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Journal Articles

Abstract CT008: First-in-human study of SYS6010, a novel EGFR targeting antibody drug conjugate (ADC) for patients with advanced solid tumors

Free
Shun Lu, Zhen Zhou, Zi-Ming Li, Zhi-Yong HE, Jian Fang, Hong-Mei Sun, Yi Gong, Ying Cheng, Yi-Bing LIU, Yu Yao, Yan Yu, Yan-Hong Shang, Xiang-Lin Yuan, Liang Han, Mingjun Zhang, Kun-Yu Yang, Liqiong Zhang, Xuechao Wan, Huanhuan Qi, Yang Yang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT008.
https://doi.org/10.1158/1538-7445.AM2025-CT008
Published: 25 April 2025
View articletitled, Abstract CT008: First-in-human study of SYS6010, a novel EGFR targeting antibody drug conjugate (ADC) for patients with advanced solid tumors
Journal Articles

Abstract LB437: LAE118, a pan mutant-selective PI3Ka inhibitor with superb activity against both the kinase domain and helical domain mutants

Free
Ming Li, Ruipeng Zhang, Meijuan Hu, Junyan Chen, Xiaofen Lin, Justin Gu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB437.
https://doi.org/10.1158/1538-7445.AM2025-LB437
Published: 25 April 2025
View articletitled, Abstract LB437: LAE118, a pan mutant-selective PI3Ka inhibitor with superb activity against both the kinase domain and helical domain mutants
Journal Articles

Abstract 7100: The relationship between social deprivation and immune suppression in Hispanic/Latina patients with breast cancer

Free
Elexa P. Rallos, Sabrina Carrel, Michelle Li, Batul Al-Zubeidy, Edgar Gonzalez, Aaron G. Baugh, Matthew Jacobo, Cheol Park, Robert Hsu, Dominic Zavala, Steven Do, Michael F. Press, Ming Li, Anastasia Martynova, Priya Jayachandran, Daphne Stewart, Chanita Hughes-Halbert, Mariana C. Stern, Evanthia T. Roussos Torres
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7100.
https://doi.org/10.1158/1538-7445.AM2025-7100
Published: 21 April 2025
View articletitled, Abstract 7100: The relationship between social deprivation and immune suppression in Hispanic/Latina patients with breast cancer
Journal Articles

Abstract 4381: Preclinical studies of HEC211909, an orally bioavailable, high potent pan-KRAS inhibitor

Free
Haiwang Liu, Hongming Xie, Fuxing Tan, Ning Kang, Ming Li, Yingjun Zhang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4381.
https://doi.org/10.1158/1538-7445.AM2025-4381
Published: 21 April 2025
View articletitled, Abstract 4381: Preclinical studies of HEC211909, an orally bioavailable, high potent pan-KRAS inhibitor
Journal Articles

Abstract 5533: Drug tolerance mechanisms in patient-derived xenograft models with epidermal growth factor receptor mutated tumors treated with tyrosine kinase inhibitors

Free
Arundhathi Arivajiagane, Quan Li, Nhu-An Pham, Ming Li, Katrina Hueniken, Takamasa Koga, Nikolina Radulovich, Ming-Sound Tsao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5533.
https://doi.org/10.1158/1538-7445.AM2025-5533
Published: 21 April 2025
View articletitled, Abstract 5533: Drug tolerance mechanisms in patient-derived xenograft models with epidermal growth factor receptor mutated tumors treated with tyrosine kinase inhibitors
Journal Articles

Abstract 813: In vitro and in vivo modelling of drug tolerance and minimal residual disease to discover effective therapeutic combination strategies for EGFR-mutated lung cancer

Free
Kristyna A. Gorospe, Ming Li, Arundhathi Arivajiagane, Nhu-An Pham, Roya Navab, Kelsie L. Thu, Ming-Sound Tsao
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 813.
https://doi.org/10.1158/1538-7445.AM2025-813
Published: 21 April 2025
View articletitled, Abstract 813: In vitro and in vivo modelling of drug tolerance and minimal residual disease to discover effective therapeutic combination strategies for EGFR-mutated lung cancer
Journal Articles

Abstract 4192: Preclinical characterization of LAE122, a novel, potent and selective WRN inhibitor for the treatment of MSI-H tumors

Free
Ming Li, Minhua Zhang, Junyan Chen, Chaojun Cai, Xiaofen Lin, Justin Gu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4192.
https://doi.org/10.1158/1538-7445.AM2025-4192
Published: 21 April 2025
View articletitled, Abstract 4192: Preclinical characterization of LAE122, a novel, potent and selective WRN inhibitor for the treatment of MSI-H tumors
Journal Articles

Abstract 5872: The gut microbiota from vasoactive intestinal peptide knock-out mice confers resistance to the growth of leukemia in wild-yype mice

Free
Kayla Robinson, Shayna Jankowski, Jian Ming Li
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5872.
https://doi.org/10.1158/1538-7445.AM2025-5872
Published: 21 April 2025
View articletitled, Abstract 5872: The gut microbiota from vasoactive intestinal peptide knock-out mice confers resistance to the growth of leukemia in wild-yype mice
Journal Articles

Abstract 7246: A natural antibody response associated with improved survival of SCLC patients can be actively induced in a SCLC mouse model and leads to significantly improved survival

Free
Diego Alejandro Velarde, Joseph Valdes, Chunli Yan, Sarah Elmalh, Hannah Lee, Daniel J. Mullen, Angie Moreno, Matthew A. Gladstone, Nicky Nie, Ming Li, Martin Kast, Ite A. Offringa
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7246.
https://doi.org/10.1158/1538-7445.AM2025-7246
Published: 21 April 2025
View articletitled, Abstract 7246: A natural antibody response associated with improved survival of SCLC patients can be actively induced in a SCLC mouse model and leads to significantly improved survival
Journal Articles

Abstract 3008: The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer

Free
Valentina Cutano, Ming Li Chia, Eleanor M. Wigmore, Stuart C. Williamson, Amanda L. Christie, Brandon Willis, James Kerr, Sophie D’Arcy, Lauren Bradshaw, Cath Eberlein, Lambert Montava Garriga, Elza de Bruin, Susan E. Critchlow, Kevin M. Brindle, Simon T Barry, Susana Ros
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3008.
https://doi.org/10.1158/1538-7445.AM2025-3008
Published: 21 April 2025
View articletitled, Abstract 3008: The interplay between FOXO3 and FOXM1 influences sensitivity to AKT inhibition in PIK3CA and PIK3CA/PTEN altered estrogen receptor positive breast cancer
Journal Articles

Abstract 3225: A meta-analysis of single agent versus combination immune checkpoint inhibitors in metastatic triple negative breast cancer

Free
Phaedon D. Zavras, Hugo R. Lara-Martinez, Qi Nie, Julius Y. Kattoula, Nicole Strossman, Zehui He, Ming Li, Romualdo Barroso-Sousa, Isaac Chan, Sara M. Tolaney, Vered Stearns, Cesar A. Santa-Maria, Evanthia T. Roussos Torres
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3225.
https://doi.org/10.1158/1538-7445.AM2025-3225
Published: 21 April 2025
View articletitled, Abstract 3225: A meta-analysis of single agent versus combination immune checkpoint inhibitors in metastatic triple negative breast cancer
Journal Articles

Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies

Available to Purchase
Yu-Wei Li, Lei-Jie Dai, Xiang-Rong Wu, Shen Zhao, Yu-Zheng Xu, Xi Jin, Yi Xiao, Ying Wang, Cai-Jin Lin, Yi-Fan Zhou, Tong Fu, Wen-Tao Yang, Ming Li, Hong Lv, Siyuan Chen, Anita Grigoriadis, Yi-Zhou Jiang, Ding Ma, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2024) 84 (21): 3669–3683.
https://doi.org/10.1158/0008-5472.CAN-23-4066
Published: 04 November 2024
View articletitled, Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Open the PDF for Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies in another window
Includes: Supplementary data
Journal Articles

VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer

Available to Purchase
Tenzin Passang, Shuhua Wang, Hanwen Zhang, Fanyuan Zeng, Po-Chih Hsu, Wenxi Wang, Jian-Ming Li, Yuan Liu, Sruthi Ravindranathan, Gregory B. Lesinski, Edmund K. Waller
Journal: Cancer Research
Cancer Res (2024) 84 (18): 2954–2967.
https://doi.org/10.1158/0008-5472.CAN-23-3628
Published: 16 September 2024
View articletitled, VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer
Open the PDF for VPAC2 Receptor Signaling Promotes Growth and Immunosuppression in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma

Available to Purchase
Shan Wan, Quan-Yao He, Yun Yang, Feng Liu, Xue Zhang, Xin Guo, Hui Niu, Yi Wang, Yi-Xuan Liu, Wen-Long Ye, Xiu-Ming Li, Xue-Mei ZhuanSun, Pu Sun, Xiao-Shun He, Guang Hu, Kai Breuhahn, Hua Zhao, Guo-Qiang Wu, Hua Wu
Journal: Cancer Research
Cancer Res (2024) 84 (11): 1872–1888.
https://doi.org/10.1158/0008-5472.CAN-23-2889
Published: 04 June 2024
View articletitled, SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma
Open the PDF for SPARC Stabilizes ApoE to Induce Cholesterol-Dependent Invasion and Sorafenib Resistance in Hepatocellular Carcinoma in another window
Includes: Supplementary data
Journal Articles

Abstract PO4-26-09: The Advantage of Artificial-Intelligence in HER2 IHC 0 and 1+ Scoring in Breast Cancer

Free
Ming Li, Hong Lv, Yizhi Zhao, Chenglu Zhu, Hansheng Li, Mingzhen Lin, Wen-Tao Yang
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO4-26-09.
https://doi.org/10.1158/1538-7445.SABCS23-PO4-26-09
Published: 02 May 2024
View articletitled, Abstract PO4-26-09: The Advantage of Artificial-Intelligence in HER2 IHC 0 and 1+ Scoring in Breast Cancer
Journal Articles

Abstract PS09-09: Multiomics profiling and molecular classification refine precision treatment strategies for HER2-positive breast cancer

Free
Yu-Wei Li, Ding Ma, Xiang-Rong Wu, Lei-Jie Dai, Shen Zhao, Yu-Zheng Xu, Xi Jin, Xiao Yi, Ying Wang, Cai-Jin Lin, Yi-Fan Zhou, Tong Fu, Wen-Tao Yang, Ming Li, Hong Lv, Yi-Zhou Jiang, Zhi-Ming Shao
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PS09-09.
https://doi.org/10.1158/1538-7445.SABCS23-PS09-09
Published: 02 May 2024
View articletitled, Abstract PS09-09: Multiomics profiling and molecular classification refine precision treatment strategies for HER2-positive breast cancer
Journal Articles

Abstract LB109: Detection of high grade intraepithelial neoplasia in colorectal cancer using a new blood-based multiplex septin9 methylation assay

Free
Youming Wu, Yongqin Tong Tong, Haitao Zhang, Yun Li, Ming Li, Lili Qiu, Wenlan Liu, Siqing Mei, Yu Mao, Yanhua Cao, Caiyan Su, Wentao Yu, Junli Wang, Taizhong Wang, Zhongyuan Zhu, Dehua Derek Yu
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB109.
https://doi.org/10.1158/1538-7445.AM2024-LB109
Published: 05 April 2024
View articletitled, Abstract LB109: Detection of high grade intraepithelial neoplasia in colorectal cancer using a new blood-based multiplex septin9 methylation assay
Journal Articles

Abstract 2112: Identification of biomarkers associated with sensitivity to a novel PCNA inhibitor (AOH1996) by CRISPRi screening

Free
Long Gu, Ming li, Chun-Wei Chen, Robert J. Hickey, Linda H. Malkas
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2112.
https://doi.org/10.1158/1538-7445.AM2024-2112
Published: 22 March 2024
View articletitled, Abstract 2112: Identification of biomarkers associated with sensitivity to a novel PCNA inhibitor (AOH1996) by CRISPRi screening
Journal Articles

Abstract 670: Preclinical candidate LAE120, a novel selective USP1 inhibitor shows effective anticancer and combination activity with PARP inhibitor

Free
Jintao Wang, Yan Chen, Junyan Chen, Ling Jiang, Xiaofen Lin, Chaojun Cai, Minhua Zhang, Ming Li, Justin Gu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 670.
https://doi.org/10.1158/1538-7445.AM2024-670
Published: 22 March 2024
View articletitled, Abstract 670: Preclinical candidate LAE120, a novel selective USP1 inhibitor shows effective anticancer and combination activity with PARP inhibitor
Journal Articles

Abstract 7132: Preclinical characterization of LAE119, a novel PARP1 selective inhibitor and trapper

Free
Ming Li, Yan Chen, Junyan Chen, Ling Jiang, Xiaofen Lin, Justin Gu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7132.
https://doi.org/10.1158/1538-7445.AM2024-7132
Published: 22 March 2024
View articletitled, Abstract 7132: Preclinical characterization of LAE119, a novel PARP1 selective inhibitor and trapper