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Miguel F. Sanmamed
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Journal Articles

Abstract LB198: A first-in-human, open-label, multicenter study of intratumoral SAR441000 (mixture of cytokine encoding mRNAs), as monotherapy and in combination with cemiplimab in patients with advanced solid tumors

Oliver Bechter, Carmen Loquai, Stephane Champiat, Jean Francois Baurain, Jean-Jacques Grob, Jochen Utikal, Sylvie Rottey, Alfonso Berrocal, Jessica Hassel, Ana Arance, Miguel F. Sanmamed, Marye Boers-Sonderen, Brian Gastman, Christoffer Gebhardt, Brant Delafontaine, Ugur Sahin, Özlem Türeci, Giovanni Abbadessa, Gianfranco Di Genova, Patrick Brueck, Rahul Marpadga, Helen Lee, Céleste Lebbe
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB198.
https://doi.org/10.1158/1538-7445.AM2023-LB198
Published: 14 April 2023
View article titled, Abstract LB198: A first-in-human, open-label, multicenter study of intratumoral SAR441000 (mixture of cytokine encoding mRNAs), as monotherapy and in combination with cemiplimab in patients with advanced solid tumors
Journal Articles

Abstract 3826: A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFα and IL-1β

Irene Olivera, Rebeca Sanz-Pamplona, Elixabet Bolaños, Inmaculada Rodriguez, Iñaki Etxeberria, Assunta Cirella, Saray Garasa, Itziar Migueliz, Iñaki Eguren, Miguel F. Sanmamed, Javier Glez-Vaz, Arantza Azpilikueta, Maite Alvarez, Maria C. Ochoa, Carlos E. De Andrea, Pedro Berraondo, Álvaro Teijeira, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3826.
https://doi.org/10.1158/1538-7445.AM2022-3826
Published: 15 June 2022
View article titled, Abstract 3826: A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFα and IL-1β
Journal Articles

Abstract CT107: Correlation of biomarkers and clinical benefit of intratumoral BO112 and pembrolizumab in patients with anti PD1 refractory melanoma

Ruth Roman, Philippe Saiag, Caroline Dutriaux, Luis de la Cruz Merino, Eduardo Castanon, Miguel F. Sanmamed, Caroline Robert, Juan F. Rodríguez-Moreno, Pablo Cerezuela-Fuentes, Ana M. Arance, María González Cao, Henry Montaudié, María Pilar López Criado, Julie Charles, Alfonso Berrocal, María del Carmen Álamo de la Gala, Enrique de Miguel, Elisa Funk-Brentano, Sorilla Prey, Eva Muñoz-Couselo, Delvys Rodríguez Abreu, Juan Martín-Liberal, Helena Escuin-Ordinas, Mark Branum, Sonia Macia, Marisol Quintero, Javier Sánchez López, Marya F. Chaney, Beatriz García-Peláez, Marta Vives-Usano, Miguel Ángel Molina, Stéphane Dalle, Iván Márquez-Rodas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT107.
https://doi.org/10.1158/1538-7445.AM2022-CT107
Published: 15 June 2022
View article titled, Abstract CT107: Correlation of biomarkers and clinical benefit of intratumoral BO112 and pembrolizumab in patients with anti PD1 refractory melanoma
Journal Articles

Abstract 628: Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies

Javier Glez-Vaz, Arantza Azpilikueta, Irene Olivera, Assunta Cirella, Álvaro Teijeira, Carmen Ochoa, Maite Álvarez, Iñaki Eguren, Carlos Luri-Rey, Miguel F. Sanmamed, Ignacio Melero
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 628.
https://doi.org/10.1158/1538-7445.AM2022-628
Published: 15 June 2022
View article titled, Abstract 628: Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies
Journal Articles

Abstract CT014: Efficacy of intratumoral BO-112 with systemic pembrolizumab in patients with advanced melanoma refractory to anti-PD-1-based therapy: Final results of SPOTLIGHT203 phase 2 study

Iván Márquez-Rodas, Caroline Dutriaux, Philippe Saiag, Luis de la Cruz Merino, Eduardo Castanon Álvarez, Caroline Robert, Juan F. Rodríguez-Moreno, Ana M. Arance, Pablo Cerezuela-Fuentes, Henry Montaudié, Miguel F. Sanmamed, María González Cao, Julie Charles, María Pilar López Criado, Alfonso Berrocal, Enrique de Miguel, Elisa Funk-Brentano, Sorilla Prey, María del Carmen Álamo de la Gala, Javier Sánchez López, Helena Escuin-Ordinas, Sonia Macia, Marisol Quintero, Marya F. Chaney, Stéphane Dalle
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT014.
https://doi.org/10.1158/1538-7445.AM2022-CT014
Published: 15 June 2022
View article titled, Abstract CT014: Efficacy of intratumoral BO-112 with systemic pembrolizumab in patients with advanced melanoma refractory to anti-PD-1-based therapy: Final results of SPOTLIGHT203 phase 2 study
Journal Articles

Abstract CT109: Radiomic features in tumor assessment, preliminary results from a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with anti PD1 refractory melanoma

Paula Moreno, Philippe Saiag, Luis de la Cruz Merino, Caroline Dutriaux, Eduardo Castanon Álvarez, Caroline Robert, Juan F. Rodríguez-Moreno, Pablo Cerezuela-Fuentes, Ana M. Arance, Henry Montaudié, Miguel F. Sanmamed, María González Cao, María Pilar López Criado, Julie Charles, Alfonso Berrocal, Enrique de Miguel, Elisa Funk-Brentano, Pablo Sau Llanas, Sorilla Prey, Eva Muñoz-Couselo, Delvys Rodríguez Abreu, Juan Martin-Liberal, Ángel Alberich-Bayarri, Javier Sánchez López, Sonia Macia, Marisol Quintero, Marya F. Chaney, Stéphane Dalle, Iván Márquez-Rodas
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT109.
https://doi.org/10.1158/1538-7445.AM2022-CT109
Published: 15 June 2022
View article titled, Abstract CT109: Radiomic features in tumor assessment, preliminary results from a phase 2 study of intratumoral administration of BO-112 with pembrolizumab in patients with anti PD1 refractory melanoma
Journal Articles

Abstract 1691: CD137 (4-1BB) costimulation of CD8 T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation

Itziar Otano, Arantza Azpilikueta, Javier Glez-Vaz, Peter Ellmark, Sara Fritzell, Gabriela Fernandez-Hoyos, Michelle Hase Nelson, Maite Alvarez, María del Carmen Ochoa, Elixabet Bolaños, Doina Cuculescu, Patricia Jauregui, Sandra Sanchez, Iñaki Etxeberría, María E. Rodriguez-Ruiz, Miguel F. Sanmamed, Alvaro Teijeira, Pedro Berraondo, Igancio Melero
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1691.
https://doi.org/10.1158/1538-7445.AM2021-1691
Published: 01 July 2021
View article titled, Abstract 1691: CD137 (4-1BB) costimulation of CD8 T cells is more potent when provided in cis than in trans with respect to CD3-TCR stimulation
Journal Articles

Abstract 6292: Novel seroprofiling assay reveals previously undescribed autoantibody responses in immunotherapy treated cancer patients

Eric Y. Wang, Connor E. Rosen, Yile Dai, Miguel F. Sanmamed, Aaron M. Ring
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6292.
https://doi.org/10.1158/1538-7445.AM2020-6292
Published: 15 August 2020
View article titled, Abstract 6292: Novel seroprofiling assay reveals previously undescribed autoantibody responses in immunotherapy treated cancer patients
Journal Articles

Abstract 1681: Simultaneous measurement and significance of PD-1, LAG-3 and TIM-3 expression in human solid tumors

Micaela Morgado, Ila Datar, Jun Wang, Miguel F. Sanmamed, Kristen McEachern, David Jenkins, Lieping Chen, Daniel Carvajal-Hausdorf, David L. Rimm, Roy S. Herbst, Kurt A. Schalper
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1681.
https://doi.org/10.1158/1538-7445.AM2018-1681
Published: 01 July 2018
View article titled, Abstract 1681: Simultaneous measurement and significance of PD-1, LAG-3 and TIM-3 expression in human solid tumors
Journal Articles

Abstract 5600: Simultaneous measurement and clinical significance of PD-1, LAG-3 and TIM-3 in non-small cell lung cancer (NSCLC)

Ila J. Datar, Jun Wang, Nikita Mani, Franz Villarroel-Espindola, Patrick Ryan, Miguel F. Sanmamed, Kristen McEachern, David Jenkins, David L. Rimm, Leiping Chen, Roy Herbst, Kurt Schalper
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5600.
https://doi.org/10.1158/1538-7445.AM2017-5600
Published: 01 July 2017
View article titled, Abstract 5600: Simultaneous measurement and clinical significance of PD-1, LAG-3 and TIM-3 in non-small cell lung cancer (NSCLC)
Journal Articles

Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming

María E. Rodriguez-Ruiz, Inmaculada Rodriguez, Saray Garasa, Benigno Barbes, Jose Luis Solorzano, Jose Luis Perez-Gracia, Sara Labiano, Miguel F. Sanmamed, Arantza Azpilikueta, Elixabet Bolaños, Alfonso R. Sanchez-Paulete, M. Angela Aznar, Ana Rouzaut, Kurt A. Schalper, Maria Jure-Kunkel, Ignacio Melero
Journal: Cancer Research
Cancer Res (2016) 76 (20): 5994–6005.
https://doi.org/10.1158/0008-5472.CAN-16-0549
Published: 13 October 2016
View article titled, Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming
Open the PDF for Abscopal Effects of Radiotherapy Are Enhanced by Combined Immunostimulatory mAbs and Are Dependent on CD8 T Cells and Crosspriming in another window
Includes: Supplementary data
Journal Articles

Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice

Miguel F. Sanmamed, Inmaculada Rodriguez, Kurt A. Schalper, Carmen Oñate, Arantza Azpilikueta, Maria E. Rodriguez-Ruiz, Aizea Morales-Kastresana, Sara Labiano, Jose L. Pérez-Gracia, Salvador Martín-Algarra, Carlos Alfaro, Guillermo Mazzolini, Francesca Sarno, Manuel Hidalgo, Alan J. Korman, Maria Jure-Kunkel, Ignacio Melero
Journal: Cancer Research
Cancer Res (2015) 75 (17): 3466–3478.
https://doi.org/10.1158/0008-5472.CAN-14-3510
Published: 31 August 2015
View article titled, Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2<sup>−/−</sup>IL2Rγ<sup>null</sup> Immunodeficient Mice
Open the PDF for Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2<sup>−/−</sup>IL2Rγ<sup>null</sup> Immunodeficient Mice in another window
Includes: Supplementary data
Journal Articles

Abstract 261: Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rγnull immunodeficient mice

Miguel F. Sanmamed, Inmaculada Rodriguez, Carmen Oñate, Arantza Azpilikueta, Maria E. Rodriguez-Ruiz, Aizea Morales-Kastresana, Sara Labiano, Jose L. Perez-Gracia, Salvador Martín-Algarra, Carlos Alfaro, Kurt A. Schalper, Guillermo Mazzolini, Francesca Sarno, Manuel Hidalgo, Alan J. Korman, Maria Jure-Kunkel, Ignacio Melero
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 261.
https://doi.org/10.1158/1538-7445.AM2015-261
Published: 01 August 2015
View article titled, Abstract 261: Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rγnull immunodeficient mice
Journal Articles

Strict Requirement for Vector-Induced Type I Interferon in Efficacious Antitumor Responses to Virally Encoded IL12

Ignacio Melero, Jose I. Quetglas, Mercedes Reboredo, Juan Dubrot, Juan R. Rodriguez-Madoz, Uxua Mancheño, Erkuden Casales, Jose I. Riezu-Boj, Marta Ruiz-Guillen, Maria C. Ochoa, Miguel F. Sanmamed, Nathalie Thieblemont, Cristian Smerdou, Sandra Hervas-Stubbs
Journal: Cancer Research
Cancer Res (2015) 75 (3): 497–507.
https://doi.org/10.1158/0008-5472.CAN-13-3356
Published: 01 February 2015
View article titled, Strict Requirement for Vector-Induced Type I Interferon in Efficacious Antitumor Responses to Virally Encoded IL12
Open the PDF for Strict Requirement for Vector-Induced Type I Interferon in Efficacious Antitumor Responses to Virally Encoded IL12 in another window
Includes: Supplementary data
Journal Articles

Abstract LB-330: Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma.

Aizea Morales-Kastresana, Miguel F. Sanmamed, Inmaculada Rodriguez, Asis Palazon, Ivan Martinez-Forero, Sara Labiano, Sandra Hervas-Stubbs, Bruno Sangro, Carmen Ochoa, Arantza Azpilikueta, Elixabet Bolaños, Ines Gütgemann, Ignacio Melero
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): LB-330.
https://doi.org/10.1158/1538-7445.AM2013-LB-330
Published: 15 April 2013
View article titled, Abstract LB-330: Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carcinoma.