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Journal Articles

Longitudinal Profiling of Circulating Tumor DNA Reveals the Evolutionary Dynamics of Metastatic Prostate Cancer during Serial Therapy

Yuehui Zhao, Naveen Ramesh, Ping Xu, Emi Sei, Min Hu, Shanshan Bai, Patricia Troncoso, Ana M. Aparicio, Christopher J. Logothetis, Paul G. Corn, Nicholas E. Navin, Amado J. Zurita

Cancer Res (2025) 85 (9): 1680–1695.

https://doi.org/10.1158/0008-5472.CAN-24-1943

Published: 02 May 2025

View articletitled, Longitudinal Profiling of Circulating Tumor DNA Reveals the Evolutionary Dynamics of Metastatic Prostate Cancer during Serial Therapy

Includes: Supplementary data

Journal Articles

Abstract 5460: C6P, a claudin 6 (CLDN6) directed ADC containing pyrolobenzodiazepine (PBD) for the treatment of advanced solid tumors

Xiaolan Yu, Shuting Wang, Lingfeng You, Zhibin Xu, Zhendong Xue, Yuchang Mao, Shuyu Cai, Jun Feng, Ting Zhang, Xin Ye, Min Hu, Feng He

Cancer Res (2025) 85 (8_Supplement_1): 5460.

https://doi.org/10.1158/1538-7445.AM2025-5460

Published: 21 April 2025

View articletitled, Abstract 5460: C6P, a claudin 6 (CLDN6) directed ADC containing pyrolobenzodiazepine (PBD) for the treatment of advanced solid tumors

Journal Articles

Abstract 6735: E-cM-Topi, a potent EGFR-cMET bispecific antibody drug conjugate, with superior anti-tumor effect in non-small-cell lung cancer (NSCLC)

Huihui Chen, Le Sun, Bing Hu, Zhiping Zhao, Ziheng Liu, Guangbao Qiu, Dongmei Bai, Ying Li, Ziwei Ren, Ting Zhang, Xin Ye, Lingfeng You, Zhendong Xue, Yuchang Mao, Huaixin Dang, Shuyu Cai, Jun Feng, Min Hu, Feng He

Cancer Res (2025) 85 (8_Supplement_1): 6735.

https://doi.org/10.1158/1538-7445.AM2025-6735

Published: 21 April 2025

View articletitled, Abstract 6735: E-cM-Topi, a potent EGFR-cMET bispecific antibody drug conjugate, with superior anti-tumor effect in non-small-cell lung cancer (NSCLC)

Journal Articles

Abstract 5453: E-M ADC, a promising EGFR-MUC1 bispecific antibody drug conjugate, with superior anti-tumor effect in a wide range of tumors

Cancer Res (2025) 85 (8_Supplement_1): 5453.

https://doi.org/10.1158/1538-7445.AM2025-5453

Published: 21 April 2025

View articletitled, Abstract 5453: E-M ADC, a promising EGFR-MUC1 bispecific antibody drug conjugate, with superior anti-tumor effect in a wide range of tumors

Journal Articles

Abstract 396: Discovery of SHR3591, a highly potent and orally bioavailable AR PROTAC for the treatment of prostate cancer

Minqiang Jia, Limin Zhang, Fanglong Yang, Gang Chen, Shouli Zhao, Weimin Wang, Jiangtao Chi, Wei Peng, Luona Wang, Huishuang Miao, Zhibin Xu, Yuchang Mao, Xun Li, Yi Mao, Shuyu Cai, Jun Feng, Min Hu, Xin Li, Feng He

Cancer Res (2025) 85 (8_Supplement_1): 396.

https://doi.org/10.1158/1538-7445.AM2025-396

Published: 21 April 2025

View articletitled, Abstract 396: Discovery of SHR3591, a highly potent and orally bioavailable AR PROTAC for the treatment of prostate cancer

Journal Articles

Abstract 5464: A novel T-cell-engager targeting BCMA and GPRC5D with balanced killing efficacy to overcome potential resistance mechanisms in multiple myeloma treatment

Xiaochuan Ma, Hanxiao Ying, Chunhong Yu, Ting Qiu, Shu Wang, Pu Pu, Zhibin Xu, Zhendong Xue, Shuyu Cai, Jun Feng, Min Hu, Feng He

Cancer Res (2025) 85 (8_Supplement_1): 5464.

https://doi.org/10.1158/1538-7445.AM2025-5464

Published: 21 April 2025

View articletitled, Abstract 5464: A novel T-cell-engager targeting BCMA and GPRC5D with balanced killing efficacy to overcome potential resistance mechanisms in multiple myeloma treatment

Journal Articles

Abstract 6438: Decoding the archetypes and ecotypes of triple-negative breast cancer in responses to chemotherapy

Cancer Res (2025) 85 (8_Supplement_1): 6438.

https://doi.org/10.1158/1538-7445.AM2025-6438

Published: 21 April 2025

View articletitled, Abstract 6438: Decoding the archetypes and ecotypes of triple-negative breast cancer in responses to chemotherapy

Journal Articles

Abstract 7615: Epithelial-mesenchymal-transition gene signature changes and poor oncological outcome in Candida-positive pancreatic ductal adenocarcinoma

Cancer Res (2024) 84 (6_Supplement): 7615.

https://doi.org/10.1158/1538-7445.AM2024-7615

Published: 22 March 2024

View articletitled, Abstract 7615: Epithelial-mesenchymal-transition gene signature changes and poor oncological outcome in Candida-positive pancreatic ductal adenocarcinoma

Journal Articles

Abstract 3146: HRA00130-C004, a novel anti-DLL3 ADC with bystander effect, high DAR and favorable safety profiles

Qingqing Yao, Changding Xue, Zhibin Xu, Lingfeng You, Zhendong Xue, Yuchang Mao, Sophie Lin, Jun Feng, Zhe Zhang, Xin Ye, Min Hu, Feng He

Cancer Res (2024) 84 (6_Supplement): 3146.

https://doi.org/10.1158/1538-7445.AM2024-3146

Published: 22 March 2024

View articletitled, Abstract 3146: HRA00130-C004, a novel anti-DLL3 ADC with bystander effect, high DAR and favorable safety profiles

Journal Articles

Abstract 4338: A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution

Hanghui Ye, Thomas McDonald, Emi Sei, Darlan Conterno Minussi, Min Hu, Chenling Tang, Junke Wang, Kaile Wang, Anna Casasent, Hui Chen, Franziska Michor, Nicholas Navin

Cancer Res (2024) 84 (6_Supplement): 4338.

https://doi.org/10.1158/1538-7445.AM2024-4338

Published: 22 March 2024

View articletitled, Abstract 4338: A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution

Journal Articles

Abstract 6933: Decoding the archetypes and eco-hubs of triple-negative breast cancer in responses to chemotherapy

Yun Yan, Yiyun Lin, Tapsi Kumar, Shanshan Bai, Jianzhuo Li, Tuan Tran, Min Hu, Elizabeth Ravenberg, Maia Rauch, Alyson Clayborn, Alastair Thompson, Bora Lim, Lei Huo, Stacy Moulder, Clinton Yam, Nicholas Navin

Cancer Res (2024) 84 (6_Supplement): 6933.

https://doi.org/10.1158/1538-7445.AM2024-6933

Published: 22 March 2024

View articletitled, Abstract 6933: Decoding the archetypes and eco-hubs of triple-negative breast cancer in responses to chemotherapy

Journal Articles

Abstract 1749: Esophageal adenocarcinoma single-cell resolution ecotypes and subtypes mediate chemoradiation resistance

Rui Ye, Yawei Qiao, Shanshan Bai, Emi Sei, Min Hu, Jianzhong He, Nan Li, Yifan Wang, Pablo Lopez, Wei Zhang, Fei Ye, Brian Weston, Emmanuel Coronel, William Ross, Phillip Ge, Bhutani Manoop, Nicholas Navin, Steven Lin

Cancer Res (2024) 84 (6_Supplement): 1749.

https://doi.org/10.1158/1538-7445.AM2024-1749

Published: 22 March 2024

View articletitled, Abstract 1749: Esophageal adenocarcinoma single-cell resolution ecotypes and subtypes mediate chemoradiation resistance

Journal Articles

Abstract 7279: Discovery of SHR1127, an orally bioavailable, highly potent and selective KRAS G12D inhibitor

Xin Li, Feng Shen, Limin Zhang, Wei Wang, Luyao Kong, Yong Bao, Yuchang Mao, Zaiyong Wang, Sophie Lin, Zhe Zhang, Jun Feng, Min Hu, Feng He

Cancer Res (2024) 84 (6_Supplement): 7279.

https://doi.org/10.1158/1538-7445.AM2024-7279

Published: 22 March 2024

View articletitled, Abstract 7279: Discovery of SHR1127, an orally bioavailable, highly potent and selective KRAS G12D inhibitor

Journal Articles

Abstract 3145: HRA00242-C004, a novel anti-PSMA ADC with high DAR reveals potent in vitro and in vivo anti-tumor efficacy

Guang Lin, Haoying Zhang, Zhibin Xu, Lingfeng You, Zhendong Xue, Yuchang Mao, Xiaoying Yang, Bing Hu, Sophie Lin, Jun Feng, Zhe Zhang, Xin Ye, Min Hu, Feng He

Cancer Res (2024) 84 (6_Supplement): 3145.

https://doi.org/10.1158/1538-7445.AM2024-3145

Published: 22 March 2024

View articletitled, Abstract 3145: HRA00242-C004, a novel anti-PSMA ADC with high DAR reveals potent in vitro and in vivo anti-tumor efficacy

Journal Articles

Abstract 5483: Macrospatial ecotype heterogeneity in early-stage breast cancer identified by spatial nucleus barcoding

Kaile Wang, Zhenna Xiao, Yiyun Lin, Runmin Wei, Shanshan Bai, Jie Ye, Rui Ye, Min Hu, Aatish Thennavan, Emi Sei, Alastair Thompson, Savitri Krishnamurthy, Nicholas Navin

Cancer Res (2024) 84 (6_Supplement): 5483.

https://doi.org/10.1158/1538-7445.AM2024-5483

Published: 22 March 2024

View articletitled, Abstract 5483: Macrospatial ecotype heterogeneity in early-stage breast cancer identified by spatial nucleus barcoding

Journal Articles

Abstract 3128: HRA00184-C004, preclinical characterization of a novel tissue factor-targeted antibody-drug conjugate

Hanxiao Ying, Lingfeng You, Ning He, Shaoyu Xu, Pu Pu, Sophie Lin, Jun Feng, Zhe Zhang, Xin Ye, Min Hu, Feng He

Cancer Res (2024) 84 (6_Supplement): 3128.

https://doi.org/10.1158/1538-7445.AM2024-3128

Published: 22 March 2024

View articletitled, Abstract 3128: HRA00184-C004, preclinical characterization of a novel tissue factor-targeted antibody-drug conjugate

Journal Articles

Abstract LB031: SHR-A1811, a novel anti-HER2 ADC with superior bystander effect, optimal DAR and favorable safety profiles

Ting Zhang, Lingfeng You, Jianyan Xu, Junzhao Yin, Bolei Qu, Yuchang Mao, Beibei Fu, Dan Cao, Linda Zhao, Jun Feng, Min Hu, Feng He

Cancer Res (2023) 83 (8_Supplement): LB031.

https://doi.org/10.1158/1538-7445.AM2023-LB031

Published: 14 April 2023

View articletitled, Abstract LB031: SHR-A1811, a novel anti-HER2 ADC with superior bystander effect, optimal DAR and favorable safety profiles

Journal Articles

Abstract 76: Reprogramming of the preinvasive breast microenvironment identified by spatial nucleus barcoding

Kaile Wang, Zhenna Xiao, Yiyun Lin, Runmin Wei, Jie Ye, Rui Ye, Min Hu, Shanshan Bai, Emi Sei, Aatish Thennavan, Bora Lim, Andrew Futreal, Alastair Thompson, Savitri Krishnamurthy, Nicholas Navin

Cancer Res (2023) 83 (7_Supplement): 76.

https://doi.org/10.1158/1538-7445.AM2023-76

Published: 04 April 2023

View articletitled, Abstract 76: Reprogramming of the preinvasive breast microenvironment identified by spatial nucleus barcoding

Journal Articles

Abstract 125: Archival single cell sequencing reveals persistent subclones over years to decades of DCIS progression

Cancer Res (2023) 83 (7_Supplement): 125.

https://doi.org/10.1158/1538-7445.AM2023-125

Published: 04 April 2023

View articletitled, Abstract 125: Archival single cell sequencing reveals persistent subclones over years to decades of DCIS progression

Journal Articles

Abstract 3131: Anaplastic transformation model in thyroid cancer revealed by single cell lineage and fate analysis

Cancer Res (2023) 83 (7_Supplement): 3131.

https://doi.org/10.1158/1538-7445.AM2023-3131

Published: 04 April 2023

View articletitled, Abstract 3131: Anaplastic transformation model in thyroid cancer revealed by single cell lineage and fate analysis

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Longitudinal Profiling of Circulating Tumor DNA Reveals the Evolutionary Dynamics of Metastatic Prostate Cancer during Serial Therapy

Abstract 5460: C6P, a claudin 6 (CLDN6) directed ADC containing pyrolobenzodiazepine (PBD) for the treatment of advanced solid tumors

Abstract 6735: E-cM-Topi, a potent EGFR-cMET bispecific antibody drug conjugate, with superior anti-tumor effect in non-small-cell lung cancer (NSCLC)

Abstract 5453: E-M ADC, a promising EGFR-MUC1 bispecific antibody drug conjugate, with superior anti-tumor effect in a wide range of tumors

Abstract 396: Discovery of SHR3591, a highly potent and orally bioavailable AR PROTAC for the treatment of prostate cancer

Abstract 5464: A novel T-cell-engager targeting BCMA and GPRC5D with balanced killing efficacy to overcome potential resistance mechanisms in multiple myeloma treatment

Abstract 6438: Decoding the archetypes and ecotypes of triple-negative breast cancer in responses to chemotherapy

Abstract 7615: Epithelial-mesenchymal-transition gene signature changes and poor oncological outcome in Candida-positive pancreatic ductal adenocarcinoma

Abstract 3146: HRA00130-C004, a novel anti-DLL3 ADC with bystander effect, high DAR and favorable safety profiles

Abstract 4338: A pan-cancer single-cell analysis of intratumoral copy number diversity and evolution

Abstract 6933: Decoding the archetypes and eco-hubs of triple-negative breast cancer in responses to chemotherapy

Abstract 1749: Esophageal adenocarcinoma single-cell resolution ecotypes and subtypes mediate chemoradiation resistance

Abstract 7279: Discovery of SHR1127, an orally bioavailable, highly potent and selective KRAS G12D inhibitor

Abstract 3145: HRA00242-C004, a novel anti-PSMA ADC with high DAR reveals potent in vitro and in vivo anti-tumor efficacy

Abstract 5483: Macrospatial ecotype heterogeneity in early-stage breast cancer identified by spatial nucleus barcoding

Abstract 3128: HRA00184-C004, preclinical characterization of a novel tissue factor-targeted antibody-drug conjugate

Abstract LB031: SHR-A1811, a novel anti-HER2 ADC with superior bystander effect, optimal DAR and favorable safety profiles

Abstract 76: Reprogramming of the preinvasive breast microenvironment identified by spatial nucleus barcoding

Abstract 125: Archival single cell sequencing reveals persistent subclones over years to decades of DCIS progression

Abstract 3131: Anaplastic transformation model in thyroid cancer revealed by single cell lineage and fate analysis

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