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Michael T. McCabe
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Journal Articles

Abstract 2994: Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents

Melissa B. Pappalardi, Mark Cockerill, Jessica L. Handler, Alexandra Stowell, Kathryn Keenan, Christian S. Sherk, Elisabeth A. Minthorn, Charles F. McHugh, Charlotte Burt, Kristen Wong, David T. Fosbenner, Mehul Patel, Jacques Briand, Helai Mohammad, Lourdes Rueda, Andrew Benowitz, Rab Prinjha, Dirk Heerding, Ryan G. Kruger, Ali Raoof, Allan Jordan, Bryan W. King, Michael T. McCabe
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2994.
https://doi.org/10.1158/1538-7445.AM2018-2994
Published: 01 July 2018
View article titled, Abstract 2994: Discovery of selective, noncovalent small molecule inhibitors of DNMT1 as an alternative to traditional DNA hypomethylating agents
Journal Articles

Abstract 5379: A potent EZH2 inhibitor exhibits long residence time and anti-tumor activity

Heidi Ott, Glenn van Aller, Jessica Ward, BaoChau Le, Cynthia Rominger, James Foley, Susan Korenchuk, Charles McHugh, Michael Butticello, Charles Blackledge, James Brackley, Joelle Burgess, Celine Duquenne, Neil Johnson, Jiri Kasparec, Louis LaFrance, Mei Li, Kenneth McNulty, Kenneth Newlander, Stuart Romeril, Stanley Schmidt, Mark Schulz, Dai-Shi Su, Dominic Suarez, Xinrong Tian, Christopher Carpenter, Juan Luengo, Ryan Kruger, Steven Knight, Michael T. McCabe
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5379.
https://doi.org/10.1158/1538-7445.AM2015-5379
Published: 01 August 2015
View article titled, Abstract 5379: A potent EZH2 inhibitor exhibits long residence time and anti-tumor activity
Journal Articles

Abstract 3514: A novel inhibitor of IDH1 abrogates 2-HG production and reverses aberrant epigenetic alterations in IDH1 mutant cells

Cynthia Rominger, Chad Quinn, Enoch Gao, Beth Pietrak, Alan Rendina, Angela Smallwood, Arthur Groy, Susan Korenchuk, Charles McHugh, Ken Wiggall, Alexander Reif, Stanley Schmidt, Hongwei Qi, Huizhen Zhao, Nestor Concha, Christopher Carpenter, Juan Luengo, Ryan Kruger, Benjamin Schwartz, Nicholas Adams, Michael T. McCabe
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3514.
https://doi.org/10.1158/1538-7445.AM2015-3514
Published: 01 August 2015
View article titled, Abstract 3514: A novel inhibitor of IDH1 abrogates 2-HG production and reverses aberrant epigenetic alterations in IDH1 mutant cells
Journal Articles

Abstract 5151: A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hyper-trimethylation

Heidi Ott, Alan Graves, Melissa Pappalardi, Ryan Kruger, Peter Tummino, Caretha Creasy, Michael T. McCabe
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5151.
https://doi.org/10.1158/1538-7445.AM2014-5151
Published: 01 October 2014
View article titled, Abstract 5151: A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hyper-trimethylation
Journal Articles

Abstract 4700: A novel selective EZH2 inhibitor exhibits anti-tumor activity in lymphoma with EZH2 activating mutations

Caretha L. Creasy, Michael T. McCabe, Susan Korenchuk, Elsie Diaz, Heidi Ott, Christine S. Thompson, Gopi Ganji, Shelby A. Gorman, Louis V. LaFrance, Martin Brandt, Charles McHugh, Sharad K. Verma, Peter J. Tummino
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 4700.
https://doi.org/10.1158/1538-7445.AM2012-4700
Published: 15 April 2012
View article titled, Abstract 4700: A novel selective EZH2 inhibitor exhibits anti-tumor activity in lymphoma with EZH2 activating mutations
Journal Articles

Abstract 1057: Mutation of EZH2 A677 in human B-cell lymphoma promotes hyper-trimethylation of H3K27

Michael T. McCabe, Alan P. Graves, Gopinath Ganji, Heidi Ott, Elsie Diaz, Wendy S. Halsey, Yong Jiang, Kimberly N. Smitheman, Melissa B. Pappalardi, Kimberly E. Allen, Stephanie Chen, Anthony Della-Pietra, Edward Dul, Ashley M. Hughes, Sara H. Thrall, Peter J. Tummino, Ryan G. Kruger, Martin Brandt, Benjamin Schwartz, Sharad K. Verma, Caretha L. Creasy
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1057.
https://doi.org/10.1158/1538-7445.AM2012-1057
Published: 15 April 2012
View article titled, Abstract 1057: Mutation of EZH2 A677 in human B-cell lymphoma promotes hyper-trimethylation of H3K27
Journal Articles

Abstract 2939: Discovery and synthesis of highly potent and selective small molecule inhibitors of the histone methyltransferase EZH2

Sharad K. Verma, Louis V. LaFrance, Xinrong Tian, Ken Newlander, Céline Duquenne, Dominic Suarez, Steven D. Knight, Joelle Burgess, James Brackley, Neil W. Johnson, Alan P. Graves, Mark Mellinger, Stuart Romeril, Seth W. Grant, Daryl Scherzer, Art Shu, Caretha L. Creasy, Ryan Kruger, Elsie Diaz, Baochau Le, Christine Thompson, Heidi Morgan-Ott, Michael T. McCabe, Charles F. McHugh, William H. Miller, Peter Tummino, Dash Dhanak
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2939.
https://doi.org/10.1158/1538-7445.AM2012-2939
Published: 15 April 2012
View article titled, Abstract 2939: Discovery and synthesis of highly potent and selective small molecule inhibitors of the histone methyltransferase EZH2
Journal Articles

Abstract LB-186: Somatic Y641 mutations in EZH2 alter the balance of di- and tri-methylation of H3K27 in diffuse large B-cell lymphomas

Elsie Diaz, Michael T. McCabe, Yong Jiang, Stephanie Chen, Melissa Pappalardi, Kimberly Smitheman, Anthony Della Pietra, Alan Graves, Ryan Kruger, Martin Brandt, Sharon Sweitzer, Benjamin Schwartz, Peter J. Tummino, Caretha L. Creasy
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): LB-186.
https://doi.org/10.1158/1538-7445.AM2011-LB-186
Published: 15 April 2011
View article titled, Abstract LB-186: Somatic Y641 mutations in EZH2 alter the balance of di- and tri-methylation of H3K27 in diffuse large B-cell lymphomas
Journal Articles

A Multifactorial Signature of DNA Sequence and Polycomb Binding Predicts Aberrant CpG Island Methylation

Michael T. McCabe, Eva K. Lee, Paula M. Vertino
Journal: Cancer Research
Cancer Res (2009) 69 (1): 282–291.
https://doi.org/10.1158/0008-5472.CAN-08-3274
Published: 31 December 2008
View article titled, A Multifactorial Signature of DNA Sequence and Polycomb Binding Predicts Aberrant CpG Island Methylation
Open the PDF for A Multifactorial Signature of DNA Sequence and Polycomb Binding Predicts Aberrant CpG Island Methylation in another window
Includes: Supplementary data
Journal Articles

Inhibition of DNA Methyltransferase Activity Prevents Tumorigenesis in a Mouse Model of Prostate Cancer

Michael T. McCabe, Jonathan A. Low, Stephanie Daignault, Michael J. Imperiale, Kirk J. Wojno, Mark L. Day
Journal: Cancer Research
Cancer Res (2006) 66 (1): 385–392.
https://doi.org/10.1158/0008-5472.CAN-05-2020
Published: 05 January 2006
View article titled, Inhibition of DNA Methyltransferase Activity Prevents Tumorigenesis in a Mouse Model of Prostate Cancer
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Includes: Supplementary data
Journal Articles

Disruption of Rb/E2F Pathway Results in Increased Cyclooxygenase-2 Expression and Activity in Prostate Epithelial Cells

Joanne N. Davis, Michael T. McCabe, Simon W. Hayward, John M. Park, Mark L. Day
Journal: Cancer Research
Cancer Res (2005) 65 (9): 3633–3642.
https://doi.org/10.1158/0008-5472.CAN-04-3129
Published: 02 May 2005
View article titled, Disruption of Rb/E2F Pathway Results in Increased Cyclooxygenase-2 Expression and Activity in Prostate Epithelial Cells
Open the PDF for Disruption of Rb/E2F Pathway Results in Increased Cyclooxygenase-2 Expression and Activity in Prostate Epithelial Cells in another window
Journal Articles

Regulation of DNA Methyltransferase 1 by the pRb/E2F1 Pathway

Michael T. McCabe, Joanne N. Davis, Mark L. Day
Journal: Cancer Research
Cancer Res (2005) 65 (9): 3624–3632.
https://doi.org/10.1158/0008-5472.CAN-04-2158
Published: 02 May 2005
View article titled, Regulation of DNA Methyltransferase 1 by the pRb/E2F1 Pathway
Open the PDF for Regulation of DNA Methyltransferase 1 by the pRb/E2F1 Pathway in another window