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Journal Articles

A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, Li Chen, Ali Foroughi pour, John D. Landua, R. Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill C. Rubinstein, Brian J. Sanderson, Michael W. Lloyd, Sergii Domanskyi, Lacey E. Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, Saul Acevedo, PDXNet Consortium, Brandi N. Davis-Dusenbery, Peter N. Robinson, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bult, Dennis A. Dean, II, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2024) 84 (13): 2060–2072.
https://doi.org/10.1158/0008-5472.CAN-23-1349
Published: 02 July 2024
View article titled, A Pan-Cancer Patient-Derived Xenograft Histology Image Repository with Genomic and Pathologic Annotations Enables Deep Learning Analysis
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Includes: Supplementary data
Journal Articles

Abstract 4399: HMGA1 is an epigenetic regulator and plays a critical role in melanoma recurrence

Haiwei Mou, Kristen DeRosa, Veronika Yakovishina, Yeqing Chen, Abdiel Mandella Reynolds, Min Xiao, Monzy Thomas, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4399.
https://doi.org/10.1158/1538-7445.AM2024-4399
Published: 22 March 2024
View article titled, Abstract 4399: HMGA1 is an epigenetic regulator and plays a critical role in melanoma recurrence
Journal Articles

Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis

Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, John David Landua, R Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill Rubinstein, Ali Foroughi pour, Lacey Elizabeth Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet consortium, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bolt, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5407.
https://doi.org/10.1158/1538-7445.AM2023-5407
Published: 04 April 2023
View article titled, Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis
Journal Articles

Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics

Brian S. White, Xingyi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Akshat M. Savaliya, Lacey E. Dobrolecki, John D. Landua, Matthew H. Bailey, Maihi Fujita, Kurt W. Evans, Bingliang Fang, Junya Fujimoto, Maria Gabriela Raso, Shidan Wang, Guanghua Xiao, Yang Xie, Sherri R. Davies, Ryan C. Fields, R Jay Mashl, Jacqueline L. Mudd, Yeqing Chen, Min Xiao, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet Consortium, Yvonne A. Evrard, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Ramaswamy Govindan, Li Ding, Shunqiang Li, Meenhard Herlyn, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Carol J. Bult, Brandi Davis-Dusenbery, Dennis A. Dean, Jeffrey H. Chuang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1202.
https://doi.org/10.1158/1538-7445.AM2022-1202
Published: 15 June 2022
View article titled, Abstract 1202: A repository of PDX histology images for exploring spatial heterogeneity and cancer dynamics
Journal Articles

Abstract LB083: BRAF dimer-selective inhibitors synergize with BRAF monomer-selective inhibitors to overcome adaptive resistance and retain therapeutic index

Christos Adamopoulos, Tamer Ahmed, Peter M. Ung, Min Xiao, Stuart Aaronson, Celina Ang, Vito Rebecca, Avner Schlessinger, Meenhard Herlyn, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB083.
https://doi.org/10.1158/1538-7445.AM2022-LB083
Published: 15 June 2022
View article titled, Abstract LB083: BRAF dimer-selective inhibitors synergize with BRAF monomer-selective inhibitors to overcome adaptive resistance and retain therapeutic index
Journal Articles

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance

Jianglan Liu, Vito W. Rebecca, Andrew V. Kossenkov, Thomas Connelly, Qin Liu, Alexis Gutierrez, Min Xiao, Ling Li, Gao Zhang, Anastasia Samarkina, Delaine Zayasbazan, Jie Zhang, Chaoran Cheng, Zhi Wei, Gretchen M. Alicea, Mizuho Fukunaga-Kalabis, Clemens Krepler, Pedro Aza-Blanc, Chih-Cheng Yang, Bela Delvadia, Cynthia Tong, Ye Huang, Maya Delvadia, Alice S. Morias, Katrin Sproesser, Patricia Brafford, Joshua X. Wang, Marilda Beqiri, Rajasekharan Somasundaram, Adina Vultur, Denitsa M. Hristova, Lawrence W. Wu, Yiling Lu, Gordon B. Mills, Wei Xu, Giorgos C. Karakousis, Xiaowei Xu, Lynn M. Schuchter, Tara C. Mitchell, Ravi K. Amaravadi, Lawrence N. Kwong, Dennie T. Frederick, Genevieve M. Boland, Joseph M. Salvino, David W. Speicher, Keith T. Flaherty, Ze'ev A. Ronai, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5230–5241.
https://doi.org/10.1158/0008-5472.CAN-20-1496
Published: 15 October 2021
View article titled, Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance
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Includes: Supplementary data
Journal Articles

Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors

Christos Adamopoulos, Tamer A. Ahmed, Maxwell R. Tucker, Peter M. Ung, Min Xiao, Zoi Karoulia, Xuewei Wu, Stuart A. Aaronson, Celina Ang, Vito Rebecca, Avner Schlessinger, Meenhard Herlyn, Qi Wang, David E. Shaw, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 78.
https://doi.org/10.1158/1538-7445.AM2021-78
Published: 01 July 2021
View article titled, Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors
Journal Articles

Abstract 5264: Selective toxicity of MX-106-4C, a survivin inhibitor, in P-glycoprotein-mediated multidrug resistant colon cancer

Zi-Ning Lei, Zhongzhi Wu, Qiu-Xu Teng, Min Xiao, Wei Li, John N. Wurpel, Zhe-Sheng Chen
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5264.
https://doi.org/10.1158/1538-7445.AM2020-5264
Published: 15 August 2020
View article titled, Abstract 5264: Selective toxicity of MX-106-4C, a survivin inhibitor, in P-glycoprotein-mediated multidrug resistant colon cancer
Journal Articles

MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

Jae Ho Seo, Young Chan Chae, Andrew V. Kossenkov, Yu Geon Lee, Hsin-Yao Tang, Ekta Agarwal, Dmitry I. Gabrilovich, Lucia R. Languino, David W. Speicher, Prashanth K. Shastrula, Alessandra Maria Storaci, Stefano Ferrero, Gabriella Gaudioso, Manuela Caroli, Davide Tosi, Massimo Giroda, Valentina Vaira, Vito W. Rebecca, Meenhard Herlyn, Min Xiao, Dylan Fingerman, Alessandra Martorella, Emmanuel Skordalakes, Dario C. Altieri
Journal: Cancer Research
Cancer Res (2019) 79 (24): 6215–6226.
https://doi.org/10.1158/0008-5472.CAN-19-1982
Published: 13 December 2019
View article titled, MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract 3659: Target validation and structural optimization of selective small molecule survivin inhibitors as potential anti-cancer agents

Jin Wang, Min Xiao, Duane D. Miller, Wei Li
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3659.
https://doi.org/10.1158/1538-7445.AM2015-3659
Published: 01 August 2015
View article titled, Abstract 3659: Target validation and structural optimization of selective small molecule survivin inhibitors as potential anti-cancer agents
Journal Articles

Abstract 2842: Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models of melanoma identify c-Met as an effective second line combination therapy target

Clemens Krepler, Min Xiao, Katrin Sproesser, Patricia Brafford, Batool Shannan, Marilda Beqiri, Wei Xu, Bradley Garman, Katherine L. Nathanson, Xiaowei Xu, Giorgos Karakousis, Gordon B. Mills, Yiling Lu, Giordano Caponigro, Markus Boehm, Malte Peters, Lynn Schuchter, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2842.
https://doi.org/10.1158/1538-7445.AM2015-2842
Published: 01 August 2015
View article titled, Abstract 2842: Personalized pre-clinical trials in BRAF inhibitor resistant patient derived xenograft models of melanoma identify c-Met as an effective second line combination therapy target
Journal Articles

Abstract 4668: Targeted, massively parallel sequencing identifies novel genetic subsets of cutaneous melanoma

Bradley Garman, Clemens Krepler, Katrin Sproesser, Patrica Brafford, Melissa Wilson, Bradley Wubbenhorst, Ravi Amaravadi, Joseph Bennett, Marilda Beqiri, Michael Davies, David Elder, Keith Flaherty, Dennie Frederick, Tara C. Gangadhar, Michael Guarino, David Hoon, Giorgos Karakousis, Nandita Mitra, Nicholas J. Petrelli, Lynn Schuchter, Batool Shannan, Jennifer Wargo, Min Xiao, Wei Xu, Xaiowei Xu, Meenhard Herlyn, Katherine Nathanson
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4668.
https://doi.org/10.1158/1538-7445.AM2015-4668
Published: 01 August 2015
View article titled, Abstract 4668: Targeted, massively parallel sequencing identifies novel genetic subsets of cutaneous melanoma
Journal Articles

Abstract B20: Design, synthesis and SAR studies of novel survivin inhibitors with potent antiproliferative properties

Min Xiao, Jin Wang, Yan Lu, Duane D. Miller, Wei Li
Journal: Cancer Research
Cancer Res (2015) 75 (14_Supplement): B20.
https://doi.org/10.1158/1538-7445.MEL2014-B20
Published: 16 July 2015
View article titled, Abstract B20: Design, synthesis and SAR studies of novel survivin inhibitors with potent antiproliferative properties
Journal Articles

Abstract 1182: Patient derived xenograft (PDX) of human melanoma to predict clinical responses

Clemens Krepler, Katrin Sproesser, Patricia Brafford, Min Xiao, Marilda Beqiri, Wei Xu, Katherine Nathanson, Jennifer Wargo, Keith Flaherty, Donald L. Morton, Dave S. Hoon, Randall Ryan, Michael Guarino, Nicholas J. Petrelli, David Elder, Xiawei Xu, Giorgos Karakousis, Lynn Schuchter, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1182.
https://doi.org/10.1158/1538-7445.AM2014-1182
Published: 01 October 2014
View article titled, Abstract 1182: Patient derived xenograft (PDX) of human melanoma to predict clinical responses
Journal Articles

Abstract 5684: Target tubulin polymerization with novel reverse ABI analogs interacting with the colchicine binding site.

Min Xiao, Sunjoo Ahn, Jianjun Chen, Jin Wang, Duane D. Miller, James T. Dalton, Wei Li
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5684.
https://doi.org/10.1158/1538-7445.AM2013-5684
Published: 15 April 2013
View article titled, Abstract 5684: Target tubulin polymerization with novel reverse ABI analogs interacting with the colchicine binding site.
Journal Articles

Abstract 5167: Notch1 is required for endothelial cell lineage differentiation from adult bone marrow stem cells in vitro

Hongwei Shao, Min Xiao, Long Cai, Freddy Radtke, Omaida C. Velazquez, Zhao-Jun Liu
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5167.
https://doi.org/10.1158/1538-7445.AM10-5167
Published: 15 April 2010
View article titled, Abstract 5167: Notch1 is required for endothelial cell lineage differentiation from adult bone marrow stem cells <em>in vitro</em>
Journal Articles

Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes

Chelsea C. Pinnix, John T. Lee, Zhao-Jun Liu, Ronan McDaid, Klara Balint, Levi J. Beverly, Patricia A. Brafford, Min Xiao, Benjamin Himes, Susan E. Zabierowski, Yumi Yashiro-Ohtani, Katherine L. Nathanson, Ana Bengston, Pamela M. Pollock, Ashani T. Weeraratna, Brian J. Nickoloff, Warren S. Pear, Anthony J. Capobianco, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2009) 69 (13): 5312–5320.
https://doi.org/10.1158/0008-5472.CAN-08-3767
Published: 01 July 2009
View article titled, Active Notch1 Confers a Transformed Phenotype to Primary Human Melanocytes
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Includes: Supplementary data
Journal Articles

Abstract #3522: A novel approach to target tumor microenvironment: targeting stromal fibroblasts by manipulation of Notch1 signaling

Hongwei Shao, Min Xiao, Mizuho Fukunaga-Kalabis, Meenhard Herlyn, Omaida Velazquez, Zhao-Jun Liu
Journal: Cancer Research
Cancer Res (2009) 69 (9_Supplement): 3522.
Published: 01 May 2009
View article titled, Abstract #3522: A novel approach to target tumor microenvironment: targeting stromal fibroblasts by manipulation of Notch1 signaling
Journal Articles

Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression

Keiran S.M. Smalley, Rooha Contractor, Thiennga K. Nguyen, Min Xiao, Robin Edwards, Viswanathan Muthusamy, Alastair J. King, Keith T. Flaherty, Marcus Bosenberg, Meenhard Herlyn, Katherine L. Nathanson
Journal: Cancer Research
Cancer Res (2008) 68 (14): 5743–5752.
https://doi.org/10.1158/0008-5472.CAN-08-0235
Published: 15 July 2008
View article titled, Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression
Open the PDF for Identification of a Novel Subgroup of Melanomas with KIT/Cyclin-Dependent Kinase-4 Overexpression in another window
Includes: Supplementary data
Journal Articles

Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression

Zhao-Jun Liu, Min Xiao, Klara Balint, Keiran S.M. Smalley, Patricia Brafford, Ruihua Qiu, Chelsea C. Pinnix, Xueli Li, Meenhard Herlyn
Journal: Cancer Research
Cancer Res (2006) 66 (8): 4182–4190.
https://doi.org/10.1158/0008-5472.CAN-05-3589
Published: 17 April 2006
View article titled, Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression
Open the PDF for Notch1 Signaling Promotes Primary Melanoma Progression by Activating Mitogen-Activated Protein Kinase/Phosphatidylinositol 3-Kinase-Akt Pathways and Up-regulating N-Cadherin Expression in another window