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Mihai Gagea
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Journal Articles

Abstract LB180: Non-cardiotoxic properties of annamycin, a clinically evaluated anthracycline and potent topoisomerase 2β poison

Rafal J. Zielinski, Krzysztof Grela, Roberto Cardenas-Zuniga, Stanislaw Skora, Izabela Fokt, Mihai Gagea, Wolfram Dempke, Waldemar Priebe
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB180.
https://doi.org/10.1158/1538-7445.AM2024-LB180
Published: 05 April 2024
View article titled, Abstract LB180: Non-cardiotoxic properties of annamycin, a clinically evaluated anthracycline and potent topoisomerase 2β poison
Journal Articles

Abstract B082: Extinction of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8+ T cells

Valerie S. LeBleu, Krishnan K. Mahadevan, Elena V. Ramirez, Yang Chen, Bingrui Li, Amari M. Sockwell, Mihai Gagea, Hikaru Sugimoto, Desiree Tampe, Michael Zeisberg, Haoqiang Ying, Abhinav K. Jain, Ronald A. DePinho, Aniban Maitra, Kathleen M. McAndrews, Raghu Kalluri
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B082.
https://doi.org/10.1158/1538-7445.PANCA2023-B082
Published: 16 January 2024
View article titled, Abstract B082: Extinction of oncogenic <em>Kras</em> in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8<sup>+</sup> T cells
Journal Articles

Abstract 6313: IND-enabling studies for GrB-Fc-IT4: in vivo efficacy, pharmacokinetics, schedule optimization and maximum tolerated dose

Ana Alvarez-Cienfuegos, Lawrence H. Cheung, Khalid A. Mohamedali, Mihai Gagea, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6313.
https://doi.org/10.1158/1538-7445.AM2023-6313
Published: 04 April 2023
View article titled, Abstract 6313: IND-enabling studies for GrB-Fc-IT4: <em>in vivo</em> efficacy, pharmacokinetics, schedule optimization and maximum tolerated dose
Journal Articles

Abstract 3821: Rapid acceleration of KRAS-mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARD

Yi Liu, Yasunori Deguchi, Daoyan Wei, Micheline J. Moussalli, Fuyao Liu, Eriko Deguchi, Donghui Li, Huamin Wang, Lovie Ann Valentin, Jennifer K. Colby, Jing Wang, Xiaofeng Zheng, Haoqiang Ying, Mihai Gagea, Baoan Ji, Jiaqi Shi, James C. Yao, Xiangsheng Zuo, Imad Shureiqi
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3821.
https://doi.org/10.1158/1538-7445.AM2022-3821
Published: 15 June 2022
View article titled, Abstract 3821: Rapid acceleration of <em>KRAS-</em>mutant pancreatic carcinogenesis via remodeling of tumor immune microenvironment by PPARD
Journal Articles

Abstract 5216: Optimizing antitumor efficacy of granzyme B human fusion constructs targeting the Fn14 antigen in solid tumors. Pre IND pharmacokinetics, schedule, dose optimization and MTD studies

Ana Alvarez De Cienfuegos, Lawrence H. Cheung, Khalid A. Mohamedali, Mihai Gagea, Michael G. Rosenblum
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5216.
https://doi.org/10.1158/1538-7445.AM2022-5216
Published: 15 June 2022
View article titled, Abstract 5216: Optimizing antitumor efficacy of granzyme B human fusion constructs targeting the Fn14 antigen in solid tumors. Pre IND pharmacokinetics, schedule, dose optimization and MTD studies
Journal Articles

Abstract 5954: Dietary sugar promotes breast tumorigenesis partially through upregulating 12 lipoxygenase/PPARd signaling and remodeling breast tumor microenvironment

Sharmistha Chakraborty, Xiangsheng Zuo, Venkatesh Hedge, Megan Tran, Yan Jiang, Mihai Gagea, Jagannadha Sastry, Peiying Yang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5954.
https://doi.org/10.1158/1538-7445.AM2022-5954
Published: 15 June 2022
View article titled, Abstract 5954: Dietary sugar promotes breast tumorigenesis partially through upregulating 12 lipoxygenase/PPARd signaling and remodeling breast tumor microenvironment
Journal Articles

Abstract 6549: Preventive effect of compound Kushen injection in radiation induced lung pneumonitis

Ting Xu, Patrea Rhea, Tara Conway, Mihai Gagea, Lirong Wu, Zhongxing Liao, Peiying Yang
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6549.
https://doi.org/10.1158/1538-7445.AM2020-6549
Published: 15 August 2020
View article titled, Abstract 6549: Preventive effect of compound Kushen injection in radiation induced lung pneumonitis
Journal Articles

Abstract 1: Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac alone

Jennifer Sarah Davis, Preeti Kanikarla, Patrick L. Yu, Mihai Gagea, Dexing Fang, Manu Sebastian, Peiying Yang, Ernest Hawk, Roderick Dashwood, Lenard M. Lichtenberger, David Menter, Scott Kopetz
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1.
https://doi.org/10.1158/1538-7445.AM2020-1
Published: 15 August 2020
View article titled, Abstract 1: Sulindac plus phospholipid is effective for polyp reduction and safer than sulindac alone
Journal Articles

Abstract 2599: Pleiotropic effects of PPARD accelerate colorectal tumorigenesis progression and invasion

Yi Liu, Yasunori Deguchi, Rui Tian, Daoyan Wei, Ling Wu, Weidong Chen, Weiguo Xu, Min Xu, Fuyao Liu, Shen Gao, Jonathan C. Jaoude, Sarah P. Chrieki, Micheline J. Moussalli, Mihai Gagea, Jeffrey S. Morris, Russell Broaddus, Xiangsheng Zuo, Imad Shureiqi
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2599.
https://doi.org/10.1158/1538-7445.AM2019-2599
Published: 01 July 2019
View article titled, Abstract 2599: Pleiotropic effects of PPARD accelerate colorectal tumorigenesis progression and invasion
Journal Articles

Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion

Yi Liu, Yasunori Deguchi, Rui Tian, Daoyan Wei, Ling Wu, Weidong Chen, Weiguo Xu, Min Xu, Fuyao Liu, Shen Gao, Jonathan C. Jaoude, Sarah P. Chrieki, Micheline J. Moussalli, Mihai Gagea, Jeffrey Morris, Russell R. Broaddus, Xiangsheng Zuo, Imad Shureiqi
Journal: Cancer Research
Cancer Res (2019) 79 (5): 954–969.
https://doi.org/10.1158/0008-5472.CAN-18-1790
Published: 01 March 2019
View article titled, Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion
Open the PDF for Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and Invasion in another window
Includes: Supplementary data
Journal Articles

Abstract 844: PPARD downregulation in cancer cells suppresses metastases by inhibiting tumor angiogenesis and EMT

Xiangsheng Zuo, Weiguo Xu, Min Xu, Rui Tian, Micheline J. Moussalli J. Moussalli, Fei Mao, Mihai Gagea, Daoyan Wei, Anil K. Sood, Imad Shureiqi
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 844.
https://doi.org/10.1158/1538-7445.AM2017-844
Published: 01 July 2017
View article titled, Abstract 844: PPARD downregulation in cancer cells suppresses metastases by inhibiting tumor angiogenesis and EMT
Journal Articles

Abstract 392: Combined targeting of MET and PI3K improves efficacy in breast cancer models with concurrent MET/PI3K aberrations

Shuying Liu, Naoto T. Ueno, Bailiang Wang, Mihai Gagea, Prahlad T. Ram, Mark Merchant, John Mendelsohn, Debasish Tripathy, Gordon B. Mills, Ana M. Gonzalez-Angulo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 392.
https://doi.org/10.1158/1538-7445.AM2016-392
Published: 15 July 2016
View article titled, Abstract 392: Combined targeting of MET and PI3K improves efficacy in breast cancer models with concurrent MET/PI3K aberrations
Journal Articles

KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis

Yongmin Yan, Zhiwei LI, Xiangyu Kong, Zhiliang Jia, Xiangsheng Zuo, Mihai Gagea, Suyun Huang, Daoyan Wei, Keping Xie
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2419–2431.
https://doi.org/10.1158/0008-5472.CAN-15-1691
Published: 14 April 2016
View article titled, KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis
Open the PDF for KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis in another window
Includes: Supplementary data
Journal Articles

A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway

Yan Jiang, Yong Pan, Patrea R. Rhea, Lin Tan, Mihai Gagea, Lorenzo Cohen, Susan M. Fischer, Peiying Yang
Journal: Cancer Research
Cancer Res (2016) 76 (1): 24–29.
https://doi.org/10.1158/0008-5472.CAN-14-3432
Published: 03 January 2016
View article titled, A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway
Open the PDF for A Sucrose-Enriched Diet Promotes Tumorigenesis in Mammary Gland in Part through the 12-Lipoxygenase Pathway in another window
Includes: Supplementary data
Journal Articles

Abstract 3735: Dietary sugar induces tumorigenesis in mammary gland partially through 12 lipoxygenase pathway

Yan Jiang, Yong Pan, Patrea R. Rhea, Lin Tan, Mihai Gagea-Iurascu, Lorenzo Cohen, Peiying Yang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3735.
https://doi.org/10.1158/1538-7445.AM2015-3735
Published: 01 August 2015
View article titled, Abstract 3735: Dietary sugar induces tumorigenesis in mammary gland partially through 12 lipoxygenase pathway
Journal Articles

Abstract 895: Genetic deletion of cyclooxygenase-2 suppresses K-ras induced lung tumorigenesis

Yong Pan, Yan Jiang, Lin Tan, Murali K. Ravoori, Mihai Gagea-Iurascu, Mihai Gagea-Iurascu, Vikus Kundra, Susan M. Fischer, Peiying Yang
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 895.
https://doi.org/10.1158/1538-7445.AM2015-895
Published: 01 August 2015
View article titled, Abstract 895: Genetic deletion of cyclooxygenase-2 suppresses K-ras induced lung tumorigenesis
Journal Articles

miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24+ Progenitor Cells

Jing Zhang, Jingjing Jiao, Silvia Cermelli, Kyle Muir, Kwang Hwa Jung, Ruhai Zou, Asif Rashid, Mihai Gagea, Sonya Zabludoff, Raghu Kalluri, Laura Beretta
Journal: Cancer Research
Cancer Res (2015) 75 (9): 1859–1867.
https://doi.org/10.1158/0008-5472.CAN-14-1254
Published: 30 April 2015
View article titled, miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24<sup>+</sup> Progenitor Cells
Open the PDF for miR-21 Inhibition Reduces Liver Fibrosis and Prevents Tumor Development by Inducing Apoptosis of CD24<sup>+</sup> Progenitor Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 1186: Patient-derived breast cancer xenografts demonstrate molecular evolution in the phosphatidylinositol 3-kinase pathway upon engraftment

Priscilla F. McAuliffe, Argun Akcakanat, Kurt Evans, Agda Karina Eterovic, Hao Zhao, Ken Chen, Takafumi Sangai, Huiqin Chen, Kim-Anh Do, Ashley M. Holder, Chandeshwar Sharma, William Fraser Symmans, Mihai Gagea, Katherine A. Naff, Aysegul Sahin, Asha S. Multani, Gordon B. Mills, Ana Maria Gonzalez-Angulo, Funda Meric-Bernstam
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1186.
https://doi.org/10.1158/1538-7445.AM2014-1186
Published: 01 October 2014
View article titled, Abstract 1186: Patient-derived breast cancer xenografts demonstrate molecular evolution in the phosphatidylinositol 3-kinase pathway upon engraftment
Journal Articles

Abstract 5554: PBI-05204, a supercritical CO2 extract of Nerium oleander, inhibits the growth of human pancreatic cancer in a Panc-1 orthotopic model by down-regulation of PI3k/mTOR pathways.

Yong Pan, Sun-Jin Kim, Patrea Rhea, Carrie Cartwright, Ho Jeong Lee, Crandell Addington, Mihai Gagea, Robert A. Newman, Peiying Yang
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 5554.
https://doi.org/10.1158/1538-7445.AM2013-5554
Published: 15 April 2013
View article titled, Abstract 5554: PBI-05204, a supercritical CO<sub>2</sub> extract of <em>Nerium oleander</em>, inhibits the growth of human pancreatic cancer in a Panc-1 orthotopic model by down-regulation of PI3k/mTOR pathways.
Journal Articles

Moesin Is a Glioma Progression Marker That Induces Proliferation and Wnt/β-Catenin Pathway Activation via Interaction with CD44

Xiaoping Zhu, Fabiana C. Morales, Nitin Kumar Agarwal, Turgut Dogruluk, Mihai Gagea, Maria-Magdalena Georgescu
Journal: Cancer Research
Cancer Res (2013) 73 (3): 1142–1155.
https://doi.org/10.1158/0008-5472.CAN-12-1040
Published: 31 January 2013
View article titled, Moesin Is a Glioma Progression Marker That Induces Proliferation and Wnt/β-Catenin Pathway Activation via Interaction with CD44
Open the PDF for Moesin Is a Glioma Progression Marker That Induces Proliferation and Wnt/β-Catenin Pathway Activation via Interaction with CD44 in another window
Includes: Supplementary data