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Michele S. Dowless
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Journal Articles

Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models

Loredana Puca, Michele S. Dowless, Carmen M. Perez-Ferreiro, Maria Jesus Ortiz-Ruiz, Gregory P. Donoho, Andrew Capen, Lysiane Huber, Sarah M. Bogner, Dongling Fei, Jason R. Manro, Chun Ping Yu, Wei Guo Xu, Rui Wang, Shuang Chen, Mark A. Hicks, Parisa Zolfaghari, Andrew Faber, Raymond Gilmour, Monica D. Ramstetter, Matthew T. Chang, Maria Jose Lallena, Xuequian Gong, David M. Hyman, Lillian M. Smyth, Barbara J. Brandhuber, Barry S. Taylor, Anke Klippel
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P4-08-02.
https://doi.org/10.1158/1538-7445.SABCS22-P4-08-02
Published: 01 March 2023
View article titled, Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models
Journal Articles

Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases

Bruce W. Konicek, Jennifer R. Stephens, Ann M. McNulty, Nathaniel Robichaud, Robert B. Peery, Chad A. Dumstorf, Michele S. Dowless, Philip W. Iversen, Stephen Parsons, Karen E. Ellis, Denis J. McCann, Jerry Pelletier, Luc Furic, Jonathan M. Yingling, Louis F. Stancato, Nahum Sonenberg, Jeremy R. Graff
Journal: Cancer Research
Cancer Res (2011) 71 (5): 1849–1857.
https://doi.org/10.1158/0008-5472.CAN-10-3298
Published: 01 March 2011
View article titled, Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases
Open the PDF for Therapeutic Inhibition of MAP Kinase Interacting Kinase Blocks Eukaryotic Initiation Factor 4E Phosphorylation and Suppresses Outgrowth of Experimental Lung Metastases in another window
Journal Articles

eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival

Jeremy R. Graff, Bruce W. Konicek, Rebecca L. Lynch, Chad A. Dumstorf, Michele S. Dowless, Ann M. McNulty, Stephen H. Parsons, Leslie H. Brail, Bruce M. Colligan, Jonathan W. Koop, Bernadette M. Hurst, James A. Deddens, Blake L. Neubauer, Louis F. Stancato, Harry W. Carter, Larry E. Douglass, Julia H. Carter
Journal: Cancer Research
Cancer Res (2009) 69 (9): 3866–3873.
https://doi.org/10.1158/0008-5472.CAN-08-3472
Published: 30 April 2009
View article titled, eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival
Open the PDF for eIF4E Activation Is Commonly Elevated in Advanced Human Prostate Cancers and Significantly Related to Reduced Patient Survival in another window
Includes: Supplementary data