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Mien-Chie Hung
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Journal Articles

Abstract P53: Inhibition of STING/Galectin-9 Axis Sensitize Anthracyclines Treatment And Induce Anti-tumor Immunity

Xian Sun, Wei-Jan Wang, Jilu Lang, Riyao Yang, Wan-Jou Shen, Linlin Sun, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2024) 84 (8_Supplement): P53.
https://doi.org/10.1158/1538-7445.FCS2023-P53
Published: 15 April 2024
View article titled, Abstract P53: Inhibition of STING/Galectin-9 Axis Sensitize Anthracyclines Treatment And Induce Anti-tumor Immunity
Journal Articles

Abstract 33: Revitalizing CAR-T cells for TNBC: Targeting phosphorylation of TCF7 to overcome T cell exhaustion

Zhou Jiang, Yu-Yi Chu, Heng-Huan Lee, Mien-Chie Hung, Liuqing Yang, Chunru Lin
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 33.
https://doi.org/10.1158/1538-7445.AM2024-33
Published: 22 March 2024
View article titled, Abstract 33: Revitalizing CAR-T cells for TNBC: Targeting phosphorylation of TCF7 to overcome T cell exhaustion
Journal Articles

Abstract 2690: The role of PCNA tyrosine phosphorylation in evading innate immune surveillance

Chuan-Chun Lee, Wan-Rong Wu, Yi-Chun Shen, Feng-Chi Chung, Yuan-Liang Wang, You-Zhe Lin, Chih-Hao Lu, Wei-Chung Cheng, Han Chang, Liang-Chih Liu, Ji-An Liang, Chang- Fang Chiu, Mien-Chie Hung, Shao-Chun Wang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2690.
https://doi.org/10.1158/1538-7445.AM2024-2690
Published: 22 March 2024
View article titled, Abstract 2690: The role of PCNA tyrosine phosphorylation in evading innate immune surveillance
Journal Articles

Abstract 416: Phosphorylation of CDK9 transduces ALK signaling to promote resistance to PARP inhibitors via RNA Pol II activated homologous recombination repair

Yu-Yi Chu, Jianjun Gao, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 416.
https://doi.org/10.1158/1538-7445.AM2023-416
Published: 04 April 2023
View article titled, Abstract 416: Phosphorylation of CDK9 transduces ALK signaling to promote resistance to PARP inhibitors via RNA Pol II activated homologous recombination repair
Journal Articles

Abstract C070: Investigation of the roles of BDKRB1 in pancreatic cancer progression and tumor microenvironment modulation

Ching-Fei Li, Jie Fu, Heng-Huan Lee, Ying-Nai Wang, Yu-Yi Chu, Paul J. Chiao, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): C070.
https://doi.org/10.1158/1538-7445.PANCA22-C070
Published: 15 November 2022
View article titled, Abstract C070: Investigation of the roles of BDKRB1 in pancreatic cancer progression and tumor microenvironment modulation
Journal Articles

Abstract 1792: FGFR3 mediated PARP1 tyrosine 158 phosphorylation promotes PARP inhibitor resistance

MeiKuang Chen, Yuan Gao, Weiya Xia, Yu-Han Wang, Jennifer K. Litton, Yu-Yi Chu, Funda Meric-Bernstam, Helen Piwnica-Worms, Banu Arun, Jordi Rodon Ahnert, Yongkun Wei, Wei-Chao Chang, Hung-Ling Wang, Coya Tapia, Constance T. Albarracin, Shao-Chun Wang, Ying-Nai Wang, Gabriel N. Hortobagyi, Chunru Lin, Liuqing Yang, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1792.
https://doi.org/10.1158/1538-7445.AM2022-1792
Published: 15 June 2022
View article titled, Abstract 1792: FGFR3 mediated PARP1 tyrosine 158 phosphorylation promotes PARP inhibitor resistance
Journal Articles

Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function

Xixi Zhao, Yongkun Wei, Yu-Yi Chu, Yintao Li, Jung-Mao Hsu, Zhou Jiang, Chunxiao Liu, Jennifer L. Hsu, Wei-Chao Chang, Riyao Yang, Li-Chuan Chan, Jingkun Qu, Shuqun Zhang, Haoqiang Ying, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2022) 82 (11): 2185–2195.
https://doi.org/10.1158/0008-5472.CAN-21-2300
Published: 06 June 2022
View article titled, Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function
Open the PDF for Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function in another window
Includes: Supplementary data
Journal Articles

AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4

Jinquan Liu, Bo Yuan, Jin Cao, Hongjie Luo, Shuchen Gu, Mengdi Zhang, Ran Ding, Long Zhang, Fangfang Zhou, Mien-Chie Hung, Pinglong Xu, Xia Lin, Jianping Jin, Xin-Hua Feng
Journal: Cancer Research
Cancer Res (2021) 81 (19): 5007–5020.
https://doi.org/10.1158/0008-5472.CAN-21-0431
Published: 01 October 2021
View article titled, AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4
Open the PDF for AMBRA1 Promotes TGFβ Signaling via Nonproteolytic Polyubiquitylation of Smad4 in another window
Includes: Supplementary data
Journal Articles

Abstract LB097: MET inhibitor enhances efficacies of gemcitabine and olaparib in pancreatic cancer cells

Meikuang Chen, Yuan Gao, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB097.
https://doi.org/10.1158/1538-7445.AM2021-LB097
Published: 01 July 2021
View article titled, Abstract LB097: MET inhibitor enhances efficacies of gemcitabine and olaparib in pancreatic cancer cells
Journal Articles

Abstract 3081: Secretory human ribonuclease 1 functions as Eph receptor A4 ligand to promote breast tumor initiation

Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Gabriel N. Hortobagyi, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 3081.
https://doi.org/10.1158/1538-7445.AM2021-3081
Published: 01 July 2021
View article titled, Abstract 3081: Secretory human ribonuclease 1 functions as Eph receptor A4 ligand to promote breast tumor initiation
Journal Articles

Abstract 120: Compartmentalized functions of epidermal growth factor receptor (EGFR) in tumorigenesis and malignant phenotypes

Lei Nie, Junwei Hou, Yu-Yi Chu, Ying-Nai Wnag, Li-Chuan Chan, Longfei Huo, Paul Chiao, Shao-Chun Wang, Mien-Chie Hung, Michael Wang
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 120.
https://doi.org/10.1158/1538-7445.AM2021-120
Published: 01 July 2021
View article titled, Abstract 120: Compartmentalized functions of epidermal growth factor receptor (EGFR) in tumorigenesis and malignant phenotypes
Journal Articles

Abstract 6527: Targeting glycosylated PD-1 induces potent anti-tumor immunity

Yuhan Wang, Linlin Sun, Riyao Yang, Jielin Liu, Yufan Qiu, Jennifer L. Hsu, Jong-ho Cha, Li-Chuan Chan, Jung-Mao Hsu, Heng-Huan Lee, Yun-Ju Lai, Kay-Hooi Khoo, Ezra M Chung, Chia-Wei Li, Yong-Soo Kim, Andrew H Park, Yi Yang, Stephen S. Yoo, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6527.
https://doi.org/10.1158/1538-7445.AM2020-6527
Published: 15 August 2020
View article titled, Abstract 6527: Targeting glycosylated PD-1 induces potent anti-tumor immunity
Journal Articles

Abstract 1027: Inhibition of c-MET upregulates PD-L1 related immune escape in lung adenocarcinoma

Xian Sun, Chia-Wei Li, Wei-Jan Wang, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1027.
https://doi.org/10.1158/1538-7445.AM2020-1027
Published: 15 August 2020
View article titled, Abstract 1027: Inhibition of c-MET upregulates PD-L1 related immune escape in lung adenocarcinoma
Journal Articles

Abstract 5682: Synergism of PARP inhibitor and MET inhibitor in multiple cancer types with intrinsic and acquired PARP inhibitor resistances

Mei-Kuang Chen, Weiya Xia, Qiongzhu Dong, Yi Du, Hung-Ling Wang, Coya Tapia, Yongkun Wei, Ye Han, Yu-Yi Chu, Clinton Yam, Yuan Gao, Yu-Han Wang, Funda Meric-Bernstam, Jinsong Liu, Shao-Chun Wang, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5682.
https://doi.org/10.1158/1538-7445.AM2020-5682
Published: 15 August 2020
View article titled, Abstract 5682: Synergism of PARP inhibitor and MET inhibitor in multiple cancer types with intrinsic and acquired PARP inhibitor resistances
Journal Articles

Abstract 4074: Reversing acquired PARPi resistance of TNBC through combined inhibition of cMet and EGFR

Yu Yi Chu, Clinton Yam, Mei-Kuang Chen, Li-Chuan Chan, Lei Nie, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4074.
https://doi.org/10.1158/1538-7445.AM2020-4074
Published: 15 August 2020
View article titled, Abstract 4074: Reversing acquired PARPi resistance of TNBC through combined inhibition of cMet and EGFR
Journal Articles

Abstract 5180: Nuclear receptor tyrosine kinase c-MET restrains efficacy of PARP inhibitor in pancreatic cancer cells

Yuan Gao, Mei-Kuang Chen, Dihua Yu, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5180.
https://doi.org/10.1158/1538-7445.AM2020-5180
Published: 15 August 2020
View article titled, Abstract 5180: Nuclear receptor tyrosine kinase c-MET restrains efficacy of PARP inhibitor in pancreatic cancer cells
Journal Articles

Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity

Linlin Sun, Chia-Wei Li, Ezra M. Chung, Riyao Yang, Yong-Soo Kim, Andrew H. Park, Yun-Ju Lai, Yi Yang, Yu-Han Wang, Jielin Liu, Yufan Qiu, Kay-Hooi Khoo, Jun Yao, Jennifer L. Hsu, Jong-Ho Cha, Li-Chuan Chan, Jung-Mao Hsu, Heng-Huan Lee, Stephen S. Yoo, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2020) 80 (11): 2298–2310.
https://doi.org/10.1158/0008-5472.CAN-19-3133
Published: 02 June 2020
View article titled, Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity
Open the PDF for Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity in another window
Includes: Supplementary data
Journal Articles

Abstract LB-092: TKI insensitive role of EGFRconfers TKI resistance via PKCδ

Pei-chih Lee, Mien-chie Hung
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-092.
https://doi.org/10.1158/1538-7445.AM2019-LB-092
Published: 01 July 2019
View article titled, Abstract LB-092: TKI insensitive role of EGFRconfers TKI resistance via PKCδ
Journal Articles

Abstract LB-258: EGFR and c-MET cooperate to enhance PARP inhibitor resistance in hepatocellular carcinoma

Qiongzhu Dong, Yi Du, Xixi Zhao, Hui Li, Chunxiao Liu, Yongkun Wei, Mien-chie Hung
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-258.
https://doi.org/10.1158/1538-7445.AM2019-LB-258
Published: 01 July 2019
View article titled, Abstract LB-258: EGFR and c-MET cooperate to enhance PARP inhibitor resistance in hepatocellular carcinoma
Journal Articles

Abstract 4122: The regulatory mechanism of PD-L1 level through ER-associated degradation

Jong-Ho Cha, Wen-Hao Yang, Weiya Xia, Yongkun Wei, Li-Chuan Chan, Chia-Wei Li, Heng-Huan Lee, Mien-Chie Hung
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4122.
https://doi.org/10.1158/1538-7445.AM2019-4122
Published: 01 July 2019
View article titled, Abstract 4122: The regulatory mechanism of PD-L1 level through ER-associated degradation