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Journal Articles

Abstract 1087: CXCR2 and its ligands modulate chemotherapy resistance in pancreatic ductal adenocarcinoma

Caitlin Molczyk, Dipakkumar R. Prajapati, Sugandha Saxena, Paran Goel, Michelle Varney, Rakesh K. Singh

Cancer Res (2021) 81 (13_Supplement): 1087.

https://doi.org/10.1158/1538-7445.AM2021-1087

Published: 01 July 2021

View article titled, Abstract 1087: CXCR2 and its ligands modulate chemotherapy resistance in pancreatic ductal adenocarcinoma

Journal Articles

Abstract 6194: Evaluation of the differential expression profile of CXC-receptor-2 ligands for potential biomarker candidates in pancreatic ductal adenocarcinoma

Sugandha Saxena, Abhilasha Purohit, Evie Ehrhorn, Pranita Atri, Caitlin Molczyk, Michelle Varney, Rakesh K. Singh

Cancer Res (2020) 80 (16_Supplement): 6194.

https://doi.org/10.1158/1538-7445.AM2020-6194

Published: 15 August 2020

View article titled, Abstract 6194: Evaluation of the differential expression profile of CXC-receptor-2 ligands for potential biomarker candidates in pancreatic ductal adenocarcinoma

Journal Articles

Abstract 1982: Sustained CXCR2 signaling promotes secretory phenotype in cancer-associated fibroblasts of pancreatic cancer via activation of NFkB

Mohammad Awaji, Michelle Varney, Abhilasha Purohit, Lingyun Wu, Sugandha Saxena, Sushil Kumar, Surinder K. Batra, Rakesh K. Singh

Cancer Res (2019) 79 (13_Supplement): 1982.

https://doi.org/10.1158/1538-7445.AM2019-1982

Published: 01 July 2019

View article titled, Abstract 1982: Sustained CXCR2 signaling promotes secretory phenotype in cancer-associated fibroblasts of pancreatic cancer via activation of NFkB

Journal Articles

Abstract 5085: CXCR2 signaling in pancreatic cancer induces a tumor supporting inflammatory phenotype of the cancer-associated fibroblasts

Mohammad Awaji, Michelle Varney, Abhilasha Purohit, Surinder Batra, Rakesh Singh

Cancer Res (2018) 78 (13_Supplement): 5085.

https://doi.org/10.1158/1538-7445.AM2018-5085

Published: 01 July 2018

View article titled, Abstract 5085: CXCR2 signaling in pancreatic cancer induces a tumor supporting inflammatory phenotype of the cancer-associated fibroblasts

Journal Articles

Abstract 942: CXCR2 acts as a checkpoint regulator of the pancreatic stellate cells activity within pancreatic cancer tumor microenvironment

Mohammad Awaji, Michelle Varney, Abhilasha Purohit, Surinder K. Batra, Rakesh K. Singh

Cancer Res (2017) 77 (13_Supplement): 942.

https://doi.org/10.1158/1538-7445.AM2017-942

Published: 01 July 2017

View article titled, Abstract 942: CXCR2 acts as a checkpoint regulator of the pancreatic stellate cells activity within pancreatic cancer tumor microenvironment

Journal Articles

Abstract 1683: Dual role of semaphorin5A in maintaining epithelial and mesenchymal phenotype in metastatic pancreatic cancer

Sugandha Saxena, Abhilasha Purohit, Michelle Varney, Surinder K. Batra, Rakesh K. Singh

Cancer Res (2016) 76 (14_Supplement): 1683.

https://doi.org/10.1158/1538-7445.AM2016-1683

Published: 15 July 2016

View article titled, Abstract 1683: Dual role of semaphorin5A in maintaining epithelial and mesenchymal phenotype in metastatic pancreatic cancer

Journal Articles

Abstract 3178: Targeting CXCR2 signaling inhibits KRAS^(G12D) induced autocrine growth transformation by suppressing ERK activation in pancreatic cancer

Abhilasha Purohit, Michelle Varney, Satya Rachagani, Pavan Myneni, Michel Ouellette, Surinder K. Batra, Rakesh K. Singh

Cancer Res (2015) 75 (15_Supplement): 3178.

https://doi.org/10.1158/1538-7445.AM2015-3178

Published: 01 August 2015

View article titled, Abstract 3178: Targeting CXCR2 signaling inhibits KRAS(G12D) induced autocrine growth transformation by suppressing ERK activation in pancreatic cancer

Journal Articles

Abstract 4874: CXCR2 signaling axis- a helping hand to KRAS(G12D) mutation in pancreatic cancer initiation

Abhilasha Purohit, Michelle Varney, Satya Rachagani, Michel Ouellette, Surinder K. Batra, Rakesh K. Singh

Cancer Res (2014) 74 (19_Supplement): 4874.

https://doi.org/10.1158/1538-7445.AM2014-4874

Published: 01 October 2014

View article titled, Abstract 4874: CXCR2 signaling axis- a helping hand to KRAS(G12D) mutation in pancreatic cancer initiation

Journal Articles

Abstract 4353: Cycloxygenase-2 inhibitor regulates p73 isoform expression pattern, inhibit growth, and induce apoptosis in NHL cell line model with 1p36 chromosomal disruption.

Hesham M. Hassan, Michelle Varney, Shantaram S. Joshi, Rakesh K. Singh, Bhavana J. Dave

Cancer Res (2013) 73 (8_Supplement): 4353.

https://doi.org/10.1158/1538-7445.AM2013-4353

Published: 15 April 2013

View article titled, Abstract 4353: Cycloxygenase-2 inhibitor regulates p73 isoform expression pattern, inhibit growth, and induce apoptosis in NHL cell line model with 1p36 chromosomal disruption.

Journal Articles

Abstract 1431: Upregulation of CXCR2 and its ligands in KRAS oncogene-induced initiation of pancreatic cancer.

Abhilasha Purohit, Michelle Varney, Satya Rachagani, Michelle Ouellete, Surinder K. Batra, Rakesh K. Singh

Cancer Res (2013) 73 (8_Supplement): 1431.

https://doi.org/10.1158/1538-7445.AM2013-1431

Published: 15 April 2013

View article titled, Abstract 1431: Upregulation of CXCR2 and its ligands in KRAS oncogene-induced initiation of pancreatic cancer.

Journal Articles

Abstract #4074: Vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 signaling directly modulates mammary tumor cell survival, growth and metastasis

Michelle Varney, Rakesh Singh

Cancer Res (2009) 69 (9_Supplement): 4074.

Published: 01 May 2009

View article titled, Abstract #4074: Vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 signaling directly modulates mammary tumor cell survival, growth and metastasis

Journal Articles

Abstract #1101: Expression of CXCR1 and CXCR2 enhances human melanoma tumorigenesis, growth and invasion

Seema Singh, Kalyan Nannuru, Anguraj Sadanandam, Michelle Varney, Rakesh Singh

Cancer Res (2009) 69 (9_Supplement): 1101.

Published: 01 May 2009

View article titled, Abstract #1101: Expression of CXCR1 and CXCR2 enhances human melanoma tumorigenesis, growth and invasion

Journal Articles

Abstract #1092: CXCR2 knock-down in mouse mammary tumor cells inhibits growth, invasion and metastasis

Kalyan Nannuru, Michelle Varney, Gibril Fadika, Rakesh Singh

Cancer Res (2009) 69 (9_Supplement): 1092.

Published: 01 May 2009

View article titled, Abstract #1092: CXCR2 knock-down in mouse mammary tumor cells inhibits growth, invasion and metastasis

Journal Articles

Host CXCR2-Dependent Regulation of Melanoma Growth, Angiogenesis, and Experimental Lung Metastasis

Seema Singh, Michelle Varney, Rakesh K. Singh

Cancer Res (2009) 69 (2): 411–415.

https://doi.org/10.1158/0008-5472.CAN-08-3378

Published: 15 January 2009

View article titled, Host CXCR2-Dependent Regulation of Melanoma Growth, Angiogenesis, and Experimental Lung Metastasis

Journal Articles

Overexpression of CXCR1 and CXCR2 promotes endothelial cell proliferation and motility by enhancing Erk1/2 phosphorylation, β-catenin relocalization and cytoskeletal rearrangement

Seema Singh, Kalyan Nannuru, Michelle Varney, Rakesh Singh

Cancer Res (2008) 68 (9_Supplement): 1074.

Published: 01 May 2008

View article titled, Overexpression of CXCR1 and CXCR2 promotes endothelial cell proliferation and motility by enhancing Erk1/2 phosphorylation, β-catenin relocalization and cytoskeletal rearrangement

Journal Articles

CXCR1 or CXCR2 knock-down inhibits cellular proliferation, survival, motility and tumor growth in human malignant melanoma

Michelle Varney, Seema Singh, Rakesh Singh

Cancer Res (2008) 68 (9_Supplement): 5099.

Published: 01 May 2008

View article titled, CXCR1 or CXCR2 knock-down inhibits cellular proliferation, survival, motility and tumor growth in human malignant melanoma

Journal Articles

Overexpression of CXCR1 or CXCR2 enhances melanoma cell proliferation, survival, invasiveness and regulates tumor growth

Seema Singh, Kalyan Nannuru, Michelle Varney, Rakesh Singh

Cancer Res (2008) 68 (9_Supplement): 5098.

Published: 01 May 2008

View article titled, Overexpression of CXCR1 or CXCR2 enhances melanoma cell proliferation, survival, invasiveness and regulates tumor growth

Journal Articles

Up-regulation of Matrix metalloproteinase (MMP-13) expression at the tumor-bone interface favors mammary tumor-induced osteolysis.

Kalyan Nannuru, Mitsuru Futakuchi, Anguraj Sadanandam, Michelle Varney, Thomas Vincent, Eric Marcusson, Rakesh Singh

Cancer Res (2008) 68 (9_Supplement): 1146.

Published: 01 May 2008

View article titled, Up-regulation of Matrix metalloproteinase (MMP-13) expression at the tumor-bone interface favors mammary tumor-induced osteolysis.

Journal Articles

Small molecule antagonists for CXCR1 and CXCR2 inhibit human colon cancer metastasis by decreasing angiogenesis and enhancing apoptosis

Michelle Varney, Aihua Li, Seema Singh, Rosemary Mayer-Ezell, Richard Bond, Rakesh Singh

Cancer Res (2007) 67 (9_Supplement): 5632.

Published: 01 May 2007

View article titled, Small molecule antagonists for CXCR1 and CXCR2 inhibit human colon cancer metastasis by decreasing angiogenesis and enhancing apoptosis

Journal Articles

Up-regulation of soluble RANKL at tumor-bone interface is critical for mammary tumor-induced osteolysis

Kalyan Nannuru, Mitsuru Futakuchi, Thomas Wilson, Rakesh Singh, Michelle Varney, Thomas Vincent, Eric Marcusson

Cancer Res (2007) 67 (9_Supplement): 2795.

Published: 01 May 2007

View article titled, Up-regulation of soluble RANKL at tumor-bone interface is critical for mammary tumor-induced osteolysis

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Abstract 1087: CXCR2 and its ligands modulate chemotherapy resistance in pancreatic ductal adenocarcinoma

Abstract 6194: Evaluation of the differential expression profile of CXC-receptor-2 ligands for potential biomarker candidates in pancreatic ductal adenocarcinoma

Abstract 1982: Sustained CXCR2 signaling promotes secretory phenotype in cancer-associated fibroblasts of pancreatic cancer via activation of NFkB

Abstract 5085: CXCR2 signaling in pancreatic cancer induces a tumor supporting inflammatory phenotype of the cancer-associated fibroblasts

Abstract 942: CXCR2 acts as a checkpoint regulator of the pancreatic stellate cells activity within pancreatic cancer tumor microenvironment

Abstract 1683: Dual role of semaphorin5A in maintaining epithelial and mesenchymal phenotype in metastatic pancreatic cancer

Abstract 3178: Targeting CXCR2 signaling inhibits KRAS^(G12D) induced autocrine growth transformation by suppressing ERK activation in pancreatic cancer

Abstract 4874: CXCR2 signaling axis- a helping hand to KRAS(G12D) mutation in pancreatic cancer initiation

Abstract 4353: Cycloxygenase-2 inhibitor regulates p73 isoform expression pattern, inhibit growth, and induce apoptosis in NHL cell line model with 1p36 chromosomal disruption.

Abstract 1431: Upregulation of CXCR2 and its ligands in KRAS oncogene-induced initiation of pancreatic cancer.

Abstract #4074: Vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 signaling directly modulates mammary tumor cell survival, growth and metastasis

Abstract #1101: Expression of CXCR1 and CXCR2 enhances human melanoma tumorigenesis, growth and invasion

Abstract #1092: CXCR2 knock-down in mouse mammary tumor cells inhibits growth, invasion and metastasis

Host CXCR2-Dependent Regulation of Melanoma Growth, Angiogenesis, and Experimental Lung Metastasis

Overexpression of CXCR1 and CXCR2 promotes endothelial cell proliferation and motility by enhancing Erk1/2 phosphorylation, β-catenin relocalization and cytoskeletal rearrangement

CXCR1 or CXCR2 knock-down inhibits cellular proliferation, survival, motility and tumor growth in human malignant melanoma

Overexpression of CXCR1 or CXCR2 enhances melanoma cell proliferation, survival, invasiveness and regulates tumor growth

Up-regulation of Matrix metalloproteinase (MMP-13) expression at the tumor-bone interface favors mammary tumor-induced osteolysis.

Small molecule antagonists for CXCR1 and CXCR2 inhibit human colon cancer metastasis by decreasing angiogenesis and enhancing apoptosis

Up-regulation of soluble RANKL at tumor-bone interface is critical for mammary tumor-induced osteolysis

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