kaneva, Ella Mi, Daniel A. Szulc, Luna Jia Zhan, Devalben Patel, Ming-Sound Tsao, Roman Fischer, Benedikt M. Kessler, Geoffrey Liu, Nikola I. Gushterov, Andreas J. Halner
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1911.
https://doi.org/10.1158/1538-7445.AM2025-1911
Published: 21 April 2025
View articletitled, Abstract 1911: Platform agnostic lung cancer plasma signature identified using multidimensional proteomics and explainable machine learning
Journal Articles

Abstract 5533: Drug tolerance mechanisms in patient-derived xenograft models with epidermal growth factor receptor mutated tumors treated with tyrosine kinase inhibitors

Free
Arundhathi Arivajiagane, Quan Li, Nhu-An Pham, Ming Li, Katrina Hueniken, Takamasa Koga, Nikolina Radulovich, Ming-Sound Tsao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5533.
https://doi.org/10.1158/1538-7445.AM2025-5533
Published: 21 April 2025
View articletitled, Abstract 5533: Drug tolerance mechanisms in patient-derived xenograft models with epidermal growth factor receptor mutated tumors treated with tyrosine kinase inhibitors
Journal Articles

Abstract 2147: Radiosensitization via ATM inhibition in small cell lung cancer leads to increased immunogenicity and tumor infiltration

Free
Bell Wu, Xiaozhuo Ran, Mary Shi, Lifang Song, Vivek Philip, Ming-Sound Tsao, Benjamin Lok
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2147.
https://doi.org/10.1158/1538-7445.AM2025-2147
Published: 21 April 2025
View articletitled, Abstract 2147: Radiosensitization via ATM inhibition in small cell lung cancer leads to increased immunogenicity and tumor infiltration
Journal Articles

Abstract 813: In vitro and in vivo modelling of drug tolerance and minimal residual disease to discover effective therapeutic combination strategies for EGFR-mutated lung cancer

Free
Kristyna A. Gorospe, Ming Li, Arundhathi Arivajiagane, Nhu-An Pham, Roya Navab, Kelsie L. Thu, Ming-Sound Tsao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 813.
https://doi.org/10.1158/1538-7445.AM2025-813
Published: 21 April 2025
View articletitled, Abstract 813: In vitro and in vivo modelling of drug tolerance and minimal residual disease to discover effective therapeutic combination strategies for EGFR-mutated lung cancer
Journal Articles

Abstract 217: Establishment of a spatially defined co-culture model of non-small cell lung cancer organoids and cancer-associated fibroblasts to investigate phenotypic heterogeneity

Free
Cheol-Kyu Park, Roya Navab, Elisa D'Arcangelo, Quan Li, Hiroyuki Ogawa, Nikolina Radulovich, Nhu-An Pham, Ming-Sound Tsao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 217.
https://doi.org/10.1158/1538-7445.AM2024-217
Published: 22 March 2024
View articletitled, Abstract 217: Establishment of a spatially defined co-culture model of non-small cell lung cancer organoids and cancer-associated fibroblasts to investigate phenotypic heterogeneity
Journal Articles

Abstract 6909: KRASG12C inhibitor resistance in patient-derived non-small cell lung cancer models

Free
Joshua C. Rosen, Nhu-An Pham, Quan Li, Pinjiang Cao, Katrina Hueniken, Takamasa Koga, Nikolina Radulovich, Alex Koers, Michael Niedbala, Sarah Ross, Adrian Sacher, Ming-Sound Tsao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6909.
https://doi.org/10.1158/1538-7445.AM2024-6909
Published: 22 March 2024
View articletitled, Abstract 6909: KRASG12C inhibitor resistance in patient-derived non-small cell lung cancer models
Journal Articles

Abstract 4755: Screening non-small cell lung cancer organoids with epigenetic probes

Free
Khadija Jafarova, Panagiotis Prinos, Nikolina Radulovich, Takamasa Koga, Cheryl Arrowsmith, Geoffrey Liu, Ming Sound Tsao
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4755.
https://doi.org/10.1158/1538-7445.AM2023-4755
Published: 04 April 2023
View articletitled, Abstract 4755: Screening non-small cell lung cancer organoids with epigenetic probes
Journal Articles

Abstract 6108: In vivo CRISPR screens identified dual function of MEN1-MLL1 in regulating tumor-microenvironment interactions

Free
Peiran Su, Yin Liu, Ming-Sound Tsao, Housheng H. He
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6108.
https://doi.org/10.1158/1538-7445.AM2022-6108
Published: 15 June 2022
View articletitled, Abstract 6108: In vivo CRISPR screens identified dual function of MEN1-MLL1 in regulating tumor-microenvironment interactions
Journal Articles

Abstract 117: Therapeutic targeting of hypoxia tolerance and oxygen consumption in pancreatic cancer

Free
Ji Zhang, Dan Cojocari, Pedro Boasquevisque, Mark Zaidi, Trevor McKee, Nikolina Radulovich, Ming-Sound Tsao, David Hedley, Marianne Koritzinsky, Bradley Wouters
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 117.
https://doi.org/10.1158/1538-7445.AM2022-117
Published: 15 June 2022
View articletitled, Abstract 117: Therapeutic targeting of hypoxia tolerance and oxygen consumption in pancreatic cancer
Journal Articles

Abstract 5895: Whole-genome characterization of lung adenocarcinomas lacking alterations in RTK/RAS/RAF/MAPK pathway

Free
Jian Carrot-Zhang, Siddhartha Devarakonda, Nicolas Robine, Xiaotong Yao, Tiago C. Silva, Jeff Damrauer, Aditya Deshpande, Ming-Sound Tsao, Christina Yao, Chris Wong, Lisui Bao, Hyo Young Choi, Ina Felau, Jean C. Zenklusen, Gordon Robertson, Tuan Trieua, Wei-Wei Liang, Meng Zhou, Esther Rheinbay, Neil Hayes, Ekta Khurana, Li Ding, Peter Laird, Olivier Elemento, John Weinstein, David Kwiatkowski, Chris Benz, Josh Stuart, Lixing Yang, Mauro Castro, William Travis, Katherine Hoadley, Ben Berman, TCGA Analysis Network, Matthew Meyerson, Ramaswamy Govindan, Marcin Imielinski
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5895.
https://doi.org/10.1158/1538-7445.AM2020-5895
Published: 15 August 2020
View articletitled, Abstract 5895: Whole-genome characterization of lung adenocarcinomas lacking alterations in RTK/RAS/RAF/MAPK pathway
Journal Articles

Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts

Free
Arvind S. Mer, Wail Ba-Alawi, Petr Smirnov, Yi X. Wang, Ben Brew, Janosch Ortmann, Ming-Sound Tsao, David W. Cescon, Anna Goldenberg, Benjamin Haibe-Kains
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4539–4550.
https://doi.org/10.1158/0008-5472.CAN-19-0349
Published: 03 September 2019
View articletitled, Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts
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Includes: Supplementary data
Journal Articles

Abstract 3378: Systematic pharmacogenomic analysis of large patient derived xenografts data

Free
Arvind Singh Mer, Wail Ba-alawi, Petr Smirnov, Yi Xiao Wang, Ben Brew, Ming-Sound Tsao, David Cescon, Anna Goldenberg, Benjamin Haibe-Kains
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3378.
https://doi.org/10.1158/1538-7445.AM2019-3378
Published: 01 July 2019
View articletitled, Abstract 3378: Systematic pharmacogenomic analysis of large patient derived xenografts data
Journal Articles

Abstract 4550: Correlations between tumor mutation burden, inflammatory profile and histological characteristics of tumor microenvironment in early-stage squamous cell lung carcinoma

Free
Hui Yu, Daniel T. Merrick, Ming-Sound Tsao, William G. Richards, Lucian R. Chirieac, Mark A. Watson, Christopher J. Rivard, David H. Harpole, Raphael Bueno, Adrie van Bokhoven, Aik-Choon Tan, Fred R. Hirsch, Wilbur A. Franklin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4550.
https://doi.org/10.1158/1538-7445.AM2019-4550
Published: 01 July 2019
View articletitled, Abstract 4550: Correlations between tumor mutation burden, inflammatory profile and histological characteristics of tumor microenvironment in early-stage squamous cell lung carcinoma
Journal Articles

Abstract 2443: Oxygen metabolism and hypoxia tolerance in organoid models of pancreatic ductal adenocarcinoma

Free
Ji Zhang, Qingquan Liu, Dan Cojocari, Mark Zaidi, Trevor McKee, Nikolina Radulovich, Ming-Sound Tsao, David Hedley, Marianne Koritzinsky, Bradly G. Wouters
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2443.
https://doi.org/10.1158/1538-7445.AM2018-2443
Published: 01 July 2018
View articletitled, Abstract 2443: Oxygen metabolism and hypoxia tolerance in organoid models of pancreatic ductal adenocarcinoma
Journal Articles

Abstract 4360: Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer

Free
Teklab Gebregiworgis, Christopher B. Marshall, Yoshihito Kano, Nikolina Radulovich, Ming-Sound Tsao, Michael Ohh, Mitsuhiko Ikura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4360.
https://doi.org/10.1158/1538-7445.AM2018-4360
Published: 01 July 2018
View articletitled, Abstract 4360: Altering the regulation of KRAS GTPase cycle via Src and SHP2 creates a potential therapeutic vulnerability for pancreatic cancer
Journal Articles

Abstract A2-49: Integrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact

Free
Michael F. Moran, Thomas Kislinger, Lei Li, Vladimir Ignatchenko, Yuhong Wei, Christine To, Paul Taylor, Jiefei Tong, Nhu An Pham, Melania Pintilie, Lakshmi Muthuswamy, Frances A. Shepherd, Ming Sound Tsao
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_1): A2-49.
https://doi.org/10.1158/1538-7445.TRANSCAGEN-A2-49
Published: 15 November 2015
View articletitled, Abstract A2-49: Integrated Omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact
Journal Articles

Abstract B2-01: Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact

Free
Michael F. Moran, Thomas Kislinger, Lei Li, Vladimir Ignatchenko, Yuhong Wei, Christine To, Paul Taylor, Jiefei Tong, Nhu An Pham, Melania Pintilie, Lakshmi Muthuswamy, Frances A. Shepherd, Ming Sound Tsao
Journal: Cancer Research
Cancer Res (2015) 75 (22_Supplement_2): B2-01.
https://doi.org/10.1158/1538-7445.COMPSYSBIO-B2-01
Published: 15 November 2015
View articletitled, Abstract B2-01: Integrated omic analysis of lung cancer reveals metabolism proteome signatures with prognostic impact
Journal Articles

Abstract 1822: Proteome signatures distinguish lung cancer subtypes, define metabolism states, and have prognostic impact

Free
Wen Zhang, Paul Taylor, Lei Li, Yuhong Wei, Jiefei Tong, Vladimir Ignatchenko, Nhu-An Pham, Thomas Kislinger, Ming-sound Tsao, Michael Moran
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1822.
https://doi.org/10.1158/1538-7445.AM2015-1822
Published: 01 August 2015
View articletitled, Abstract 1822: Proteome signatures distinguish lung cancer subtypes, define metabolism states, and have prognostic impact
Journal Articles

Abstract A106: BRCA mutation sensitizes pancreatic tumors to treatment with cisplatin

Free
Ines Lohse, Pinjian Cao, Emin Ibrahimov, Ming-Sound Tsao, David W. Hedley
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A106.
https://doi.org/10.1158/1538-7445.PANCA2014-A106
Published: 30 June 2015
View articletitled, Abstract A106: BRCA mutation sensitizes pancreatic tumors to treatment with cisplatin
Journal Articles

Abstract A102: Combination treatment with hypoxia-activated prodrug TH-302 and radiation reduce pancreatic tumor initiating cells and tumor growth in patient-derived xenografts

Free
Ines Lohse, Joanna Rasowski, Pinjian Cao, Melania Pintilie, Trevor Do, Emin Ibrahimov, Ming-Sound Tsao, Richard P. Hill, David W. Hedley
Journal: Cancer Research
Cancer Res (2015) 75 (13_Supplement): A102.
https://doi.org/10.1158/1538-7445.PANCA2014-A102
Published: 30 June 2015
View articletitled, Abstract A102: Combination treatment with hypoxia-activated prodrug TH-302 and radiation reduce pancreatic tumor initiating cells and tumor growth in patient-derived xenografts