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Michel Sadelain
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Journal Articles

Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer

Zeda Zhang, Xin Fang, Yu-jui Ho, Sascha Haubner, Friederike Kogel, Clemens Hinterleitner, Stella Paffenholz, Kevin Chen, Wei Luan, Amanda Kulick, Gertrude Gunset, Andreina Garcia Angus, Jing Zhang, Zijian Xu, Adam Wang, Qingwen Jiang, Elisa de Stanchina, Britta Weigelt, Dmitriy Zamarin, Aveline Filliol, Judith Feucht, Jorge Mansilla-Soto, Corina Amor, Michel Sadelain, Scott Lowe
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 115.
https://doi.org/10.1158/1538-7445.AM2024-115
Published: 22 March 2024
View article titled, Abstract 115: Developing uPAR CAR T Cells for High-Grade Serous Ovarian Cancer
Journal Articles

Abstract 1150: CD70 HIT T cells overcome tumor antigen heterogeneity in renal cell carcinoma

Sophie A. Hanina, Michael Lopez, Huiyong Zhao, Rajasekhar Vinagolu, Ritesh Kotecha, A Ari Hakimi, John H. Healey, Jorge Mansilla-Soto, Michel Sadelain
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1150.
https://doi.org/10.1158/1538-7445.AM2023-1150
Published: 04 April 2023
View article titled, Abstract 1150: CD70 HIT T cells overcome tumor antigen heterogeneity in renal cell carcinoma
Journal Articles

Abstract 5583: SUV39H1 disruption enhances the persistence and anti-tumor efficacy of CD28-costimulated human CAR T cells

Nayan Jain, Zeguo Zhao, Richard Koche, Yosi Gozlan, David Brocks, Tali Raveh-Sadka, Danny Wells, Anton Dobrin, Yuzhe Shi, Michael Lopez, Gertrude Gunset, Michel Sadelain
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5583.
https://doi.org/10.1158/1538-7445.AM2022-5583
Published: 15 June 2022
View article titled, Abstract 5583: <em>SUV39H1</em> disruption enhances the persistence and anti-tumor efficacy of CD28-costimulated human CAR T cells
Journal Articles

Abstract PR-003: High quality neoantigens are immunoedited in long-term pancreatic cancer survivors

Luis A. Rojas, Marta Łuksza, Zachary M. Sethna, Kevin Soares, Joanne Leung, Jayon Lihm, David Hoyos, Anton Dobrin, Rajya Kappagantula, Alvin Makohon-Moore, Amber Johns, Anthony Gill, Masataka Amisaki, Pablo Guasp, Abderezak Zebboudj, Rebecca Yu, Adrienne Kaya Chandra, Zagaa Odgerel, Michel Sadelain, Erin Patterson, Christine Iacobuzio-Donahue, Benjamin D. Greenbaum, Vinod P. Balachandran
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PR-003.
https://doi.org/10.1158/1538-7445.PANCA21-PR-003
Published: 15 November 2021
View article titled, Abstract PR-003: High quality neoantigens are immunoedited in long-term pancreatic cancer survivors
Journal Articles

Abstract LB153: Emergence of a hyper-proliferative phenotype in TET2 edited human CAR T cells

Nayan Jain, Zeguo Zhao, Archana Iyer, Michael Lopez, Judith Feucht, Richard Koche, Julie Yang, Yingqian Zhan, Michel Sadelain
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB153.
https://doi.org/10.1158/1538-7445.AM2021-LB153
Published: 01 July 2021
View article titled, Abstract LB153: Emergence of a hyper-proliferative phenotype in <em>TET2</em> edited human CAR T cells
Journal Articles

Abstract LB-378: Regional delivery of clinical-grade mesothelin-targeted CAR T cells with cell-intrinsic PD-1 checkpoint blockade: Translation to a phase I trial

Stefan Kiesgen, Camille Linot, Hue T. Quach, Jasmeen Saini, Rebecca Bellis, Srijita Banerjee, Zhaohua Hou, Navin K. Chintala, Michel Sadelain, Prasad S. Adusumilli
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-378.
https://doi.org/10.1158/1538-7445.AM2020-LB-378
Published: 15 August 2020
View article titled, Abstract LB-378: Regional delivery of clinical-grade mesothelin-targeted CAR T cells with cell-intrinsic PD-1 checkpoint blockade: Translation to a phase I trial
Journal Articles

Abstract 3245: FT819 path to IND: First-of-kind off-the-shelf CAR19 T-cell for B cell malignancies

Mili Mandal, Raedun Clarke, Sjoukje van der Stegen, Chia-Wei Chang, Yi-Shin Lai, Alec Witty, Mushtaq Husain, Cheng-Jang Wu, Bi-Huei Yang, Chad Dufaud, Gloria Hsia, Helena Shaked, Laurel Stokely, Helen Chu, Mochtar Pribadi, Gilberto Hernandez, Jason ORourke, Alma Gutierrez, Ramzey Abujarour, Tom Lee, Jolanta Stefanski, Juan Zhen, Meilan Wu, Isabelle Riviere, Michel Sadelain, Bahram Valamehr
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3245.
https://doi.org/10.1158/1538-7445.AM2020-3245
Published: 15 August 2020
View article titled, Abstract 3245: FT819 path to IND: First-of-kind off-the-shelf CAR19 T-cell for B cell malignancies
Journal Articles

Abstract CT036: A phase I clinical trial of malignant pleural disease treated with regionally delivered autologous mesothelin-targeted CAR T cells: Safety and efficacy

Prasad S. Adusumilli, Marjorie G. Zauderer, Valerie W. Rusch, Roisin E. O'Cearbhaill, Amy Zhu, Daniel A. Ngai, Erin McGee, Navin K. Chintala, John C. Messinger, Alain Vincent, Elizabeth F. Halton, Claudia Diamonte, John Pineda, Shanu Modi, Stephen B. Solomon, David R. Jones, Renier J. Brentjens, Isabelle Rivière, Michel Sadelain
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT036.
https://doi.org/10.1158/1538-7445.AM2019-CT036
Published: 01 July 2019
View article titled, Abstract CT036: A phase I clinical trial of malignant pleural disease treated with regionally delivered autologous mesothelin-targeted CAR T cells: Safety and efficacy
Journal Articles

Abstract LB-073: Generation of novel single cell-derived engineered master pluripotent cell line as a renewable source for off-the-shelf TCR-less CAR T cells in support of first-of-kind clinical trial

Ramzey Abujarour, Yi-Shin Lai, Mochtar Pribadi, Tom Lee, Megan Robinson, Chelsea Ruller, Sjoukje Van der Stegen, Xiuyan Wang, Jolanta Stefanski, Juan Zhen, Jason Dinella, Greg Bonello, Janel Huffman, Helen Chu, Raedun Clarke, Alec Witty, Amanda Medcalf, Jaeger Davis, Stacey Moreno, Pieter Lindenbergh, Isabelle Riviere, Michel Sadelain, Bahram Valamehr
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-073.
https://doi.org/10.1158/1538-7445.AM2019-LB-073
Published: 01 July 2019
View article titled, Abstract LB-073: Generation of novel single cell-derived engineered master pluripotent cell line as a renewable source for off-the-shelf TCR-less CAR T cells in support of first-of-kind clinical trial
Journal Articles

Abstract LB-108: Generation of off-the-shelf TCR-less CAR-targeted cytotoxic T cells from renewable pluripotent cells for cancer immunotherapy

Raedun L. Clarke, Sjoukje van der Stegen, Tom Lee, Jorge Mansilla-Soto, Chia-wei Chang, Jeffrey Sasaki, Mushtaq Husain, Eigen Peralta, Ian Hardy, Edwin Ortiz, Isabelle Riviere, Michel Sadelain, Bahram Valamehr
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-108.
https://doi.org/10.1158/1538-7445.AM2018-LB-108
Published: 01 July 2018
View article titled, Abstract LB-108: Generation of off-the-shelf TCR-less CAR-targeted cytotoxic T cells from renewable pluripotent cells for cancer immunotherapy
Journal Articles

Abstract 2567: Novel therapeutic interventions to alleviate CAR T cell-induced cytokine release syndrome

Theodoros Giavridis, Sjoukje J. van der Stegen, Justin Eyquem, Mohamad Hamieh, Michel Sadelain
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2567.
https://doi.org/10.1158/1538-7445.AM2018-2567
Published: 01 July 2018
View article titled, Abstract 2567: Novel therapeutic interventions to alleviate CAR T cell-induced cytokine release syndrome
Journal Articles

Abstract CT078: Impact of disease burden and transplant on long-term survival after CD19 CAR therapy in adults with relapsed B-cell acute lymphoblastic leukemia

Jae H. Park, Isabelle Rivere, Xiuyan Wang, Brigitte Senechal, Kevin Curran, Craig Sauter, Yongzeng Wang, Bianca Santomasso, Daniel Li, Renier Brentjens, Michel Sadelain
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): CT078.
https://doi.org/10.1158/1538-7445.AM2017-CT078
Published: 01 July 2017
View article titled, Abstract CT078: Impact of disease burden and transplant on long-term survival after CD19 CAR therapy in adults with relapsed B-cell acute lymphoblastic leukemia
Journal Articles

Abstract 2309: T-cell development from T cell-derived induced pluripotent stem cell

Sjoukje J.C. van der Stegen, Maria Themeli, Justin Eyquem, Jorge Mansilla-Soto, Michel Sadelain
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2309.
https://doi.org/10.1158/1538-7445.AM2016-2309
Published: 15 July 2016
View article titled, Abstract 2309: T-cell development from T cell-derived induced pluripotent stem cell
Journal Articles

Abstract IA07: Chimeric antigen receptor T cells for cancer immunotherapy

Kevin J. Curran, Lewis B. Silverman, Rachel Kobos, Nancy A. Kernan, Steven P. Margossian, Jae H. Park, Craig S. Sauter, Victoria Szenes, Xiuyan Wang, Richard J. O'Reilly, Michel Sadelain, Isabelle Riviere, Reiner J. Brentjens
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): IA07.
https://doi.org/10.1158/1538-7445.PEDCA15-IA07
Published: 04 April 2016
View article titled, Abstract IA07: Chimeric antigen receptor T cells for cancer immunotherapy
Journal Articles

Abstract B27: A preclinical mouse model of orthotopic pleural cancer that facilitates noninvasive quantitative monitoring of tumor progression and therapy response

Elliot L. Servais, Marissa C. Velez, Valerie W. Rusch, Michel Sadelain, Prasad S. Adusumilli
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): B27.
https://doi.org/10.1158/0008-5472.FBCR09-B27
Published: 28 October 2014
View article titled, Abstract B27: A preclinical mouse model of orthotopic pleural cancer that facilitates noninvasive quantitative monitoring of tumor progression and therapy response
Journal Articles

Abstract CT102: Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia

Michel Sadelain, Renier Brentjens, Marco Davila, Isabelle Riviere, Xiuyan Wang, Shirley Bartido, Jae Park, Diana Bouhassira, Kevin Curran, Stephen Chung, Jolanta Stefanski, Oriana Borquez-Ojeda, Sergio Giralt
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): CT102.
https://doi.org/10.1158/1538-7445.AM2014-CT102
Published: 01 October 2014
View article titled, Abstract CT102: Efficacy and toxicity management of 19-28z CAR T cell therapy in B cell acute lymphoblastic leukemia
Journal Articles

PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD

Arnab Ghosh, Amanda M. Holland, Yildirim Dogan, Nury L. Yim, Uttam K. Rao, Lauren F. Young, Mallory L. West, Natalie V. Singer, Hae Lee, Il-Kang Na, Jennifer J. Tsai, Robert R. Jenq, Olaf Penack, Alan M. Hanash, Cecilia Lezcano, George F. Murphy, Chen Liu, Michel Sadelain, Martin G. Sauer, Derek Sant'Angelo, Marcel R.M. van den Brink
Journal: Cancer Research
Cancer Res (2013) 73 (15): 4687–4696.
https://doi.org/10.1158/0008-5472.CAN-12-4699
Published: 31 July 2013
View article titled, PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD
Open the PDF for PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD in another window
Includes: Supplementary data
Journal Articles

Abstract 2748: Prostate-specific inhibition of PI3 Kinase and protein synthesis as a therapy for advanced hormone-refractory prostate cancer

Daniele Baiz, Young A Choi, Yelena Karpova, Dana Yancey, Sazzad Hassan, Michel Sadelain, Waldemar Debinski, George Kulik
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2748.
https://doi.org/10.1158/1538-7445.AM2012-2748
Published: 15 April 2012
View article titled, Abstract 2748: Prostate-specific inhibition of PI3 Kinase and protein synthesis as a therapy for advanced hormone-refractory prostate cancer
Journal Articles

Abstract 3499: CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma

Reuben Benjamin, Maud Condomines, Gertrude Gunset, Michel Sadelain
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3499.
https://doi.org/10.1158/1538-7445.AM2012-3499
Published: 15 April 2012
View article titled, Abstract 3499: CD56 targeted chimeric antigen receptors for immunotherapy of multiple myeloma
Journal Articles

Abstract 4743: Genetically engineered allogeneic T Cells for BMT immunotherapy: Expression of TRAIL and PLZF selectively enhances GVT and abrogates GVHD

Arnab Ghosh, Amanda M. Holland, Yildirim Dogan, Nury Yim, Uttam K. Rao, Lauren F. Young, Odette M. Smith, Robert Jenq, Il-Kang Na, Jennifer J. Tsai, Natalie Singer, Mallory West, Olaf Penack, Alan M. Hanash, Derek Sant'Angelo, Michel Sadelain, Marcel RM van den Brink
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4743.
https://doi.org/10.1158/1538-7445.AM2011-4743
Published: 15 April 2011
View article titled, Abstract 4743: Genetically engineered allogeneic T Cells for BMT immunotherapy: Expression of TRAIL and PLZF selectively enhances GVT and abrogates GVHD